公开(公告)号：US11179397B2

公开(公告)日：2021-11-23

申请号：US16591092

申请日：2019-10-02

Applicant: Gilead Sciences, Inc.

Inventor： Gregory Chin ,  Michael O' Neil Hanrahan Clarke ,  Xiaochun Han ,  Tim Hansen ,  Yunfeng Eric Hu ,  Dmitry Koltun ,  Ryan McFadden ,  Michael R. Mish ,  Eric Q. Parkhill ,  David Sperandio ,  Lianhong Xu ,  Hai Yang

IPC: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  C07D471/04 ,  C07D471/10 ,  C07D519/00

Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating cancers.

公开(公告)号：US20190255085A1

公开(公告)日：2019-08-22

申请号：US16265016

申请日：2019-02-01

Applicant: GILEAD SCIENCES, INC.

Inventor： Michael O' Neil Hanrahan Clarke ,  Joy Yang Feng ,  Robert Jordan ,  Richard L. Mackman ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/706 ,  A61K31/7056

Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.

公开(公告)号：US20190194223A1

公开(公告)日：2019-06-27

申请号：US16203112

申请日：2018-11-28

Applicant: Gilead Sciences, Inc.

Inventor： Michael O' Neil Hanrahan Clarke ,  Richard L. Mackman ,  Dustin Siegel

IPC: C07D495/04 ,  C07D519/00 ,  C07H7/06 ,  C07H11/04

CPC classification number: C07D495/04 ,  C07D519/00 ,  C07H7/06 ,  C07H11/04

Abstract: Provided herein are formulations, methods and substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds.

公开(公告)号：US20190055253A1

公开(公告)日：2019-02-21

申请号：US16045371

申请日：2018-07-25

Applicant: Gilead Sciences, Inc.

Inventor： Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Richard L. Mackman ,  Dustin Siegel

IPC: C07D487/04 ,  C07F9/6561 ,  C07H7/06 ,  C07D405/04 ,  C07D405/14

CPC classification number: C07D487/04 ,  A61P31/16 ,  C07D405/04 ,  C07D405/14 ,  C07F9/6561 ,  C07H7/06

Abstract: Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds.

公开(公告)号：US20180340004A1

公开(公告)日：2018-11-29

申请号：US15950442

申请日：2018-04-11

Applicant: Gilead Sciences, Inc.

Inventor： Michael O' Neil Hanrahan Clarke ,  Richard L. Mackman ,  Dustin Siegel

IPC: C07H19/06 ,  A61K31/7072 ,  A61K31/7068 ,  C07H19/073 ,  C07H19/10

Abstract: Provided herein are formulations, methods and substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds.

公开(公告)号：US20170226140A1

公开(公告)日：2017-08-10

申请号：US15414351

申请日：2017-01-24

Applicant: Gilead Sciences, Inc.

Inventor： Michael O' Neil Hanrahan Clarke ,  Choung U. Kim ,  Willard Lew

IPC: C07F9/6558 ,  C07D487/04

CPC classification number: C07F9/65586 ,  A61K31/137 ,  A61K31/192 ,  A61K31/235 ,  A61K31/351 ,  A61K31/4965 ,  A61K31/7056 ,  A61K31/706 ,  A61K38/21 ,  A61K45/06 ,  C07D487/04 ,  C07H7/06 ,  C07H17/02 ,  A61K2300/00

Abstract: Provided are methods for treating Orthomyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein R2 is halogen. The compounds, compositions, and methods provided are particularly useful for the treatment of Human Influenza virus infections.

公开(公告)号：US20170071964A1

公开(公告)日：2017-03-16

申请号：US15267433

申请日：2016-09-16

Applicant: Gilead Sciences, Inc.

Inventor： Michael O' Neil Hanrahan Clarke ,  Joy Yang Feng ,  Robert Jordan ,  Richard L. Mackman ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/706 ,  A61K45/06

CPC classification number: A61K31/706 ,  A61K31/7056 ,  A61K2300/00

Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.

Abstract translation: 其中核苷糖的1'位置被取代。 提供的化合物，组合物和方法特别可用于治疗Lassa病毒和Junin病毒感染。

公开(公告)号：US11007208B2

公开(公告)日：2021-05-18

申请号：US16863566

申请日：2020-04-30

Applicant: GILEAD SCIENCES, INC.

Inventor： Michael O' Neil Hanrahan Clarke ,  Joy Yang Feng ,  Robert Jordan ,  Richard L. Mackman ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/7056 ,  A61K31/706

Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.

公开(公告)号：US10941177B2

公开(公告)日：2021-03-09

申请号：US16016369

申请日：2018-06-22

Applicant: Gilead Sciences, Inc.

Inventor： Michael O' Neil Hanrahan Clarke

IPC: C07H19/23 ,  A61K31/706 ,  A61K45/06 ,  C07H19/12

Abstract: Provided are compounds of Formula I, as well as pharmaceutical compositions containing compounds of Formula I and methods for treating Orthomyxoviridae virus infections by administering these compounds. The compounds, compositions, and methods provided are particularly useful for the treatment of Human Influenza virus infections.

公开(公告)号：US20200087337A1

公开(公告)日：2020-03-19

申请号：US16565888

申请日：2019-09-10

Applicant: Gilead Sciences, Inc.

Inventor： Michael O' Neil Hanrahan Clarke ,  Richard L. Mackman ,  Dustin Siegel

IPC: C07H19/06 ,  C07H19/10 ,  C07H19/073 ,  A61K31/7068 ,  A61K31/7072

Abstract: Provided herein are formulations, methods and substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds.