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公开(公告)号：US20100303857A1
公开(公告)日：2010-12-02
申请号：US12612625
申请日：2009-11-04
申请人： Gary J. Nabel , Zhi-yong Yang , Nancy Sullivan , Anthony Sanchez
发明人： Gary J. Nabel , Zhi-yong Yang , Nancy Sullivan , Anthony Sanchez
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/55522 , A61K2039/70 , C12N2710/10343 , C12N2760/14122 , C12N2760/14134 , C12N2760/14222
摘要： The present invention relates generally to viral vaccines and, more specifically, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by infection with filovirus.
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12.发明申请公开(公告)号：US20100298414A1
公开(公告)日：2010-11-25
申请号：US12612621
申请日：2009-11-04
申请人： Gary J. Nabel , Zhi-yong Yang , Nancy Sullivan , Anthony Sanchez
发明人： Gary J. Nabel , Zhi-yong Yang , Nancy Sullivan , Anthony Sanchez
IPC分类号： A61K31/7088 , A61P37/04
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/55522 , A61K2039/70 , C12N2710/10343 , C12N2760/14122 , C12N2760/14134 , C12N2760/14222
摘要： The present invention relates generally to viral vaccines and, more specifically, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by infection with filovirus.
摘要翻译： 本发明一般涉及病毒疫苗，更具体地涉及针对由病毒感染引起的病毒或疾病引起免疫应答的病毒疫苗和方法。
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公开(公告)号：US08637036B2
公开(公告)日：2014-01-28
申请号：US13429286
申请日：2012-03-23
申请人： John R. Mascola , Richard T. Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary J. Nabel , Peter D. Kwong , Tongqing Zhou , Mark Connors , William R. Schief
发明人： John R. Mascola , Richard T. Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary J. Nabel , Peter D. Kwong , Tongqing Zhou , Mark Connors , William R. Schief
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2740/10011 , C12N2740/16011 , C12N2740/16111
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
摘要翻译： 公开了特异性结合HIV-1 gp120的CD4结合位点的单克隆中和抗体。 还公开了特异性结合HIV-1 gp41的单克隆中和抗体。 还公开了这些抗体的鉴定，以及这些抗体的用途。 还提供了用于增强使用表位支架探针的任何抗体的结合和中和活性的方法。
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公开(公告)号：US20120244166A1
公开(公告)日：2012-09-27
申请号：US13429279
申请日：2012-03-23
申请人： John R. Mascola , Richard T. Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary J. Nabel , Peter D. Kwong , Tongqing Zhou , Mark Connors , Gilad Ofek , Lawrence Shapiro , Jiang Zhu , William R. Schief
发明人： John R. Mascola , Richard T. Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary J. Nabel , Peter D. Kwong , Tongqing Zhou , Mark Connors , Gilad Ofek , Lawrence Shapiro , Jiang Zhu , William R. Schief
IPC分类号： A61K39/395 , C12N15/63 , C12N1/21 , C12N1/19 , A61P31/18 , C12N15/74 , G01N21/64 , C07K16/10 , C12N15/13 , C12N9/96 , C12N5/10
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2740/10011 , C12N2740/16011 , C12N2740/16111
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and uses of these antibodies, are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
摘要翻译： 公开了特异性结合HIV-1 gp120的CD4结合位点的单克隆中和抗体。 还公开了特异性结合HIV-1 gp41的单克隆中和抗体。 还公开了这些抗体的鉴定以及这些抗体的用途。 还提供了用于增强使用表位支架探针的任何抗体的结合和中和活性的方法。
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公开(公告)号：US5863904A
公开(公告)日：1999-01-26
申请号：US533942
申请日：1995-09-26
申请人： Gary J. Nabel , Zhi-yong Yang , Elizabeth G. Nabel
发明人： Gary J. Nabel , Zhi-yong Yang , Elizabeth G. Nabel
IPC分类号： C12N15/09 , A01N43/04 , A61K31/00 , A61K31/70 , A61K35/76 , A61K38/00 , A61K38/17 , A61K48/00 , A61P9/00 , A61P35/00 , C07K14/47 , C12N7/00 , C12N15/00 , C12N15/63 , C12N15/85 , C12R1/645 , C12N15/79
CPC分类号： C07K14/4703 , A61K38/1709 , A61K48/00
摘要： The p21 gene encodes a cyclin dependent kinase inhibitor which affects cell cycle progression, but the role of this gene product in altering tumor growth has not been established. The present inventors have now discovered that the growth of malignant cells in vivo is inhibited by expression of p21. Expression of p21 resulted in an accumulation of cells in G.sub.0 /G.sub.1, alteration in morphology, and cell differentiation.
摘要翻译： p21基因编码影响细胞周期进程的细胞周期蛋白依赖性激酶抑制剂，但该基因产物在改变肿瘤生长中的作用尚未确定。 本发明人现已发现，通过p21的表达抑制体内恶性细胞的生长。 p21的表达导致细胞在G0 / G1中的积累，形态的改变和细胞分化。
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公开(公告)号：US20120237523A1
公开(公告)日：2012-09-20
申请号：US13429286
申请日：2012-03-23
申请人： John R. Mascola , Richard T. Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary J. Nabel , Peter D. Kwong , Tongqing Zhou , Mark Connors , Gilad Ofek , Lawrence Shapiro , Jiang Zhu , William R. Schief
发明人： John R. Mascola , Richard T. Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary J. Nabel , Peter D. Kwong , Tongqing Zhou , Mark Connors , Gilad Ofek , Lawrence Shapiro , Jiang Zhu , William R. Schief
IPC分类号： A61K39/42 , C12N15/13 , A61P31/18 , G01N33/566 , G01N33/569 , C12N1/21 , C12N5/10 , C12N1/19 , C07K16/10 , C12N15/63
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2740/10011 , C12N2740/16011 , C12N2740/16111
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
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公开(公告)号：US08106027B2
公开(公告)日：2012-01-31
申请号：US12612621
申请日：2009-11-04
申请人： Gary J. Nabel , Zhi-yong Yang , Nancy Sullivan , Anthony Sanchez
发明人： Gary J. Nabel , Zhi-yong Yang , Nancy Sullivan , Anthony Sanchez
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/55522 , A61K2039/70 , C12N2710/10343 , C12N2760/14122 , C12N2760/14134 , C12N2760/14222
摘要： The present invention relates generally to viral vaccines and, more specifically, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by infection with filovirus.
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公开(公告)号：US20100068217A1
公开(公告)日：2010-03-18
申请号：US12438913
申请日：2007-08-24
申请人： Peter D. Kwong , Gilad Ofek , Javier Guenaga , Richard Wyatt , Zhi-yong Yang , Tongqing Zhou , Gary J Nabel , Min Tang , William Schief , David Baker
发明人： Peter D. Kwong , Gilad Ofek , Javier Guenaga , Richard Wyatt , Zhi-yong Yang , Tongqing Zhou , Gary J Nabel , Min Tang , William Schief , David Baker
CPC分类号： G16B15/00
摘要： Computational protocols for the design of epitope-protein scaffolds which elicit selected neutralizing antibodies are disclosed, and related compositions and uses.
摘要翻译： 公开了引发选定的中和抗体的表位 - 蛋白质支架设计的计算方案，以及相关的组合物和用途。
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公开(公告)号：US08124592B2
公开(公告)日：2012-02-28
申请号：US12612625
申请日：2009-11-04
申请人： Gary J. Nabel , Zhi-yong Yang , Nancy Sullivan , Anthony Sanchez
发明人： Gary J. Nabel , Zhi-yong Yang , Nancy Sullivan , Anthony Sanchez
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/55522 , A61K2039/70 , C12N2710/10343 , C12N2760/14122 , C12N2760/14134 , C12N2760/14222
摘要： The present invention relates generally to viral vaccines and, more specifically, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by infection with filovirus.
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20.发明授权Combination for site-specifically transforming cells in vivo comprising a double-balloon catheter and nucleic acid comprising a gene encoding P21 失效用于体内特异性转化体内的细胞的组合，包括双气囊导管和包含编码P21的基因的核酸公开(公告)号：US07087582B1
公开(公告)日：2006-08-08
申请号：US09663889
申请日：2000-09-18
申请人： Gary J. Nabel , Zhi-yong Yang , Elizabeth G. Nabel
发明人： Gary J. Nabel , Zhi-yong Yang , Elizabeth G. Nabel
CPC分类号： C12N15/86 , A61K9/0019 , A61K31/70 , A61K31/711 , A61K38/1709 , A61K38/1774 , A61K38/45 , A61K48/005 , C12N2710/10343 , A61K2300/00
摘要： The present invention provides a combination including a double-balloon catheter and a nucleic acid encoding the cyclin dependent kinase inhibitor p21. The nucleic acid may also encode HLA-B7, an immunotherapeutic agent, a cytokine or a prodrug converting enzyme.
摘要翻译： 本发明提供了包括双气囊导管和编码细胞周期蛋白依赖性激酶抑制剂p21的核酸的组合。 核酸还可以编码HLA-B7，免疫治疗剂，细胞因子或前药转化酶。
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