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    Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
    18.
    发明申请
    Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis 审中-公开
    用于诊断和治疗涉及血管生成的疾病的组合物和方法

    公开(公告)号：US20040043927A1

    公开(公告)日：2004-03-04

    申请号：US10081056

    申请日：2002-02-20

    Applicant: GENENTECH, INC.

    Inventor： Kevin P. Baker ,  Napoleone Ferrara ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Scot A. Marsters ,  James Pan ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Weilan Ye

    IPC: A61K038/17 ,  C07H021/04 ,  C12N009/00 ,  C12P021/02 ,  C12N005/06 ,  C07K014/435

    CPC classification number: C07K14/515 ,  A61K38/00 ,  C07K2319/00 ,  G01N2800/32

    Abstract: Compositions and methods are disclosed for stimulating or inhibiting angiogeniesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

    Abstract translation: 公开了用于刺激或抑制包括人在内的哺乳动物的血管生成和/或心血管化的组合物和方法。 药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。 可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如创伤，各种癌症和血管障碍，包括动脉粥样硬化和心脏肥大。 此外，本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

    Methods and compositions for detection and quantitation of nucleic acid analytes
    19.
    发明申请
    Methods and compositions for detection and quantitation of nucleic acid analytes 审中-公开
    用于检测和定量核酸分析物的方法和组合物

    公开(公告)号：US20040009506A1

    公开(公告)日：2004-01-15

    申请号：US10401520

    申请日：2003-03-28

    Applicant: GENENTECH, INC.

    Inventor： Jean-Philippe F. Stephan ,  Siao Ping Tsai ,  Wai Lee Tan Wong ,  Todd Billeci

    IPC: C12Q001/68

    CPC classification number: C12Q1/6837 ,  C12Q1/682 ,  C12Q2525/161 ,  C12Q2537/125 ,  C12Q2565/519 ,  C12Q2525/101 ,  C12Q2563/131

    Abstract: The present invention provides novel solution phase hybridization-based methods for detecting and quantitating nucleic acid analytes. Methods comprising use of novel capture polymers and/or signaling systems are provided. Use of these novel capture polymers and/or signaling systems provides significant improvements in signal to noise ratio, specificity, sensitivity and ease of development and use as compared to existing solution phase nucleic acid detection and quantitation methods. The invention further provides compositions, kits and articles of manufacture for practicing methods of the present invention.

    Abstract translation: 本发明提供了用于检测和定量核酸分析物的新型溶液相杂交方法。 提供了包括使用新的捕获聚合物和/或信号系统的方法。 与现有的溶液相核酸检测和定量方法相比，这些新型捕获聚合物和/或信号系统的使用提供了信噪比，特异性，灵敏度和易于开发和使用的显着改善。 本发明还提供了用于本发明的实践方法的组合物，试剂盒和制品。

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