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    Synthesis of tetramisole, levamisole and their derivatives
    13.
    发明授权
    Synthesis of tetramisole, levamisole and their derivatives 失效
    四咪唑，左旋咪唑及其衍生物的合成

    公开(公告)号：US4370482A

    公开(公告)日：1983-01-25

    申请号：US315788

    申请日：1981-10-28

    申请人： Sivaraman Raghu ,  Arthur K. Hoffmann ,  Balwant Singh

    发明人： Sivaraman Raghu ,  Arthur K. Hoffmann ,  Balwant Singh

    IPC分类号： C07D233/32 ,  C07D233/38 ,  C07D233/42 ,  C07D233/70 ,  C07D513/04

    CPC分类号： C07D233/42 ,  C07D233/32 ,  C07D233/38 ,  C07D233/70

    摘要： A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives, and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of the anthelmintic levamisole, (-)-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazols, and its derivatives through conventional resolution procedures. The new process also permits the direct manufacture of optically active 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidone and their 3-acylated derivatives, optically active 1-(2-alkoxyethyl)-4-phenylimidazolidine-2-thiones, and levamisole, the levorotatory isomer of tetramisole, using catalytic amounts of a chiral reducing agent, with the elimination of conventional resolution procedures.

    摘要翻译： 1-（2-烷氧基乙基）-4-苯基-4-咪唑啉-2-酮，1-（2-烷氧基乙基）-4-苯基-2-咪唑烷酮，1-（2-烷氧基乙基） 4-苯基 - 咪唑烷-2-硫酮，某些相应的1-（2-羟基乙基）衍生物及其3-酰化衍生物以及某些相关化合物，其在制备驱虫剂的新方法中都可用作中间体 左旋咪唑，（ - ） - 2,3,5,6-四氢-6-苯基咪唑并[2,1-b]噻唑及其衍生物。 光学活性的1-（2-烷氧基乙基）-4-苯基-2-咪唑烷酮及其3-酰化衍生物，光学活性的1-（2-烷氧基乙基）-4-苯基咪唑烷-2-硫杂 和左旋咪唑，左旋咪唑的左旋异构体，使用催化量的手性还原剂，消除常规拆分方法。

    Synthesis of tetramisole, levamisole and their derivatives
    14.
    发明授权
    Synthesis of tetramisole, levamisole and their derivatives 失效
    四咪唑，左旋咪唑及其衍生物的合成

    公开(公告)号：US4314066A

    公开(公告)日：1982-02-02

    申请号：US878049

    申请日：1978-02-15

    申请人： Sivaraman Raghu ,  Arthur K. Hoffmann ,  Balwant Singh

    发明人： Sivaraman Raghu ,  Arthur K. Hoffmann ,  Balwant Singh

    IPC分类号： C07D233/32 ,  C07D233/38 ,  C07D233/42 ,  C07D233/70

    CPC分类号： C07D233/32 ,  C07D233/38 ,  C07D233/42 ,  C07D233/70

    摘要： A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives, and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of the anthelmintic levamisole, (-)-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives through conventional resolution procedures. The new process also permits the direct manufacture of optically active 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidone and their 3-acylated derivatives, optically active 1-(2-alkoxyethyl)-4-phenylimidazolidine-2-thiones, and levamisole, the levorotatory isomer of tetramisole, using catalytic amounts of a chiral reducing agent, with the elimination of conventional resolution procedures.

    摘要翻译： 1-（2-烷氧基乙基）-4-苯基-4-咪唑啉-2-酮，1-（2-烷氧基乙基）-4-苯基-2-咪唑烷酮，1-（2-烷氧基乙基） 4-苯基 - 咪唑烷-2-硫酮，某些相应的1-（2-羟基乙基）衍生物及其3-酰化衍生物以及某些相关化合物，其在制备驱虫剂的新方法中都可用作中间体 左旋咪唑，（ - ） - 2,3,5,6-四氢-6-苯基咪唑并[2,1-b]噻唑及其衍生物。 光学活性的1-（2-烷氧基乙基）-4-苯基-2-咪唑烷酮及其3-酰化衍生物，光学活性的1-（2-烷氧基乙基）-4-苯基咪唑烷-2-硫杂 和左旋咪唑，左旋咪唑的左旋异构体，使用催化量的手性还原剂，消除常规拆分方法。

    Synthesis of ethambutol
    15.
    发明授权
    Synthesis of ethambutol 失效
    乙胺丁醇的合成

    公开(公告)号：US3944618A

    公开(公告)日：1976-03-16

    申请号：US493802

    申请日：1974-08-01

    申请人： Balwant Singh

    发明人： Balwant Singh

    IPC分类号： C07C89/00 ,  C07C89/04 ,  C07C91/04

    CPC分类号： C07C231/10 ,  C07C233/13 ,  C07C249/02 ,  C07C257/02 ,  C07B2200/07 ,  Y02P20/582

    摘要： D-2-Amino-1-butanol, for the synthesis of ethambutol hydrochloride, d,d'-2,2'-(ethylenediimino)di-1-butanol dihydrochloride, is produced in high purity and good yields by the reaction of butene-1, a nitrile, preferably an excess of acetonitrile, and chlorine to form N-[1-(chloromethyl)propyl]acetimidoyl chloride which is hydrolyzed to dl-2-amino-1-butanol, which can be isolated as the hydrochloride, or free base, or a mixture, resolved with L(+)-tartaric acid and the d-2-amino-1-butanol reacted with ethylene dichloride and then hydrochloric acid to form ethambutol hydrochloride. A minimum of by-products which are conveniently split out permits the economical synthesis of a pharmaceutical grade product.

    摘要翻译： 用于合成乙胺丁醇盐酸盐d，d'-2,2' - （乙二胺基）二-1-丁醇二盐酸盐的D-2-氨基-1-丁醇通过丁烯反应以高纯度和良好的收率生产 -1，腈，优选过量的乙腈和氯，以形成水解成dl-2-氨基-1-丁醇的N- [1-（氯甲基）丙基]亚氨代乙酰氯，其可以作为盐酸盐分离， 或游离碱或混合物，用L（+） - 酒石酸和d-2-氨基-1-丁醇分解，与二氯乙烷反应，然后与盐酸反应，形成乙胺丁醇盐酸盐。 方便分开的最少副产物允许经济地合成药物级产品。

    Digital circuit for frequency and timing characterization
    16.
    发明授权
    Digital circuit for frequency and timing characterization 有权
    用于频率和时序表征的数字电路

    公开(公告)号：US07242179B2

    公开(公告)日：2007-07-10

    申请号：US11023054

    申请日：2004-12-27

    申请人： Ruchir Saraswat ,  Balwant Singh ,  Hina Mushir

    发明人： Ruchir Saraswat ,  Balwant Singh ,  Hina Mushir

    IPC分类号： G01R31/28

    CPC分类号： G01R31/31727 ,  G01R31/31922

    摘要： A digital circuit operating frequency characterizer provides a combination of frequency and duty cycle characterization. The digital circuit operating frequency characterizer includes a programmable frequency generator, a programmable edge variator, a test engine, and a control circuit. The programmable frequency generator provides one or more output signals, and the programmable edge variator is coupled to one or more outputs of the programmable frequency generator for adjusting duty cycle. The test engine uses the outputs from the programmable edge variator and/or programmable frequency generator to apply a defined test signal sequence to a circuit under test and produce a status output after evaluating the outputs received from the circuit under test. The control circuit is connected to the control inputs of the programmable frequency generator, programmable edge variator, and the status output of the test engine. The control circuit synchronizes their operations and performs the combination of frequency and duty cycle characterization.

    摘要翻译： 数字电路工作频率表征器提供频率和占空比表征的组合。 数字电路工作频率表征器包括可编程频率发生器，可编程边缘变换器，测试引擎和控制电路。 可编程频率发生器提供一个或多个输出信号，并且可编程边缘变换器耦合到可编程频率发生器的一个或多个输出端，用于调整占空比。 测试引擎使用可编程边沿变换器和/或可编程频率发生器的输出，将定义的测试信号序列应用于被测电路，并在评估从被测电路接收的输出后产生状态输出。 控制电路连接到可编程频率发生器，可编程边沿变换器和测试引擎的状态输出的控制输入。 控制电路使其操作同步并执行频率和占空比表征的组合。

    On-chip storage memory for storing variable data bits
    17.
    发明申请
    On-chip storage memory for storing variable data bits 有权
    用于存储可变数据位的片上存储器

    公开(公告)号：US20050232028A1

    公开(公告)日：2005-10-20

    申请号：US11102463

    申请日：2005-04-08

    申请人： Swapnil Bahl ,  Balwant Singh

    发明人： Swapnil Bahl ,  Balwant Singh

    IPC分类号： G06F5/06 ,  G06F5/10 ,  G11C7/10 ,  G11C5/00

    CPC分类号： G06F5/10 ,  G11C7/1006

    摘要： An improved on-chip storage memory and method for storing variable data bits, the memory including an on-chip storage memory system for storing variable data bits that has a memory for storing data bits, a wrapper for converting the memory into a first-in first-out (FIFO) memory, and a controller for performing operations on the memory. In operation, the memory is converted into a FIFO memory after storing data, and output logic selects data to be output in a serial manner.

    摘要翻译： 一种用于存储可变数据位的改进的片上存储器和方法，所述存储器包括用于存储具有用于存储数据位的存储器的可变数据位的片上存储存储器系统，用于将存储器转换为先进先出 先进先出（FIFO）存储器和用于对存储器执行操作的控制器。 在操作中，存储器在存储数据之后被转换为FIFO存储器，并且输出逻辑选择要以串行方式输出的数据。

    Vinyl-terminated and carbamylmethylated nitrogen-containing heterocyclic compounds
    19.
    发明授权
    Vinyl-terminated and carbamylmethylated nitrogen-containing heterocyclic compounds 失效
    乙烯基封端和氨甲酰甲基化含氮杂环化合物

    公开(公告)号：US5410051A

    公开(公告)日：1995-04-25

    申请号：US79184

    申请日：1993-06-17

    申请人： Peter S. Forgione ,  William A. Henderson ,  Balwant Singh ,  Yuhshi Luh

    发明人： Peter S. Forgione ,  William A. Henderson ,  Balwant Singh ,  Yuhshi Luh

    IPC分类号： C07D251/70 ,  C08F290/14 ,  C08F299/06 ,  C08L75/16 ,  C09D4/06 ,  C09J4/06 ,  C09J175/16 ,  C07D251/54 ,  C07D487/04

    CPC分类号： C09J175/16 ,  C07D251/70 ,  C08F290/14 ,  C08F299/06 ,  C08L75/16 ,  C09D4/06 ,  C09J4/06

    摘要： Disclosed are novel nitrogen containing heterocyclic compounds and novel vinyl terminated polyurethane/polyamide polymers together with the use of both of these compounds in a novel adhesive and coating composition. The nitrogen containing heterocyclic compounds of the invention contain two vinyl-terminated substituents and at least one carbamylmethyl substituent and have a nucleus selected from melamine, oligomers of melamine, benzoguanamine, and oligomers of benzoguanamine, glycoluril and oligomers of glycoluril, cyclohexylguanamine, oligomers of cyclohexylguanamine, acetoguanamine, and oligomers of acetoguanamine. The vinyl terminated polyurethane compounds of the invention have a molecular weight of from about 3000 to about 80000, and contain at least two vinyl end groups.

    摘要翻译： 公开了新颖的含氮杂环化合物和新颖的乙烯基封端的聚氨酯/聚酰胺聚合物，以及在新的粘合剂和涂料组合物中使用这两种化合物。 本发明的含氮杂环化合物含有两个乙烯基封端的取代基和至少一个氨甲酰甲基取代基，并具有选自三聚氰胺，三聚氰胺，苯并胍胺的低聚物，苯并胍胺，甘脲和甘脲的低聚物，环己基胍胺，环己基胍胺的低聚物 ，乙酰胍胺和乙酰胍胺的低聚物。 本发明的乙烯基封端的聚氨酯化合物的分子量为约3000至约80000，并含有至少两个乙烯基端基。

    Heat resistant resin composition comprising polymers of N-(substituted) maleimides and improved process for the preparation of said maleimides
    20.
    发明授权
    Heat resistant resin composition comprising polymers of N-(substituted) maleimides and improved process for the preparation of said maleimides 失效
    耐热树脂组合物包含N-（取代）马来酰亚胺的聚合物和改进的制备所述马来酰亚胺的方法

    公开(公告)号：US5314950A

    公开(公告)日：1994-05-24

    申请号：US7225

    申请日：1993-01-22

    申请人： Balwant Singh ,  Robert J. Tynik

    发明人： Balwant Singh ,  Robert J. Tynik

    IPC分类号： C08F22/36 ,  C08F22/40 ,  C08F291/00 ,  C08F291/02 ,  C08L33/24 ,  C08L35/00 ,  C08L35/06 ,  C08L51/04 ,  C08F122/40 ,  C08F222/40

    CPC分类号： C08L35/00 ,  C08L35/06 ,  C08L51/04 ,  C08L2201/08

    摘要： Novel resin compositions are provided which possess excellent heat resistance and thermal color stability, alone, or in admixture with bulk resins. The claimed resin compositions comprise homo- and/or copolymers of N-(2,3-dimethylphenyl) maleimide, alone, or in further combination with resins composed of copolymer components, such as vinyl copolymers and rubber-grafted vinyl copolymer resins. The resin compositions have improved heat resistance and produce molded articles with desirably light colors. Also provided is an improved process to make maleimide monomers by using selected polar solvents whereby the amount of uncyclizable trans-amic acid is held at tolerable levels and the desired maleimide is obtained in high yields, free from by-products.

    摘要翻译： 提供了新的树脂组合物，它们单独具有优异的耐热性和热色稳定性，或与本体树脂混合。 所要求保护的树脂组合物包含单独的N-（2,3-二甲基苯基）马来酰亚胺或与由共聚物组分如乙烯基共聚物和橡胶接枝的乙烯基共聚物树脂组成的树脂的进一步组合的均聚物和/或共聚物。 树脂组合物具有改善的耐热性，并且生产具有期望的浅色的模塑制品。 还提供了通过使用选择的极性溶剂制备马来酰亚胺单体的改进方法，由此使可循环的反式氨基酸的量保持在可耐受水平，并且以高产率获得所需的马来酰亚胺，不含副产物。