公开(公告)号：US06592550B1

公开(公告)日：2003-07-15

申请号：US09663747

申请日：2000-09-15

申请人： Scott E. Boatman ,  David G. Burton ,  Michael C. Hoffa ,  David R. Lessard ,  David A. Drewes, Jr. ,  Maggie A. Z. Hupcey

发明人： Scott E. Boatman ,  David G. Burton ,  Michael C. Hoffa ,  David R. Lessard ,  David A. Drewes, Jr. ,  Maggie A. Z. Hupcey

IPC分类号： A61M3100

CPC分类号： C08G69/48 ,  A61L29/06 ,  C08F283/04 ,  C08L77/00 ,  C08F218/16

摘要： A medical device (10) includes a catheter shaft (11) including inner and outer catheter shafts (12 and 14), and an expandable balloon (18) carried by the catheter shaft (11). The balloon (18) is made from an irradiation cross-linked mixture of a polyamide elastomer and at least one additional cross-linking reactant. The polyamide elastomer can be a polyester amide, a polyether ester amide or a polyether amide, and is preferably a nylon block copolymer. The cross-linking reactant can be: (a) a difunctional material, (b) a trifunctional material, (c) a tetrafunctional material, or (d) an aromatic molecule containing at least two ring substituents, each of the ring substituents having labile hydrogens at a benzylic site therein. The cross-linking reactant can also be diallyl phthalate or meta-phenylene dimaleimide. Irradiation is carried out by exposure to an electron beam or to ultraviolet, X- or gamma radiation, preferably at a total fluence of about 0.5 to about 20 megarads. The amount of the cross-linking reactant is selected to avoid the formation of gelling during the process by which the balloon (18) is made, and the amount of the cross-linking agent and the irradiation fluence are selected to give the balloon a strength generally about equal to that which would be obtained by mere irradiation.

公开(公告)号：US06464720B2

公开(公告)日：2002-10-15

申请号：US09822066

申请日：2001-03-30

申请人： Scott E. Boatman ,  Kimberly D. Brummett ,  Thomas A. Osborne

发明人： Scott E. Boatman ,  Kimberly D. Brummett ,  Thomas A. Osborne

IPC分类号： A61F206

CPC分类号： A61F2/915 ,  A61F2/88 ,  A61F2/91 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2002/91583 ,  A61F2230/0054 ,  A61F2250/0036 ,  A61F2250/0098 ,  A61L31/022 ,  A61L31/18

摘要： A radially expandable stent (10) made from a cannula or sheet of biocompatible material that includes at least one longitudinal segment (14) comprised of a series of laterally interconnected closed cells (13). Each closed cell of a longitudinal segment is defined laterally by a pair of longitudinal struts (15, 16) that are interconnected at each end by a circumferentially adjustable member (19, 20). When the stent is expanded using a balloon (47), the opposing circumferentially adjustable members deform to allow circumferential expansion of the longitudinal segment, while the length of the segment, as defined by the longitudinal struts, is maintained. Self-expanding versions of the stent utilize a nickel-titanium alloy. Adjacent longitudinal segments are joined by flexible interconnection segments (21) that permit the stent to bend laterally. The flexible interconnection segment is comprised of curvilinear struts (22, 23) that form a series of serpentine bends (81) that distribute lateral bending forces. In a preferred embodiment, a short strut interconnects longitudinal segments and an adjacent interconnection segment. Each interconnection strut attaches to the longitudinal segment within a region (27) at the end (17) of a longitudinal strut (15) dividing two adjacent closed cells.

摘要翻译： 一种由包括生物相容性材料的套管或片材制成的径向可扩张的支架（10），其包括由一系列横向互连的闭孔（13）构成的至少一个纵向段（14）。 纵向段的每个闭合单元由一对纵向支柱（15,16）侧向地限定，所述纵向支柱在每个端部由周向可调节构件（19,20）互连。 当使用球囊（47）扩张支架时，相对的周向可调部件变形以允许纵向段的周向膨胀，而由纵向支柱限定的段的长度保持。 自扩张型支架采用镍钛合金。 相邻的纵向段通过柔性互连段（21）连接，允许支架横向弯曲。 柔性互连部分由曲线支柱（22,23）组成，其形成分布横向弯曲力的一系列蛇形弯曲部（81）。 在优选实施例中，短支柱将纵向段和相邻互连段互连。 每个互连支柱在分开两个相邻闭孔的纵向支柱（15）的端部（17）处的区域（27）内附接到纵向段。

公开(公告)号：US08911399B2

公开(公告)日：2014-12-16

申请号：US13221384

申请日：2011-08-30

申请人： Scott E. Boatman

发明人： Scott E. Boatman

IPC分类号： A61M29/00 ,  A61M25/10

CPC分类号： A61M25/1011 ,  A61M25/104 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2206/20

摘要： Balloon catheters, and methods of treatment therewith, are provided including an inflatable first balloon at least partially enclosed by an expandable second balloon that has holes. The annular space between the first balloon and the second balloon is configured to promote delivery of the fluid evenly through holes in the second balloon to avoid problems of underloading and/or overloading. Preferably, the annular space is in communication with the holes, and the annular space is configured to receive and then to release and distribute the fluid via the holes in a substantially uniform manner such that even amounts of fluid are released in the distal and proximal holes. The first balloon may have various configurations including being tapered relative to the second balloon. The second balloon may also be tapered accordingly. The device may also include raised portions disposed in the annular space and configured to define channels having various configurations.

摘要翻译： 球囊导管及其处理方法包括可充气的第一气囊，其至少部分地由具有孔的可扩张的第二气囊包围。 第一球囊和第二球囊之间的环形空间构造成促进流体均匀地传送到第二球囊中的孔，以避免下载和/或过载的问题。 优选地，环形空间与孔连通，并且环形空间构造成容纳并随后以基本均匀的方式通过孔释放和分布流体，使得均匀量的流体在远端和近端孔中释放 。 第一气球可以具有各种构造，包括相对于第二气囊是锥形的。 第二气囊也可以相应地变细。 该装置还可以包括设置在环形空间中并被构造成限定具有各种构造的通道的隆起部分。

公开(公告)号：US08292912B2

公开(公告)日：2012-10-23

申请号：US11450912

申请日：2006-06-09

申请人： David G. Burton ,  Scott E. Boatman

发明人： David G. Burton ,  Scott E. Boatman

IPC分类号： A61M29/00

CPC分类号： A61M25/0054 ,  A61M25/10

摘要： A balloon catheter is provided to minimize curving of the balloon when the balloon is expanded with an inflation media. The balloon catheter has an elastic inner shaft that stretches longitudinally as inflation pressure in the balloon is increased. The balloon catheter may also have an inner shaft with a portion that is corrugated to allow longitudinal stretching of the inner shaft.

摘要翻译： 气球导管被设置成当气囊用充气介质膨胀时使球囊的弯曲最小化。 气球导管具有弹性内轴，其随着球囊中的充气压力增加而纵向延伸。 球囊导管也可以具有内轴，其具有波纹状的部分，以允许内轴的纵向拉伸。

公开(公告)号：US20110313355A1

公开(公告)日：2011-12-22

申请号：US13221403

申请日：2011-08-30

申请人： Scott E. Boatman

发明人： Scott E. Boatman

IPC分类号： A61M25/10

CPC分类号： A61M25/1011 ,  A61M25/104 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2206/20

摘要： Balloon catheters, and methods of treatment therewith, are provided including an inflatable first balloon at least partially enclosed by an expandable second balloon that has holes. The annular space between the first balloon and the second balloon is configured to promote delivery of the fluid evenly through holes in the second balloon to avoid problems of underloading and/or overloading. Preferably, the annular space is in communication with the holes, and the annular space is configured to receive and then to release and distribute the fluid via the holes in a substantially uniform manner such that even amounts of fluid are released in the distal and proximal holes. The first balloon may have various configurations including being tapered relative to the second balloon. The second balloon may also be tapered accordingly. The device may also include raised portions disposed in the annular space and configured to define channels having various configurations.

公开(公告)号：US08034022B2

公开(公告)日：2011-10-11

申请号：US12411106

申请日：2009-03-25

申请人： Scott E. Boatman

发明人： Scott E. Boatman

IPC分类号： A61M29/00

CPC分类号： A61M25/1011 ,  A61M25/104 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2206/20

摘要： Multiple-balloon catheters, and methods of treatment therewith, are provided including an inflatable inner balloon at least partially enclosed by an expandable outer balloon that has holes. The annular space between the inner balloon and the outer balloon is configured to promote delivery of the fluid evenly through holes in the outer balloon to avoid problems of underloading and/or overloading. Preferably, the annular space is in communication with the holes, and the annular space is configured to receive and then to release and distribute the fluid via the holes in a substantially uniform manner such that even amounts of fluid are released in the distal and proximal holes. The inner balloon may have various configurations including being tapered relative to the outer balloon. The outer balloon may also be tapered accordingly. The device may also include raised portions disposed in the annular space and configured to define channels having various configurations.

摘要翻译： 提供了多气囊导管及其处理方法，包括至少部分地由具有孔的可膨胀外球囊封闭的可充气内球囊。 内球囊和外球囊之间的环形空间构造成促进流体均匀地输送到外球囊中的孔中，以避免下载和/或过载的问题。 优选地，环形空间与孔连通，并且环形空间构造成容纳并随后以基本均匀的方式通过孔释放和分布流体，使得均匀量的流体在远端和近端孔中释放 。 内囊可以具有各种构型，包括相对于外球囊是锥形的。 外球囊也可以相应地变细。 该装置还可以包括设置在环形空间中并被构造成限定具有各种构造的通道的隆起部分。

公开(公告)号：US07803149B2

公开(公告)日：2010-09-28

申请号：US10618977

申请日：2003-07-14

申请人： Brian L. Bates ,  Scott E. Boatman ,  David G. Burton ,  Michael C. Hoffa ,  Darin G. Schaeffer ,  Jason S. Sturgeon ,  Anthony O. Ragheb

发明人： Brian L. Bates ,  Scott E. Boatman ,  David G. Burton ,  Michael C. Hoffa ,  Darin G. Schaeffer ,  Jason S. Sturgeon ,  Anthony O. Ragheb

IPC分类号： A61M31/00

CPC分类号： A61M25/10 ,  A61F2/82 ,  A61F2/844 ,  A61F2/86 ,  A61F2/958 ,  A61F2210/0014 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0025 ,  A61F2250/0026 ,  A61F2250/0067 ,  A61F2250/0081 ,  A61F2250/0098 ,  A61F2310/00011 ,  A61L27/54 ,  A61L29/08 ,  A61L29/085 ,  A61L29/16 ,  A61L29/18 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/06 ,  A61M25/1029 ,  A61M25/104 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2250/00

摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.

摘要翻译： 一种涂覆的医疗装置（10），包括适于引入患者的通道或容器中的结构（12）。 该结构优选由其上设置有生物活性材料层（18）的无孔基材（14）形成。 该医疗装置优选为其上沉积有生物活性物质层的可植入支架或球囊（26）。 支架可以围绕气囊定位，另一层生物活性材料放置在整个结构上并延伸超过定位的支架的端部。 气囊的端部延伸超过支架的端部并且包括其上的生物活性材料，用于将生物活性材料输送到与其接触的血管壁的细胞。 气囊还包括位于气囊的基部和生物活性材料层之间的一层亲水材料（58）。

公开(公告)号：US07485250B2

公开(公告)日：2009-02-03

申请号：US10463749

申请日：2003-06-16

申请人： Scott E. Boatman ,  David G. Burton ,  Michael C. Hoffa ,  David R. Lessard ,  David A. Drewes, Jr. ,  Maggie A. Z. Hupcey

发明人： Scott E. Boatman ,  David G. Burton ,  Michael C. Hoffa ,  David R. Lessard ,  David A. Drewes, Jr. ,  Maggie A. Z. Hupcey

IPC分类号： B29C35/08 ,  D01F1/02 ,  A61M29/00

CPC分类号： C08G69/48 ,  A61L29/06 ,  C08F283/04 ,  C08L77/00 ,  C08F218/16

摘要： A medical device (10) includes a catheter shaft (11) including inner and outer catheter shafts (12 and 14), and an expandable balloon (18) carried by the catheter shaft (11). The balloon (18) is made from an irradiation cross-linked mixture of a polyamide elastomer and at least one additional cross-linking reactant. The polyamide elastomer can be a polyester amide, a polyether ester amide or a polyether amide, and is preferably a nylon block copolymer. The cross-linking reactant can be: (a) a difunctional material, (b) a trifunctional material, (c) a tetrafunctional material, or (d) an aromatic molecule containing at least two ring substituents, each of the ring substituents having labile hydrogens at a benzylic site therein. The cross-linking reactant can also be diallyl phthalate or meta-phenylene dimaleimide. Irradiation is carried out by exposure to an electron beam or to ultraviolet, X- or gamma radiation, preferably at a total fluence of about 0.5 to about 20 megarads. The amount of the cross-linking reactant is selected to avoid the formation of gelling during the process by which the balloon (18) is made, and the amount of the cross-linking agent and the irradiation fluence are selected to give the balloon a strength generally about equal to that which would be obtained by mere irradiation.

摘要翻译： 医疗装置（10）包括导管轴（11），其包括内导管轴和外导管轴（12和14）和由导管轴（11）承载的可膨胀气囊（18）。 球囊（18）由聚酰胺弹性体和至少一种另外的交联反应物的照射交联混合物制成。 聚酰胺弹性体可以是聚酯酰胺，聚醚酯酰胺或聚醚酰胺，优选为尼龙嵌段共聚物。 交联反应物可以是：（a）双官能材料，（b）三官能材料，（c）四官能材料，或（d）含有至少两个环取代基的芳族分子，每个环取代基具有不稳定性 在其苄基位点处的氢。 交联反应物也可以是邻苯二甲酸二烯丙酯或间亚苯基二马来酰亚胺。 照射通过暴露于电子束或紫外线，X射线或γ射线进行，优选以约0.5至约20兆拉德的总注量。 选择交联反应物的量以避免在制备气囊（18）的过程中形成胶凝，并且选择交联剂的量和照射注量以使球囊具有强度 通常大约等于仅通过照射获得的能量。

公开(公告)号：US06881209B2

公开(公告)日：2005-04-19

申请号：US09848742

申请日：2001-05-03

申请人： Scott E. Boatman ,  David G. Burton ,  Michael C. Hoffa ,  Thomas A. Osborne ,  David A. Drewes, Jr. ,  David R. Lessard ,  Maggie A. Z. Hupcey

发明人： Scott E. Boatman ,  David G. Burton ,  Michael C. Hoffa ,  Thomas A. Osborne ,  David A. Drewes, Jr. ,  David R. Lessard ,  Maggie A. Z. Hupcey

IPC分类号： A61L29/06 ,  C08F283/04 ,  C08G69/48 ,  A61M25/00 ,  B29C45/00 ,  B29C47/00 ,  B29D9/00

CPC分类号： A61M25/0009 ,  A61L29/06 ,  B29C35/08 ,  B29K2077/00 ,  B29L2031/7542 ,  C08F283/04 ,  C08G69/48 ,  Y10T29/4998 ,  C08L77/00 ,  C08F218/16

摘要： A medical device (110) including a catheter shaft (111) and a unitarily and continuously formed portion (108) having a varying durometer, and optionally including an expandable balloon (18, 118). One or both of the unitarily and continuously formed portion (108) and the balloon (18, 118) are made from an irradiation cross-linked or cross-linkable mixture of a polyamide elastomer and at least one additional cross-linking reactant. The polyamide elastomer can be a polyester amide, a polyether ester amide or a polyether amide, and is preferably a nylon block copolymer. The aromatic molecule can be 1,3,5 triethyl benzene; 1,2,4 triethyl benzene; and 1,3,5 triisopropyl benzene. The cross-linking reactant can be: (a) a difunctional material, (b) a trifunctional material, (c) a tetrafunctional material, or (d) an aromatic molecule containing at least two ring substituents, each of the ring substituents having labile hydrogens at a benzylic site therein. The cross-linking reactant can also be diallyl phthalate or meta-phenylene dimaleimide.

摘要翻译： 一种医疗装置（110），包括导管轴（111）和具有变化的硬度的整体连续形成部分（108），并且可选地包括可膨胀气囊（18,118）。 整体和连续形成的部分（108）和球囊（18,118）中的一个或两个由聚酰胺弹性体和至少一种另外的交联反应物的照射交联或可交联混合物制成。 聚酰胺弹性体可以是聚酯酰胺，聚醚酯酰胺或聚醚酰胺，优选为尼龙嵌段共聚物。 芳族分子可以是1,3,5三乙基苯; 1,2,4三乙苯; 和1,3,5三异丙基苯。 交联反应物可以是：（a）双官能材料，（b）三官能材料，（c）四官能材料，或（d）含有至少两个环取代基的芳族分子，每个环取代基具有不稳定性 在其苄基位点处的氢。 交联反应物也可以是邻苯二甲酸二烯丙酯或间亚苯基二马来酰亚胺。

公开(公告)号：US06447540B1

公开(公告)日：2002-09-10

申请号：US08971113

申请日：1997-11-14

申请人： Arthur B. Fontaine ,  Susan DosPassos ,  Brian L. Bates ,  Scott E. Boatman ,  Michael C. Hoffa ,  Thomas A. Osborne

发明人： Arthur B. Fontaine ,  Susan DosPassos ,  Brian L. Bates ,  Scott E. Boatman ,  Michael C. Hoffa ,  Thomas A. Osborne

IPC分类号： A61F206

CPC分类号： A61F2/97 ,  A61F2/95 ,  A61F2/958 ,  A61F2002/9511 ,  A61F2002/9583 ,  A61M25/0668 ,  A61M25/10

摘要： A stent deployment device (10) includes a catheter (12), a stent (14) positioned on the catheter (12), and a sleeve (16) carried on the catheter (12). The sleeve (16) has a portion (18) extending fully over and containing the stent (14). The stent deployment device (10) also includes a mechanism (20) for splitting at least the portion (18) of the sleeve (16) extending over the stent (14) and, preferably, for splitting the entire sleeve (16). Splitting of the sleeve portion (18) permits expansion of the stent (14). The mechanism (20) can include an inflatable, nondistending balloon (22) carried on the catheter (12), the stent (14) and the sleeve portion (18) being positioned over the balloon (22). The stent (14) can be self-expanding or can be expanded by the balloon (22) itself. Alternatively, the mechanism (20) can include a bulbous end (24) on the catheter (12). Longitudinal movement of the bulbous catheter end (24) with respect to the sleeve (16) splits at least the sleeve portion (18), permitting expansion of the stent (14). As further alternatives, the mechanism (20) can include a garrote (66) connected to the sleeve or a partial segment (62) of the sleeve (16) folded back alongside the stent (14). The sleeve (16) can be the same length as the catheter (12) or can be shorter than the catheter (12). In the former case, the mechanism (20) can include a pair of graspable wings (56) for splitting the full length of the sleeve (16). It is preferred that at least the portion (18) of the sleeve (16) extending over the stent (14) includes a longitudinally extending structure 46 for ensuring that the sleeve portion (18) will in fact split upon operation of the mechanism (20).

摘要翻译： 支架展开装置（10）包括导管（12），定位在导管（12）上的支架（14）和承载在导管（12）上的套筒（16）。 套筒（16）具有完全延伸并且容纳支架（14）的部分（18）。 支架展开装置（10）还包括一个机构（20），用于至少分开延伸在支架（14）上的套筒（16）的部分（18），并且优选地用于分割整个套筒（16）。 套筒部分（18）的分裂允许支架（14）膨胀。 机构（20）可以包括承载在导管（12）上的可膨胀的非重排球囊（22），支架（14）和套筒部分（18）定位在球囊（22）上方。 支架（14）可以是自膨胀的，或者可以由气囊（22）自身扩张。 或者，机构（20）可以包括在导管（12）上的球根端（24）。 球根导管端部（24）相对于套筒（16）的纵向移动至少分开套筒部分（18），从而允许支架（14）的膨胀。 作为另外的替代方案，机构（20）可以包括连接到套筒的衣壳（66）或套管（16）的沿着支架（14）折回的部分段（62）。 套筒（16）可以与导管（12）的长度相同，或者可以比导管（12）短。 在前一种情况下，机构（20）可以包括用于分离套筒（16）的全长的一对可抓握翼（56）。 优选地，延伸在支架（14）上的套筒（16）的至少部分（18）包括纵向延伸的结构46，用于确保套筒部分（18）实际上将在