公开(公告)号：US08546750B2

公开(公告)日：2013-10-01

申请号：US12163030

申请日：2008-06-27

Applicant: Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins

Inventor： Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins

IPC: H01J49/00

CPC classification number: H01J49/0422 ,  H01J49/04 ,  H01J49/044 ,  H01J49/0468 ,  H01J49/06 ,  H01J49/26 ,  Y10T436/24

Abstract: A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.

公开(公告)号：US20100148059A1

公开(公告)日：2010-06-17

申请号：US12656701

申请日：2010-02-12

Applicant: Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins ,  Ilia Tomski

Inventor： Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins ,  Ilia Tomski

IPC: H01J49/26

CPC classification number: G01N30/7233 ,  H01J49/04 ,  H01J49/067 ,  H01J49/107

Abstract: An interface for mass spectrometers. The interface uses non coaxial sampling pathways of the analyte ion beam prior to entering the entrance of a mass spectrometer for decreasing chemical background, and can be done in such a way as to permit multiple sprayers, increasing sample throughput and sensitivity for LC/MS (liquid chromatography/MS). The interface includes an ion source having an exit from which a beam of analyte ions are emitted, a curtain plate and an aperture in the curtain plate member, an orifice plate having an orifice therein. The orifice plate is being spaced from the curtain plate member defining a flow passageway therebetween, and the aperture in the orifice plate is aligned with a sample entrance to a first vacuum stage of a mass spectrometer maintained substantially lower than atmospheric pressure. The aperture in the curtain plate member is non coaxially aligned with the orifice in the orifice plate and the interface includes a gas flow mechanism for directing a counter flow gas into the flow passageway.

Abstract translation: 质谱仪界面。 在进入质谱仪入口以减少化学背景之前，界面使用分析物离子束的非同轴取样路径，并且可以以允许多个喷雾器，增加LC / MS的样品通量和灵敏度的方式进行 液相色谱/质谱）。 该界面包括离子源，其具有从其分离的离子束射出的出口，帘板和帘板构件中的孔，其中具有孔口的孔板。 孔板与限定其间的流动通道的帘板构件间隔开，并且孔板中的孔与进入维持在基本上低于大气压的质谱仪的第一真空级的样品入口对准。 帘板构件中的孔与孔板中的孔不同轴地对准，并且界面包括用于将逆流气体引导到流动通道中的气流机构。

公开(公告)号：US07659505B2

公开(公告)日：2010-02-09

申请号：US12024752

申请日：2008-02-01

Applicant: Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins ,  Serguei Savtchenko

Inventor： Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins ,  Serguei Savtchenko

IPC: H01J49/26 ,  H01J49/10 ,  B01D59/44

CPC classification number: H01J49/10 ,  H01J49/24 ,  Y10S438/961

Abstract: An ion source and method for providing ionized particles to a molecular/atomic analyser, such as a mass spectrometer, are disclosed. The ion source includes a vessel defining a channel; a gas inlet extending from the gas source into the channel, for introducing a gas flow into the channel; a sample inlet extending into the channel for introducing sample within the channel; and an ionizer to ionize the sample in the channel. The vessel is sufficiently sealed to allow the channel to be pressurized, at a pressure in excess of 100 Torr. At least one gas source maintains the pressure of the channel at a pressure in excess of 100 Torr and the pressure exterior to the channel at a pressure in excess of 0.1 Torr and provides a gas flow that sweeps across the ionizer to guide and entrain ions from the ionizer to the outlet.

Abstract translation: 公开了用于向分子/原子分析仪（例如质谱仪）提供离子化颗粒的离子源和方法。 离子源包括限定通道的容器; 从气体源延伸到通道中的气体入口，用于将气流引入通道中; 延伸到通道中的样品入口，用于将样品引入通道内; 以及电离器，用于使通道中的样品电离。 容器被充分密封，以允许通道在超过100托的压力下被加压。 至少一个气体源将通道的压力保持在超过100托的压力和在超过0.1托的压力下的通道外部的压力，并提供扫过电离器以引导和夹带离子的气流 电离器到出口。

公开(公告)号：US20090218484A1

公开(公告)日：2009-09-03

申请号：US12437203

申请日：2009-05-07

Applicant: Gholamreza Javahery ,  Lisa Cousins ,  Charles Jolliffe ,  Ilia Tomski

Inventor： Gholamreza Javahery ,  Lisa Cousins ,  Charles Jolliffe ,  Ilia Tomski

IPC: B01D59/44

CPC classification number: H01J49/066

Abstract: An ion guide includes multiple stages. An electric field within each stage guides ions along a guide axis. Within each stage, amplitude and frequency, and resolving potential of the electric field may be independently varied. The geometry of the rods maintains a similarly shaped field from stage to stage, allowing efficient guidance of the ions along the axis. In particular, each rod segment of the ith of stage has a cross sectional radius ri, and a central axis located a distance Ri+ri from the guide axis. The ratio ri/Ri and is substantially constant along the guide axis, thereby preserving the shape of the field.

Abstract translation: 离子导向器包括多个阶段。 每个阶段内的电场沿引导轴引导离子。 在每个阶段内，可以独立地改变振幅和频率以及电场的分辨能力。 杆的几何形状保持了从阶段到阶段的类似形状的场，允许离子沿轴线的有效引导。 特别地，平台的第i个的每个杆段具有横截面半径ri，并且中心轴线定位于与引导轴线的距离Ri + ri。 比率ri / Ri并且沿引导轴线基本上恒定，从而保持场的形状。

公开(公告)号：US20070181800A1

公开(公告)日：2007-08-09

申请号：US11652649

申请日：2007-01-12

Applicant: Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins ,  Ilia Tomski

Inventor： Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins ,  Ilia Tomski

IPC: H01J49/00

CPC classification number: G01N30/7233 ,  H01J49/04 ,  H01J49/067 ,  H01J49/107

Abstract: An interface for mass spectrometers. The interface uses non coaxial sampling pathways of the analyte ion beam prior to entering the entrance of a mass spectrometer for decreasing chemical background, and can be done in such a way as to permit multiple sprayers, increasing sample throughput and sensitivity for LC/MS (liquid chromatography/MS). The interface includes an ion source having an exit from which a beam of analyte ions are emitted, a curtain plate and an aperture in the curtain plate member, an orifice plate having an orifice therein. The orifice plate is being spaced from the curtain plate member defining a flow passageway therebetween, and the aperture in the orifice plate is aligned with a sample entrance to a first vacuum stage of a mass spectrometer maintained substantially lower than atmospheric pressure. The aperture in the curtain plate member is non coaxially aligned with the orifice in the orifice plate and the interface includes a gas flow mechanism for directing a counter flow gas into the flow passageway.

Abstract translation: 质谱仪界面。 在进入质谱仪入口以减少化学背景之前，界面使用分析物离子束的非同轴取样路径，并且可以以允许多个喷雾器，增加LC / MS的样品通量和灵敏度的方式进行 液相色谱/质谱）。 该界面包括离子源，其具有从其分离的离子束射出的出口，帘板和帘板构件中的孔，其中具有孔口的孔板。 孔板与限定其间的流动通道的帘板构件间隔开，并且孔板中的孔与进入维持在基本上低于大气压的质谱仪的第一真空级的样品入口对准。 帘板构件中的孔与孔板中的孔不同轴地对准，并且界面包括用于将逆流气体引导到流动通道中的气流机构。

公开(公告)号：US20220223399A1

公开(公告)日：2022-07-14

申请号：US17403033

申请日：2021-08-16

Applicant: Frenny Kaushal ,  Gholamreza Javahery ,  Lisa Cousins ,  Charles Jolliffe

Inventor： Frenny Kaushal ,  Gholamreza Javahery ,  Lisa Cousins ,  Charles Jolliffe

IPC: H01J49/16 ,  H01J49/42 ,  H01J49/06

Abstract: An ionizer includes a probe having multiple coaxially aligned conduits. The conduits may carry liquids, and nebulizing and heating gases at various flow rates and temperatures, for generation of ions from a liquid source. An outermost conduit defines an entrainment region that transports and entrains ions in a gas for a defined distance along the length of the conduits. In embodiments, various voltages may be applied to the multiple conduits to aid in ionization and to guide ions. Depending on the voltages applied to the multiple conduits and electrodes, the ionizer can act as an electrospray, APCI, or APPI source. Further, the ionizer may include a source of photons or a source of corona ionization. Formed ions may be provided to a downstream mass analyser.

公开(公告)号：US20140197333A1

公开(公告)日：2014-07-17

申请号：US13740985

申请日：2013-01-14

Applicant: Charles Jolliffe ,  Lisa Cousins ,  Gholamreza Javahery

Inventor： Charles Jolliffe ,  Lisa Cousins ,  Gholamreza Javahery

IPC: H01J49/04

CPC classification number: H01J49/044 ,  H01J49/062

Abstract: A mass analyzer includes a desolvation chamber into which an upstream gas is injected to provide a counter-flow to said downstream flow in the chamber. The counter-flow may slow the downstream flow of solvated ionized particles in the chamber, while allowing lighter desolvated ions to travel toward an outlet aperture of the desolvation chamber.

Abstract translation: 质量分析器包括去溶剂化室，注入上游气体以向腔室中的所述下游流动提供逆流。 逆流可以减缓腔室中溶剂化的离子化颗粒的下游流动，同时允许较轻的去溶剂离子朝向去溶剂化室的出口孔行进。

公开(公告)号：US08008619B2

公开(公告)日：2011-08-30

申请号：US12656701

申请日：2010-02-12

Applicant: Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins ,  Ilia Tomski

Inventor： Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins ,  Ilia Tomski

IPC: H01J49/26 ,  H01J49/10

CPC classification number: G01N30/7233 ,  H01J49/04 ,  H01J49/067 ,  H01J49/107

Abstract: An interface for mass spectrometers. The interface uses non coaxial sampling pathways of the analyte ion beam prior to entering the entrance of a mass spectrometer for decreasing chemical background, and can be done in such a way as to permit multiple sprayers, increasing sample throughput and sensitivity for LC/MS (liquid chromatography/MS). The interface includes an ion source having an exit from which a beam of analyte ions are emitted, a curtain plate and an aperture in the curtain plate member, an orifice plate having an orifice therein. The orifice plate is being spaced from the curtain plate member defining a flow passageway therebetween, and the aperture in the orifice plate is aligned with a sample entrance to a first vacuum stage of a mass spectrometer maintained substantially lower than atmospheric pressure. The aperture in the curtain plate member is non coaxially aligned with the orifice in the orifice plate and the interface includes a gas flow mechanism for directing a counter flow gas into the flow passageway.

Abstract translation: 质谱仪界面。 在进入质谱仪入口以减少化学背景之前，界面使用分析物离子束的非同轴取样路径，并且可以以允许多个喷雾器，增加LC / MS的样品通量和灵敏度的方式进行 液相色谱/质谱）。 该界面包括离子源，其具有从其分离的离子束射出的出口，帘板和帘板构件中的孔，其中具有孔口的孔板。 孔板与限定其间的流动通道的帘板构件间隔开，并且孔板中的孔与进入维持在基本上低于大气压的质谱仪的第一真空级的样品入口对准。 帘板构件中的孔与孔板中的孔不同轴地对准，并且界面包括用于将逆流气体引导到流动通道中的气流机构。

公开(公告)号：US20100252729A1

公开(公告)日：2010-10-07

申请号：US12762783

申请日：2010-04-19

Applicant: Charles JOLLIFFE ,  Lisa Cousins ,  Gholamreza Javahery

Inventor： Charles JOLLIFFE ,  Lisa Cousins ,  Gholamreza Javahery

IPC: H01J49/02

CPC classification number: H01J49/025 ,  H01J49/0095

Abstract: An ion detector includes collision surfaces for converting both positively and negatively charged ions into emitted secondary electrons. Secondary electrons may be detected using an electron detector, than may, for example include an electron multiplier. Conveniently, secondary electrons (or electrons emitted by the multiplier) may be detected using an electron pulse counter.

Abstract translation: 离子检测器包括用于将正电荷和带负电荷的离子转换成发射的二次电子的碰撞表面。 可以使用电子检测器检测二次电子，例如可以包括电子倍增器。 方便地，可以使用电子脉冲计数器检测二次电子（或乘法器发射的电子）。

公开(公告)号：US20080258052A1

公开(公告)日：2008-10-23

申请号：US12163030

申请日：2008-06-27

Applicant: Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins

Inventor： Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins

IPC: H01J49/28

CPC classification number: H01J49/0422 ,  H01J49/04 ,  H01J49/044 ,  H01J49/0468 ,  H01J49/06 ,  H01J49/26 ,  Y10T436/24

Abstract: A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.

Abstract translation: 公开了具有改进的灵敏度和降低的化学背景的质谱仪界面。 质谱仪界面提供改进的去溶剂化学选择性和离子迁移。 部分溶剂化离子的流动沿曲折路径输送到流动扰动区域，其中离子和中性分子碰撞和混合。 热能被施加到扰动区域以促进至少一些离子化颗粒从任何附着的杂质的释放，从而增加流动中具有特征m / z比的离子化颗粒的浓度。 还可以进行分子反应和低压离子化方法以选择性去除或增强特定的离子。