公开(公告)号：US07980699B2

公开(公告)日：2011-07-19

申请号：US12418841

申请日：2009-04-06

申请人： Daniel R. Neal ,  Leander Zickler

发明人： Daniel R. Neal ,  Leander Zickler

IPC分类号： A61B3/00 ,  A61B3/10

CPC分类号： G06T5/50 ,  A61F9/00804 ,  A61F9/00827 ,  A61F2009/00848 ,  A61F2009/00851 ,  A61F2009/00872 ,  A61F2009/0088 ,  A61F2009/00882 ,  G06T7/33 ,  G06T2207/20221 ,  G06T2207/30041

摘要： Devices, systems, and methods that facilitate optical analysis, particularly for the diagnosis and treatment of refractive errors of the eye. Embodiments of the invention may facilitate the use of multi-modal diagnostic instruments and instrument systems, making it easier to acquire and fuse data from different measurements of the eye. For example, wavefront aberrometry may be fused with corneal topography, optical coherence topography and wavefront, optical coherence topography and topography, pachymetry and wavefront, etc. While some of these different optical datasets may be obtained simultaneously, it is often difficult and/or disadvantageous to attempt to acquire the images or other data at exactly the same time. Advantageously, both patient movement between measurements (and/or during a measurement sequence) can be identified, as well as changes in the eye itself (including those induced by the measurement, such as changes in the size of the pupil, changes in pupil location, etc.).

摘要翻译： 便于光学分析的设备，系统和方法，特别是诊断和治疗眼睛屈光不正的方法。 本发明的实施例可以促进多模式诊断仪器和仪器系统的使用，从而更容易地从眼睛的不同测量获取和融合数据。 例如，波前像差法可以与角膜地形学，光学相干形貌和波前融合，光学相干形貌和地形学，厚度测量和波前等。虽然这些不同的光学数据集中的一些可以同时获得，但是通常是困难和/或不利的 尝试在完全相同的时间获取图像或其他数据。 有利的是，可以确定测量之间（和/或在测量序列期间）患者之间的移动以及眼睛本身的变化（包括由测量引起的变化，例如瞳孔尺寸的变化，瞳孔位置的变化 等）。

公开(公告)号：US20070173797A1

公开(公告)日：2007-07-26

申请号：US11341917

申请日：2006-01-26

申请人： Leander Zickler

发明人： Leander Zickler

IPC分类号： A61B18/18

CPC分类号： A61B18/20 ,  A61B2017/00725 ,  A61F9/00804 ,  A61F9/00812 ,  A61F2009/00848 ,  A61F2009/00855 ,  A61F2009/00872

摘要： Systems and method for determining ablation beam characteristics are provided. Methods include ablating an article with the ablation beam to form a test location having an ablation depth, transmitting a first beam through the test location of the article, transmitting a second beam through a reference location, and determining an ablation beam characteristic based on a phase relationship of the first beam and the second beam downstream of the article. Systems include a light source assembly transmitting a first beam through an ablated test location of an article and a second beam through a reference location disposed outside of the test location, a sensor assembly detecting a first beam and second beam superimposition downstream of the article, and a phase relationship code module for determining a phase relationship between the first beam and the second beam, based on the first beam and second beam superimposition.

摘要翻译： 提供了确定消融光束特性的系统和方法。 方法包括用消融束消融物品以形成具有消融深度的测试位置，透射穿过物品的测试位置的第一光束，通过参考位置传输第二光束，以及基于相位确定消融光束特性 第一光束和第二光束在物品下游的关系。 系统包括光源组件，其将第一光束穿过物品的消融测试位置和通过设置在测试位置外部的参考位置的第二光束传输;检测第一光束和第二光束叠加在物品下游的传感器组件，以及 相位关系码模块，用于基于第一光束和第二光束叠加来确定第一光束和第二光束之间的相位关系。

公开(公告)号：US20110149239A1

公开(公告)日：2011-06-23

申请号：US12909756

申请日：2010-10-21

申请人： Daniel R. Neal ,  Thomas D. Raymond ,  Leander Zickler

发明人： Daniel R. Neal ,  Thomas D. Raymond ,  Leander Zickler

IPC分类号： A61B3/103 ,  A61B3/10 ,  A61B3/11

CPC分类号： A61B3/0025 ,  A61B3/1015 ,  A61B3/103 ,  A61B3/112 ,  G02C7/027 ,  G02C7/04

摘要： Devices, systems, and methods that facilitate optical analysis, particularly for the diagnosis and treatment of refractive errors of the eye. An optical diagnostic method for an eye includes obtaining a sequence of aberration measurements of the eye, identifying an outlier aberration measurement of the sequence of aberration measurements, and excluding the outlier aberration measurement from the sequence of aberration measurements to produce a qualified sequence of aberration measurements. The sequence of aberrations measurements can be obtained by using a wavefront sensor. An optical correction for the eye can be formulated in response to the qualified sequence of aberration measurements.

摘要翻译： 便于光学分析的设备，系统和方法，特别是诊断和治疗眼睛屈光不正的方法。 用于眼睛的光学诊断方法包括获得眼睛的像差测量序列，识别像差测量序列的异常像差测量，并从像差测量序列排除异常值像差测量，以产生合格的像差测量序列 。 可以通过使用波前传感器来获得像差测量序列。 可以根据合格的像差测量序列来制定眼睛的光学校正。

公开(公告)号：US20080287928A1

公开(公告)日：2008-11-20

申请号：US12121635

申请日：2008-05-15

申请人： Mark E. Arnoldussen ,  Jonathan Wong ,  Benjamin A. Logan ,  Leander Zickler

发明人： Mark E. Arnoldussen ,  Jonathan Wong ,  Benjamin A. Logan ,  Leander Zickler

IPC分类号： A61F9/008 ,  A61B18/20

CPC分类号： A61F9/00814 ,  A61B2017/00057 ,  A61B2017/00154 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/00817 ,  A61F2009/00844 ,  A61F2009/00846 ,  A61F2009/00848 ,  A61F2009/00872 ,  A61F2009/0088 ,  A61F2009/00882 ,  A61F2009/00885 ,  A61F2009/00897

摘要： Systems and methods for removing an epithelial layer disposed over a stromal layer in a cornea irradiate a region of the epithelial layer with a pulsed beam of ablative radiation. The ablative radiation is scanned to vary the location of the beam within the region in accordance with a pulse sequence. The pulse sequence is arranged to enhance optical feedback based on a tissue fluorescence of the epithelial layer. The penetration of the epithelial layer is detected in response to the optical feedback. The use of scanning with the pulse sequence arranged to enhance optical feedback allows large areas of the epithelium to be ablated such penetration of the epithelial layer can be detected.

摘要翻译： 用于去除设置在角膜上的基质层上的上皮层的系统和方法用消融辐射的脉冲束照射上皮层的区域。 根据脉冲序列扫描烧蚀辐射以改变该区域内的光束的位置。 布置脉冲序列以增强基于上皮层的组织荧光的光学反馈。 响应于光学反馈检测上皮层的穿透。 使用布置为增强光学反馈的脉冲序列的扫描允许大面积的上皮被消融，可以检测到上皮层的穿透。

公开(公告)号：US20080077239A1

公开(公告)日：2008-03-27

申请号：US11534200

申请日：2006-09-21

申请人： Leander Zickler ,  Rakhi Jain ,  Jim Deacon

发明人： Leander Zickler ,  Rakhi Jain ,  Jim Deacon

IPC分类号： A61F2/16

CPC分类号： A61F2/1613 ,  A61F2002/009 ,  A61F2002/1681 ,  A61F2002/1696 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2250/0053 ,  A61F2250/0096 ,  A61F2250/0098 ,  H04W52/146 ,  H04W52/367

摘要： An intraocular lens for providing vision to a subject contains an optic, a support structure coupled to the optic. The intraocular lens also includes a textured surface and/or subsurface layer. The optic is disposed about an optical axis and comprises an anterior surface and an opposing posterior surface, the surfaces being configured to focus light when implanted within an eye having a capsular bag. The textured surface is disposed over a surface portion of the intraocular lens and includes a plurality of periodically-spaced protrusions, each protrusion having a smooth distal face and a sharp corner edge configured to engage a wall of the capsular bag and/or at least one cell disposed along the wall. The subsurface layer is configured to scatter an amount of light that is at least twice the amount of light scattered by portions of the material adjacent the subsurface layer or at least twice the amount of light scattered by another intraocular lens that does not have the subsurface layer, but which is otherwise substantially equivalent.

公开(公告)号：US08246609B2

公开(公告)日：2012-08-21

申请号：US12494092

申请日：2009-06-29

申请人： Leander Zickler ,  Scott J. Catlin ,  Andrew Y Pang

发明人： Leander Zickler ,  Scott J. Catlin ,  Andrew Y Pang

IPC分类号： A61B18/18

CPC分类号： A61F2/145 ,  A61F2/1451 ,  A61F9/00804 ,  A61F2009/0088 ,  A61F2009/00882

摘要： Method and system for modifying a refractive profile associated with an eye having a recipient cornea. The method includes obtaining a corneal tissue inlay from a donor cornea, forming a recipient bed in the recipient cornea, and positioning the corneal tissue inlay into the recipient bed to correct the refractive profile of the eye with the refractive profile of the corneal tissue. The system includes a laser assembly outputting a pulsed laser beam, and a controller coupled to the laser assembly. The controller directs the laser assembly to incise a corneal tissue inlay from a donor cornea, form a recipient bed in the recipient cornea having a contour matching the contour of the inlay, register the inlay with the recipient bed, determine a position of the inlay, and determine a position change for the inlay based on the position of the inlay to align the refractive profile of the inlay with the refractive profile of the eye.

摘要翻译： 用于修改与具有受体角膜的眼睛相关联的折射轮廓的方法和系统。 该方法包括从供体角膜获得角膜组织镶嵌物，在接受者角膜中形成受体床，以及将角膜组织镶嵌物定位在受体床中，以校正眼睛的屈光轮廓与角膜组织的折射轮廓。 该系统包括输出脉冲激光束的激光组件和耦合到激光组件的控制器。 控制器指示激光组件切割来自供体角膜的角膜组织镶嵌物，在受体角膜中形成具有与镶嵌轮廓相匹配的轮廓的受体床，将嵌体与受体床注册，确定嵌体的位置， 并且基于嵌体的位置来确定嵌体的位置变化，以使嵌体的折射轮廓与眼睛的折射轮廓对准。

公开(公告)号：US20100082017A1

公开(公告)日：2010-04-01

申请号：US12239462

申请日：2008-09-26

申请人： Leander Zickler ,  Jim Deacon

发明人： Leander Zickler ,  Jim Deacon

IPC分类号： A61F9/008

CPC分类号： A61F9/008 ,  A61F2/16 ,  A61F2/1624 ,  A61F2/1629 ,  A61F9/0017 ,  A61F9/007 ,  A61F9/00834 ,  A61F2002/1681 ,  A61F2002/1699 ,  A61F2009/00848 ,  A61F2009/0087 ,  A61F2009/0088 ,  A61F2250/0006 ,  A61F2250/0008 ,  G02C2202/14

摘要： A system of modifying an intraocular device located within an eye, wherein the system includes a laser assembly and a controller coupled to the laser assembly. The laser assembly outputs a pulsed laser beam having a pulse width between about 300 picoseconds and about 10 femtoseconds, and the controller directs the laser assembly to output the pulsed laser beam into the intraocular device. One or more slip zones are formed within the intraocular device in response thereto, and the slip zones are configured to modify a refractive profile of the intraocular device. A method of modifying a refractive profile of an eye having an intraocular device implanted therein, wherein the method includes determining a corrected refractive profile for the eye based on an initial refractive profile, identifying one or more locations within the intraocular device based on the corrected refractive profile, and directing a pulsed laser beam at the locations to produce the corrected refractive profile.

摘要翻译： 一种修改位于眼睛内的眼内装置的系统，其中所述系统包括激光组件和耦合到所述激光组件的控制器。 激光组件输出具有在约300皮秒和约10飞秒之间的脉冲宽度的脉冲激光束，并且控制器引导激光组件将脉冲激光束输出到眼内装置中。 一个或多个滑动区域响应于眼内装置形成，并且滑动区域被配置为改变眼内装置的折射轮廓。 一种修改眼睛装置植入其中的眼睛的折射分布的方法，其中该方法包括基于初始折射分布来确定眼睛的经校正的折射轮廓，基于矫正的屈光度来识别眼内装置内的一个或多个位置 并且在该位置处引导脉冲激光束以产生校正的折射分布。

公开(公告)号：US20090316112A1

公开(公告)日：2009-12-24

申请号：US12418841

申请日：2009-04-06

申请人： Daniel R. Neal ,  Leander Zickler

发明人： Daniel R. Neal ,  Leander Zickler

IPC分类号： A61B3/11 ,  A61B3/10 ,  A61B3/107

CPC分类号： G06T5/50 ,  A61F9/00804 ,  A61F9/00827 ,  A61F2009/00848 ,  A61F2009/00851 ,  A61F2009/00872 ,  A61F2009/0088 ,  A61F2009/00882 ,  G06T7/33 ,  G06T2207/20221 ,  G06T2207/30041

摘要： Devices, systems, and methods that facilitate optical analysis, particularly for the diagnosis and treatment of refractive errors of the eye. Embodiments of the invention may facilitate the use of multi-modal diagnostic instruments and instrument systems, making it easier to acquire and fuse data from different measurements of the eye. For example, wavefront aberrometry may be fused with corneal topography, optical coherence topography and wavefront, optical coherence topography and topography, pachymetry and wavefront, etc. While some of these different optical datasets may be obtained simultaneously, it is often difficult and/or disadvantageous to attempt to acquire the images or other data at exactly the same time. Advantageously, both patient movement between measurements (and/or during a measurement sequence) can be identified, as well as changes in the eye itself (including those induced by the measurement, such as changes in the size of the pupil, changes in pupil location, etc.).

摘要翻译： 便于光学分析的设备，系统和方法，特别是诊断和治疗眼睛屈光不正的方法。 本发明的实施例可以促进多模式诊断仪器和仪器系统的使用，从而更容易地从眼睛的不同测量获取和融合数据。 例如，波前像差法可以与角膜地形学，光学相干形貌和波前融合，光学相干形貌和地形学，厚度测量和波前等。虽然这些不同的光学数据集中的一些可以同时获得，但是通常是困难和/或不利的 尝试在完全相同的时间获取图像或其他数据。 有利的是，可以确定测量之间（和/或在测量序列期间）患者之间的移动以及眼睛本身的变化（包括由测量引起的变化，例如瞳孔尺寸的变化，瞳孔位置的变化 等）。

公开(公告)号：US07116688B2

公开(公告)日：2006-10-03

申请号：US10635154

申请日：2003-08-06

申请人： Thomas Sauter ,  Leander Zickler

发明人： Thomas Sauter ,  Leander Zickler

IPC分类号： H01S3/10 ,  H01S3/117

CPC分类号： H01S3/235 ,  H01S3/0057 ,  H01S3/0606 ,  H01S3/08004 ,  H01S3/08059 ,  H01S3/09408 ,  H01S3/09415 ,  H01S3/10046 ,  H01S3/10069 ,  H01S3/10092 ,  H01S3/1022 ,  H01S3/1312 ,  H01S2301/04

摘要： A laser system for generating at least one pulse and/or pulse sequence(s) of pulses having at least one specified property, such as pulse energy, duration, peak intensity, pulse form and/or timing includes an amplifying cavity. The amplification process is monitored in the amplifying cavity to obtain data about at least one property of the pulse sequence and/or the single pulse(s). The system also compares the obtained data with reference data and it controls at least one switching means for inputting, outputting and/or retaining the pulse(s) in the amplifying cavity such that at least one property of the pulse sequences and/or the pulses at an output of the laser system has substantially a specified value.

摘要翻译： 用于产生具有至少一个特定特性（例如脉冲能量，持续时间，峰值强度，脉冲形式和/或定时）的至少一个脉冲和/或脉冲序列的激光系统包括放大腔。 在放大腔中监视放大过程以获得关于脉冲序列和/或单个脉冲的至少一个性质的数据。 该系统还将获得的数据与参考数据进行比较，并且它控制至少一个切换装置，用于输入，输出和/或保持放大腔中的脉冲，使得脉冲序列和/或脉冲的至少一个特性 在激光系统的输出端具有基本上特定的值。

公开(公告)号：US09504376B2

公开(公告)日：2016-11-29

申请号：US12909756

申请日：2010-10-21

申请人： Daniel R. Neal ,  Thomas D. Raymond ,  Leander Zickler

发明人： Daniel R. Neal ,  Thomas D. Raymond ,  Leander Zickler

IPC分类号： G02B26/08 ,  G02B26/10 ,  G02B26/12 ,  A61B3/00

CPC分类号： A61B3/0025 ,  A61B3/1015 ,  A61B3/103 ,  A61B3/112 ,  G02C7/027 ,  G02C7/04

摘要： Devices, systems, and methods that facilitate optical analysis, particularly for the diagnosis and treatment of refractive errors of the eye. An optical diagnostic method for an eye includes obtaining a sequence of aberration measurements of the eye, identifying an outlier aberration measurement of the sequence of aberration measurements, and excluding the outlier aberration measurement from the sequence of aberration measurements to produce a qualified sequence of aberration measurements. The sequence of aberrations measurements can be obtained by using a wavefront sensor. An optical correction for the eye can be formulated in response to the qualified sequence of aberration measurements.

摘要翻译： 便于光学分析的设备，系统和方法，特别是诊断和治疗眼睛屈光不正的方法。 用于眼睛的光学诊断方法包括获得眼睛的像差测量序列，识别像差测量序列的异常像差测量，并从像差测量序列排除异常值像差测量，以产生合格的像差测量序列 。 可以通过使用波前传感器来获得像差测量序列。 可以根据合格的像差测量序列来制定眼睛的光学校正。