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公开(公告)号：US5568133A
公开(公告)日：1996-10-22
申请号：US570814
申请日：1995-12-12
申请人： Bernhard Durrer , Hans Botschi , Peter Gruber
发明人： Bernhard Durrer , Hans Botschi , Peter Gruber
IPC分类号： G08B17/113 , G08B23/00
CPC分类号： G08B17/113
摘要： Upon insertion of a fire alarm insert into a corresponding fire alarm mounting, the insert covers the mounting. The insert has a movable fastening comprising a ring, for example, for fastening the insert to the mounting. Indicator elements are included for indicating proper positioning of the insert relative to the mounting.
摘要翻译： 在将火警报警插入物插入相应的火灾报警装置后，插入物将覆盖安装件。 插入件具有可移动的紧固件，其包括例如用于将插入件紧固到安装件上的环。 包括指示元件用于指示插入件相对于安装件的正确定位。
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公开(公告)号：US5364646A
公开(公告)日：1994-11-15
申请号：US33659
申请日：1993-03-16
申请人： Peter Gruber , Willy Roth , Gottfried Schepky
发明人： Peter Gruber , Willy Roth , Gottfried Schepky
CPC分类号： A61K31/50 , A61K9/2013 , A61K9/2077 , A61K9/4841 , A61K9/4858 , Y10S514/96 , Y10S514/962
摘要： Pharmaceutical forms of pimobendan for oral administration comprising citric acid, whereby a constant, satisfactory resorption is ensured even when there are major pH fluctuations in the gastrointestinal tract.
摘要翻译： 用于口服给药的匹莫苯胺的药物形式包括柠檬酸，由此即使当胃肠道中存在主要的pH波动时也确保恒定的令人满意的吸收。
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13.发明授权公开(公告)号：US09775807B2
公开(公告)日：2017-10-03
申请号：US12441629
申请日：2007-09-14
申请人： Peter Gruber , Dirk Spickermann
发明人： Peter Gruber , Dirk Spickermann
CPC分类号： A61K9/2009 , A61K9/1611
摘要： The invention relates to solid medicinal forms containing at least one active ingredient and at least one pharmaceutically compatible, water soluble drying agent which is selected from the group consisting of trimagnesium dicitrate and/or calcium chloride, the solid medicinal form having a drying loss of at most 6% and a relative equilibrium moisture content of 25% or less. The invention also relates to solid medicinal forms containing a moisture-sensitive active ingredient and trimagnesium dicitrate.
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公开(公告)号：US09205054B2
公开(公告)日：2015-12-08
申请号：US11887066
申请日：2006-03-22
申请人： Peter Gruber , Wolfgang Mohr
发明人： Peter Gruber , Wolfgang Mohr
CPC分类号： A61K9/1694 , A61K9/1688
摘要： A process for producing a solubilized ibuprofen, preferably in the form of a granulate, the process comprising the steps of: providing a mixture comprising solid ibuprofen and a first base selected from the group consisting of sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, sodium glycinate, potassium glycinate and tribasic sodium and potassium phosphates and mixtures thereof, and reacting the ibuprofen and the first base in essentially dry state. The obtainable granulate and the pharmaceutical compositions and dosage forms that may be produced therefrom are distinguished by their high solubility and rapid disintegration and dissolution in aqueous media, by their good flow properties and compressibility, by rapidly achieving onset of analgesic effect.
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15.发明授权Oral dosage form for propiverine or its pharmaceutically acceptable salts with an extended release of the active ingredient 有权丙泊酚或其药学上可接受的盐的延长释放活性成分的口服剂型公开(公告)号：US07943176B2
公开(公告)日：2011-05-17
申请号：US10492270
申请日：2002-10-08
申请人： Thomas Gramatte , Peter Gruber , Michael Heschel , Dirk Pamperin , Jan Ploen , Steffen Scheithauser , Wolfgang Wehner , Peter Guldner
发明人： Thomas Gramatte , Peter Gruber , Michael Heschel , Dirk Pamperin , Jan Ploen , Steffen Scheithauser , Wolfgang Wehner , Peter Guldner
IPC分类号： A61K9/14
CPC分类号： A61K9/2009 , A61K9/2054 , A61K9/2846 , A61K9/5026 , A61K9/5078 , A61K31/445
摘要： By suitable retardation oral pharmaceutical compositions containing propiverine or one or several pharmaceutically acceptable salts thereof in an amount of 4 mg to 60 mg propiverine and having a prolonged release of the active agent are produced. Preferably a blend of active agent and optionally one or more acidic substances having a pKa value of less than 6.65 are provided with a retarding coating or are embedded in a matrix which is then optionally coated with further retarding layers.
摘要翻译： 通过合适的阻滞剂，可以制备含有丙哌嗪或其一种或多种药学上可接受的盐的药物组合物，其量为4mg至60mg propiverine并且具有延长的活性剂释放。 优选地，具有pKa值小于6.65的活性剂和任选的一种或多种酸性物质的混合物具有延迟涂层或嵌入基质中，然后任选地涂覆有进一步的阻滞层。
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公开(公告)号：US20090175940A1
公开(公告)日：2009-07-09
申请号：US11887066
申请日：2006-03-22
申请人： Peter Gruber
发明人： Peter Gruber
IPC分类号： A61K9/36 , C07C51/00 , A61K31/192 , A61K9/28
CPC分类号： A61K9/1694 , A61K9/1688
摘要： A process for producing a solubilized ibuprofen, preferably in the form of a granulate, the process comprising the steps of: providing a mixture comprising solid ibuprofen and a first base selected from the group consisting of sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, sodium glycinate, potassium glycinate and tribasic sodium and potassium phosphates and mixtures thereof, and reacting the ibuprofen and the first base in essentially dry state. The obtainable granulate and the pharmaceutical compositions and dosage forms that may be produced therefrom are distinguished by their high solubility and rapid disintegration and dissolution in aqueous media, by their good flow properties and compressibility, by rapidly achieving onset of analgesic effect.
摘要翻译： 生产溶解性布洛芬的方法，优选为颗粒形式，该方法包括以下步骤：提供包含实心布洛芬和选自氢氧化钠，氢氧化钾，碳酸钠，碳酸钾的第一碱的混合物 甘氨酸钠，甘氨酸钾和磷酸三钠和磷酸三钠及其混合物，并以基本干燥的状态使布洛芬与第一碱反应。 通过迅速达到镇痛作用的开始，其可由其产生的可获得的颗粒和药物组合物和剂型通过它们的高溶解度和在水性介质中的快速崩解和溶解，通过其良好的流动性能和可压缩性来区分。
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公开(公告)号：US20050109823A1
公开(公告)日：2005-05-26
申请号：US10721494
申请日：2003-11-25
申请人： Peter Gruber , Lannie Bolde
发明人： Peter Gruber , Lannie Bolde
CPC分类号： B23K3/0638 , B23K3/053 , B23K3/0607
摘要： A solder feeding device having a reservoir, a drive unit, a first lead, and a second lead is provided. The reservoir melts solid solder wire into molten solder, while the drive unit selectively feeds the solid solder wire into the reservoir. The first and second leads are in electrical communication with the drive unit. The first lead is positioned in the reservoir so that it electrically communicates with the second lead through the molten solder when the molten solder reaches a triggering level, but so that it does not electrically communicate with the second lead when the level is below the triggering level. The drive unit feeds the solid solder wire into the reservoir based upon a state of electrical communication between the first and second leads.
摘要翻译： 提供具有储存器，驱动单元，第一引线和第二引线的焊料馈送装置。 储存器将固体焊丝熔化成熔融焊料，而驱动单元选择性地将固体焊丝馈送到储存器中。 第一和第二引线与驱动单元电连通。 第一引线定位在储存器中，使得当熔融焊料达到触发水平时，其通过熔融焊料与第二引线电连通，但是当电平低于触发电平时它不与第二引线电连通 。 驱动单元基于第一和第二引线之间的电连通状态将固体焊丝馈送到储存器中。
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公开(公告)号：US5745063A
公开(公告)日：1998-04-28
申请号：US867205
申请日：1997-06-02
申请人： Peter Gruber , Raul Cermeno , Heinz Lienhard
发明人： Peter Gruber , Raul Cermeno , Heinz Lienhard
IPC分类号： G01R21/133 , G06F7/60 , G06G7/161 , G06J1/00 , H03M3/00
CPC分类号： G06G7/161 , G01R21/133 , G06F7/602 , G06J1/00
摘要： In a circuit at least one of the signals (u�t! or i�t!) is transmitted to a signal input of a sigma-delta modulator operated at a first clock frequency (1/T.sub.S) the output of which is connected to at least one of two signal inputs of a multiplication/addition element (3). The arrangement is used for example in electricity counters and makes it possible to calculate sums of products by means of simple shift and algebraic adding operations while maintaining closely the precision achievable with a classic multiplication. The arrangement is especially advantageous if the multiplications are done on a semiconductor chip.
摘要翻译： 在电路中，信号（u [t]或i [t]）中的至少一个被发送到以第一时钟频率（1 / TS）操作的Σ-Δ调制器的信号输入，其输出连接到 乘法/加法元件（3）的两个信号输入中的至少一个。 该布置用于例如电计数器，并且可以通过简单的移位和代数相加操作来计算乘积的总和，同时保持与经典乘法可实现的精度。 如果在半导体芯片上进行乘法，则该布置是特别有利的。
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公开(公告)号：US4758142A
公开(公告)日：1988-07-19
申请号：US906743
申请日：1986-09-12
申请人： Gunther M. Voss , Volker I. Glasel , Peter Gruber , Walter Bubeck
发明人： Gunther M. Voss , Volker I. Glasel , Peter Gruber , Walter Bubeck
IPC分类号： B05B1/14 , A23P1/02 , A23P1/10 , A61J3/10 , A61K9/28 , B05B7/04 , B30B11/00 , B30B15/00 , B29C33/58
CPC分类号： B30B15/0011 , Y10S425/115
摘要： The invention is directed to a process and apparatus for dotting molding tools with droplets of liquid or suspended lubricant in the production of shaped articles in the pharmaceutical, food, or catalyst fields. Pressurized lubricant solutions or suspensions and pressurized gas are alternately passed through capillaries, in conjunction with alternating single-substance nozzles, in such a way that drops are formed on the nozzle surface, in between the jets of gas, and are then detached from this surface and directed to specific zones of pressing tools. The apparatus comprises fast-acting valves for the brief release of pressurized gases and lubricant liquids or suspensions. The delivery lines of a gas valve and a liquid valve combine upstream of a capillary, and single-substance nozzles are mounted at the end of the capillaries.
摘要翻译： 本发明涉及一种用于在制药，食品或催化剂领域中成形制品的生产中点滴具有液体液滴或悬浮润滑剂的模制工具的方法和装置。 加压的润滑剂溶液或悬浮液和加压气体与交替的单一物质喷嘴交替地通过毛细管，使得在喷嘴表面之间，在气体喷射之间形成液滴，然后从该表面分离 并针对特定的按压工具区域。 该装置包括用于短暂释放加压气体和润滑剂液体或悬浮液的快速作用阀。 气体阀和液体阀的输送管线组合在毛细管的上游，单个物质的喷嘴安装在毛细管的末端。
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公开(公告)号：US4596705A
公开(公告)日：1986-06-24
申请号：US539998
申请日：1983-10-07
IPC分类号： C07D487/04 , A61K9/00 , A61K9/16 , A61K9/20 , A61K9/48 , A61K9/50 , A61K9/52 , A61K31/505 , A61K47/12 , A61P7/02 , A61K9/22
CPC分类号： A61K9/2013 , A61K31/505 , A61K9/4841 , A61K9/5078
摘要： This invention relates to vehicles for the administration of mopidamol. More specifically, this invention relates to a method of treating cardiovascular disorders, malignancy, or thrombosis in a host in need of such treatment which comprises administering to said host a cardiovascularly, antimetastic, or antithrombotic effective amount of a composition comprised of (i) mopidamol or an acid addition salt thereof and (ii) at least one pharmacologically acceptable acid or acid substance, the total amount of acid from acid addition salt present and acid or acid substance being in a ratio of at least about 1 acid equivalent to 1 mol of mopidamol.
摘要翻译： 本发明涉及给予莫匹达莫的载体。 更具体地说，本发明涉及在需要这种治疗的宿主中治疗心血管疾病，恶性肿瘤或血栓形成的方法，该方法包括向所述宿主施用心血管，抗重复或抗血栓形成的有效量的组合物，所述组合物包含（i）莫比达莫 或其酸加成盐和（ii）至少一种药理学上可接受的酸或酸物质，存在酸加成盐的酸的总量和酸或酸性物质的比例为至少约1当量酸1摩尔 莫比达莫
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