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公开(公告)号:US20090291917A1
公开(公告)日:2009-11-26
申请号:US12399015
申请日:2009-03-05
申请人: Tsutomu Akama , Yong-Kang Zhang , Charles Z. Ding , Jacob J. Plattner , Kirk R. Maples , Yvonne Freund , Virginia Sanders , Yi Xia , Stephen J. Baker , James A. Nieman , Xiaosong Lu , Marcelo Sales , Rashmi Sharma , Rajeshwar Singh , Robert T. Jacobs , Daitao Chen , Michael Richard Kevin Alley
发明人: Tsutomu Akama , Yong-Kang Zhang , Charles Z. Ding , Jacob J. Plattner , Kirk R. Maples , Yvonne Freund , Virginia Sanders , Yi Xia , Stephen J. Baker , James A. Nieman , Xiaosong Lu , Marcelo Sales , Rashmi Sharma , Rajeshwar Singh , Robert T. Jacobs , Daitao Chen , Michael Richard Kevin Alley
IPC分类号: A61K31/69 , C07F5/02 , A61P19/00 , A61P25/00 , A61P9/00 , A61P27/02 , A61P37/00 , A61P3/00 , A61P1/00
CPC分类号: C07F5/025 , A61K31/69 , C07F5/04 , Y02A50/411
摘要: Compounds and methods of treating anti-inflammatory conditions are disclosed.
摘要翻译: 公开了治疗抗炎症状的化合物和方法。
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公开(公告)号:US07608723B2
公开(公告)日:2009-10-27
申请号:US11251440
申请日:2005-10-14
申请人: Rustum S. Boyce , Yi Xia , Hongyan Guo , Kris G. Mendenhull , Annette O. Walter , Weibo Wang
发明人: Rustum S. Boyce , Yi Xia , Hongyan Guo , Kris G. Mendenhull , Annette O. Walter , Weibo Wang
IPC分类号: C07D209/10 , C07D235/14 , A61K31/33
CPC分类号: C07D403/12 , C07D209/14 , C07D235/14 , C07D401/12 , C07D403/04 , C07D403/14
摘要: The present invention relates to new indole and benzimidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
摘要翻译: 本发明涉及新的吲哚和苯并咪唑化合物及其药学上可接受的盐,酯或前药,新化合物的组合物和药学上可接受的载体,以及新化合物的用途。 本发明的化合物具有以下通式:
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13.
公开(公告)号:US20070123546A1
公开(公告)日:2007-05-31
申请号:US11541462
申请日:2006-09-28
申请人: Timothy Machajewski , Cynthia Shafer , Christopher McBride , William Antonios-McCrea , Brandon Doughan , Barry Levine , Yi Xia , Maureen McKeena , X. Wang , Kris Mendenhall , Yasheen Zhou , Baoquing Gong , Dan Gu , John Dolan , John Tulinsky , Kristin Brinner , Zhenhai Gao
发明人: Timothy Machajewski , Cynthia Shafer , Christopher McBride , William Antonios-McCrea , Brandon Doughan , Barry Levine , Yi Xia , Maureen McKeena , X. Wang , Kris Mendenhall , Yasheen Zhou , Baoquing Gong , Dan Gu , John Dolan , John Tulinsky , Kristin Brinner , Zhenhai Gao
IPC分类号: A61K31/519 , C07D487/02 , C07D211/54
CPC分类号: C07D211/86 , C07D471/04
摘要: Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nervous system diseases.
摘要翻译: 公开了2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物,其立体异构体,互变异构体,其药学上可接受的盐和前药; 包括药学上可接受的载体和一种或多种2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物的组合物,单独或与至少一种额外的 治疗剂。 还公开了将2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物单独使用或与至少一种另外的治疗剂组合使用的方法,用于预防 或治疗细胞增殖,病毒,自身免疫,心血管和中枢神经系统疾病。
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公开(公告)号:US08343944B2
公开(公告)日:2013-01-01
申请号:US12844748
申请日:2010-07-27
申请人: Yi Xia , Michael Richard Kevin Alley , Yasheen Zhou , Rajeshwar Singh , Charles Ding , Kathy Cao , Jacob J. Plattner , Ligong Ou , Guofeng Jia , Neerja Saraswat , Sreekanth Ramachandran , Ding Zhou
发明人: Yi Xia , Michael Richard Kevin Alley , Yasheen Zhou , Rajeshwar Singh , Charles Ding , Kathy Cao , Jacob J. Plattner , Ligong Ou , Guofeng Jia , Neerja Saraswat , Sreekanth Ramachandran , Ding Zhou
CPC分类号: C07F5/025 , A61K31/69 , A61K45/06 , A61K2300/00
摘要: This invention largely relates to 3,4,6-trisubstituted benzoxaborole compounds, and their use for treating bacterial infections.
摘要翻译: 本发明主要涉及3,4,6-三取代苯并恶唑化合物及其用于治疗细菌感染的用途。
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公开(公告)号:US20120214765A1
公开(公告)日:2012-08-23
申请号:US13236543
申请日:2011-09-19
申请人: Tsutomu Akama , Yong-Kang Zhang , Charles Z. Ding , Jacob J. Plattner , Kirk R. Maples , Yvonne Freund , Virginia Sanders , Yi Xia , Stephen J. Baker , James A. Nieman , Xiaosong Lu , Marcelo Sales , Rashmi Sharma , Rajeshwar Singh , Robert T. Jacobs , Daitao Chen , Michael Richard Kevin Alley
发明人: Tsutomu Akama , Yong-Kang Zhang , Charles Z. Ding , Jacob J. Plattner , Kirk R. Maples , Yvonne Freund , Virginia Sanders , Yi Xia , Stephen J. Baker , James A. Nieman , Xiaosong Lu , Marcelo Sales , Rashmi Sharma , Rajeshwar Singh , Robert T. Jacobs , Daitao Chen , Michael Richard Kevin Alley
CPC分类号: C07F5/025 , A61K31/69 , C07F5/04 , Y02A50/411
摘要: Compounds and methods of treating anti-inflammatory conditions are disclosed.
摘要翻译: 公开了治疗抗炎症状的化合物和方法。
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公开(公告)号:US08129358B2
公开(公告)日:2012-03-06
申请号:US12312389
申请日:2007-11-08
申请人: Yi Xia , Kris G. Mendenhall , Paul A. Barsanti , Annette O. Walter , David Duhl , Paul A. Renhowe
发明人: Yi Xia , Kris G. Mendenhall , Paul A. Barsanti , Annette O. Walter , David Duhl , Paul A. Renhowe
IPC分类号: A61K31/553 , A61K31/54 , A61K31/535 , A61K31/495 , A61K31/505 , A61K31/44 , A61K31/445 , A61K31/41 , C07D267/02 , C07D279/10 , C07D413/02 , C07D211/30 , C07D401/02 , C07D249/08
CPC分类号: C07D401/12 , C07D249/08 , C07D403/12 , C07D413/12
摘要: Disclosed are new substituted pyrazole and triazole compounds of Formula (I) and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the derivatives together with pharmaceutically acceptable carriers, and uses thereof:
摘要翻译: 公开了式(I)的新的取代的吡唑和三唑化合物及其药学上可接受的盐,酯或前药,衍生物的组合物和药学上可接受的载体,及其用途:
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公开(公告)号:US08039450B2
公开(公告)日:2011-10-18
申请号:US12399015
申请日:2009-03-05
申请人: Tsutomu Akama , Yong-Kang Zhang , Charles Z. Ding , Jacob J. Plattner , Kirk R. Maples , Yvonne Freund , Virginia Sanders , Yi Xia , Stephen J. Baker , James A. Nieman , Xiaosong Lu , Marcelo Sales , Rashmi Sharma , Rajeshwar Singh , Robert Jacobs , Daitao Chen , Michael Richard Kevin Alley
发明人: Tsutomu Akama , Yong-Kang Zhang , Charles Z. Ding , Jacob J. Plattner , Kirk R. Maples , Yvonne Freund , Virginia Sanders , Yi Xia , Stephen J. Baker , James A. Nieman , Xiaosong Lu , Marcelo Sales , Rashmi Sharma , Rajeshwar Singh , Robert Jacobs , Daitao Chen , Michael Richard Kevin Alley
CPC分类号: C07F5/025 , A61K31/69 , C07F5/04 , Y02A50/411
摘要: Compounds and methods of treating anti-inflammatory conditions are disclosed.
摘要翻译: 公开了治疗抗炎症状的化合物和方法。
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公开(公告)号:US07855295B2
公开(公告)日:2010-12-21
申请号:US11042474
申请日:2005-01-24
申请人: Weibo Wang , Zhi-Jie Ni , Paul Barsanti , Sabina Pecchi , Yi Xia , Nathan Brammeier , Megan C. Phillips , Eliza Jazan , Kelly Wayman , David Dibble , Jie-Kai Cheng
发明人: Weibo Wang , Zhi-Jie Ni , Paul Barsanti , Sabina Pecchi , Yi Xia , Nathan Brammeier , Megan C. Phillips , Eliza Jazan , Kelly Wayman , David Dibble , Jie-Kai Cheng
IPC分类号: A61K31/437 , C07D487/04
CPC分类号: C07D471/04
摘要: Tetrahydrocarboline compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the tetrahydrocarboline compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the tetrahydrocarboline compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.
摘要翻译: 四氢咔啉化合物,其药学上可接受的盐和前药; 包括药学上可接受的载体和一种或多种四氢咔啉化合物的组合物,单独或与至少一种另外的治疗剂组合。 单独使用四氢咔啉化合物或与至少一种另外的治疗剂组合使用的方法可用于预防或治疗增殖性疾病。
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19.
公开(公告)号:US07671059B2
公开(公告)日:2010-03-02
申请号:US11541462
申请日:2006-09-28
申请人: Timothy D. Machajewski , Cynthia M. Shafer , Christopher McBride , William Antonios-McCrea , Brandon M. Doughan , Barry H. Levine , Yi Xia , Maureen McKenna , X. Michael Wang , Kris Mendenhall , Yasheen Zhou , Kristin Brinner , Zhenhai Gao , Daniel Poon , Paul Barsanti , Xiaodong Lin , Abran Costales , Alice Rico , Nathan Brammeier , Teresa Pick , Paul A. Renhowe
发明人: Timothy D. Machajewski , Cynthia M. Shafer , Christopher McBride , William Antonios-McCrea , Brandon M. Doughan , Barry H. Levine , Yi Xia , Maureen McKenna , X. Michael Wang , Kris Mendenhall , Yasheen Zhou , Kristin Brinner , Zhenhai Gao , Daniel Poon , Paul Barsanti , Xiaodong Lin , Abran Costales , Alice Rico , Nathan Brammeier , Teresa Pick , Paul A. Renhowe
IPC分类号: A61K31/519 , A61K31/5355 , C07D471/04 , C07D487/04 , C07D413/06 , A61P35/00
CPC分类号: C07D211/86 , C07D471/04
摘要: Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nervous system diseases.
摘要翻译: 公开了2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物,其立体异构体,互变异构体,其药学上可接受的盐和前药; 包括药学上可接受的载体和一种或多种2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物的组合物,单独或与至少一种额外的 治疗剂。 还公开了将2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物单独使用或与至少一种另外的治疗剂组合使用的方法,用于预防 或治疗细胞增殖,病毒,自身免疫,心血管和中枢神经系统疾病。
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公开(公告)号:US08461135B2
公开(公告)日:2013-06-11
申请号:US13236543
申请日:2011-09-19
申请人: Tsutomu Akama , Yong-Kang Zhang , Charles Z. Ding , Jacob J. Plattner , Kirk R. Maples , Yvonne Freund , Virginia Sanders , Yi Xia , Stephen J. Baker , James A. Nieman , Xiaosong Lu , Marcelo Sales , Rashmi Sharma , Rajeshwar Singh , Robert T. Jacobs , Daitao Chen , Michael Richard Kevin Alley
发明人: Tsutomu Akama , Yong-Kang Zhang , Charles Z. Ding , Jacob J. Plattner , Kirk R. Maples , Yvonne Freund , Virginia Sanders , Yi Xia , Stephen J. Baker , James A. Nieman , Xiaosong Lu , Marcelo Sales , Rashmi Sharma , Rajeshwar Singh , Robert T. Jacobs , Daitao Chen , Michael Richard Kevin Alley
CPC分类号: C07F5/025 , A61K31/69 , C07F5/04 , Y02A50/411
摘要: Compounds and methods of treating anti-inflammatory conditions are disclosed.
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