公开(公告)号：US11554377B2

公开(公告)日：2023-01-17

申请号：US16606869

申请日：2018-01-29

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Viktor Shkolnikov ,  Daixi Xin

IPC: B03C5/02 ,  B01D17/06

Abstract: An object separator may include a substrate, a fluid channel supported by the substrate, a pair of electrodes along the fluid channel to form a dielectrophoretic force to interact with an object entrained in a fluid and an inertial pump supported by the substrate to move the fluid along the fluid channel.

公开(公告)号：US11481964B2

公开(公告)日：2022-10-25

申请号：US16605949

申请日：2018-04-27

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Yang Lei ,  Viktor Shkolnikov ,  Daixi Xin

IPC: G06T15/00 ,  G06T15/20 ,  G06T17/00

Abstract: A three-dimensional volume modeling method may include rotating a three-dimensional biological object having a translucent outer surface to different angular positions, capturing different two-dimensional images of the three-dimensional biological object, each of the different two-dimensional images being at a different angular position, and modeling an exterior of the three-dimensional biological object based upon the different two-dimensional images. The method may further involve identifying a point of an internal structure of the three-dimensional biological object each of the two-dimensional images and modeling the internal structure of the three-dimensional biological object in three-dimensional space relative to the exterior of the three-dimensional biological object by triangulating the point amongst the different two-dimensional images using a three-dimensional volumetric template of the three-dimensional biological object.

公开(公告)号：US20210403849A1

公开(公告)日：2021-12-30

申请号：US16606742

申请日：2018-04-27

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Viktor Shkolnikov ,  Daixi Xin ,  Yang Lei

IPC: C12M1/00 ,  C12M1/42 ,  C12M1/34 ,  C12N5/00 ,  C12M3/06

Abstract: A cellular object imaging system may include a growth platform. The growth platform may include a body having a cellular fluid suspension region, a media supply passage extending within the body to the cellular object fluid suspension region, at least one fluid pump on the body to selectively deliver media to the cellular object fluid suspension region, a waste discharge passage extending within the body from the cellular object fluid suspension region and a cellular object rotator on the body adjacent the cellular object fluid suspension region to rotate a cellular object within the cellular object fluid suspension region. The cellular object fluid suspension region permits optical imaging of the cellular object suspended in a fluid during rotation by the cellular object rotator.

公开(公告)号：US12115534B2

公开(公告)日：2024-10-15

申请号：US17047359

申请日：2018-07-26

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Viktor Shkolnikov ,  Daixi Xin ,  Ken Ward

IPC: B01L3/00 ,  G01N35/00

CPC classification number: B01L3/508 ,  B01L3/5085 ,  G01N35/0099 ,  B01L2200/0668 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/12 ,  B01L2400/0424

Abstract: An example system includes a well plate having at least one well, an array of electrodes positioned on a surface of a bottom floor of the well, and a controller to direct electrical voltage to the electrodes to generate a non-uniform electrical field. The electrical field is to direct an object in the electrical field to a target position in the well.

公开(公告)号：US11485944B2

公开(公告)日：2022-11-01

申请号：US16606841

申请日：2018-04-04

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Viktor Shkolnikov ,  Daixi Xin

IPC: C12M3/06 ,  C12M1/00 ,  C12M1/42 ,  B01L3/00 ,  F04B19/00 ,  F04B43/04 ,  F04B43/06 ,  F04B9/103

Abstract: The present disclosure is drawn to microfluidic cellular membrane modification devices. In one example, a microfluidic cellular membrane modification device can include a microfluidic channel including a pumping portion and an electric field portion. An electrode pair can be positioned about the electric field portion. A bidirectional pump can be in fluid communication with the microfluidic channel at the pumping portion to move fluid backward and forward through the electric field portion.

公开(公告)号：US20220250070A1

公开(公告)日：2022-08-11

申请号：US17415213

申请日：2019-09-14

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Viktor Shkolnikov ,  Chien-Hua Chen ,  Daixi Xin

IPC: B01L3/00 ,  B03C5/02

Abstract: A fluid entrained particle separation system may include a particle separator, a main fluid passage extending along an axis to guide translational fluid flow along the axis to the particle separator and a side fluid inlet connected to the main fluid passage to generate a vortex about the axis. The vortex concentrates less dense material in the fluid flow towards the axis.

公开(公告)号：US20210366181A1

公开(公告)日：2021-11-25

申请号：US16605949

申请日：2018-04-27

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Yang Lei ,  Viktor Shkolnikow ,  Daixi Xin

IPC: G06T15/20 ,  G06T17/00

Abstract: A three-dimensional volume modeling method may include rotating a three-dimensional biological object having a translucent outer surface to different angular positions, capturing different two-dimensional images of the three-dimensional biological object, each of the different two-dimensional images being at a different angular position, and modeling an exterior of the three-dimensional biological object based upon the different two-dimensional images. The method may further involve identifying a point of an internal structure of the three-dimensional biological object each of the two-dimensional images and modeling the internal structure of the three-dimensional biological object in three-dimensional space relative to the exterior of the three-dimensional biological object by triangulating the point amongst the different two-dimensional images using a three-dimensional volumetric template of the three-dimensional biological object.

公开(公告)号：US20210264687A1

公开(公告)日：2021-08-26

申请号：US17256353

申请日：2018-10-03

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Yang Lei ,  Viktor Shkolnikov ,  Daixi Xin

IPC: G06T19/20 ,  G06T17/10 ,  G06T7/564

Abstract: An example method includes capturing a plurality of images of a rotating object using an imaging device optically coupled to a microscope. The method removing a first portion of a model of the rotating object based on a first contour of the rotating object in a first image of the plurality of images. The method includes orienting the model based on an amount of rotation of the rotating object between capture of the first image and capture of a second image of the plurality of images. The method also includes removing a second portion of the model of the rotating object based on a second contour of the rotating object in the second image.

公开(公告)号：US20210033842A1

公开(公告)日：2021-02-04

申请号：US16606239

申请日：2018-04-27

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Viktor Shkolnikov ,  Daixi Xin ,  Yang Lei

IPC: G02B21/36 ,  G06T17/00 ,  H04N5/232 ,  G01N33/483

Abstract: A three-dimensional object modeling method may include applying a nonrotating nonuniform electric field to apply a dielectrophoretic torque to a three-dimensional object to rotate the three-dimensional object, capturing images of the object at different angles during rotation of the object and forming a three-dimensional model of the object based on the captured images.