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公开(公告)号：US20230174908A1
公开(公告)日：2023-06-08
申请号：US17911553
申请日：2020-04-30
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Alexander GOVYADINOV , Viktor SHKOLNIKOV
Abstract: In example implementations, an apparatus is provided. The apparatus includes a channel, a reagent chamber, a synthetic jet channel, and an energy source. The channel is to hold a cell. The reagent chamber is coupled to the channel and stores a reagent. The synthetic jet channel is coupled to the channel and the reagent chamber. The energy source is located in the synthetic jet channel to heat a liquid in the synthetic jet channel to create a synthetic jet that carries the reagent through towards the cell to inject the reagent into the cell.
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公开(公告)号：US20230016934A1
公开(公告)日：2023-01-19
申请号：US17782805
申请日：2020-03-26
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Viktor SHKOLNIKOV , Kenneth J. WARD
IPC: G01N1/38 , G01N15/10 , G01N33/487
Abstract: In one example in accordance with the present disclosure, a cell preparation system is described. The cell preparation system includes a fluidic channel to transport cells in single file past multiple detection devices. The cell preparation system also includes a series of detection devices. Each detection device includes 1) a constriction to deform a cell found therein and 2) a sensor to measure a state within the constriction. The cell preparation system also includes a controller. The controller analyzes outputs from multiple sensors to 1) verify a single file transport of cells through the system and 2) identify a cell that passes through the fluidic channel.
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公开(公告)号：US20210213451A1
公开(公告)日：2021-07-15
申请号：US16076074
申请日：2017-04-23
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Viktor SHKOLNIKOV , Chien-Hua CHEN
Abstract: A fluid entrained particle separator may include an inlet passage to direct particles entrained in a fluid, a first separation passage branching from the inlet passage, a second separation passage branching from the inlet passage and electrodes to create electric field exerting a dielectrophoretic force on the particles to direct the particles to the first separation passage or the second separation passage, wherein the first separation passage, the second separation passage, the electric field and the dielectrophoretic force extend in a plane.
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公开(公告)号：US20210197199A1
公开(公告)日：2021-07-01
申请号：US16076553
申请日：2017-07-12
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Viktor SHKOLNIKOV , Michael W. CUMBIE , Chien-Hua CHEN
IPC: B01L3/00
Abstract: A channel layer of a digital microfluidic device may include a number of sample wells located on a first side of the die, a number of first capillary channels fluidically coupled to each of the sample wells, the first capillary channels drawing a fluid from the sample wells using capillary forces, a capillary break fluidically coupled to each of the first capillary channels to dispense a portion of the fluid drawn from the sample wells through the capillary forces, a number of intermediate chambers fluidically coupled to the capillary break, a number of second capillary channels fluidically coupled to the intermediate chambers, the second capillary channels drawing the fluid from the intermediate chambers using capillary forces, and a number of mixing chambers fluidically coupled to the second capillary channels into which the capillary forces of the second capillary channels cause the fluid to enter the mixing chambers.
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公开(公告)号：US20210190694A1
公开(公告)日：2021-06-24
申请号：US16074298
申请日：2016-04-20
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Ning GE , Anita ROGACS , Viktor SHKOLNIKOV , Alexander GOVYADINOV
IPC: G01N21/65
Abstract: A surface enhanced Raman scattering (SERS) sensor may include a substrate, an electrically conductive layer having a first portion spaced from a second portion by a gap, an electrically resistive layer in contact with and extending between the first portion and the second portion of the electrically conductive layer to form an electrically resistive bridge across the gap that heats the nano fingers in response to electrical current flowing across the bridge from the first portion to the second portion and nano fingers extending upward from the bridge.
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Patent Agency Ranking
公开(公告)号：US20200038872A1
公开(公告)日：2020-02-06
申请号：US16494827
申请日：2017-04-21
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Michael W. Cumbie , Viktor SHKOLNIKOV , Chien-Hua CHEN
IPC: B01L3/00
Abstract: An apparatus includes a polymer base layer having a surface. A die that includes a fluid manipulation surface that is substantially coplanar with the surface of the polymer base layer. The die includes a control electrode to generate an electric field to perform microfluidic manipulation of fluid across the fluid manipulation surface of the die.
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17.发明公开公开(公告)号：US20230285970A1
公开(公告)日：2023-09-14
申请号：US17692589
申请日：2022-03-11
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Viktor SHKOLNIKOV , Alexander GOVYADINOV
CPC classification number: B01L3/502761 , C12Q3/00 , G01N21/6428 , B01L2200/025 , B01L2200/027 , B01L2200/0652 , B01L2200/16 , B01L2300/0654 , B01L2400/02 , G01N2021/6439
Abstract: An example apparatus comprises a first microfluidic channel fluidically coupled to a first reservoir containing a carrier fluid, the first microfluidic channel including a reaction region, a fluid droplet generator, and a fluid ejector fluidically coupled to the first microfluidic channel and disposed downstream from the reaction region of the first microfluidic channel. The fluid droplet generator includes a portion of the first microfluidic channel and a second microfluidic channel that intersects the first microfluidic channel and is fluidically coupled to a second reservoir containing a reaction fluid, where the reaction fluid including a plurality of cells and fluorescently-labeled capture reagents to form reaction products with a target molecule secreted by the plurality of cells.
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公开(公告)号：US20230073786A1
公开(公告)日：2023-03-09
申请号：US17467098
申请日：2021-09-03
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Yang LEI , Viktor SHKOLNIKOV , Daixi XIN
Abstract: For some examples, an apparatus to effect particle separation may include a dielectrophoretic particle separator that may separate particles within a focused particle stream. The dielectrophoretic particle separator may apply an electric field to the particles. An imaging system may capture images of the particles passing through a separation region of the dielectrophoretic particle separator. An image processing and control system may process the images to obtain information regarding the particles and may adjust an operating parameter of the dielectrophoretic separator based upon the information regarding the particles.
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公开(公告)号：US20230011683A1
公开(公告)日：2023-01-12
申请号：US17782601
申请日：2020-01-23
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Alexander GOVYADINOV , Viktor SHKOLNIKOV
Abstract: An example apparatus comprises a thermal cell lysis chamber, including a substrate and a lid coupled to the substrate to form a microfluidic channel therethrough. The apparatus includes cell detection circuitry to detect presence of a cell within the microfluidic channel and to detect lysis of the cell. The apparatus also includes a thermal lysing element disposed in the lid to apply heat to a cell detected by the cell detection circuitry, and lysis control circuitry. The lysis control circuitry is to regulate a temperature applied by the thermal lysing element, based on detection by the cell detection circuitry of a cell within the microfluidic channel and based on detection by the cell detection circuitry of a lysis event, and record the temperature applied by the thermal lysing element at which the lysis event occurred.
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公开(公告)号：US20220032298A1
公开(公告)日：2022-02-03
申请号：US17297219
申请日：2019-02-01
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Alexander GOVYADINOV , Viktor SHKOLNIKOV
Abstract: In one example in accordance with the present disclosure, a cell sorting device is described. The cell sorting device includes a microfluidic channel to serially transport individual cells from a volume of cells along a flow path. A sensor disposed in the microfluidic channel distinguishes between a cell to be analyzed and waste fluid. The cell sorting device includes at least two fluid transport devices disposed within the microfluidic channel. The at least two fluid transport devices include a cell ejector to, responsive to detection of a cell to be analyzed, eject the cell to be analyzed from the cell sorting device and a waste transport device to direct the waste fluid to a waste reservoir.
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