公开(公告)号：US07541257B2

公开(公告)日：2009-06-02

申请号：US11519064

申请日：2006-09-12

申请人： Eiji Ishikawa ,  Takaaki Aoki

发明人： Eiji Ishikawa ,  Takaaki Aoki

IPC分类号： H01L21/76

CPC分类号： H01L31/035281 ,  B81B2201/058 ,  B81B2201/06 ,  B81C1/00071 ,  B81C2201/0169 ,  Y02E10/50

摘要： A semiconductor device includes: a silicon substrate; and a silicon oxide film disposed on the silicon substrate. The silicon oxide film includes a part, which separates from a surface of the silicon substrate, so that the silicon oxide film provides a three-dimensional construction. By using the three-dimensional construction, an additional function such as a resistor or a capacitor is easily added in the device. Further, a manufacturing method of this three-dimensional construction is simple and has a low cost.

摘要翻译： 半导体器件包括：硅衬底; 以及设置在硅衬底上的氧化硅膜。 氧化硅膜包括从硅衬底的表面分离的部分，使得氧化硅膜提供三维结构。 通过使用三维构造，在该装置中容易添加诸如电阻器或电容器的附加功能。 此外，该三维构造的制造方法简单，成本低。

公开(公告)号：US20070066052A1

公开(公告)日：2007-03-22

申请号：US11519064

申请日：2006-09-12

申请人： Eiji Ishikawa ,  Takaaki Aoki

发明人： Eiji Ishikawa ,  Takaaki Aoki

IPC分类号： H01L21/4763 ,  H01L29/06

CPC分类号： H01L31/035281 ,  B81B2201/058 ,  B81B2201/06 ,  B81C1/00071 ,  B81C2201/0169 ,  Y02E10/50

摘要： A semiconductor device includes: a silicon substrate; and a silicon oxide film disposed on the silicon substrate. The silicon oxide film includes a part, which separates from a surface of the silicon substrate, so that the silicon oxide film provides a three-dimensional construction. By using the three-dimensional construction, an additional function such as a resistor or a capacitor is easily added in the device. Further, a manufacturing method of this three-dimensional construction is simple and has a low cost.

摘要翻译： 半导体器件包括：硅衬底; 以及设置在硅衬底上的氧化硅膜。 氧化硅膜包括从硅衬底的表面分离的部分，使得氧化硅膜提供三维结构。 通过使用三维构造，在该装置中容易添加诸如电阻器或电容器的附加功能。 此外，该三维构造的制造方法简单，成本低。

公开(公告)号：US20070242347A1

公开(公告)日：2007-10-18

申请号：US11808754

申请日：2007-06-12

申请人： Eiji Ishikawa ,  Hiroto Ikeda ,  Hiroyuki Deguchi

发明人： Eiji Ishikawa ,  Hiroto Ikeda ,  Hiroyuki Deguchi

IPC分类号： H04B10/12

CPC分类号： H04B10/2937 ,  H01S3/302 ,  H04B10/0775 ,  H04B10/2916 ,  H04B2210/078 ,  H04B2210/08

摘要： A reliable optical transmission system with an improved signal control mechanism that avoids abrupt power variations of light beams, thereby preventing optical supervisory channel (OSC) signals from experiencing errors. An optical amplifier amplifies main signals under the control of an optical amplifier controller, which spends a first predetermined time to raise the output power of the optical amplifier up to a desired level. A pump light source produces a pump beam for injection to a fiber-optic transmission line so as to make it serve as an amplifying medium. The pump light source is controlled by a pump light source controller that spends a second predetermined time to raise the pump beam to a desired power level. This stepwise start-up process of the amplifier power and pump beam power prevents OSC signals from experiencing abrupt power variations.

公开(公告)号：US20050213196A1

公开(公告)日：2005-09-29

申请号：US11138492

申请日：2005-05-27

申请人： Eiji Ishikawa ,  Toshihiro Otani

发明人： Eiji Ishikawa ,  Toshihiro Otani

IPC分类号： G02F1/35 ,  H01S3/00 ,  H04B10/077 ,  H04B10/079 ,  H04B10/2507 ,  H04B10/2537 ,  H04B10/29 ,  H04B10/294 ,  H04B10/297

CPC分类号： H04B10/2916

摘要： An optical transmission system wherein a main signal light is amplified by Raman amplification, and noise light (ASS light) produced by the Raman amplification can be corrected with a simple configuration and with high accuracy. The optical transmission system comprises, in each transmission section: a cutoff section for transmitting/cutting off a main signal light outputted from the optical transmitter on the preceding stage and inputted into the Raman amplification medium on an optical transmission line; a control section for varying the power of the pumping light supplied to the Raman amplification medium and changing the state of the cutoff section depending on the variation of the pumping light power; a monitor section for measuring the power of the pumping light supplied to the Raman amplification medium and the power of the light propagated through the optical transmission line and inputted into an optical transmitter on the succeeding stage; and a processing section for separately detecting the power of the main signal light and the power of the ASS light on the basis of the results of the measurement by the monitor section, and correcting the ASS light.

摘要翻译： 一种光传输系统，其中主信号光通过拉曼放大放大，并且可以以简单的配置和高精度校正由拉曼放大产生的噪声光（ASS光）。 光传输系统包括：在每个传输部分中：切断部分，用于传输/切断在前级上的光发射机输出并在光传输线上输入到拉曼放大介质中的主信号光; 控制部分，用于改变提供给拉曼放大介质的泵浦光的功率，并根据泵浦光功率的变化改变截止部分的状态; 用于测量提供给拉曼放大介质的泵浦光的功率和通过光传输线传播并输入到后级光发射机的光的功率的监视器部分; 以及处理部分，用于根据监视部分的测量结果分别检测主信号光的功率和ASS光的功率，并校正ASS光。

公开(公告)号：US6063564A

公开(公告)日：2000-05-16

申请号：US124767

申请日：1998-07-30

申请人： Eiji Ishikawa ,  Setsuko Ishikawa

发明人： Eiji Ishikawa ,  Setsuko Ishikawa

IPC分类号： G01N33/543 ,  G01N33/569 ,  C12Q1/70

CPC分类号： G01N33/56988 ,  G01N33/54306

摘要： An assay method capable of efficiently trapping an analyte in a certain amount of a reaction liquid in a short reaction time, the method being characterized in that only a part of a solid phase coated with a substance that specifically binds to the substance to be assayed is immersed in a pool of the reaction liquid containing the analyte, and this part of the solid phase is exchanged during the reaction, so that any surface of the solid phase can be immersed in the reaction liquid once in a predetermined time, and an assay kit for the assay based on this principle. In comparison with the conventional assay methods wherein the entire area of a limited solid phase surface is brought into contact with a certain amount of a reaction liquid, or wherein a test solution is diluted to bring the entirety of a certain surface area of the solid phase into contact therewith, the inventive method can increase reaction speed, which in turn results in trapping of the analyte on the solid phase efficiently in a short time. This reaction system can be used for the detection of an enzyme label in an enzyme immunoassay.

摘要翻译： 一种能够在短的反应时间内有效地捕获一定量的反应液中的分析物的分析方法，其特征在于，只有一部分用特异性结合被测定物质的物质涂覆的固相是 浸入含有分析物的反应液体池中，并且在反应期间交换固相的这一部分，使得固相的任何表面可以在预定时间内浸入反应液中一次，并且测定试剂盒 用于基于该原理的测定。 与常规测定方法相比，其中有限的固相表面的整个区域与一定量的反应液体接触，或者其中将测试溶液稀释以使固相的整个表面积的整体 本发明的方法可以提高反应速度，从而在短时间内有效地将分析物捕获在固相上。 该反应体系可用于检测酶免疫测定中的酶标记。

公开(公告)号：US5618120A

公开(公告)日：1997-04-08

申请号：US293419

申请日：1994-08-22

申请人： Eiji Ishikawa

发明人： Eiji Ishikawa

IPC分类号： B41J2/05 ,  B41J29/42 ,  B41J29/48 ,  B41J29/50 ,  B65H7/14 ,  G01D15/28

CPC分类号： B41J29/42

摘要： A recording apparatus having means for detecting a recordable area on a recording medium comprises the structures of measuring means capable of measuring the reflective luminous energy of a recording medium and of means for holding the recording medium, means for holding the data on the basis of the reflective luminous energy of the means for holding the recording medium and the data on the basis of the reflective luminous energy of the recording medium, which are measured by the measuring means, and means for setting by both of the data a threshold value utilized for determining the boundary between the recording medium and the means for holding the medium.

摘要翻译： 具有用于检测记录介质上的可记录区域的装置的记录装置包括能够测量记录介质的反射光能的测量装置的结构和用于保持记录介质的装置，用于基于 用于保持记录介质的装置的反射光能和基于由测量装置测量的记录介质的反射光能的数据，以及用于通过两个数据设置用于确定的阈值的装置 记录介质和用于保持介质的装置之间的边界。

公开(公告)号：US5137807A

公开(公告)日：1992-08-11

申请号：US380751

申请日：1989-07-17

申请人： Shinichi Yoshida ,  Eiji Ishikawa ,  Akira Oshima ,  Yasuo Bai ,  Yasuteru Muragaki ,  Kazushi Iwata ,  Kenichi Obata ,  Yasuo Nagai

发明人： Shinichi Yoshida ,  Eiji Ishikawa ,  Akira Oshima ,  Yasuo Bai ,  Yasuteru Muragaki ,  Kazushi Iwata ,  Kenichi Obata ,  Yasuo Nagai

IPC分类号： A61K39/00 ,  C12Q1/00 ,  C12Q1/26 ,  G01N33/573 ,  G01N33/577

CPC分类号： G01N33/573 ,  Y10S436/811 ,  Y10S436/82

摘要： The present invention is directed to a method for detecting hepatic diseases which are associated with fibrosis by determining the level of human prolyl hydroxylase in a serum sample which comprises:(a) contacting a serum sample of a patient suspected of having said hepatic disease associated with fibrosis with a monoclonal antibody specific to the .beta.-subunit of human prolyl hydroxylase to form an antigen antibody complex bound on a solid support;(b) contacting said antigen antibody complex bound on said solid support with an enzyme-labeled monoclonal or enzyme-labeled polyclonal antibody specific to human prolyl hydroxylase to form an antibody antigen enzyme-labeled antibody complex; and(c) measuring the amount of enzyme activity of said bound antibody antigen enzyme-labeled antibody complex to determine the level of human prolyl hydroxylase present in said serum sample.

摘要翻译： 本发明涉及通过测定血清样品中人脯氨酰羟化酶水平来检测与纤维化相关的肝病的方法，该方法包括：（a）使疑似患有所述肝病的患者的血清样品与 纤维化与对人脯氨酰羟化酶的β亚单位特异的单克隆抗体形成结合在固体支持物上的抗原抗体复合物; （b）将结合在所述固体支持物上的所述抗原抗体复合物与人脯氨酰羟化酶特异性的酶标记的单克隆或酶标记的多克隆抗体接触以形成抗体抗原酶标记的抗体复合物; 和（c）测量所述结合的抗体抗体酶标记的抗体复合物的酶活性的量以确定存在于所述血清样品中的人脯氨酰羟化酶的水平。

公开(公告)号：US4657853A

公开(公告)日：1987-04-14

申请号：US650868

申请日：1984-09-14

申请人： J. William Freytag ,  Eiji Ishikawa

发明人： J. William Freytag ,  Eiji Ishikawa

IPC分类号： G01N33/535 ,  G01N33/563 ,  G01N33/50 ,  C12N9/96 ,  C12Q1/00

CPC分类号： G01N33/563 ,  G01N33/535 ,  Y10S435/81 ,  Y10S435/964 ,  Y10S435/966

摘要： An enzyme is cross linked to form a polymerized enzyme which is covalently coupled to an antibody or antibody fragment. The use of the antibody-polymeric enzyme conjugate in immunoassays provides enhanced signal generation and, therefore, short assay time and high sensitivity.

摘要翻译： 将酶交联以形成共价偶联于抗体或抗体片段的聚合酶。 免疫测定中抗体 - 聚合酶结合物的使用提供了增强的信号产生，因此提供了短的测定时间和高灵敏度。

公开(公告)号：US09388474B2

公开(公告)日：2016-07-12

申请号：US14239409

申请日：2012-08-31

申请人： Hiroyuki Kubota ,  Hiroshi Makino ,  Takafumi Sakai ,  Eiji Ishikawa ,  Kenji Oishi

发明人： Hiroyuki Kubota ,  Hiroshi Makino ,  Takafumi Sakai ,  Eiji Ishikawa ,  Kenji Oishi

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/04

CPC分类号： C12Q1/689

摘要： Provided are an oligonucleotide which realizes specific and highly sensitive detection of toxigenic C. difficile, and a method for detecting toxigenic C. difficile, the method employing the oligonucleotide.1) A primer pair containing an oligonucleotide having a nucleotide sequence represented by SEQ ID NO: 1, and an oligonucleotide having a nucleotide sequence represented by SEQ ID NO: 2; or a primer pair having complementary sequences to the nucleotide sequences. 2) A primer pair containing an oligonucleotide having a nucleotide sequence represented by SEQ ID NO: 4, and an oligonucleotide having a nucleotide sequence represented by SEQ ID NO: 5; or a primer pair having complementary sequences to the nucleotide sequences.

摘要翻译： 提供了实现特异性和高度灵敏的产生艰难梭菌的检测的寡核苷酸，以及使用该寡核苷酸的方法，用于检测致病性艰难梭菌的方法。 1）一种引物对，其含有具有由SEQ ID NO：1表示的核苷酸序列的寡核苷酸和具有由SEQ ID NO：2表示的核苷酸序列的寡核苷酸; 或与核苷酸序列具有互补序列的引物对。 2）含有具有SEQ ID NO：4所示的核苷酸序列的寡核苷酸的引物对和具有由SEQ ID NO：5表示的核苷酸序列的寡核苷酸; 或与核苷酸序列具有互补序列的引物对。

公开(公告)号：US07312918B2

公开(公告)日：2007-12-25

申请号：US11138492

申请日：2005-05-27

申请人： Eiji Ishikawa ,  Toshihiro Otani

发明人： Eiji Ishikawa ,  Toshihiro Otani

IPC分类号： H01S4/00 ,  H04B10/12

CPC分类号： H04B10/2916

摘要： An optical transmission system wherein a main signal light is amplified by Raman amplification, and noise light (ASS light) produced by the Raman amplification can be corrected with a simple configuration and with high accuracy. The optical transmission system includes, in each transmission section: a cutoff section for transmitting/cutting off a main signal light outputted from the optical transmitter on the preceding stage and inputted into the Raman amplification medium on an optical transmission line; a control section for varying the power of the pumping light supplied to the Raman amplification medium and changing the state of the cutoff section depending on the variation of the pumping light power; a monitor section for measuring the power of the pumping light supplied to the Raman amplification medium and the power of the light propagated through the optical transmission line and inputted into an optical transmitter on the succeeding stage; and a processing section for separately detecting the power of the main signal light and the power of the ASS light on the basis of the results of the measurement by the monitor section, and correcting the ASS light.

摘要翻译： 一种光传输系统，其中主信号光通过拉曼放大放大，并且可以以简单的配置和高精度校正由拉曼放大产生的噪声光（ASS光）。 光传输系统包括：在每个传输部分中：切断部分，用于发射/切断在前级上的光发射机输出的主信号光，并输入到光传输线上的拉曼放大介质; 控制部分，用于改变提供给拉曼放大介质的泵浦光的功率，并根据泵浦光功率的变化改变截止部分的状态; 用于测量提供给拉曼放大介质的泵浦光的功率和通过光传输线传播并输入到后级光发射机的光的功率的监视器部分; 以及处理部分，用于根据监视部分的测量结果分别检测主信号光的功率和ASS光的功率，并校正ASS光。