公开(公告)号：US5137807A

公开(公告)日：1992-08-11

申请号：US380751

申请日：1989-07-17

申请人： Shinichi Yoshida ,  Eiji Ishikawa ,  Akira Oshima ,  Yasuo Bai ,  Yasuteru Muragaki ,  Kazushi Iwata ,  Kenichi Obata ,  Yasuo Nagai

发明人： Shinichi Yoshida ,  Eiji Ishikawa ,  Akira Oshima ,  Yasuo Bai ,  Yasuteru Muragaki ,  Kazushi Iwata ,  Kenichi Obata ,  Yasuo Nagai

IPC分类号： A61K39/00 ,  C12Q1/00 ,  C12Q1/26 ,  G01N33/573 ,  G01N33/577

CPC分类号： G01N33/573 ,  Y10S436/811 ,  Y10S436/82

摘要： The present invention is directed to a method for detecting hepatic diseases which are associated with fibrosis by determining the level of human prolyl hydroxylase in a serum sample which comprises:(a) contacting a serum sample of a patient suspected of having said hepatic disease associated with fibrosis with a monoclonal antibody specific to the .beta.-subunit of human prolyl hydroxylase to form an antigen antibody complex bound on a solid support;(b) contacting said antigen antibody complex bound on said solid support with an enzyme-labeled monoclonal or enzyme-labeled polyclonal antibody specific to human prolyl hydroxylase to form an antibody antigen enzyme-labeled antibody complex; and(c) measuring the amount of enzyme activity of said bound antibody antigen enzyme-labeled antibody complex to determine the level of human prolyl hydroxylase present in said serum sample.

摘要翻译： 本发明涉及通过测定血清样品中人脯氨酰羟化酶水平来检测与纤维化相关的肝病的方法，该方法包括：（a）使疑似患有所述肝病的患者的血清样品与 纤维化与对人脯氨酰羟化酶的β亚单位特异的单克隆抗体形成结合在固体支持物上的抗原抗体复合物; （b）将结合在所述固体支持物上的所述抗原抗体复合物与人脯氨酰羟化酶特异性的酶标记的单克隆或酶标记的多克隆抗体接触以形成抗体抗原酶标记的抗体复合物; 和（c）测量所述结合的抗体抗体酶标记的抗体复合物的酶活性的量以确定存在于所述血清样品中的人脯氨酰羟化酶的水平。

公开(公告)号：US07684713B2

公开(公告)日：2010-03-23

申请号：US11593591

申请日：2006-11-07

申请人： Yoshikazu Terayama ,  Noriaki Mizuguchi ,  Eiji Ishikawa ,  Takashi Toyomaki ,  Kenichi Kaburagi ,  Takeshi Hoshida ,  Jens Rasmussen ,  Akihiko Isomura

发明人： Yoshikazu Terayama ,  Noriaki Mizuguchi ,  Eiji Ishikawa ,  Takashi Toyomaki ,  Kenichi Kaburagi ,  Takeshi Hoshida ,  Jens Rasmussen ,  Akihiko Isomura

IPC分类号： H04B10/00

CPC分类号： H04B10/66

摘要： A calculation processing unit controls temperature of a Peltier device based on a slope of a waveform obtained by subtracting a waveform of a B-arm monitoring signal from a waveform of an A-arm monitoring signal and a value obtained by subtracting a value B of the B-arm monitoring signal from a value A of the A-arm monitoring signal. Similarly, the calculation processing unit controls a phase of the A-arm and a phase of the B-arm. An A-arm side micro-controller controls temperature of an A-arm side heater 22 based on the value of the A-arm monitoring signal, and controls the phase of the A-arm. A B-arm side micro-controller controls temperature of a B-arm side heater based on the value B of the B-arm monitoring signal, and controls the phase of the B-arm.

摘要翻译： 计算处理单元基于通过从A臂监视信号的波形中减去B臂监视信号的波形而获得的波形的斜率，以及通过从A臂监视信号的波形中减去B的值得到的值来控制珀耳帖装置的温度 B臂监控信号从A臂A值监控信号。 类似地，计算处理单元控制A臂的相位和B臂的相位。 A臂侧微型控制器基于A臂监视信号的值来控制A臂侧加热器22的温度，并且控制A臂的相位。 B臂侧微控制器基于B臂监控信号的值B控制B臂侧加热器的温度，并控制B臂的相位。

公开(公告)号：US07642194B2

公开(公告)日：2010-01-05

申请号：US11505375

申请日：2006-08-17

申请人： Yuji Kato ,  Eiji Ishikawa ,  Yutaka Kudou ,  Satoshi Tani ,  Kazuo Takata

发明人： Yuji Kato ,  Eiji Ishikawa ,  Yutaka Kudou ,  Satoshi Tani ,  Kazuo Takata

IPC分类号： H01L21/302

CPC分类号： H01L21/3065 ,  H01J37/32192 ,  H01J37/32623 ,  H01J37/32678

摘要： A method of etching for forming a groove in a SOI substrate includes a forming step, in which a mixed gas plasma is formed by using a mixed gas of a fluorinate gas and an oxygenic gas, and an applying step, in which a high-frequency bias is intermittently applied to the SOI substrate. In the applying step, the high-frequency bias is a temporally modulated high-frequency electricity. According to the method of etching, a yielding rate and a productivity can be improved.

摘要翻译： 在SOI衬底中形成沟槽的蚀刻方法包括：通过使用氟化物气体和含氧气体的混合气体形成混合气体等离子体的形成工序和施加工序，其中高频 偏压被间歇地施加到SOI衬底。 在施加步骤中，高频偏置是时间调制的高频电。 根据蚀刻方法，可以提高屈服率和生产率。

公开(公告)号：US07251072B2

公开(公告)日：2007-07-31

申请号：US10635723

申请日：2003-08-07

申请人： Toshihiro Ohtani ,  Tsukasa Takahashi ,  Eiji Ishikawa ,  Hiroto Ikeda ,  Hiroyuki Deguchi

发明人： Toshihiro Ohtani ,  Tsukasa Takahashi ,  Eiji Ishikawa ,  Hiroto Ikeda ,  Hiroyuki Deguchi

IPC分类号： H04B10/17

CPC分类号： H04B10/2937 ,  H01S3/302 ,  H04B10/0775 ,  H04B10/2916 ,  H04B2210/078 ,  H04B2210/08

摘要： A reliable optical transmission system with an improved signal control mechanism that avoids abrupt power variations of light beams, thereby preventing optical supervisory channel (OSC) signals from experiencing errors. An optical amplifier amplifies main signals under the control of an optical amplifier controller, which spends a first predetermined time to raise the output power of the optical amplifier up to a desired level. A pump light source produces a pump beam for injection to a fiber-optic transmission line so as to make it serve as an amplifying medium. The pump light source is controlled by a pump light source controller that spends a second predetermined time to raise the pump beam to a desired power level. This stepwise start-up process of the amplifier power and pump beam power prevents OSC signals from experiencing abrupt power variations.

摘要翻译： 一种具有改进的信号控制机制的可靠的光传输系统，其避免了光束的突然功率变化，从而防止光监控信道（OSC）信号经历错误。 光放大器在光放大器控制器的控制下放大主信号，光放大器控制器花费第一预定时间将光放大器的输出功率提高到期望的水平。 泵浦光源产生用于注射到光纤传输线的泵浦光束，以使其用作放大介质。 泵浦光源由泵浦光源控制器控制，泵控制器花费第二预定时间将泵浦光束升高到期望的功率水平。 放大器功率和泵浦波束功率的逐步启动过程防止OSC信号经历突然的功率变化。

公开(公告)号：US06750965B2

公开(公告)日：2004-06-15

申请号：US10161247

申请日：2002-05-31

申请人： Hiroshi Ando ,  Eiji Ishikawa

发明人： Hiroshi Ando ,  Eiji Ishikawa

IPC分类号： G01J302

CPC分类号： G02B7/1825 ,  G01J3/12

摘要： There is provided a mirror supporting structure for a monochromator capable of turning the mirrors about axis lines which cross each other, thereby adjusting the attachment angles of the mirrors in two directions. The mirror supporting structure for a monochromator comprises first angle adjusting means for turning the mirrors about each first axis line which does not cross each plane direction of the mirrors and second angle adjusting means for turning the mirrors about each second axis line which does not cross each plane direction of the mirrors at right angles but is parallel with a line crossing the first axis line. The first angle adjusting means comprises a first leg member and a second leg member which are disposed to be spaced from each other, and a support member installed between the first leg member and the second leg member and supporting the mirrors, and wherein the mirrors are supported by the support member in a manner that each plane direction of the mirrors does not cross the installing direction of the support member at right angles, and the support member can be turned about a line which is parallel with the installing direction of the support member.

摘要翻译： 提供了一种用于单色器的反射镜支撑结构，其能够绕相互交叉的轴线转动反射镜，从而在两个方向上调整反射镜的附着角度。 用于单色仪的反射镜支撑结构包括第一角度调节装置，用于围绕不跨过反射镜的每个平面方向的每个第一轴线转动反射镜;以及第二角度调节装置，用于将镜子围绕不相交的每个第二轴线转动 反射镜的平面方向成直角，但是与穿过第一轴线的线平行。 第一角度调节装置包括彼此分开设置的第一腿部构件和第二腿部构件，以及安装在第一腿部构件和第二腿部构件之间并支撑反射镜的支撑构件，并且其中反射镜是 由支撑构件支撑，使得反射镜的每个平面方向不以直角跨过支撑构件的安装方向，并且支撑构件可以围绕与支撑构件的安装方向平行的线旋转 。

公开(公告)号：US5888834A

公开(公告)日：1999-03-30

申请号：US548128

申请日：1995-10-25

申请人： Eiji Ishikawa ,  Hidetaka Nakamoto ,  Satoshi Tanaka

发明人： Eiji Ishikawa ,  Hidetaka Nakamoto ,  Satoshi Tanaka

IPC分类号： B01L3/00 ,  C12M1/34 ,  G01N33/53 ,  G01N33/543 ,  G01N21/00 ,  G01N31/22

CPC分类号： B01L3/5085 ,  G01N33/5304 ,  G01N33/54306 ,  Y10S435/961 ,  Y10S436/807 ,  Y10S436/81 ,  Y10S436/824

摘要： An immunoassay plate for an immune complex transfer immunoassay, comprising a well type solid phase and a dip stick type solid phase which can be inserted into said well type solid phase, wherein the dip stick type solid phase is coated with either substance (A) or (B) to be mentioned below and the well type solid phase is coated with the other, remaining substance, and these solid phases are used as the two solid phases to be used for an immune complex transfer immunoassay:(A): a substance having a reactive group which specifically binds to a functional group previously introduced onto a substance, which specifically forms an immune complex with a test substance(B): a substance having a reactive group capable of specifically binding to the test substance in the immune complex, a substance which specifically forms an immune complex with the test substance, or a functional group conjugated in advance with said substance, provided that the moiety which binds to the reactive group of (A) does not bind to the reactive group of (B) and vice versa. According to the present invention, an immune complex transfer immunoassay can be markedly simplified. Consequently, a highly sensitive immune complex transfer immunoassay can be conducted with ease and with high precision.

摘要翻译： 一种用于免疫复合物转移免疫测定的免疫测定板，包括井型固相和浸渍棒型固相，其可以插入所述孔型固相中，其中浸渍棒型固相用物质（A）或 （B），井型固相被另外的剩余物质包覆，这些固相用作免疫复合物转移免疫测定中使用的两个固相：（A）：具有 特异性结合预先引入到与测试物质（B）形成免疫复合物的物质上的官能团的反应性基团：具有能够与免疫复合物中的测试物质特异性结合的反应性基团的物质， 与试验物质特异性形成免疫复合物的物质或与所述物质预先缀合的官能团，条件是结合（A ）不与（B）的反应性基团结合，反之亦然。 根据本发明，可以显着简化免疫复合物转移免疫测定。 因此，可以容易且高精度地进行高度灵敏的免疫复合物转移免疫测定。

公开(公告)号：US5236830A

公开(公告)日：1993-08-17

申请号：US431476

申请日：1989-11-03

申请人： Eiji Ishikawa

发明人： Eiji Ishikawa

IPC分类号： G01N33/543

CPC分类号： G01N33/543 ,  Y10S436/822

摘要： A method of assay for antigen comprising the following sequential steps (A), (B), (C) and (D):(A): the antigen to be assayed in a subject solution is bound with a functional group or marker to form a modified antigen;(B): the modified antigen is bound to a carrier via an antibody against the antigen, and then the carrier is separated from the subject solution;(C): Either (a) or (b):(a) the modified antigen is dissociated from the carrier; or(b) the modified antigen-antibody complex comprising the modified antigen and the antibody against the antigen is dissociated from the carrier; and(D): the modified antigen or modified antigen-antibody complex of Step (C) is assayed.This method permits assay for antigens with high sensitivity based on characteristic features of the sandwich method, using an antibody against a single epitopic site, and also permits assay for low molecular substances, which have never been assayed by the conventional sandwich method, with higher sensitivity in comparison with the conventional competitive method.

公开(公告)号：US07541257B2

公开(公告)日：2009-06-02

申请号：US11519064

申请日：2006-09-12

申请人： Eiji Ishikawa ,  Takaaki Aoki

发明人： Eiji Ishikawa ,  Takaaki Aoki

IPC分类号： H01L21/76

CPC分类号： H01L31/035281 ,  B81B2201/058 ,  B81B2201/06 ,  B81C1/00071 ,  B81C2201/0169 ,  Y02E10/50

摘要： A semiconductor device includes: a silicon substrate; and a silicon oxide film disposed on the silicon substrate. The silicon oxide film includes a part, which separates from a surface of the silicon substrate, so that the silicon oxide film provides a three-dimensional construction. By using the three-dimensional construction, an additional function such as a resistor or a capacitor is easily added in the device. Further, a manufacturing method of this three-dimensional construction is simple and has a low cost.

摘要翻译： 半导体器件包括：硅衬底; 以及设置在硅衬底上的氧化硅膜。 氧化硅膜包括从硅衬底的表面分离的部分，使得氧化硅膜提供三维结构。 通过使用三维构造，在该装置中容易添加诸如电阻器或电容器的附加功能。 此外，该三维构造的制造方法简单，成本低。

公开(公告)号：US20070066052A1

公开(公告)日：2007-03-22

申请号：US11519064

申请日：2006-09-12

申请人： Eiji Ishikawa ,  Takaaki Aoki

发明人： Eiji Ishikawa ,  Takaaki Aoki

IPC分类号： H01L21/4763 ,  H01L29/06

CPC分类号： H01L31/035281 ,  B81B2201/058 ,  B81B2201/06 ,  B81C1/00071 ,  B81C2201/0169 ,  Y02E10/50

摘要： A semiconductor device includes: a silicon substrate; and a silicon oxide film disposed on the silicon substrate. The silicon oxide film includes a part, which separates from a surface of the silicon substrate, so that the silicon oxide film provides a three-dimensional construction. By using the three-dimensional construction, an additional function such as a resistor or a capacitor is easily added in the device. Further, a manufacturing method of this three-dimensional construction is simple and has a low cost.

摘要翻译： 半导体器件包括：硅衬底; 以及设置在硅衬底上的氧化硅膜。 氧化硅膜包括从硅衬底的表面分离的部分，使得氧化硅膜提供三维结构。 通过使用三维构造，在该装置中容易添加诸如电阻器或电容器的附加功能。 此外，该三维构造的制造方法简单，成本低。

公开(公告)号：US20070242347A1

公开(公告)日：2007-10-18

申请号：US11808754

申请日：2007-06-12

申请人： Eiji Ishikawa ,  Hiroto Ikeda ,  Hiroyuki Deguchi

发明人： Eiji Ishikawa ,  Hiroto Ikeda ,  Hiroyuki Deguchi

IPC分类号： H04B10/12

CPC分类号： H04B10/2937 ,  H01S3/302 ,  H04B10/0775 ,  H04B10/2916 ,  H04B2210/078 ,  H04B2210/08

摘要： A reliable optical transmission system with an improved signal control mechanism that avoids abrupt power variations of light beams, thereby preventing optical supervisory channel (OSC) signals from experiencing errors. An optical amplifier amplifies main signals under the control of an optical amplifier controller, which spends a first predetermined time to raise the output power of the optical amplifier up to a desired level. A pump light source produces a pump beam for injection to a fiber-optic transmission line so as to make it serve as an amplifying medium. The pump light source is controlled by a pump light source controller that spends a second predetermined time to raise the pump beam to a desired power level. This stepwise start-up process of the amplifier power and pump beam power prevents OSC signals from experiencing abrupt power variations.