公开(公告)号：US20120184845A1

公开(公告)日：2012-07-19

申请号：US13294601

申请日：2011-11-11

申请人： Hiroshi Ishikawa ,  Gadi Wollstein ,  Joel S. Schuman ,  Yu-Ying Liu ,  James M. Rehg ,  Mei Chen

发明人： Hiroshi Ishikawa ,  Gadi Wollstein ,  Joel S. Schuman ,  Yu-Ying Liu ,  James M. Rehg ,  Mei Chen

IPC分类号： A61B3/14 ,  G06K9/00

CPC分类号： A61B3/102 ,  G06K9/4642 ,  G06K2009/4666

摘要： Systems and methods of analyzing an optical coherence tomography image of a retina are discussed. A 2-dimensional slice of the image can be aligned to produce an approximately horizontal image of the retina and an edge map based at least in part on the aligned slice. Also, at least one global representation can be determined based on a (multi-scale) spatial division, such as multi-scale spatial pyramid, on the slice and/or edge map. Creating the local features is based on the specified cell structure of the global representation. The local features can be constructed based on local binary pattern (LBP)-based features. Additionally, a slice can be categorized into one or more categories via one or more classifiers (e.g., support vector machines). Each category can be associated with at least one ocular pathology, and classifying can be based on the constructed global descriptors, which can include the LBP-based local descriptors.

摘要翻译： 讨论了分析视网膜的光学相干断层图像的系统和方法。 图像的二维切片可以被对准以至少部分地基于对齐的切片来产生视网膜的近似水平的图像和边缘图。 此外，可以基于切片和/或边缘图上的（多尺度）空间划分（例如多尺度空间金字塔）来确定至少一个全局表示。 创建局部特征是基于全局表示的指定单元格结构。 可以基于局部二进制模式（LBP）的特征构建局部特征。 此外，切片可以经由一个或多个分类器（例如，支持向量机）被分类为一个或多个类别。 每个类别可以与至少一个眼部病理学相关联，并且分类可以基于构建的全局描述符，其可以包括基于LBP的局部描述符。

公开(公告)号：US20110212418A1

公开(公告)日：2011-09-01

申请号：US13040672

申请日：2011-03-04

申请人： Taka Nakahara ,  Hiroshi Ishikawa ,  Soh Sato ,  Masato Ohta

发明人： Taka Nakahara ,  Hiroshi Ishikawa ,  Soh Sato ,  Masato Ohta

IPC分类号： A61C8/00 ,  C12N5/071

CPC分类号： A61L27/3604 ,  A61L27/3804 ,  A61L27/3865

摘要： A method for forming at least a tooth root in a tooth containing a tooth crown, including: forming a culture core containing the tooth and a cell-containing base material, the tooth being wrapped with the cell-containing base material, and culturing the culture core in a medium to form at least the tooth root in the tooth contained therein, wherein the cell-containing base material contains at least one kind of cells selected from periodontal ligament-derived cells, bone marrow-derived cells, dental follicle-derived cells, dental pulp-derived cells and dental papilla-derived cells, and the medium contains a component contained in a conditioned medium of a serum-free-cultured cell line of a human uterocervical squamous carcinoma cell line; an additive containing at least one selected from IL-1β, IL-6, IL-8, IL-9, EGF, IGF-I, GH, PDGF-AB, VEGF, LIF, HGF, FGF-2, FGF-1, BMP-2, BMP-4, M-CSF, dexamethasone, insulin, thyroxine, thyrocalcitonin, ascorbic acid and β-glycerophosphate; or both of them.

摘要翻译： 一种在含有牙冠的牙齿中至少形成齿根的方法，包括：形成含有牙齿的培养核和含细胞的基材，所述牙齿用含细胞的基材包裹，并培养培养物 在培养基中形成至少在其中含有的牙齿中的牙根，其中所述含细胞的基质材料含有选自牙周韧带衍生的细胞，骨髓来源的细胞，来自牙囊的细胞中的至少一种细胞 牙髓源细胞和来自乳头乳头的细胞，培养基含有人子宫颈鳞状细胞癌细胞系的无血清培养细胞系的条件培养基中所含的成分， 含有选自IL-1和bgr，IL-6，IL-8，IL-9，EGF，IGF-1，GH，PDGF-AB，VEGF，LIF，HGF，FGF-2，FGF-1中的至少一种的添加剂 ，BMP-2，BMP-4，M-CSF，地塞米松，胰岛素，甲状腺素，降钙素原，抗坏血酸和甘油磷酸酯; 或者他们两个。

公开(公告)号：US20110176716A1

公开(公告)日：2011-07-21

申请号：US13056510

申请日：2009-08-06

申请人： Jong S. Kim ,  Hiroshi Ishikawa ,  Joel S. Schuman ,  Gadi Wollstein

发明人： Jong S. Kim ,  Hiroshi Ishikawa ,  Joel S. Schuman ,  Gadi Wollstein

IPC分类号： G06K9/00

CPC分类号： G06T3/0075 ,  A61B3/102

摘要： Advances in optical coherence tomography (OCT) have prompted a transition from time domain OCT, providing 2D OCT images, to spectral domain OCT, which has a 3D imaging capability. Yet conventional technology offers little toward the goal of inter-device compatibility between extant 2D OCT images and newer 3D OCT images for the same or comparable subjects, as in the context of ongoing monitoring the quantitative status of a patient's eyes. The inventive methodology is particularly useful to identify the scan location of tissue in a 2D OCT image within the 3D volumetric data, thereby allowing clinicians to image a patient via 3D OCT, based on available 2D OCT images, with minimal inter-device variation.

摘要翻译： 光学相干断层扫描（OCT）的进展促使从具有3D成像能力的光谱域OCT向时域OCT提供2D OCT图像的转变。 然而，传统技术对于相同或可比较的对象的现有2D OCT图像和较新的3D OCT图像之间的设备间兼容性的目标几乎没有提供，如在持续监测患者眼睛的定量状态的情况下。 本发明的方法对于识别3D体积数据内的2D OCT图像中的组织的扫描位置特别有用，由此允许临床医生通过3D OCT基于可用的2D OCT图像以最小的装置间变化来对患者进行图像化。

公开(公告)号：US20100331421A1

公开(公告)日：2010-12-30

申请号：US12875463

申请日：2010-09-03

申请人： Toru Nishibayashi ,  Tetsuya Sato ,  Masaaki Odomi ,  Kinue Ohguro ,  Hiroshi Ishikawa

发明人： Toru Nishibayashi ,  Tetsuya Sato ,  Masaaki Odomi ,  Kinue Ohguro ,  Hiroshi Ishikawa

IPC分类号： A01N37/52 ,  A01P1/00

CPC分类号： A61K31/155 ,  A01N47/44 ,  A01N25/30 ,  A01N2300/00

摘要： The present invention provides a disinfectant and/or bactericidal aqueous composition containing an olanexidine acid addition salt and and a cyclodextrin.

摘要翻译： 本发明提供含有奥拉西丁酸加成盐和环糊精的消毒剂和/或杀菌水性组合物。

公开(公告)号：US07825080B2

公开(公告)日：2010-11-02

申请号：US11588395

申请日：2006-10-27

申请人： Kazuyoshi Miyata ,  Yasuhide Inoue ,  Akifumi Hagi ,  Motoya Kikuchi ,  Hitoshi Ohno ,  Kinji Hashimoto ,  Kinue Ohguro ,  Tetsuya Sato ,  Hidetsugu Tsubouchi ,  Hiroshi Ishikawa ,  Takashi Okamura ,  Koushi Iwata

发明人： Kazuyoshi Miyata ,  Yasuhide Inoue ,  Akifumi Hagi ,  Motoya Kikuchi ,  Hitoshi Ohno ,  Kinji Hashimoto ,  Kinue Ohguro ,  Tetsuya Sato ,  Hidetsugu Tsubouchi ,  Hiroshi Ishikawa ,  Takashi Okamura ,  Koushi Iwata

IPC分类号： C11D7/26 ,  C11D7/32 ,  C11D7/50

CPC分类号： A61K9/0014 ,  A01N47/44 ,  A61K31/155 ,  A61K31/191 ,  A61K31/522 ,  A61K45/06 ,  A61K47/12 ,  A61L2/18 ,  A01N37/36 ,  A01N25/32 ,  A01N2300/00 ,  A61K2300/00

摘要： The present invention provides a disinfectant that contains olanexidine in a concentration sufficient to exhibit an effective bactericidal effect, and that has hardly any side effects such as skin irritation. Specifically, the present invention provides a disinfectant containing an aqueous solution that contains olanexidine and at least an equimolar amount of gluconic acid, and substantially contains neither an acid other than gluconic acid nor a salt of the acid other than gluconic acid.

摘要翻译： 本发明提供一种消毒剂，其含有浓度足以显示出有效杀菌作用的奥拉西丁，并且几乎没有任何副作用，例如皮肤刺激。 具体而言，本发明提供一种含有含有奥拉西丁和至少等摩尔量葡萄糖酸的水溶液的消毒剂，除了葡萄糖酸以外，基本上既不含葡萄糖酸以外的酸也不含有酸。

公开(公告)号：US07747426B2

公开(公告)日：2010-06-29

申请号：US11292775

申请日：2005-12-02

申请人： Hiroaki Nakamura ,  Naoto Sato ,  Naoshi Tabuchi ,  Hiroshi Ishikawa

发明人： Hiroaki Nakamura ,  Naoto Sato ,  Naoshi Tabuchi ,  Hiroshi Ishikawa

IPC分类号： G06F17/50

CPC分类号： G06F17/5022 ,  G06F9/4843

摘要： A system, such as hardware or software system having a number of modules, is simulated using multi-tasking computer code. Simulation computer code launches tasks simulating system execution, where each task corresponds to a module. Each task requests a processing delay to a common scheduler. Upon the common scheduler receiving a processing delay request, the common scheduler instructs a scheduling method processor to update a task-remaining time for at least one task. The scheduling method processor updates the task-remaining time for at least one task based at least on a scheduling approach. The common scheduler sends a wait request to a preexisting simulation system to delay a module that corresponds to the task by a length of time, based on the task-remaining time for the task and the scheduling approach. The preexisting simulation system delays the module that corresponds to the task by the length of time of the wait request.

摘要翻译： 使用多任务计算机代码来模拟诸如具有多个模块的硬件或软件系统的系统。 模拟计算机代码启动模拟系统执行的任务，其中每个任务对应于一个模块。 每个任务向公共调度程序请求处理延迟。 在公共调度器接收到处理延迟请求时，公共调度器指示调度方法处理器更新至少一个任务的任务剩余时间。 调度方法处理器至少基于调度方法来更新至少一个任务的任务剩余时间。 公共调度器根据任务剩余时间和调度方式，向预先存在的模拟系统发送等待请求，以将与任务相对应的模块延迟一段时间。 预先存在的模拟系统将与任务相对应的模块延迟等待请求的时间长度。

公开(公告)号：US20100067900A1

公开(公告)日：2010-03-18

申请号：US12585516

申请日：2009-09-16

申请人： Hiroshi Ishikawa ,  Toshifumi Hasama ,  Hitoshi Kawashima ,  Kenji Kintaka ,  Masahiko Mori ,  Hisato Uetsuka ,  Hiroyuki Tsuda ,  Keisuke Sorimoto

发明人： Hiroshi Ishikawa ,  Toshifumi Hasama ,  Hitoshi Kawashima ,  Kenji Kintaka ,  Masahiko Mori ,  Hisato Uetsuka ,  Hiroyuki Tsuda ,  Keisuke Sorimoto

IPC分类号： G02F2/00 ,  H04J14/00

CPC分类号： G02F1/31 ,  G02B6/12014 ,  G02B6/12016 ,  G02B6/12021 ,  G02B6/2713 ,  G02B6/2793 ,  G02B6/30 ,  G02B6/3548 ,  G02B6/356 ,  G02F2203/58 ,  G02F2203/585

摘要： An optical waveguide-type wavelength domain switch includes a waveguide-type multi/demultiplexing device laminate comprising three or more laminated waveguide-type multi/demultiplexing devices, a lens system positioned on a demultiplex side of the waveguide-type multi/demultiplexing device laminate, and a reflective optical phase-modulating cell positioned on an opposite side of the waveguide-type multi/demultiplexing device laminate to the lens system. The lens system includes a lens alignment composed of plural lenses in one-to-one correspondence with the waveguide-type multi/demultiplexing devices and having a light-collecting or collimating function in the lens-aligning direction, an image-magnifying optical system having an N:1 (N>1) image-magnifying function arranged on the optical phase-modulating cell side of the lens alignment, an f-f lens (Y) arranged on the optical phase-modulating cell side of the image-magnifying optical system, and having a light-collecting or collimating function in the same direction as the lens-aligning direction of the lens alignment, and an f-f lens (X) having a light-collecting or collimating function in a perpendicular direction to the lens-aligning direction of the lens alignment.

摘要翻译： 光波导型波长域开关包括：波导型多路解复用器件层叠体，其包含三个或更多个层叠波导型多路解复用器件，位于波导型多路解复用器件层叠体的解复用侧的透镜系统， 以及反射光学相位调制单元，其位于与所述透镜系统的所述波导型多路解复用器件层叠体的相反侧。 透镜系统包括由多个透镜组成的透镜对准，与波导型多路/多路分离装置一一对应，并且在透镜对准方向上具有聚光或准直功能，图像放大光学系统具有 配置在透镜对准的光学相位调制单元侧的N：1（N> 1）图像放大功能，配置在图像放大光学系统的光学相位调制单元侧的ff透镜（Y） 并且在与透镜对准方向的透镜对准方向相同的方向上具有聚光或准直功能，以及在与透镜对准方向垂直的方向上具有聚光或准直功能的ff透镜（X） 镜头对准。

公开(公告)号：US07567736B2

公开(公告)日：2009-07-28

申请号：US12153975

申请日：2008-05-28

申请人： Hiroshi Ishikawa ,  Toshifumi Hasama ,  Masahiko Mori ,  Hisato Uetsuka

发明人： Hiroshi Ishikawa ,  Toshifumi Hasama ,  Masahiko Mori ,  Hisato Uetsuka

IPC分类号： G02B6/26

CPC分类号： G02B6/356 ,  G02B6/12011 ,  G02B6/12014 ,  G02B6/12019 ,  G02B6/12023 ,  G02B6/12028 ,  G02B6/29397 ,  G02B6/3556 ,  G02F1/133553

摘要： A waveguide type wavelength domain optical switch includes an input/output port including at least three waveguide spectrometers stacked in thickness direction, a first lens for collecting light outputted from an input port of the input/output port in one axis direction, a second lens for collecting light outputted from the first lens in a direction orthogonal to the collecting direction of the first lens, and an optical phase modulation cell for reflecting light outputted from the second lens through the second lens and the first lens to an output port of the input/output port. Alternatively, the input/output port may include at least two waveguide spectrometers and a waveguide optical coupler circuit stacked in thickness direction.

摘要翻译： 波导型波长域光开关包括：输入/输出端口，其包括沿厚度方向堆叠的至少三个波导光谱仪;第一透镜，用于收集从一个轴方向的输入/输出端口的输入端口输出的光;第二透镜， 从与第一透镜的收集方向正交的方向收集从第一透镜输出的光;以及光学相位调制单元，用于将从第二透镜输出的光通过第二透镜和第一透镜反射到输入/ 输出端口 或者，输入/输出端口可以包括至少两个波导光谱仪和沿厚度方向堆叠的波导光耦合器电路。

公开(公告)号：US07320253B2

公开(公告)日：2008-01-22

申请号：US11073944

申请日：2005-03-08

申请人： Toshio Hanazawa ,  Masaaki Ono ,  Tsutomu Miyashita ,  Hiroshi Tokunaga ,  Hiroshi Ishikawa

发明人： Toshio Hanazawa ,  Masaaki Ono ,  Tsutomu Miyashita ,  Hiroshi Tokunaga ,  Hiroshi Ishikawa

IPC分类号： G01P15/125

CPC分类号： G01P15/123 ,  G01P15/18 ,  G01P21/00 ,  G01P2015/084

摘要： The present invention provides the stress detection method for force sensor device with multiple axis sensor device and force sensor device employing this method, whose installation angle is arbitrary. The stress detection method includes, first and second force sensors whose detection axes are orthogonal to each other. When the detection axis of first force sensor forms angle θ with direction of detected stress Ax, and the stress component of direction perpendicular to direction of the detected stress Ax is Az, output Apx of the axis direction of first force sensor is found as Apx=αx (Ax×cos θ+Az×sin θ), and output Apz of the axis direction of the second force sensor is found as Apz=αz (Ax×sin θ+Az×cos θ), and, when αx and αz are detection sensitivity coefficients of first and second force sensors respectively, the detection sensitivity coefficient αz of second force sensor is set as αz=αx tan θ, and the detected stress Ax is found as Ax=(Apx−Apz)/αx(cos θ−tan θ×sin θ).

摘要翻译： 本发明提供了具有多轴传感器装置的力传感器装置和采用该方法的力传感器装置的应力检测方法，其安装角度是任意的。 应力检测方法包括检测轴彼此正交的第一和第二力传感器。 当第一力传感器的检测轴与检测到的应力Ax的方向形成角度θ，并且垂直于检测应力的方向的方向的应力分量为Az时，第一力传感器的轴方向的输出Apx被发现为Apx = （Axxcosθ+Azxsinθ），第二力传感器的轴方向的输出Apz被找到为Apz =αz（Axxsinθ+Azxcosθ） ，并且当αx和αz分别是第一和第二力传感器的检测灵敏度系数时，第二和第二力传感器的检测灵敏度系数αz 力传感器被设置为α =α×tanθθ，并且检测到的应力Ax被发现为Ax =（Apx-Apz）/α SUB>（cosθ-tan角蛋白θ）。

公开(公告)号：US20070277614A1

公开(公告)日：2007-12-06

申请号：US11808138

申请日：2007-06-06

申请人： Yuji Takahashi ,  Fumihiko Nakazawa ,  Hiroshi Ishikawa ,  Masanori Yachi ,  Takayuki Yamaji ,  Minoru Ohta

发明人： Yuji Takahashi ,  Fumihiko Nakazawa ,  Hiroshi Ishikawa ,  Masanori Yachi ,  Takayuki Yamaji ,  Minoru Ohta

IPC分类号： G01H11/06 ,  G01P9/04 ,  G01P1/04

CPC分类号： G01H11/08

摘要： A vibration sensor includes a vibration body, a drive circuit that vibrates the vibration body, a sense circuit that refers to a reference signal associated with a drive signal for the drive circuit and detects a physical state of the vibration body on the basis of a sense signal related to vibration of the vibration body, and a capacitor provided between the drive circuit and ground. The capacitor has a temperature characteristic of a capacitance value defined so as to compensate for at least a part of the temperature characteristic of a sensitivity of the sense signal to the vibration of the vibration body.

摘要翻译： 振动传感器包括：振动体，使振动体振动的驱动电路;感测电路，其参考与驱动电路的驱动信号相关联的参考信号，并根据感觉检测振动体的物理状态 与振动体的振动有关的信号，以及设置在驱动电路和地之间的电容器。 电容器具有电容值的温度特性，其定义为补偿感测信号对振动体的振动的灵敏度的温度特性的至少一部分。