公开(公告)号：US08822212B2

公开(公告)日：2014-09-02

申请号：US13040672

申请日：2011-03-04

Applicant: Taka Nakahara ,  Hiroshi Ishikawa ,  Soh Sato ,  Masato Ohta

Inventor： Taka Nakahara ,  Hiroshi Ishikawa ,  Soh Sato ,  Masato Ohta

IPC: C12N5/00 ,  A61C13/00 ,  A61L27/36 ,  A61L27/38

CPC classification number: A61L27/3604 ,  A61L27/3804 ,  A61L27/3865

Abstract: A method for forming at least a tooth root in a tooth containing a tooth crown, including: forming a culture core containing the tooth and a cell-containing base material, the tooth being wrapped with the cell-containing base material, and culturing the culture core in a medium to form at least the tooth root in the tooth contained therein, wherein the cell-containing base material contains at least one kind of cells selected from periodontal ligament-derived cells, bone marrow-derived cells, dental follicle-derived cells, dental pulp-derived cells and dental papilla-derived cells, and the medium contains a component contained in a conditioned medium of a serum-free-cultured cell line of a human uterocervical squamous carcinoma cell line; an additive containing at least one selected from IL-1β, IL-6, IL-8, IL-9, EGF, IGF-I, GH, PDGF-AB, VEGF, LIF, HGF, FGF-2, FGF-1, BMP-2, BMP-4, M-CSF, dexamethasone, insulin, thyroxine, thyrocalcitonin, ascorbic acid and β-glycerophosphate; or both of them.

Abstract translation: 一种在含有牙冠的牙齿中至少形成齿根的方法，包括：形成含有牙齿的培养核和含细胞的基材，所述牙齿用含细胞的基材包裹，并培养培养物 在培养基中形成至少在其中含有的牙齿中的牙根，其中所述含细胞的基质材料含有选自牙周韧带衍生的细胞，骨髓来源的细胞，来自牙囊的细胞中的至少一种细胞 牙髓源细胞和来自乳头乳头的细胞，培养基含有人子宫颈鳞状细胞癌细胞系的无血清培养细胞系的条件培养基中所含的成分， 含有选自IL-1和bgr，IL-6，IL-8，IL-9，EGF，IGF-1，GH，PDGF-AB，VEGF，LIF，HGF，FGF-2，FGF-1中的至少一种的添加剂 ，BMP-2，BMP-4，M-CSF，地塞米松，胰岛素，甲状腺素，降钙素原，抗坏血酸和甘油磷酸酯; 或者他们两个。

公开(公告)号：US08066253B2

公开(公告)日：2011-11-29

申请号：US11144018

申请日：2005-06-03

Applicant: Masato Ohta ,  Teruo Iwai ,  Masaya Hiramatsu

Inventor： Masato Ohta ,  Teruo Iwai ,  Masaya Hiramatsu

IPC: B28B5/00

CPC classification number: B29C33/14 ,  B29C44/1271 ,  Y10T24/45958 ,  Y10T24/4599

Abstract: An embedment member of a foamed resin article such as a seat pad formed in a mold. The mold is provided with engaging projections and a pocket portion formed in or on an inner surface of a core thereof. A surface of the embedment member is positioned to face the core and the surface is superposed onto the surface of the core such that the projections enter into large opening portions. Then, the embedment member is slid in such a manner as to introduce the projections into narrow portions and wide portions, thereby retaining the embedment member to the core. In this state, an end portion of the embedment member is fitted into the pocket portion. To release the foamed resin article from the mold, the foamed resin article is slid in a direction opposite to the direction of the aforementioned sliding.

Abstract translation: 泡沫树脂制品的嵌入构件，例如形成在模具中的座垫。 模具设置有接合突起和形成在其芯的内表面中或其内表面上的袋状部分。 嵌入构件的表面被定位成面对芯，并且表面被叠置在芯的表面上，使得突起进入大的开口部分。 然后，嵌入构件以将凸起引入狭窄部分和宽部分的方式滑动，从而将嵌入构件保持在芯部上。 在这种状态下，嵌入部件的端部嵌入袋部。 为了从模具中释放发泡树脂制品，发泡树脂制品沿与上述滑动方向相反的方向滑动。

公开(公告)号：US20090227527A1

公开(公告)日：2009-09-10

申请号：US12362938

申请日：2009-01-30

Applicant: Je-Tae Woo ,  Masato Ohta ,  Takayuki Yonezama ,  Toshiaki Teruya ,  Byung-Yoon Cha ,  Kazuo Nagai ,  Toshihiro Akihisa ,  Hiroyuki Akazawa

Inventor： Je-Tae Woo ,  Masato Ohta ,  Takayuki Yonezama ,  Toshiaki Teruya ,  Byung-Yoon Cha ,  Kazuo Nagai ,  Toshihiro Akihisa ,  Hiroyuki Akazawa

IPC: A61K31/70 ,  A61K31/335 ,  A61K31/05

CPC classification number: C07D313/00 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/05 ,  A61K31/065 ,  A61K31/335 ,  A61K31/7048 ,  A61K36/18 ,  C07H15/24 ,  C07H15/26 ,  C07H17/08 ,  A23V2200/30 ,  A23V2200/312 ,  A23V2250/21 ,  A23V2200/306

Abstract: The present invention provides a highly safe pharmaceutical composition for preventing and/or treating bone disease, a pharmaceutical preparation comprising thereof, a health food comprising thereof, a functional food comprising thereof. Since the present invention comprises the arylheptanoid compound shown in the following formula (I) and the derivatives thereof, it enables to prevent and/or treat the bone disease. (In the formula (I), R1 and R5 are a functional group selected from the group consisting of a hydrogen atom, alkyl group having carbon numbers 1 to 3, monosaccharide and disaccharide; R2, R3, and R4 are a functional group selected from the group consisting of a hydrogen atom, an oxygen atom, alkyl group having carbon numbers 1 to 3, monosaccharide and disaccharide; R5 may be bound on meta-position against heptylene group of another aryl group to form a ring.)

Abstract translation: 本发明提供了用于预防和/或治疗骨疾病的高度安全的药物组合物，包含其的药物制剂，包含其的保健食品，由其组成的功能性食品。 由于本发明包括下式（I）所示的芳基庚类化合物及其衍生物，因此能够预防和/或治疗骨病。 （式（I）中，R 1和R 5为选自氢原子，碳原子数1〜3的烷基，单糖和二糖的官能团; R2，R3，R4为选自 由氢原子，氧原子，碳数为1〜3的烷基，单糖和二糖组成的组; R5可以与另一个芳基的亚庚基的间位结合形成环。）

公开(公告)号：US5265169A

公开(公告)日：1993-11-23

申请号：US775809

申请日：1991-10-11

Applicant: Masato Ohta ,  Yasuhiko Yokomori ,  Toshiyuki Furuta

Inventor： Masato Ohta ,  Yasuhiko Yokomori ,  Toshiyuki Furuta

IPC: G01N21/17 ,  G01N21/75 ,  G01N21/82 ,  G01N33/543 ,  G06K9/00

CPC classification number: G01N21/82 ,  G01N2021/755 ,  G01N2201/0407 ,  G01N2201/0446 ,  G01N2201/127

Abstract: A method for identifying the presence or absence of an aggregation of particles distributed on a translucent surface includes the steps of providing a light sensing device for sensing light incident thereon and producing an output value which represents the intensity of the incident light, and identifying a first output value which is produced by the light sensing device when there is no light incident thereon. The method also identifies a second output value which is produced by the light sensing means when, with no particles present on the translucent surface, light is directed through the translucent surface onto the light sensing device. With a distribution of particles deposited on the translucent surface, light is directed through the translucent surface and onto the light sensing device, causing the light sensing device to produce a third output value. A final output value is then determined as a function of said first, second and third output values.

Abstract translation: 用于识别分布在半透明表面上的颗粒的聚集的存在或不存在的方法包括以下步骤：提供用于感测入射在其上的光的光感测装置，并产生表示入射光强度的输出值，并且识别第一 当没有光入射时由光检测装置产生的输出值。 该方法还识别由光感测装置产生的第二输出值，当在半透明表面上没有颗粒存在时，光被引导通过透光表面到光感测装置上。 随着沉积在半透明表面上的颗粒的分布，光被引导通过半透明表面并且到达光感测装置，使光感测装置产生第三输出值。 然后确定最终输出值作为所述第一，第二和第三输出值的函数。

公开(公告)号：US5169601A

公开(公告)日：1992-12-08

申请号：US516101

申请日：1990-04-27

Applicant: Masato Ohta ,  Naoki Ozawa ,  Yasuhiko Yokomori

Inventor： Masato Ohta ,  Naoki Ozawa ,  Yasuhiko Yokomori

IPC: B01L3/00 ,  G01N21/82 ,  G01N33/53

CPC classification number: B01L3/5085 ,  G01N21/82 ,  G01N33/5302

Abstract: An immunological agglutination detecting apparatus including an agglutination examination plate having one or more reaction vessels each provided with a bottom face of which at least a part is slanted. A light emitting source is arranged at one side of the agglutination examination plate. A light receiver is situated on the other side thereof. Respective images of the agglutination patterns formed on the bottom faces of the reaction vessels are focussed on the light receiver through individual lenses in order to detect, by an electrical device, the agglutination patterns which are formed by the shining light from the light emitting source. In the preferred embodiment, the light emitting source is one or more rows of primary point sources, each corresponding to a particular vessel in the plate, and one or more supplementary point sources adjacent the ends of the row or rows. The intensity of the primary and supplementary light sources can be separately adjusted.

Abstract translation: 一种免疫凝集检测装置，其包括具有一个或多个反应容器的凝集检查板，每个反应容器的底面至少部分倾斜。 发光源布置在凝集检查板的一侧。 光接收器位于其另一侧。 形成在反应容器的底面上的凝集图案的各图像通过各个透镜聚焦在光接收器上，以便通过电子装置检测由来自发光源的发光光形成的凝集图案。 在优选实施例中，发光源是一行或多行主要点源，每一个源点对应于板中的特定容器，以及一个或多个与行或行的端部相邻的补充点源。 主光源和辅助光源的强度可以单独调整。

公开(公告)号：US5096835A

公开(公告)日：1992-03-17

申请号：US520093

申请日：1990-05-07

Applicant: Yasuhiko Yokomori ,  Masato Ohta ,  Masahide Kimura ,  Kunio Kurata ,  Yoshinobu Kubo ,  Yoshiharu Matsuoka

Inventor： Yasuhiko Yokomori ,  Masato Ohta ,  Masahide Kimura ,  Kunio Kurata ,  Yoshinobu Kubo ,  Yoshiharu Matsuoka

IPC: G01N33/543 ,  G01N21/17 ,  G01N21/59 ,  G01N21/82

CPC classification number: G01N21/82 ,  G01N2021/5957 ,  G01N2201/04 ,  Y10S436/805

Abstract: The aggregation pattern of particles is determined by obtaining luminous intensity curves representative of the particle aggregation pattern, obtaining a first threshold face by cutting the curves with a plane positioned at a first given height, obtaining a second threshold face by cutting the curves with a plane positioned at a second given height and determining the particle aggregation pattern by calculating the ratio of the area of the first threshold face to the area of the second threshold face.

Abstract translation: 通过获得表示颗粒聚集图案的亮度曲线来确定颗粒的聚集图案，通过用位于第一给定高度的平面切割曲线获得第一阈值面，通过用平面切割曲线获得第二阈值面 定位在第二给定高度，并通过计算第一阈值面积的面积与第二阈值面积的面积的比率来确定粒子聚集模式。

公开(公告)号：US20110212418A1

公开(公告)日：2011-09-01

申请号：US13040672

申请日：2011-03-04

Applicant: Taka Nakahara ,  Hiroshi Ishikawa ,  Soh Sato ,  Masato Ohta

Inventor： Taka Nakahara ,  Hiroshi Ishikawa ,  Soh Sato ,  Masato Ohta

IPC: A61C8/00 ,  C12N5/071

CPC classification number: A61L27/3604 ,  A61L27/3804 ,  A61L27/3865

Abstract: A method for forming at least a tooth root in a tooth containing a tooth crown, including: forming a culture core containing the tooth and a cell-containing base material, the tooth being wrapped with the cell-containing base material, and culturing the culture core in a medium to form at least the tooth root in the tooth contained therein, wherein the cell-containing base material contains at least one kind of cells selected from periodontal ligament-derived cells, bone marrow-derived cells, dental follicle-derived cells, dental pulp-derived cells and dental papilla-derived cells, and the medium contains a component contained in a conditioned medium of a serum-free-cultured cell line of a human uterocervical squamous carcinoma cell line; an additive containing at least one selected from IL-1β, IL-6, IL-8, IL-9, EGF, IGF-I, GH, PDGF-AB, VEGF, LIF, HGF, FGF-2, FGF-1, BMP-2, BMP-4, M-CSF, dexamethasone, insulin, thyroxine, thyrocalcitonin, ascorbic acid and β-glycerophosphate; or both of them.

Abstract translation: 一种在含有牙冠的牙齿中至少形成齿根的方法，包括：形成含有牙齿的培养核和含细胞的基材，所述牙齿用含细胞的基材包裹，并培养培养物 在培养基中形成至少在其中含有的牙齿中的牙根，其中所述含细胞的基质材料含有选自牙周韧带衍生的细胞，骨髓来源的细胞，来自牙囊的细胞中的至少一种细胞 牙髓源细胞和来自乳头乳头的细胞，培养基含有人子宫颈鳞状细胞癌细胞系的无血清培养细胞系的条件培养基中所含的成分， 含有选自IL-1和bgr，IL-6，IL-8，IL-9，EGF，IGF-1，GH，PDGF-AB，VEGF，LIF，HGF，FGF-2，FGF-1中的至少一种的添加剂 ，BMP-2，BMP-4，M-CSF，地塞米松，胰岛素，甲状腺素，降钙素原，抗坏血酸和甘油磷酸酯; 或者他们两个。

公开(公告)号：US5210612A

公开(公告)日：1993-05-11

申请号：US705637

申请日：1991-05-24

Applicant: Toshiyuki Furuta ,  Yasuhiko Yokomori ,  Masato Ohta ,  Hideo Suda ,  Naoki Ozawa ,  Shogo Kida

Inventor： Toshiyuki Furuta ,  Yasuhiko Yokomori ,  Masato Ohta ,  Hideo Suda ,  Naoki Ozawa ,  Shogo Kida

IPC: H04N1/028 ,  H04N1/19 ,  H04N5/335 ,  H04N5/341 ,  H04N5/353 ,  H04N5/372 ,  H04N5/376 ,  H04N5/378

CPC classification number: H04N5/335

Abstract: A CCD driving circuit for reading and outputting data from a plurality of CCD sensors, each CCD sensor being actuable to convert an image into data by first optically sensing the image during a first time period and thereafter converting the optically-sensed image into data during a second time period, including a driving arrangement for actuating the CCD sensors such that the first time periods associated therewith are staggered so that the second time periods associated therewith do not overlap each other. A multiplexing arrangement is provided for multiplexing and outputting the data read from each of the CCD sensors.

Abstract translation: 一种用于从多个CCD传感器读取和输出数据的CCD驱动电路，每个CCD传感器可致动以通过在第一时间段期间首先光学地感测图像将图像转换成数据，然后将光学感测图像在 第二时间段，包括用于致动CCD传感器的驱动装置，使得与其相关联的第一时间段交错，使得与其相关联的第二时间段彼此不重叠。 提供多路复用装置，用于复用和输出从每个CCD传感器读取的数据。

公开(公告)号：US07527808B2

公开(公告)日：2009-05-05

申请号：US10475729

申请日：2002-04-26

Applicant: Masato Ohta

Inventor： Masato Ohta

IPC: A61K9/14 ,  A61K9/20 ,  A61K9/48

CPC classification number: A61K31/546 ,  A61K9/146 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/4858 ,  A61K9/4866

Abstract: An objective of the present invention is to provide an amorphous cefditoren pivoxil composition possessing excellent stability and dissolvability and to provide a production process of the amorphous composition. The amorphous cefditoren pivoxil composition according to the present invention comprises cefditoren pivoxil and a pharmaceutically acceptable organic polymeric compound, wherein the composition is obtainable by grinding a crystalline cefditoren pivoxil in the presence of a pharmaceutically acceptable organic polymeric compound to convert the crystalline cefditoren pivoxil to an amorphous substance.

Abstract translation: 本发明的目的是提供具有优异稳定性和溶解性的无定形头孢托仑匹酯组合物，并提供无定形组合物的制备方法。 根据本发明的无定形头孢托仑匹酯组合物包含匹戊头孢托仑和药学上可接受的有机聚合化合物，其中所述组合物可通过在药学上可接受的有机高分子化合物存在下研磨结晶头孢托仑匹酯来获得，以将结晶头孢托仑匹酯转化为 无定形物质。

公开(公告)号：US20120286445A1

公开(公告)日：2012-11-15

申请号：US13574130

申请日：2011-01-27

Applicant: Masato Ohta

Inventor： Masato Ohta

IPC: B29C44/12 ,  B29C44/06

CPC classification number: B29C33/16 ,  B29C33/14 ,  B29C44/1228 ,  B29C44/1233 ,  B29C44/351 ,  B29C44/58 ,  B29K2105/0809 ,  B29K2623/06 ,  B29K2623/12 ,  B29L2031/58

Abstract: Disclosed is a mold for foam molding capable of making the operation to attach a reinforcing member to an inner surface of a mold easier, capable of sufficiently preventing entry of foam synthetic resin between the reinforcing member and the inner surface of the mold at the time of foam-molding, and capable of preventing the reinforcing member from becoming wrinkled; and also provided is a method for producing a foam-molded member which has a reinforcing member using this mold for foam molding. A mold 20 for foam molding is used to foam-mold a seat pad 1 which is provided with a seat pad main body 2 and a reinforcing member 10 disposed on the back side of the seat pad main body 2. At the time of foam-molding, the reinforcing member 10 is disposed inside the mold 20 and an end edge of the reinforcing member 10 is secured to the inner surface of the mold 20 by a securing means. A tension application means is provided which applies tension to the end edge of the reinforcing member 10 in a direction to separate from the securing means.

Abstract translation: 公开了一种用于发泡成型的模具，其能够更容易地将加强构件附接到模具的内表面，能够充分防止泡沫合成树脂在加强构件与模具的内表面之间进入时 发泡成型，能够防止加强部件起皱; 并且还提供了一种使用该模具进行发泡成型的具有加强构件的发泡成型构件的制造方法。 用于发泡成型的模具20用于对设置有座垫主体2和设置在座椅垫主体2的背侧的加强构件10的座垫1进行发泡模塑。 加强构件10设置在模具20的内部，并且加强构件10的端边缘通过固定装置固定到模具20的内表面。 提供张力施加装置，其在与固定装置分离的方向上向加强构件10的端部边缘施加张力。