公开(公告)号：US08854048B2

公开(公告)日：2014-10-07

申请号：US13262866

申请日：2011-03-10

申请人： Toshihiro Otani ,  Hisashi Harada ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Taizo Honda

发明人： Toshihiro Otani ,  Hisashi Harada ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Taizo Honda

IPC分类号： G01N27/62 ,  A61N5/10

CPC分类号： H01J37/304 ,  A61N5/1048 ,  A61N5/1071 ,  A61N5/1077 ,  A61N2005/1087 ,  H01J47/02

摘要： In a particle beam therapy system which scans a particle beam and irradiates the particle beam to an irradiation position of an irradiation subject and has a dose monitoring device for measuring a dose of the particle beam and an ionization chamber smaller than the dose monitoring device, the ionization chamber measuring a dose of a particle beam passing through the dose monitoring device, the dose of the particle beam irradiated by the dose monitoring device is measured; the dose of the particle beam passing through the dose monitoring device is measured by the small ionization chamber; and a correction coefficient of the dose measured by the dose monitoring device corresponding to the irradiation position is found based on the dose of the particle beam measured by the small ionization chamber.

摘要翻译： 在粒子束治疗系统中，扫描粒子束并将粒子束照射到照射对象的照射位置，并且具有用于测量粒子束的剂量和小于剂量监测装置的电离室的剂量监测装置， 电离室测量通过剂量监测装置的粒子束的剂量，测量由剂量监测装置照射的粒子束的剂量; 通过小电离室测量通过剂量监测装置的粒子束的剂量; 并且基于由小电离室测量的粒子束的剂量，求出由与照射位置对应的剂量监测装置测量的剂量的校正​​系数。

公开(公告)号：US09067066B2

公开(公告)日：2015-06-30

申请号：US14356629

申请日：2012-03-27

申请人： Yukiko Yamada ,  Hisashi Harada ,  Taizo Honda ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose

发明人： Yukiko Yamada ,  Hisashi Harada ,  Taizo Honda ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose

IPC分类号： G21K5/04 ,  A61N5/10

CPC分类号： A61N5/1048 ,  A61N5/1043 ,  A61N5/1077 ,  A61N2005/1074 ,  A61N2005/1087 ,  H05H13/04 ,  H05H2277/11

摘要： A control unit is provided with, a retaining section that retains a plurality of operation patterns each being a pattern of operation to be periodically repeated by an accelerator, the operation patterns having respective operation conditions adjusted for different emission times of an particle beam, to cause a deflection electromagnet in the accelerator to have an intended magnetic field intensity even under a presence of a hysteresis; a reading section for a plurality of slices of an irradiation target in a depth direction, which reads an irradiation condition for each of the slices; a selection section that selects the operation pattern suitable for each of the slices, on the basis of the read irradiation condition; and a main control section that controls, for each of the slices, the accelerator on the basis of the selected operation pattern and an irradiation device on the basis of the irradiation condition.

摘要翻译： 控制单元设置有保持部，其保持多个操作模式，每个操作模式是由加速器周期性重复的操作模式，所述操作模式具有针对粒子束的不同发射次数调整的各自的操作条件，以使得 加速器中的偏转电磁体即使在滞后的情况下也具有预期的磁场强度; 用于读取每个切片的照射条件的用于在深度方向上的照射目标的多个切片的读取部分; 选择部，其基于读取的照射条件选择适合于每个切片的操作模式; 以及主控制部，其基于所述照射条件，基于所选择的操作模式和照射装置对每个切片进行加速器的控制。

公开(公告)号：US20140323793A1

公开(公告)日：2014-10-30

申请号：US14356629

申请日：2012-03-27

申请人： Yukiko Yamada ,  Hisashi Harada ,  Taizo Honda ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose

发明人： Yukiko Yamada ,  Hisashi Harada ,  Taizo Honda ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose

IPC分类号： A61N5/10

CPC分类号： A61N5/1048 ,  A61N5/1043 ,  A61N5/1077 ,  A61N2005/1074 ,  A61N2005/1087 ,  H05H13/04 ,  H05H2277/11

摘要： A control unit is provided with, a retaining section that retains a plurality of operation patterns each being a pattern of operation to be periodically repeated by an accelerator, the operation patterns having respective operation conditions adjusted for different emission times of an particle beam, to cause a deflection electromagnet in the accelerator to have an intended magnetic field intensity even under a presence of a hysteresis; a reading section for a plurality of slices of an irradiation target in a depth direction, which reads an irradiation condition for each of the slices; a selection section that selects the operation pattern suitable for each of the slices, on the basis of the read irradiation condition; and a main control section that controls, for each of the slices, the accelerator on the basis of the selected operation pattern and an irradiation device on the basis of the irradiation condition.

摘要翻译： 控制单元设置有保持部，其保持多个操作模式，每个操作模式是由加速器周期性重复的操作模式，所述操作模式具有针对粒子束的不同发射次数调整的各自的操作条件，以使得 加速器中的偏转电磁体即使在滞后的情况下也具有预期的磁场强度; 用于读取每个切片的照射条件的用于在深度方向上的照射目标的多个切片的读取部分; 选择部，其基于读取的照射条件选择适合于每个切片的操作模式; 以及主控制部，其基于所述照射条件，基于所选择的操作模式和照射装置对每个切片进行加速器的控制。

公开(公告)号：US20120229143A1

公开(公告)日：2012-09-13

申请号：US13262866

申请日：2011-03-10

申请人： Toshihiro Otani ,  Hisashi Harada ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Taizo Honda

发明人： Toshihiro Otani ,  Hisashi Harada ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Taizo Honda

IPC分类号： G01N27/62

CPC分类号： H01J37/304 ,  A61N5/1048 ,  A61N5/1071 ,  A61N5/1077 ,  A61N2005/1087 ,  H01J47/02

摘要： In a particle beam therapy system which scans a particle beam and irradiates the particle beam to an irradiation position of an irradiation subject and has a dose monitoring device for measuring a dose of the particle beam and an ionization chamber smaller than the dose monitoring device, the ionization chamber measuring a dose of a particle beam passing through the dose monitoring device, the dose of the particle beam irradiated by the dose monitoring device is measured; the dose of the particle beam passing through the dose monitoring device is measured by the small ionization chamber; and a correction coefficient of the dose measured by the dose monitoring device corresponding to the irradiation position is found based on the dose of the particle beam measured by the small ionization chamber.

摘要翻译： 在粒子束治疗系统中，扫描粒子束并将粒子束照射到照射对象的照射位置，并且具有用于测量粒子束的剂量和小于剂量监测装置的电离室的剂量监测装置， 电离室测量通过剂量监测装置的粒子束的剂量，测量由剂量监测装置照射的粒子束的剂量; 通过小电离室测量通过剂量监测装置的粒子束的剂量; 并且基于由小电离室测量的粒子束的剂量，求出由与照射位置对应的剂量监测装置测量的剂量的校正​​系数。

公开(公告)号：US08350234B2

公开(公告)日：2013-01-08

申请号：US13127112

申请日：2008-12-24

申请人： Yuehu Pu ,  Toshihiro Otani

发明人： Yuehu Pu ,  Toshihiro Otani

IPC分类号： A61N5/10

CPC分类号： A61N5/1048 ,  A61N2005/1056 ,  A61N2005/1087

摘要： Light from a light source is made to be reflected by a light source mirror and to pass through a variable collimator, an irradiation field shape shaped by the variable collimator is projected on a photographing screen by the light passed through the variable collimator, a projection portion of the photographing screen is photographed by a photographic device, and an image photographed by the photographic device is analyzed by an image processor.

摘要翻译： 使来自光源的光由光源反射镜反射并穿过可变准直器，通过可变准直仪形成的照射场形状，通过可变准直器的光投射在拍摄屏幕上，突出部 通过摄影装置拍摄拍摄画面，并且通过图像处理器分析由照相装置拍摄的图像。

公开(公告)号：US20110204262A1

公开(公告)日：2011-08-25

申请号：US13127112

申请日：2008-12-24

申请人： Yuehu Pu ,  Toshihiro Otani

发明人： Yuehu Pu ,  Toshihiro Otani

IPC分类号： A61N5/10

CPC分类号： A61N5/1048 ,  A61N2005/1056 ,  A61N2005/1087

摘要： Light from a light source is made to be reflected by a light source mirror and to pass through a variable collimator, an irradiation field shape shaped by the variable collimator is projected on a photographing screen by the light passed through the variable collimator, a projection portion of the photographing screen is photographed by a photographic device, and an image photographed by the photographic device is analyzed by an image processor.

摘要翻译： 使来自光源的光由光源反射镜反射并穿过可变准直器，通过可变准直仪形成的照射场形状，通过可变准直器的光投影在拍摄屏幕上，突出部 通过摄影装置拍摄拍摄画面，并且通过图像处理器分析由照相装置拍摄的图像。

公开(公告)号：US07312918B2

公开(公告)日：2007-12-25

申请号：US11138492

申请日：2005-05-27

申请人： Eiji Ishikawa ,  Toshihiro Otani

发明人： Eiji Ishikawa ,  Toshihiro Otani

IPC分类号： H01S4/00 ,  H04B10/12

CPC分类号： H04B10/2916

摘要： An optical transmission system wherein a main signal light is amplified by Raman amplification, and noise light (ASS light) produced by the Raman amplification can be corrected with a simple configuration and with high accuracy. The optical transmission system includes, in each transmission section: a cutoff section for transmitting/cutting off a main signal light outputted from the optical transmitter on the preceding stage and inputted into the Raman amplification medium on an optical transmission line; a control section for varying the power of the pumping light supplied to the Raman amplification medium and changing the state of the cutoff section depending on the variation of the pumping light power; a monitor section for measuring the power of the pumping light supplied to the Raman amplification medium and the power of the light propagated through the optical transmission line and inputted into an optical transmitter on the succeeding stage; and a processing section for separately detecting the power of the main signal light and the power of the ASS light on the basis of the results of the measurement by the monitor section, and correcting the ASS light.

摘要翻译： 一种光传输系统，其中主信号光通过拉曼放大放大，并且可以以简单的配置和高精度校正由拉曼放大产生的噪声光（ASS光）。 光传输系统包括：在每个传输部分中：切断部分，用于发射/切断在前级上的光发射机输出的主信号光，并输入到光传输线上的拉曼放大介质; 控制部分，用于改变提供给拉曼放大介质的泵浦光的功率，并根据泵浦光功率的变化改变截止部分的状态; 用于测量提供给拉曼放大介质的泵浦光的功率和通过光传输线传播并输入到后级光发射机的光的功率的监视器部分; 以及处理部分，用于根据监视部分的测量结果分别检测主信号光的功率和ASS光的功率，并校正ASS光。

公开(公告)号：US5963357A

公开(公告)日：1999-10-05

申请号：US891785

申请日：1997-07-14

申请人： Yoshinobu Kubota ,  Yasuhiro Omori ,  Toshihiro Otani ,  Tomoyuki Itoh

发明人： Yoshinobu Kubota ,  Yasuhiro Omori ,  Toshihiro Otani ,  Tomoyuki Itoh

IPC分类号： G02F1/03 ,  G02F1/01 ,  G02F1/225 ,  G02F1/035

CPC分类号： G02F1/0123 ,  G02F1/225

摘要： An optical modulator for modulating light emitted from a signal light source has a substrate having electrooptic effect, an optical waveguide of a Mach-Zehnder type formed on the substrate, an electrode formed on the substrate to control light propagated in the optical waveguide, an interference light generating means for making radiation light radiated from the optical waveguide and signal light leaking from the optical waveguide interfere with each other to generate interference light, and emitting the interference light from an end surface of the substrate, a photo-detector for monitoring the interference light of the radiation light and the signal light, and a signal controlling circuit for controlling an operating point of the optical modulator according to a change of the interference light monitored by the photo-detector It is thereby possible to prevent degradation of a distinction ratio due to a shift of the operating point of the optical modulator so as to allow stable optical modulation, while facilitating a design of the mechanism of the optical modulator.

摘要翻译： 用于调制从信号光源发出的光的光调制器具有具有电光效应的基板，形成在基板上的马赫 - 策德尔型光波导，形成在基板上的电极，用于控制在光波导中传播的光，干涉 用于产生从光波导辐射的辐射光的光产生装置和从光波导泄漏的信号光相互干扰以产生干涉光，并从基板的端面发射干涉光，用于监测干涉的光检测器 照射光和信号光的光，以及用于根据光检测器所监视的干涉光的变化来控制光调制器的工作点的信号控制电路，从而可以防止由于 到光调制器的工作点的移动，以便允许稳定的光学 l调制，同时有助于光调制器的机制的设计。

公开(公告)号：US5889912A

公开(公告)日：1999-03-30

申请号：US921014

申请日：1997-08-29

申请人： Toshihiro Otani ,  Tomoyuki Ito ,  Yoshinobu Kubota ,  Yasuhiro Omori

发明人： Toshihiro Otani ,  Tomoyuki Ito ,  Yoshinobu Kubota ,  Yasuhiro Omori

IPC分类号： G02B6/122 ,  G02B6/12 ,  G02F1/035 ,  G02F1/21 ,  G02F1/225 ,  G02B6/10

CPC分类号： G02B6/12 ,  G02B2006/12159 ,  G02F1/0356 ,  G02F1/2255 ,  G02F2001/212

摘要： An optical waveguide device including a package housing having an element mounting surface, an element inserting groove opening to the element mounting surface, and a cutout as a space opening to an inner surface of the element inserting groove; and an optical waveguide element having a dielectric substrate, an optical waveguide formed in a surface of the dielectric substrate, and an electrode formed over the surface of the dielectric substrate, the optical waveguide element being inserted and fixed in the element inserting groove of the package housing by using an adhesive. The cutout opens also to the element mounting surface. In applying the adhesive to the bottom surface of the element inserting groove and inserting the optical waveguide element into the element inserting groove, the adhesive flows into the cutout and is prevented from flowing up to the element mounting surface. Further, a working space for application of the adhesive to the bottom surface of the element inserting groove can be ensured by the cutout.

摘要翻译： 一种光波导装置，包括具有元件安装表面的封装壳体，通向元件安装表面的元件插入槽以及通向元件插入槽内表面的开口的切口; 以及具有电介质基板的光波导元件，形成在电介质基板的表面的光波导，以及在电介质基板的表面上形成的电极，光波导元件被插入并固定在封装的元件插入槽内 通过使用粘合剂进行住房。 切口也打开到元件安装表面。 在将粘合剂施加到元件插入槽的底表面并将光波导元件插入元件插入槽中时，粘合剂流入切口并防止其向元件安装表面流动。 此外，可以通过切口来确保用于将粘合剂施加到元件插入槽的底面的工作空间。

公开(公告)号：US5215714A

公开(公告)日：1993-06-01

申请号：US709062

申请日：1991-05-30

申请人： Satoru Okada ,  Yoshiteru Mizuno ,  Takayoshi Izumi ,  Toshihiro Otani

发明人： Satoru Okada ,  Yoshiteru Mizuno ,  Takayoshi Izumi ,  Toshihiro Otani

IPC分类号： G01N35/10

CPC分类号： G01N35/1009 ,  G01N2035/1025 ,  G01N2035/1086 ,  G01N35/1004

摘要： A buffer solution is sampled from a buffer solution vessel and is dispensed into a reaction vessel on a reaction table by first sampling/dispensing means, and a specimen containing an antigen or antibody to be measured is sampled from a specimen vessel and is dispensed into the reaction vessel by second sampling/dispensing means. A reagent containing insoluble carriers to which is bonded an antibody or antigen that specifically reacts with the antigen or antibody in the specimen is sampled from a reagent vessel and dispensed into the reaction vessel by third sampling/dispensing means. The entire reaction table is shaken continuously during mixing of the buffer solution, reagent and specimen, and the reaction vessel is maintained in an isothermal state. A stable antigen-antibody reaction in the resulting reaction solution is thus promoted to form an agglutinate of the insoluble carriers. The reaction solution is sampled from the reaction vessel and dispensed into a sample chamber by fourth sampling/dispensing means. The dispensed reaction solution is transferred to a detector through which the insoluble carriers are passed and in which a signal is generated based upon a difference in terms of electrical or optical characteristics. The degree of agglutination of the insoluble carriers is obtained as a numerical value, thus making it possible to quantify the antigen or antibody of interest contained in the specimen.

摘要翻译： 缓冲溶液从缓冲溶液容器中取样，并通过第一取样/分配装置分配到反应台上的反应容器中，并从样品容器中取出含有待测量的抗原或抗体的样品，并将其分配到 反应容器通过第二采样/分配装置。 从试剂容器中取出含有与试样中的抗原或抗体特异性反应的抗体或抗原结合的不溶性载体的试剂，并通过第三取样/分注装置分配到反应容器中。 在缓冲溶液，试剂和试样的混合过程中，整个反应台连续摇动，反应容器保持在等温状态。 因此促进所得反应溶液中的稳定的抗原 - 抗体反应形成不溶性载体的凝集物。 反应溶液从反应容器中取样并通过第四取样/分配装置分配到样品室中。 分配的反应溶液转移到不可溶载体通过的检测器，并且基于电或光学特性的差异产生信号。 获得不溶性载体的凝集度作为数值，从而可以定量试样中包含的感兴趣的抗原或抗体。