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    Pharmaceutical compositions of 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline
    12.
    发明授权
    Pharmaceutical compositions of 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline 有权
    1-氧代-2-（2,6-二氧代哌啶-3-基）-4-氨基异二氢吲哚的药物组合物

    公开(公告)号：US07119106B2

    公开(公告)日：2006-10-10

    申请号：US10337602

    申请日：2003-01-06

    申请人： George W. Muller ,  David I. Stirling ,  Roger Shen-Chu Chen

    发明人： George W. Muller ,  David I. Stirling ,  Roger Shen-Chu Chen

    IPC分类号： A61K31/445 ,  C07D401/04

    CPC分类号： C07D401/04

    摘要： Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNFα in a mammal. Typical embodiments are 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafuoroisoindoline and 1,3-dioxo-2-(2,6-dioxo-3 -methylpiperidin-3-yl)-4-aminoisoindoline.

    摘要翻译： 取代的2-（2,6-二氧代哌啶-3-基）苯二酰亚胺和1-氧代-2-（2,6-二氧代哌啶-3-基）异吲哚啉降低哺乳动物TNFalpha的水平。 典型的实施方案是1-氧代-2-（2,6-二氧代-3-甲基哌啶-3-基）-4,5,6,7-四氟异吲哚啉和1,3-二氧代-2-（2,6-二氧代 - 3-甲基哌啶-3-基）-4-氨基异吲哚啉。

    Enantiomeric enrichment and stereoselective synthesis of chiral amines
    18.
    发明授权
    Enantiomeric enrichment and stereoselective synthesis of chiral amines 失效
    手性胺的对映体富集和立体选择性合成

    公开(公告)号：US5169780A

    公开(公告)日：1992-12-08

    申请号：US549830

    申请日：1990-07-09

    申请人： David I. Stirling ,  Andrew L. Zeitlin ,  George W. Matcham ,  James D. Rozzell, Jr.

    发明人： David I. Stirling ,  Andrew L. Zeitlin ,  George W. Matcham ,  James D. Rozzell, Jr.

    IPC分类号： C12N9/10 ,  C12P7/26 ,  C12P41/00

    CPC分类号： C12N9/1096 ,  C12P41/006 ,  C12P7/26

    摘要： Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process can be used to stereoselectively sythesize one chiral form from ketones substantially to the exclusion of the other. An aqueous solution of chiral amines after being brought into contact with an omega-amino acid transaminase and an amino acceptor is treated with a water-immiscible organic solvent, the aqueous and organic phases are separated, and the aqueous phase can be recirculated for further contact with the transaminase.

    摘要翻译： 其中氨基在手性取代的仲碳原子上的胺可通过ω-氨基酸转氨酶的作用而被对映体富集，该氨基酸转氨酶具有优先将两种手性形式之一转化为酮的性质。 该方法可用于立体选择性地将酮的一种手性形式基本上与另一种不同。 与ω-氨基酸转氨酶和氨基受体接触后手性胺的水溶液用水不混溶的有机溶剂处理，水相和有机相被分离，水相可再循环以进一步接触 与转氨酶。