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11.发明申请公开(公告)号：US20100152441A1
公开(公告)日：2010-06-17
申请号：US11917394
申请日：2006-06-16
IPC分类号： C07D498/04
CPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/06 , C07D491/04 , C07D513/04
摘要： The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.
摘要翻译： 本发明涉及表现出抗菌活性的化合物，其制备方法，含有它们作为活性成分的药物组合物，它们作为药物的用途，以及它们在制备用于治疗温暖的细菌感染的药物中的用途， 血液动物如人类。 特别地，本发明涉及可用于治疗温血动物如人的细菌感染的化合物，更具体地涉及这些化合物在制备用于治疗温血动物细菌感染的药物中的用途，例如 作为人类
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12.发明申请Aminopiperidine Quinolines and Their Azaisosteric Analogues with Antibacterial Activity 审中-公开氨基哌啶喹啉及其具有抗菌活性的阿片类兴奋剂类似物公开(公告)号：US20090131444A1
公开(公告)日：2009-05-21
申请号：US11914799
申请日：2006-05-23
IPC分类号： A61K31/517 , A61K31/4709 , A61K31/502 , A61K31/4745 , A61K31/445 , C07D475/02 , C07D471/02 , C07D403/02 , C07D401/02 , A61K31/525
CPC分类号： C07D471/04 , C07D491/04
摘要： The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm blooded animals such as humans.
摘要翻译： 本发明涉及显示抗菌活性的化合物，其制备方法，含有它们作为活性成分的药物组合物，它们作为药物的用途及其在制备用于治疗温血细菌感染的药物中的用途 动物如人类。 特别地，本发明涉及可用于治疗温血动物如人的细菌感染的化合物，更具体地涉及这些化合物在制备用于治疗温血动物细菌感染的药物中的用途，例如 人类。
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![Pyrazolo [3,4-d] pyrimidine derivatives and their use in the treatment of h.pylori infection](/abs-image/US/2007/01/04/US20070004761A1/abs.jpg.150x150.jpg)
13.发明申请Pyrazolo [3,4-d] pyrimidine derivatives and their use in the treatment of h.pylori infection 审中-公开吡唑并[3,4-d]嘧啶衍生物及其在治疗幽门螺杆菌感染中的应用公开(公告)号：US20070004761A1
公开(公告)日：2007-01-04
申请号：US10539936
申请日：2003-12-19
申请人： Gregory Basarab , Joseph Eyermann , Madhusudhan Gowravaram , Ohryinka Green , Lawrence MacPherson , Marshall Morningstar , Thanh Nguyen
发明人： Gregory Basarab , Joseph Eyermann , Madhusudhan Gowravaram , Ohryinka Green , Lawrence MacPherson , Marshall Morningstar , Thanh Nguyen
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04
摘要： This invention relates to novel compounds having the structural diagram (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of H. pylori infection.
摘要翻译： 本发明涉及具有结构图（I）及其药物组合物及其使用方法的新型化合物。 这些新型化合物提供治疗或预防幽门螺杆菌感染。
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14.发明授权Substituted benzimidazoles as non-nucleoside inhibitors of reverse transcriptase 失效取代的苯并咪唑作为逆转录酶的非核苷抑制剂公开(公告)号：US06894068B2
公开(公告)日：2005-05-17
申请号：US10119634
申请日：2002-04-09
IPC分类号： A61K31/4184 , A61K31/4439 , A61P31/18 , A61P37/04 , A61P43/00 , C07D235/06 , C07D235/08 , C07D235/12 , C07D235/18 , C07D235/22 , C07D401/04 , C07D401/06 , A61K31/415 , A61K31/47 , A61K31/495 , A61K31/70 , A61K43/42
CPC分类号： C07D235/06 , C07D235/08 , C07D235/12 , C07D235/18 , C07D401/04 , C07D401/06
摘要： The present invention provides compositions and methods for the treatment of HIV infection. In particular, the present invention provides non-nucleoside inhibitors of reverse transcriptase (RT), as well as methods to treat HIV infection using these non-nucleoside inhibitors of RT. In preferred embodiments, the present invention provides a novel class of substituted benzimidazoles, effective in the inhibition of human immunodeficiency virus (HIV) RT.
摘要翻译： 本发明提供了用于治疗HIV感染的组合物和方法。 特别地，本发明提供了逆转录酶（RT）的非核苷抑制剂，以及使用这些RT的非核苷抑制剂治疗HIV感染的方法。 在优选的实施方案中，本发明提供了有效抑制人类免疫缺陷病毒（HIV）RT的新型取代的苯并咪唑。
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15.发明授权Substituted benzimidazoles, and methods of use thereof, for the inhibition of HIV reverse transcription and for the treatment of HIV infection 失效取代的苯并咪唑及其使用方法，用于抑制HIV逆转录和治疗HIV感染公开(公告)号：US06369235B1
公开(公告)日：2002-04-09
申请号：US09380171
申请日：2000-02-01
IPC分类号： C07D23518
CPC分类号： C07D235/06 , C07D235/08 , C07D235/12 , C07D235/18 , C07D401/04 , C07D401/06
摘要： The present invention provides compositions and methods for the treatment of HIV infection. In particular, the present invention provides non-nucleoside inhibitors of reverse transcriptase (RT), as well as methods to treat HIV infection using these non-nucleoside inhibitors of RT. In preferred embodiments, the present invention provides a novel class of substituted benzimidazoles, effective in the inhibition of human immunodeficiency virus (HIV) RT.
摘要翻译： 本发明提供了用于治疗HIV感染的组合物和方法。 特别地，本发明提供了逆转录酶（RT）的非核苷抑制剂，以及使用这些RT的非核苷抑制剂治疗HIV感染的方法。 在优选的实施方案中，本发明提供了有效抑制人类免疫缺陷病毒（HIV）RT的新型取代的苯并咪唑。
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16.发明授权公开(公告)号：US08124602B2
公开(公告)日：2012-02-28
申请号：US12964366
申请日：2010-12-09
IPC分类号： A61K31/438 , A61K31/498 , C07D401/06 , C07D403/06
CPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/06 , C07D491/04 , C07D513/04
摘要： The present invention relates to compounds of Formula V(A): that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds of Formula V(A) useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.
摘要翻译： 本发明涉及式V（A）的化合物：其表现出抗菌活性，其制备方法，含有它们作为活性成分的药物组合物，其用作药物及其在制备药物中的用途 治疗温血动物如人类的细菌感染。 特别地，本发明涉及用于治疗温血动物如人的细菌感染的式V（A）化合物，更具体地说涉及这些化合物在制备用于治疗细菌感染的药物中的用途 在温血动物如人类。
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公开(公告)号：US20090062236A1
公开(公告)日：2009-03-05
申请号：US11699758
申请日：2007-01-29
IPC分类号： A61K31/675 , C12N5/00 , C12N5/02 , A61K31/175 , A61K31/131 , A61K31/28 , A61K31/10 , A61K31/53
CPC分类号： A61K47/64 , A61K47/54 , A61K47/55 , A61K47/554 , A61K47/557
摘要： The compositions and methods disclosed herein provide heterobifunctional programmable genotoxic compounds that can be designed to kill selected cells present in a heterogenous cell population. The present compounds comprise a first agent that inflicts damage on cellular DNA, and a second agent that attracts a macromolecular cell component such as a protein, which in turn shields genomic lesions from repair. Unrepaired lesions therefore persist in the cellular genome and contribute to the death of selected cells. In contrast, lesions formed in nonselected cells, which lack the cell component, are unshielded and thus are repaired. As a result, compounds described herein are less toxic to nonselected cells. Compounds of this invention can be designed to cause the selective killing of transformed cells, viral-infected cells and the like.
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公开(公告)号：US07371757B2
公开(公告)日：2008-05-13
申请号：US10567797
申请日：2004-08-12
申请人： Marshall Morningstar , Gregory Basarab , Charles Joseph Eyermann , Madhu Gowravaram , Oluyinka Green , Andrew Kiely , Lawrence MacPherson , Nguyen Thanh
发明人： Marshall Morningstar , Gregory Basarab , Charles Joseph Eyermann , Madhu Gowravaram , Oluyinka Green , Andrew Kiely , Lawrence MacPherson , Nguyen Thanh
IPC分类号： A01N43/54 , A61K31/505 , C07D239/00 , C07D471/00 , C07D487/00 , C07D491/00
CPC分类号： C07D487/14
摘要： This invention relates to novel compounds having formula: (I) or (II) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of H. pylori infection.
摘要翻译： 本发明涉及具有式（I）或（II）的新化合物及其药物组合物及其使用方法。 这些新型化合物提供治疗或预防幽门螺杆菌感染。
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公开(公告)号：US07342012B2
公开(公告)日：2008-03-11
申请号：US11070335
申请日：2005-03-03
申请人： Ila Sircar , Paul Furth , Bradley R. Teegarden , Marshall Morningstar , Nicholas Smith , Ronald C. Griffith
发明人： Ila Sircar , Paul Furth , Bradley R. Teegarden , Marshall Morningstar , Nicholas Smith , Ronald C. Griffith
IPC分类号： C07D487/04 , A61K31/4985
CPC分类号： C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention relates to a compound of the following formula: or a pharmaceutically acceptable salt thereof. Also disclosed are compositions containing the compound and methods of preparing and using the compounds. The compounds of the invention are useful in treating αLβ2 adhesion mediated conditions in a mammal.
摘要翻译： 本发明涉及下式的化合物或其药学上可接受的盐。 还公开了含有该化合物的组合物和制备和使用该化合物的方法。 本发明的化合物可用于治疗哺乳动物中的α2 L 2β2/2粘附介导的病症。
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![Pyrazolo[3,4-d]pyrimidines inhibiting H. pylori infections](/abs-image/US/2007/10/23/US07285558B2/abs.jpg.150x150.jpg)
公开(公告)号：US07285558B2
公开(公告)日：2007-10-23
申请号：US10481178
申请日：2002-06-28
申请人： Gregory Basarab , Joseph Eyermann , Madhusudhan Gowravaram , Oluyinka Green , Lawrence MacPherson , Marshall Morningstar , Thanh Nguyen
发明人： Gregory Basarab , Joseph Eyermann , Madhusudhan Gowravaram , Oluyinka Green , Lawrence MacPherson , Marshall Morningstar , Thanh Nguyen
IPC分类号： C07D271/02 , C07D473/00 , A61K31/519
CPC分类号： C07D239/545 , C07D409/12 , C07D487/04
摘要： Compounds having the general formula and pharmaceutical compositions containing them, and their use in the treatment or prophylaxis of H. pylori infection.
摘要翻译： 具有通式的化合物和含有它们的药物组合物，以及它们在治疗或预防幽门螺杆菌感染中的用途。
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