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43 条记录 (耗时 0.036 秒)

    Controlling protein levels in eucaryotic organisms
    11.
    发明授权
    Controlling protein levels in eucaryotic organisms 失效
    控制真核生物中的蛋白质水平

    公开(公告)号：US07273920B2

    公开(公告)日：2007-09-25

    申请号：US10345281

    申请日：2003-01-16

    申请人： John H. Kenten ,  Steven F. Roberts

    发明人： John H. Kenten ,  Steven F. Roberts

    IPC分类号： A61K38/00 ,  C12P21/04 ,  C12P13/10 ,  C12P13/06 ,  G01N33/53

    CPC分类号： C07K14/005 ,  A61K38/00 ,  C07K14/00 ,  C12N2740/16222 ,  Y02A50/463

    摘要： The invention relates to novel compounds comprising a ubiquitination recognition element and a protein binding element. The invention also relates to the use of said compounds for modulating the level and/or activity of a target protein. The compounds are useful for the treatment of disease such as infections, inflammatory conditions, cancer and genetic diseases. The compounds are also useful as insecticides and herbicides.

    摘要翻译： 本发明涉及包含泛素识别元件和蛋白质结合元件的新型化合物。 本发明还涉及所述化合物用于调节靶蛋白的水平和/或活性的用途。 该化合物可用于治疗感染，炎性病症，癌症和遗传疾病等疾病。 这些化合物也可用作杀虫剂和除草剂。

    Controlling protein levels in eucaryotic organisms
    13.
    发明授权
    Controlling protein levels in eucaryotic organisms 失效
    控制真核生物中的蛋白质水平

    公开(公告)号：US06306663B1

    公开(公告)日：2001-10-23

    申请号：US09406781

    申请日：1999-09-28

    申请人： John H. Kenten ,  Steven F. Roberts

    发明人： John H. Kenten ,  Steven F. Roberts

    IPC分类号： G01N33566

    CPC分类号： C07K14/005 ,  A61K38/00 ,  C07K14/00 ,  C12N2740/16222 ,  Y02A50/463

    摘要： The invention relates to novel compounds comprising a ubiquitination recognition element and a protein binding element. The invention also relates to the use of said compounds for modulating the level and/or activity of a target protein. The compounds are useful for the treatment of disease such as infections, inflammatory conditions, cancer and genetic diseases. The compounds are also useful as insecticides and herbicides.

    摘要翻译： 本发明涉及包含泛素识别元件和蛋白质结合元件的新型化合物。 本发明还涉及所述化合物用于调节靶蛋白的水平和/或活性的用途。 该化合物可用于治疗感染，炎性病症，癌症和遗传疾病等疾病。 这些化合物也可用作杀虫剂和除草剂。

    Compounds and methods for the selective treatment of cancer and bacterial infections
    18.
    发明授权
    Compounds and methods for the selective treatment of cancer and bacterial infections 失效
    用于选择性治疗癌症和细菌感染的化合物和方法

    公开(公告)号：US06218519B1

    公开(公告)日：2001-04-17

    申请号：US08635243

    申请日：1996-04-12

    申请人： John H. Kenten ,  David M. Simpson

    发明人： John H. Kenten ,  David M. Simpson

    IPC分类号： C07H1524

    CPC分类号： C07H15/252

    摘要： The present invention relates to compounds containing an anthracyclinone group such as doxorubicin, daunorubicin or a derivative thereof. The compounds of the invention also contain ester, glycoside or glucuronide structures which are hydrolyzed by the corresponding esterase, glycosidase or glucuronidase. These compounds possess potent cytotoxic activity which is developed after the hydrolysis of the ester or glycoside group of the compound and are effective in the inhibition of tumor cells and bacterial growth after activation.

    摘要翻译： 本发明涉及含有蒽环类基团的化合物，例如多柔比星，柔红霉素或其衍生物。 本发明的化合物还含有由相应的酯酶，糖苷酶或葡糖苷酸酶水解的酯，糖苷或葡糖苷酸结构。 这些化合物具有强效的细胞毒活性，其在化合物的酯或糖苷基团水解后发展，并且在活化后有效抑制肿瘤细胞和细菌生长。