公开(公告)号：US5792056A

公开(公告)日：1998-08-11

申请号：US777347

申请日：1996-12-27

申请人： Martin R. Prince

发明人： Martin R. Prince

IPC分类号： A61K49/18 ,  G01R33/28 ,  G01R33/561 ,  G01R33/563 ,  A61B3/055

CPC分类号： A61K49/18 ,  A61B5/411 ,  A61B5/416 ,  A61M5/007 ,  A61M5/1456 ,  A61M5/16827 ,  G01R33/5601 ,  G01R33/563 ,  G01R33/5635 ,  A61B5/201 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/56308

摘要： The present invention is a technique and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue by correlating the collection of a predetermined portion of data of a magnetic resonance contrast image during the arterial phase of the magnetic resonance contrast enhancement. The arterial phase of the contrast enhancement may be described as a period of a maximum, substantially elevated, or elevated contrast concentration in the artery of interest relative to adjacent veins. The present invention includes a detection system for monitoring and detecting the arrival of the contrast agent in the artery and tissues of interest. When the concentration of contrast agent in the artery of the region of interest is maximum, substantially elevated or elevated (e.g., about 20-50% greater than the response of the region of interest to a series of magnetic resonance pulses before administration of a magnetic resonance contrast agent), a predetermined portion of the magnetic resonance image data (e.g., data which is representative of the center of k-space) may be acquired. Thus, the present invention facilitates synchronization between collecting the central portion of k-space image data with the arterial phase of contrast enhancement. The center of k-space corresponds to the lowest spatial frequency data which dominates image contrast.

公开(公告)号：US5304228A

公开(公告)日：1994-04-19

申请号：US919150

申请日：1992-07-23

申请人： Martin R. Prince

发明人： Martin R. Prince

IPC分类号： A61B18/22 ,  A61B18/24 ,  G02B6/255 ,  G02B6/26 ,  C03B37/023

CPC分类号： G02B6/2552 ,  A61B18/245 ,  G02B6/262 ,  A61B2018/2266

摘要： An apparatus for delivery of high intensity laser radiation of large spot size into arteries and a method for making same are disclosed. An optical radiating apparatus is formed on one end of a light-conducting optical fiber such that high intensity laser radiation leaves the optical radiation apparatus with a spot size that is expanded to a diameter significantly larger than the optical fiber diameter. The apparatus comprises a small diameter, flexible fiber which tapers to a large diameter, smooth, rounded ball tip. The taper allows the beam to expand to several millimeters in diameter and thereby ablate a large channel through an occluded artery. The smooth ball tip minimizes the chance of mechanical dissection or performation. The fiber material is continuous such that there are no optical interfaces. The light radiation apparatus is manufactured to ensure uniformity of light intensity and the ability to transmit intense light without developing regions of mechanical, thermal or optical damage to the apparatus.

摘要翻译： 公开了一种用于将大斑点的高强度激光辐射输送到动脉中的装置及其制造方法。 在导光光纤的一端形成光辐射装置，使得高强度激光辐射离开光辐射装置，其光点尺寸扩大到明显大于光纤直径的直径。 该装置包括一个小直径的柔性纤维，其逐渐变细到大直径，平滑的圆形球头。 锥形允许束扩张至直径几毫米，从而通过闭塞动脉消融大通道。 平滑的球头使机械解剖或形态的机会最小化。 纤维材料是连续的，使得没有光学界面。 制造光辐射装置以确保光强度的均匀性和传递强光的能力，而不会对该装置发生机械，热或光学损伤的区域。

公开(公告)号：US07734078B2

公开(公告)日：2010-06-08

申请号：US12475797

申请日：2009-06-01

申请人： Martin R. Prince ,  Ramin Zabih ,  Yi Wang ,  Richard Watts ,  Junhwan Kim ,  Jeff Bezanson ,  Hale Ersoy

发明人： Martin R. Prince ,  Ramin Zabih ,  Yi Wang ,  Richard Watts ,  Junhwan Kim ,  Jeff Bezanson ,  Hale Ersoy

IPC分类号： G06K9/00

CPC分类号： G06T5/50 ,  G06K2209/05 ,  G06T2207/10076 ,  G06T2207/10088 ,  G06T2207/30101 ,  Y10S128/92 ,  Y10S128/922

摘要： In time-resolved contrast-enhanced magnetic resonance angiography, a measure quantifying image quality provides a basis for generating a linear filtered composite image by facilitating selection of a mask and an arterial phase image for subtraction. Filtering of individual pixels of a temporal series of images provides enhanced contrast in a single image by allowing the temporal behavior of the pixel intensity to denote representation as an artery, vein or background tissue. Motion artifacts are suppressed by re-registering sequential images, adjusting weighting before averaging and subtraction and filtering the Fourier data to eliminate data corrupted by motion or other phenomena.

摘要翻译： 在时间分辨的对比度增强磁共振血管造影术中，量化图像质量的度量为通过促进选择掩模和用于减法的动脉相位图像生成线性滤波的复合图像提供了基础。 通过使像素强度的时间行为表示为动脉，静脉或背景组织，对时间序列图像中的各个像素进行滤波，从而在单个图像中提供增强的对比度。 通过重新注册顺序图像来抑制运动伪影，在平均和减法之前调整加权并对傅立叶数据进行滤波以消除由运动或其他现象损坏的数据。

公开(公告)号：US20090245606A1

公开(公告)日：2009-10-01

申请号：US12475797

申请日：2009-06-01

申请人： Martin R. Prince ,  Ramin Zabih ,  Yi Wang ,  Richard Watts ,  Junhwan Kim ,  Jeff Bezanson ,  Hale Ersoy

发明人： Martin R. Prince ,  Ramin Zabih ,  Yi Wang ,  Richard Watts ,  Junhwan Kim ,  Jeff Bezanson ,  Hale Ersoy

IPC分类号： G06K9/00

CPC分类号： G06T5/50 ,  G06K2209/05 ,  G06T2207/10076 ,  G06T2207/10088 ,  G06T2207/30101 ,  Y10S128/92 ,  Y10S128/922

摘要： In time-resolved contrast-enhanced magnetic resonance angiography, a measure quantifying image quality provides a basis for generating a linear filtered composite image by facilitating selection of a mask and an arterial phase image for subtraction. Filtering of individual pixels of a temporal series of images provides enhanced contrast in a single image by allowing the temporal behavior of the pixel intensity to denote representation as an artery, vein or background tissue. Motion artifacts are suppressed by re-registering sequential images, adjusting weighting before averaging and subtraction and filtering the Fourier data to eliminate data corrupted by motion or other phenomena.

摘要翻译： 在时间分辨的对比度增强磁共振血管造影术中，量化图像质量的度量为通过促进选择掩模和用于减法的动脉相位图像生成线性滤波的复合图像提供了基础。 通过使像素强度的时间行为表示为动脉，静脉或背景组织，对时间序列图像中的各个像素进行滤波，从而在单个图像中提供增强的对比度。 通过重新注册顺序图像来抑制运动伪影，在平均和减法之前调整加权并对傅立叶数据进行滤波以消除由运动或其他现象损坏的数据。

公开(公告)号：US06243600B1

公开(公告)日：2001-06-05

申请号：US09061102

申请日：1998-04-16

申请人： Martin R. Prince

发明人： Martin R. Prince

IPC分类号： A61B5055

CPC分类号： A61B5/416 ,  A61B5/201 ,  A61B5/411 ,  A61B5/7285 ,  A61K49/18 ,  G01R33/281 ,  G01R33/5601 ,  G01R33/5619 ,  G01R33/563 ,  G01R33/56308

摘要： The present invention is a method and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue. The method and apparatus adapts the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space. The technique and apparatus temporally correlates the timing of a maximum or substantially elevated rate of infusion and the mapping of k-space according to the location of the artery of interest, the size of the artery of interest, the physical condition of the patient, the time delay due to the configuration of the contrast agent delivery system, and/or the type of pulse sequence employed by the imaging apparatus. Adapting the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space provides a period of a maximum or substantially elevated contrast concentration in the artery of interest relative to adjacent veins during collection of at least a portion of the image data corresponding to the center of k-space.

摘要翻译： 本发明是一种用于相对于相邻静脉和背景组织提供感兴趣的动脉的优先增强的方法和装置。 所述方法和装置使最大或基本上提高的输注速率的时间适应与对应于k空间中心的图像数据的收集相关。 技术和设备根据感兴趣的动脉的位置，感兴趣的动脉的大小，患者的身体状况，时间上相关联的最大或基本上升高的输注速率的时间和k空间的映射 由于造影剂传送系统的配置引起的时间延迟和/或成像装置采用的脉冲序列的类型。 适应最大或基本上提高的输注速率的时间与对应于k空间中心的图像数据的收集相关联，提供在收集期间相对于相邻静脉的感兴趣动脉中的最大或基本上升高的对比浓度的周期 的图像数据的至少一部分对应于k空间的中心。

公开(公告)号：US5799649A

公开(公告)日：1998-09-01

申请号：US715736

申请日：1996-09-19

申请人： Martin R. Prince

发明人： Martin R. Prince

IPC分类号： A61K49/18 ,  G01R33/28 ,  G01R33/561 ,  G01R33/563 ,  A61B5/055

CPC分类号： A61K49/18 ,  A61B5/02007 ,  A61B5/055 ,  G01R33/563 ,  A61B5/201 ,  A61B5/416 ,  A61B5/7285 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/56308

摘要： The present invention is a technique and apparatus for acquiring anatomic information used in diagnosing and characterizing abdominal aortic aneurismal disease and the like. This technique provides anatomic information, in the form of images, using a combination of a plurality of magnetic resonance angiography sequences, including a spin-echo and four contrast enhanced (e.g., gadolinium) magnetic resonance angiography sequences. The anatomic images may be used in, for example, pre-operative, operative and post-operative evaluation of aortic pathology, including aneurysms, atherosclerosis, and occlusive disease of branch vessels such as the renal arteries. The gadolinium-enhanced magnetic resonance angiography provides sufficient anatomic detail to detect aneurysms and all relevant major branch vessel abnormalities seen at angiography operation. This technique and apparatus allows for imaging the aorta at a fraction of the cost of conventional aortography and without the risks of arterial catheterization or iodinated contrast.

公开(公告)号：US5746208A

公开(公告)日：1998-05-05

申请号：US689270

申请日：1996-08-06

申请人： Martin R. Prince

发明人： Martin R. Prince

IPC分类号： A61K49/18 ,  G01R33/28 ,  G01R33/561 ,  G01R33/563 ,  A61B5/055

CPC分类号： A61B5/416 ,  A61B5/411 ,  A61K49/18 ,  G01R33/5601 ,  G01R33/563 ,  A61B5/201 ,  A61B5/7285 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/56308

摘要： The present invention is a method and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue. The method and apparatus adapts the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space. The technique and apparatus temporally correlates the timing of a maximum or substantially elevated rate of infusion and the mapping of k-space according to the location of the artery of interest, the size of the artery of interest, the physical condition of the patient, the time delay due to the configuration of the contrast agent delivery system, and/or the type of pulse sequence employed by the imaging apparatus. Adapting the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space provides a period of a maximum or substantially elevated contrast concentration in the artery of interest relative to adjacent veins during collection of at least a portion of the image data corresponding to the center of k-space.

公开(公告)号：US5192278A

公开(公告)日：1993-03-09

申请号：US537925

申请日：1990-06-13

申请人： Gary B. Hayes ,  Carter Kittrell ,  Martin R. Prince ,  Jill M. Tobin ,  Michael S. Feld

发明人： Gary B. Hayes ,  Carter Kittrell ,  Martin R. Prince ,  Jill M. Tobin ,  Michael S. Feld

IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B18/00 ,  A61B18/22 ,  A61B18/24 ,  G02B6/42

CPC分类号： G02B6/4296 ,  A61B18/245 ,  A61B2017/00061 ,  A61B2017/22061 ,  A61B2018/1861 ,  A61B2018/2238 ,  G02B6/3504 ,  G02B6/3508 ,  G02B6/3512 ,  G02B6/3516 ,  G02B6/3548 ,  G02B6/3598

摘要： A molded fiber-optic plug for retaining optical fibers in a fixed position within a laser catheter is disclosed in which an optically polished tubular moldable plug body is used to secure a plurality of optical fibers within a laser catheter.

摘要翻译： 公开了一种用于将光纤保持在激光导管内的固定位置的模制光纤塞，其中使用光学抛光的管状可模塑塞体将多个光纤固定在激光导管内。

公开(公告)号：US4967745A

公开(公告)日：1990-11-06

申请号：US235721

申请日：1988-08-17

申请人： Gary B. Hayes ,  Carter Kittrell ,  Martin R. Prince ,  Jill M. Tobin ,  Michael S. Feld

发明人： Gary B. Hayes ,  Carter Kittrell ,  Martin R. Prince ,  Jill M. Tobin ,  Michael S. Feld

IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B18/00 ,  A61B18/22 ,  A61B18/24 ,  G02B6/42

CPC分类号： A61B18/245 ,  G02B6/4296 ,  A61B2017/00061 ,  A61B2017/22061 ,  A61B2018/1861 ,  A61B2018/2238 ,  G02B6/3504 ,  G02B6/3508 ,  G02B6/3512 ,  G02B6/3516 ,  G02B6/3548 ,  G02B6/3598

摘要： A molded fiber-optic plug for retaining optical fibers in a fixed position within a laser catheter is disclosed in which an optically polished tubular moldable plug body is used to secure a plurality of optical fibers within a laser catheter.

摘要翻译： 公开了一种用于将光纤保持在激光导管内的固定位置的模制光纤塞，其中使用光学抛光的管状可模塑塞体将多个光纤固定在激光导管内。

公开(公告)号：US20100174175A1

公开(公告)日：2010-07-08

申请号：US12725140

申请日：2010-03-16

申请人： Martin R. Prince

发明人： Martin R. Prince

IPC分类号： A61B5/055

CPC分类号： A61B5/055 ,  A61B5/02007

摘要： Technique and apparatus for acquiring anatomic information used in diagnosing and characterizing abdominal aortic aneurismal disease and the like. This technique provides anatomic information, in the form of images, using a combination of a plurality of magnetic resonance angiography sequences, including a spin-echo and four contrast enhanced (e.g., gadolinium) magnetic resonance angiography sequences. The anatomic images may be used in, for example, pre-operative, operative and post-operative evaluation of aortic pathology, including aneurysms, atherosclerosis, and occlusive disease of branch vessels such as the renal arteries. The gadolinium-enhanced magnetic resonance angiography provides sufficient anatomic detail to detect aneurysms and all relevant major branch vessel abnormalities seen at angiography operation. This technique and apparatus allows for imaging the aorta at a fraction of the cost of conventional aortography and without the risks of arterial catheterization or iodinated contrast.

摘要翻译： 用于获取用于诊断和表征腹主动脉瘤性疾病等的解剖信息的技术和装置。 该技术以图像的形式使用包括自旋回波和四个对比度增强（例如，钆）磁共振血管造影序列的多个磁共振血管造影术序列的组合来提供解剖信息。 解剖图像可以用于例如主动脉病理学的术前，手术和术后评价，包括动脉瘤，动脉粥样硬化和分支血管如肾动脉的闭塞性疾病。 钆增强磁共振血管造影提供足够的解剖学细节来检测血管造影术中所见的动脉瘤和所有相关主要分支血管异常。 该技术和装置允许以常规造影术的成本的一小部分成像主动脉，并且不存在动脉导管插入或碘化对比的风险。