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    High density homopolymer blends
    11.
    发明申请
    High density homopolymer blends 有权
    高密度均聚物共混物

    公开(公告)号：US20060047078A1

    公开(公告)日：2006-03-02

    申请号：US11206969

    申请日：2005-08-18

    申请人： John Swabey ,  Patrick Lam ,  Sarah Marshall

    发明人： John Swabey ,  Patrick Lam ,  Sarah Marshall

    IPC分类号： C08L23/04

    CPC分类号： C08L23/06 ,  C08L2205/02 ,  C08L2666/06

    摘要： A blend of ethylene homopolymers contains at least one blend component having a very low molecular weight and a narrow molecular weight distribution. The blend has surprisingly high density and low hexane extractables. The blend is suitable for the manufacture of a wide variety of plastic goods including extruded goods and molded goods. Plastic film prepared from the blends of this invention have a low Water Vapor Transmission Rate (“WVTR”).

    摘要翻译： 乙烯均聚物的共混物含有至少一种具有非常低分子量和窄分子量分布的共混物组分。 该混合物具有惊人的高密度和低的己烷可萃取物。 该混合物适用于制造各种塑料制品，包括挤压制品和模制品。 由本发明的共混物制备的塑料膜具有低的水蒸气透过率（“WVTR”）。

    Drug target that promotes secretory granule-granule fusion
    13.
    发明申请
    Drug target that promotes secretory granule-granule fusion 审中-公开
    促进分泌颗粒 - 颗粒融合的药物靶标

    公开(公告)号：US20120058931A1

    公开(公告)日：2012-03-08

    申请号：US12796035

    申请日：2010-09-03

    申请人： Haruo Kasai ,  Noriko Takahashi ,  Vesa Olkkonen ,  Herbert Y. Gaisano ,  Patrick Lam

    发明人： Haruo Kasai ,  Noriko Takahashi ,  Vesa Olkkonen ,  Herbert Y. Gaisano ,  Patrick Lam

    IPC分类号： A61K38/00 ,  G01N33/566 ,  C07K2/00

    CPC分类号： G01N33/68 ,  G01N33/6872 ,  G01N2500/00

    摘要： Munc18 proteins facilitate formation of SNARE complexes known to mediate membrane fusion. Much is known about the fusion of secretory granule (SG) to plasma membrane, mediated by Munc18a-SNARE complexes. It has been found that another Munc18 isoform, Munc18b, mediates SG-SG fusion which causes potentiation of secretion. The present invention has identified specific site mutations within Munc18b which further increased (called KR mutant) or reduced (called E59K mutant) SG-SG fusion compared to wild type (WT) Munc18b, causing amplification or reduction of insulin secretion, respectively. Compounds identified that mimic the actions of Munc18b-WT and Munc18b-KR mutant which increase SG-SG fusion, and those which mimic Munc18b-E59K mutant that block SG-SG fusion, are useful for treating and/or preventing diseases and/or conditions, whose underlying bases are a deficiency or excess of SG-SG fusion, respectively. These compounds also include conserved domains in Munc18a and Munc18c that mimic the KR and E59K sites in Munc18b.

    摘要翻译： Munc18蛋白有助于形成已知介导膜融合的SNARE复合物。 已知关于由Munc18a-SNARE复合物介导的分泌颗粒（SG）与质膜的融合。 已经发现另一种Munc18同种型Munc18b介导导致分泌增强的SG-SG融合物。 本发明鉴定了与野生型（WT）Munc18b相比分别进一步增加（称为KR突变体）或降低（称为E59K突变体）SG-SG融合物的Munc18b中的特异性位点突变，分别导致胰岛素分泌的扩增或降低。 鉴定出模拟Munc18b-WT和Munc18b-KR突变体增加SG-SG融合物的作用的化合物，以及模拟阻断SG-SG融合物的Munc18b-E59K突变体的化合物可用于治疗和/或预防疾病和/或病症 ，其基础分别为SG-SG融合体的缺乏或过量。 这些化合物还包括Munc18a和Munc18c中的保守结构域，其模拟Munc18b中的KR和E59K位点。