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    Bioerodible, implantable medical devices incorporating supersaturated magnesium alloys
    13.
    发明授权
    Bioerodible, implantable medical devices incorporating supersaturated magnesium alloys 有权
    可生物蚀刻的，可植入医疗器械的超饱和镁合金

    公开(公告)号：US08435281B2

    公开(公告)日：2013-05-07

    申请号：US12421928

    申请日：2009-04-10

    申请人： Jan Weber

    发明人： Jan Weber

    IPC分类号： A61F2/06

    CPC分类号： A61L27/047 ,  A61L31/022 ,  A61L31/148

    摘要： A bioerodible, implantable medical device that includes a supersaturated magnesium alloy. The magnesium alloy includes magnesium and at least one alloying element present in a concentration in excess of the equilibrium solid solubility concentration of the alloying element in hexagonal close-packed magnesium [at 25° C.].

    摘要翻译： 包含过饱和镁合金的生物蚀刻可植入医疗器械。 镁合金包括镁和至少一种合金元素，其浓度超过六方密堆积镁[25℃]中合金元素的平衡固溶度浓度。

    Bifurcation delivery system
    15.
    发明授权
    Bifurcation delivery system 失效
    分岔运送系统

    公开(公告)号：US08353944B2

    公开(公告)日：2013-01-15

    申请号：US11079756

    申请日：2005-03-14

    申请人： Jan Weber ,  Karl A. Jagger ,  Tracee Eidenschink

    发明人： Jan Weber ,  Karl A. Jagger ,  Tracee Eidenschink

    IPC分类号： A61F2/06

    CPC分类号： A61F2/958 ,  A61F2/856 ,  A61F2/954 ,  A61F2002/30426 ,  A61F2220/0025 ,  A61M25/0043 ,  A61M2025/0058 ,  A61M2025/1045

    摘要： A catheter assembly comprises a catheter shaft having a proximal region a distal region and a rotational seal therebetween. The rotational seal comprises a first component fixedly engaged to the proximal region and a second component fixedly engaged to the distal region. The components engaged in an overlapping arrangement. The rotational seal is actuatable between a non-activated and activated states. In the non-activated state the first component and the second component are separated by a gap which provides for the distal region of the catheter shaft to be rotatable relative to the proximal region. In the activated state at least a portion of the first component and the second component being sealingly engaged together such that distal region is made static relative to the proximal region.

    摘要翻译： 导管组件包括导管轴，所述导管轴具有近端区域和远端区域之间的旋转密封。 旋转密封件包括固定地接合到近侧区域的第一部件和固定地接合到远侧区域的第二部件。 组件从事重叠布置。 旋转密封可在非激活状态和激活状态之间启动。 在非活化状态下，第一部件和第二部件被间隙隔开，该间隙使得导管轴的远侧区域相对于近端区域可旋转。 在激活状态下，第一部件和第二部件的至少一部分被密封地接合在一起，使得远侧区域相对于近端区域被制成静止的。

    Method and apparatus for forming a feature in a workpiece by laser ablation with a laser beam having an adjustable intensity profile to redistribute the energy density impinging on the workpiece
    17.
    发明授权
    Method and apparatus for forming a feature in a workpiece by laser ablation with a laser beam having an adjustable intensity profile to redistribute the energy density impinging on the workpiece 失效
    通过具有可调强度分布的激光束通过激光烧蚀在工件中形成特征的方法和装置，以重新分布冲击在工件上的能量密度

    公开(公告)号：US08158904B2

    公开(公告)日：2012-04-17

    申请号：US10918841

    申请日：2004-08-13

    申请人： Jan Weber ,  Thomas J. Holman

    发明人： Jan Weber ,  Thomas J. Holman

    IPC分类号： B23K26/38 ,  B23K26/06

    CPC分类号： B23K26/066 ,  B23K26/073 ,  B23K26/384 ,  B23K26/389

    摘要： A method and apparatus is provided for removing material from an outer surface of a workpiece such as a catheter or other medical device. The method begins by generating a laser beam having an intensity profile and directing the laser beam onto the outer surface of the workpiece. After the laser beam is generated, its intensity profile is adjusted by a component such as a diffractive optical element (DOE) or a holographic optical element (HOE) so that material can be removed from the workpiece by ablation in a prescribed manner.

    摘要翻译： 提供了用于从诸如导管或其它医疗装置的工件的外表面去除材料的方法和装置。 该方法通过产生具有强度分布并将激光束引导到工件的外表面上的激光束开始。 在产生激光束之后，其强度分布由诸如衍射光学元件（DOE）或全息光学元件（HOE）的部件调节，使得可以通过以规定的方式通过烧蚀从材料中去除材料。

    Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
    18.
    发明授权
    Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 有权
    用于与电力源一起递送治疗剂的内部医疗装置

    公开(公告)号：US08152759B2

    公开(公告)日：2012-04-10

    申请号：US12077603

    申请日：2008-03-20

    申请人： Liliana Atanasoska ,  Thomas J. Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    发明人： Liliana Atanasoska ,  Thomas J. Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    IPC分类号： A61M29/00

    CPC分类号： A61N1/325 ,  A61N1/05 ,  A61N1/306 ,  A61N1/327

    摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.

    摘要翻译： 本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。 电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。 在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。 此外，治疗剂源适于将治疗剂引入电场。 另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。 在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

    VESSEL OCCLUDING MATERIAL EXTRACTOR
    20.
    发明申请
    VESSEL OCCLUDING MATERIAL EXTRACTOR 有权

    公开(公告)号：US20120035635A1

    公开(公告)日：2012-02-09

    申请号：US13276575

    申请日：2011-10-19

    申请人： Jan Weber ,  Steven M. Spencer

    发明人： Jan Weber ,  Steven M. Spencer

    IPC分类号： A61B17/22

    CPC分类号： A61B17/22031 ,  A61B17/221 ,  A61B17/320725 ,  A61B2017/22034 ,  A61B2017/22094 ,  A61B2017/2212 ,  A61F2/013

    摘要： Methods, devices, and systems for extracting vessel occluding material are provided. An embodiment of a vessel occluding material extractor includes a host structure, a plurality of expandable members, a slide mechanism, and a circumferential member. The host structure has an elongate axis. The expandable members are connected to the host structure arrayed radially around the elongate axis. The slide mechanism is connected to the expandable members and adjacent the host structure, and is slidable in the direction of the elongate axis. The circumferential member is connected to the expandable members between the connection of the slide mechanism and the host structure to the expandable members.

    摘要翻译： 提供了提取容器闭塞材料的方法，装置和系统。 容器闭塞材料提取器的实施例包括主体结构，多个可扩张构件，滑动机构和周向构件。 主机结构具有细长轴。 可扩展构件连接到径向围绕细长轴线排列的主体结构。 滑动机构连接到可扩展构件并且与主体结构相邻，并且可以沿着细长轴线的方向滑动。 圆周构件在滑动机构和主体结构的连接件之间的可扩张构件连接到可扩展构件。