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公开(公告)号：US08267992B2
公开(公告)日：2012-09-18
申请号：US12715577
申请日：2010-03-02
申请人： Liliana Atanasoska , James Lee Shippy, III , Tom Holman , Michael S. Arney , Victor Schoenle , Frank Genovese , James Q. Feng , Aiden Flanagan , Jan Weber
发明人： Liliana Atanasoska , James Lee Shippy, III , Tom Holman , Michael S. Arney , Victor Schoenle , Frank Genovese , James Q. Feng , Aiden Flanagan , Jan Weber
IPC分类号： A61F2/06
CPC分类号： A61L31/148 , A61L27/34 , A61L27/446 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/128 , A61L31/16 , A61L2300/416 , A61L2300/604 , A61L2400/12 , A61L2420/04 , C08L67/04
摘要： A medical implant includes a bioerodible portion that includes a bioerodible polymer and a bioerodible metal. The bioerodible polymer matrix degrades under physiological conditions to form acidic degradation products. The bioerodible metal degrades under physiological conditions to form basic degradation products. The acidic degradation products and the basic degradation products buffer at least a portion of the medical implant. In one aspect, the bioerodible portion includes a bioerodible polymer matrix and a bioerodible metal within the bioerodible polymer matrix. In another aspect, the medical implant can include a body, a plurality of discrete deposits of the bioerodible polymer on the body, and a plurality of discrete deposits of the bioerodible metal on the body.
摘要翻译： 医疗植入物包括生物腐蚀性部分，其包括生物可蚀解聚合物和生物腐蚀性金属。 生物可蚀解聚合物基质在生理条件下降解形成酸性降解产物。 生物腐蚀金属在生理条件下降解形成碱性降解产物。 酸性降解产物和碱性降解产物缓冲至少一部分医用植入物。 在一个方面，生物可蚀解部分包括生物可腐蚀聚合物基质和生物可腐蚀的聚合物基质内的生物可腐蚀金属。 在另一方面，医疗植入物可以包括主体，身体上的生物可蚀解聚合物的多个离散沉积物，以及身体上的生物可腐蚀金属的多个离散沉积物。
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公开(公告)号：US20100222873A1
公开(公告)日：2010-09-02
申请号：US12715577
申请日：2010-03-02
申请人： Liliana Atanasoska , James Lee Shippy, III , Tom Holman , Michael S. Amey , Victor Schoenle , Frank Genovese , James Q. Feng , Aiden Flanagan , Jan Weber
发明人： Liliana Atanasoska , James Lee Shippy, III , Tom Holman , Michael S. Amey , Victor Schoenle , Frank Genovese , James Q. Feng , Aiden Flanagan , Jan Weber
CPC分类号： A61L31/148 , A61L27/34 , A61L27/446 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/128 , A61L31/16 , A61L2300/416 , A61L2300/604 , A61L2400/12 , A61L2420/04 , C08L67/04
摘要： A medical implant includes a bioerodible portion that includes a bioerodible polymer and a bioerodible metal. The bioerodible polymer matrix degrades under physiological conditions to form acidic degradation products. The bioerodible metal degrades under physiological conditions to form basic degradation products. The acidic degradation products and the basic degradation products buffer at least a portion of the medical implant. In one aspect, the bioerodible portion includes a bioerodible polymer matrix and a bioerodible metal within the bioerodible polymer matrix. In another aspect, the medical implant can include a body, a plurality of discrete deposits of the bioerodible polymer on the body, and a plurality of discrete deposits of the bioerodible metal on the body.
摘要翻译： 医疗植入物包括生物腐蚀性部分，其包括生物可蚀解聚合物和生物腐蚀性金属。 生物可蚀解聚合物基质在生理条件下降解形成酸性降解产物。 生物腐蚀金属在生理条件下降解形成碱性降解产物。 酸性降解产物和碱性降解产物缓冲至少一部分医用植入物。 在一个方面，生物可蚀解部分包括生物可腐蚀聚合物基质和生物可腐蚀的聚合物基质内的生物可腐蚀金属。 在另一方面，医疗植入物可以包括主体，身体上的生物可蚀解聚合物的多个离散沉积物，以及身体上的生物可腐蚀金属的多个离散沉积物。
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公开(公告)号：US20100008970A1
公开(公告)日：2010-01-14
申请号：US12334113
申请日：2008-12-12
申请人： Barry O'Brien , Ben Arcand , James Lee Shippy, III , Liliana Atanasoska , Aiden Flanagan , John T. Clarke , Tim O'Connor , Yixin Xu , Dave McMorrow , Jan Weber , John Kremer , Michael Kuehling , Dominique Seidel
发明人： Barry O'Brien , Ben Arcand , James Lee Shippy, III , Liliana Atanasoska , Aiden Flanagan , John T. Clarke , Tim O'Connor , Yixin Xu , Dave McMorrow , Jan Weber , John Kremer , Michael Kuehling , Dominique Seidel
IPC分类号： A61K31/337 , A61F2/00 , B05D1/02
CPC分类号： A61L31/088 , A61L31/16 , A61L2300/45 , A61L2300/61
摘要： A drug-eluting endoprosthesis that includes a bioerodible metal portion and a therapeutic agent. In some aspects, the endoprosthesis includes a plurality of discrete deposits and a plurality of overlying layers each overlying one of the plurality of discrete deposits. Each discrete deposit includes one or more therapeutic agents and each overlying layer includes one or more bioerodible metals. In other aspects, the bioerodible metal portion includes at least two bioerodible metal regions having different electronegativities. The at least two bioerodible metal regions being in electrical contact with each other. The bioerodible metal erodes in a physiological environment to release the therapeutic agent.
摘要翻译： 包括生物腐蚀性金属部分和治疗剂的药物洗脱内用假体。 在一些方面，内假体包括多个离散沉积物和多个覆盖层，每个覆盖层覆盖多个离散沉积物之一。 每个离散沉积物包括一种或多种治疗剂，并且每个上覆层包括一种或多种生物可腐蚀金属。 在其他方面，生物腐蚀性金属部分包括具有不同电负性的至少两个生物可腐蚀金属区域。 所述至少两个生物浸渍金属区域彼此电接触。 生物腐蚀性金属在生理环境中侵蚀以释放治疗剂。
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公开(公告)号：US08728170B1
公开(公告)日：2014-05-20
申请号：US11694436
申请日：2007-03-30
CPC分类号： A61L27/40 , A61L27/14 , A61L27/50 , A61L27/58 , A61L2400/12
摘要： A bioerodible conductive tissue scaffold that can provide, e.g., improved tissue growth.
摘要翻译： 可以提供例如改善的组织生长的生物蚀蚀性导电组织支架。
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公开(公告)号：US08417356B2
公开(公告)日：2013-04-09
申请号：US13009655
申请日：2011-01-19
申请人： Jeannette C. Polkinghorne , Robert W. Warner , James Q. Feng , James Lee Shippy, III , Ljiljana Liliana Atanasoska
发明人： Jeannette C. Polkinghorne , Robert W. Warner , James Q. Feng , James Lee Shippy, III , Ljiljana Liliana Atanasoska
IPC分类号： A61N1/05
CPC分类号： A61N1/0565
摘要： A biomimetic electrode material including a fibrous matrix including a conductive polymer and an ion conducting polymeric material is described. The biomimetic electrode material may be used in a number of body-implantable applications including cardiac and neuro-stimulation applications. The biomimetic electrode material can be formed using electrospinning and other related processes. The biomimetic electrode may facilitate efficient charge transport from ionically conductive tissue to the electronically conductive electrode, and may induce surrounding tissue to attach or interface directly to the implanted device, increasing the biocompatibility of the device.
摘要翻译： 描述了包括包含导电聚合物和离子导电聚合材料的纤维基质的仿生电极材料。 仿生电极材料可用于许多可植入人体的应用，包括心脏和神经刺激应用。 仿生电极材料可以使用静电纺丝和其它相关工艺形成。 仿生电极可以促进从离子导电组织到电子导电电极的有效电荷输送，并且可以诱导周围组织附着或直接连接到植入装置，增加装置的生物相容性。
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公开(公告)号：US20090118815A1
公开(公告)日：2009-05-07
申请号：US11934463
申请日：2007-11-02
IPC分类号： A61F2/06
CPC分类号： B05D1/12 , A61L31/08 , A61L31/146 , C23C24/04
摘要： Endoprosthesis includes coatings of selected porosity formed of particulates of ceramics, metals, drugs and/or polymers.
摘要翻译： 内置假体包括由陶瓷，金属，药物和/或聚合物颗粒形成的选定孔隙的涂层。
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公开(公告)号：US08834560B2
公开(公告)日：2014-09-16
申请号：US13051496
申请日：2011-03-18
申请人： Jan Weber , Liliana Atanasoska , James Lee Shippy, III , Torsten Scheuermann , Daniel J. Gregorich , Michael P. Meyer
发明人： Jan Weber , Liliana Atanasoska , James Lee Shippy, III , Torsten Scheuermann , Daniel J. Gregorich , Michael P. Meyer
CPC分类号： A61L31/088 , A61L31/044 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/16 , Y10T29/49826 , C08L67/04
摘要： Among other things, a bio-erodible implantable endoprosthesis comprises a member that includes (a) a core having a surface, and (b) a bio-erodible metal on a least a portion of the surface of the core, wherein the bio-erodible metal erodes more slowly than the core and includes openings through which physiological fluids can access the core upon implantation.
摘要翻译： 除其他之外，生物可蚀刻的可植入内用假体包括一种构件，其包括（a）具有表面的芯，和（b）所述芯的表面的至少一部分上的生物可侵蚀金属，其中所述生物可蚀刻 金属腐蚀比核心更慢，并且包括生理流体在植入时可通过其进入核心的开口。
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公开(公告)号：US20110245905A1
公开(公告)日：2011-10-06
申请号：US13051496
申请日：2011-03-18
申请人： Jan Weber , Liliana Atanasoska , James Lee Shippy, III , Torsten Scheuermann , Daniel J. Gregorich , Michael P. Meyer
发明人： Jan Weber , Liliana Atanasoska , James Lee Shippy, III , Torsten Scheuermann , Daniel J. Gregorich , Michael P. Meyer
CPC分类号： A61L31/088 , A61L31/044 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/16 , Y10T29/49826 , C08L67/04
摘要： Among other things, a bio-erodible implantable endoprosthesis comprises a member that includes (a) a core having a surface, and (b) a bio-erodible metal on a least a portion of the surface of the core, wherein the bio-erodible metal erodes more slowly than the core and includes openings through which physiological fluids can access the core upon implantation.
摘要翻译： 除其他之外，生物可蚀刻的可植入内用假体包括一种构件，其包括（a）具有表面的芯，和（b）所述芯的表面的至少一部分上的生物可侵蚀金属，其中所述生物可蚀刻 金属腐蚀比核心更慢，并且包括生理流体在植入时可通过其进入核心的开口。
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公开(公告)号：US08771343B2
公开(公告)日：2014-07-08
申请号：US11763770
申请日：2007-06-15
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61F2/91 , A61F2002/30322 , A61F2250/0026 , A61F2250/0056 , A61F2310/00616 , A61F2310/0097 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/00 , B05D1/32
摘要： Medical devices, such as endoprostheses, and methods of making the devices are described. In some embodiments, a medical device includes a body of interconnected bands and connectors forming an elongated tubular structure having an inner luminal wall surface and an outer abluminal wall surface and defining a central lumen or passageway. The inner luminal wall surface and side wall surface of the bands and connectors forming transverse passageways through the elongated tubular structure can bear a coating of hydrophilic material and the outer abluminal wall surface of the tubular structure can bear a coating of hydrophobic material.
摘要翻译： 描述医疗装置，例如内用假体，以及制造装置的方法。 在一些实施例中，医疗装置包括互连带的主体和形成细长管状结构的连接器，其具有内管腔壁表面和外侧腔壁表面，并限定中央腔或通道。 形成穿过细长管状结构的横向通道的带和连接件的内腔壁表面和侧壁表面可以承受亲水材料的涂层，并且管状结构的外侧壁面可承受疏水材料的涂层。
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