-
公开(公告)号：US12084475B2
公开(公告)日：2024-09-10
申请号：US17324150
申请日：2021-05-19
Applicant: Janssen Biotech, Inc.
Inventor： Vadim Dudkin , Shalom Goldberg , Michael J. McCauley , Kristen Wiley
CPC classification number: C07K1/1077 , A61K47/549 , A61K47/62 , A61K47/68 , C07K2317/41 , C07K2319/30 , C07K2319/91
Abstract: Provided herein are methods for site-specific conjugation of glycan intact antibodies by a transglutaminase. According to particular embodiments, the reaction conditions are maintained or reduced to a low-ionic strength condition, which allows for efficient and fast conjugation without the need for antibody deglycosylation. Also described are pharmaceutical compositions and uses related to the conjugation method.
-
公开(公告)号：US20240270870A1
公开(公告)日：2024-08-15
申请号：US18631269
申请日：2024-04-10
Applicant: Janssen Biotech, Inc.
Inventor： Shalom Goldberg , Donna Klein , Neeraj Kohli , Theresa Marie McDevitt , Steven J. Orcutt
CPC classification number: C07K16/3069 , A61K47/6869 , A61P35/04 , C07K2317/51 , C07K2317/56 , C07K2317/72 , C07K2317/94
Abstract: Disclosed herein are antibodies or antigen binding fragments thereof that bind prostate specific membrane antigen (PSMA), polynucleotides, vectors, host cells, radioconjugates, antibody drug conjugates and methods of treating cancer using the same.
-
公开(公告)号：US12054534B2
公开(公告)日：2024-08-06
申请号：US16949078
申请日：2020-10-13
Applicant: Janssen Biotech, Inc.
Inventor： Rosa Cardoso , Michael Diem , Shalom Goldberg , Linus Hyun , Steven Jacobs , Donna Klein , Karyn O'Neil , Tracy Spinka-Doms
IPC: G01N33/574 , A61K51/08 , C07K14/78 , A61K38/00
CPC classification number: C07K14/78 , A61K51/08 , G01N33/57434 , A61K38/00 , G01N2333/705
Abstract: PSMA binding FN3 domains, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
-
公开(公告)号：US20220143231A1
公开(公告)日：2022-05-12
申请号：US17522144
申请日：2021-11-09
Applicant: Janssen Biotech, Inc.
Inventor： Rhys Salter , Vadim Y. Dudkin , Fengbin Song , Wei Zhang , Shalom Goldberg , John Keith
Abstract: The present invention is directed to compounds and pharmaceutically acceptable salts thereof, immunoconjugates, radioimmunoconjugates thereof, pharmaceutical compositions containing said compounds and immunoconjugates, radioimmunoconjugates thereof, and the use of said compounds and immunoconjugates, radioimmunoconjugates thereof, in the treatment of neuroplastic diseases or disorders.
-
公开(公告)号：US20170362301A1
公开(公告)日：2017-12-21
申请号：US15629090
申请日：2017-06-21
Applicant: Janssen Biotech, Inc.
Inventor： Mark Anderson , Ricardo Attar , Michael Diem , Linus Hyun , Alastair King , Steven Jacobs , Shalom Goldberg , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
IPC: C07K14/78
Abstract: Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules comprising one or more free cysteine amino acids are prepared by mutagenizing a nucleic acid sequence of a parent molecule and replacing one or more amino acid residues by cysteine to encode the cysteine engineered FN3 domain containing monospecific or bispecific molecules; expressing the cysteine engineered FN3 domain containing molecules; and recovering the cysteine engineered FN3 domain containing molecule. Isolated cysteine engineered monospecific or bispecific FN3 domain containing molecules may be covalently attached to a detection label or a drug moiety and used therapeutically.
-
Patent Agency Ranking
公开(公告)号：US12240790B2
公开(公告)日：2025-03-04
申请号：US16955094
申请日：2018-12-17
Applicant: Janssen Biotech, Inc.
Inventor： Vadim Dudkin , Shalom Goldberg , Joseph Erhardt , Rhys Salter , Theresa McDevitt
Abstract: Improved methods of radiolabeling antibodies using click chemistry are described. Also described are pharmaceutical compositions and uses related to the radiolabeled antibodies produced by the methods.
-
公开(公告)号：US12227593B2
公开(公告)日：2025-02-18
申请号：US17324148
申请日：2021-05-19
Applicant: Janssen Biotech, Inc.
Inventor： Vadim Dudkin , Shalom Goldberg , Michael J. McCauley , Kristen Wiley , Rebecca Wissner
Abstract: Engineered antibodies useful for site-specific conjugation by a transglutaminase are described. Also described are methods of site-specific conjugation of the antibodies, the site-specifically conjugated antibodies, and pharmaceutical compositions and uses related to the site-specifically conjugated antibodies.
-
公开(公告)号：US20240238461A1
公开(公告)日：2024-07-18
申请号：US18516304
申请日：2023-11-21
Applicant: Janssen Biotech, Inc.
Inventor： Rhys Salter , Vadim Y. Dudkin , Fengbin Song , Wei Zhang , Shalom Goldberg , John Keith
CPC classification number: A61K51/1096 , A61K47/545 , A61K47/55 , A61K47/6803 , A61K51/0497
Abstract: The present invention is directed to compounds and pharmaceutically acceptable salts thereof, immunoconjugates, radioimmunoconjugates thereof, pharmaceutical compositions containing said compounds and immunoconjugates, radioimmunoconjugates thereof, and the use of said compounds and immunoconjugates, radioimmunoconjugates thereof, in the treatment of neuroplastic diseases or disorders.
-
公开(公告)号：US11987641B2
公开(公告)日：2024-05-21
申请号：US17895295
申请日：2022-08-25
Applicant: Janssen Biotech, Inc.
Inventor： Shalom Goldberg , Donna Klein , Neeraj Kohli , Theresa Marie McDevitt , Steven J. Orcutt
CPC classification number: C07K16/3069 , A61K47/6869 , A61P35/04 , C07K2317/51 , C07K2317/56 , C07K2317/72 , C07K2317/94
Abstract: Disclosed herein are antibodies or antigen binding fragments thereof that bind prostate specific membrane antigen (PSMA), polynucleotides, vectors, host cells, radioconjugates, antibody drug conjugates and methods of treating cancer using the same.
-
公开(公告)号：US11702475B2
公开(公告)日：2023-07-18
申请号：US17303425
申请日：2021-05-28
Applicant: Janssen Biotech, Inc.
Inventor： Shalom Goldberg , Steven Jacobs , Tricia Lin , Karyn O'Neil
CPC classification number: C07K16/2863 , C07K14/78 , G01N33/74 , A61K2039/505 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/00 , C07K2319/30 , C07K2319/31
Abstract: Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules comprising one or more free cysteine amino acids are prepared by mutagenizing a nucleic acid sequence of a parent molecule and replacing one or more amino acid residues by cysteine to encode the cysteine engineered FN3 domain containing monospecific or bispecific molecules; expressing the cysteine engineered FN3 domain containing molecules; and recovering the cysteine engineered FN3 domain containing molecule. Isolated cysteine engineered monospecific or bispecific FN3 domain containing molecules may be covalently attached to a detection label or a drug moiety and used therapeutically.
-
-
-
-
-
-
-
-
-
Search Results
25
records
(took 0.02 seconds)
