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公开(公告)号：US07199363B2
公开(公告)日：2007-04-03
申请号：US10964791
申请日：2004-10-14
CPC分类号： H01J49/405 , H01J49/0031
摘要： A mass spectrometer is disclosed comprising an ion source 4, a field free or drift region 5 and an ion mirror 7 comprising a reflectron. Metastable parent ions which spontaneously fragment by Post Source Decay whilst passing through the field free or drift region 5 are arranged to enter the ion mirror 7 and be reflected by the reflectron towards an ion detector 8 when the reflectron is maintained at a certain voltage. The process is then repeated with the reflectron being maintained at a slightly lower voltage. Two related sets of time of flight or mass spectral data are obtained for the two different voltage settings of the reflectron. From the two data sets the different times of flight for the same species of fragment ion can be determined. The mass to charge ratio of the parent ion which fragmented to produce the particular species of fragment ion can then be determined from the times of flight of the fragment ions.
摘要翻译： 公开了一种质谱仪，其包括离子源4，无场或漂移区5以及包括反射镜的离子镜7。 当通过场自由或漂移区域5时通过后源衰变自发分裂的亚稳态亲本离子被布置成当反射器保持在一定电压时进入离子反射镜7并被反射器反射离子检测器8。 然后重复该过程，其中反射器保持在稍低的电压。 对于反射镜的两个不同的电压设置，获得两组相关的飞行时间或质谱数据。 从两个数据集可以确定相同种类的碎片离子的不同飞行时间。 然后可以从片段离子的飞行时间确定碎片化以产生特定种类的碎片离子的母体离子的质荷比。
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公开(公告)号：US20080111071A1
公开(公告)日：2008-05-15
申请号：US11876108
申请日：2007-10-22
IPC分类号： H01J49/28
CPC分类号： H01J49/405 , H01J49/421
摘要： A mass filter is disclosed comprising an orthogonal acceleration electrode 9. Ions entering the mass filter are orthogonally accelerated by the orthogonal acceleration electrode 9 in a primary acceleration region 2 and enter a flight region 3. The ions 6,7,8 are then reflected by a reflectron 4 and are directed towards an exit region of the mass filter. Ions having a desired mass to charge ratio are arranged to arrive in the primary acceleration region 2 at a time when a voltage pulse applied to the orthogonal acceleration electrode 9 falls from a maximum to zero. Ions having a desired mass to charge ratio are orthogonally decelerated such that they have a zero component of velocity in the orthogonal direction. Accordingly, ions having a desired mass to charge ratio exit the mass filter in an axial direction.
摘要翻译： 公开了一种包括正交加速电极9的质量过滤器。 进入质量过滤器的离子通过正加速电极9在主加速区域2中正交加速并进入飞行区域3。 然后离子6,7,8被反射器4反射并且被引向质量过滤器的出口区域。 具有期望的质荷比的离子被布置成在施加到正交加速电极9的电压脉冲从最大值降到零的时刻到达主加速区域2。 具有期望的质荷比的离子正交减速，使得它们在正交方向上具有零分量的速度。 因此，具有期望质荷比的离子沿轴向离开质量过滤器。
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公开(公告)号：US09080936B2
公开(公告)日：2015-07-14
申请号：US13055612
申请日：2009-07-27
CPC分类号： H01J49/12 , G01N24/00 , H01J49/0009 , H01J49/0072 , H01J49/0495 , H01J49/107 , H01J49/165 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode (14) located within an isolation valve (15) which is provided in the vacuum chamber. Reagent vapor may be provided through the tubular electrode (14) which is then subsequently ionized by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.
摘要翻译： 公开了质谱仪，其包括在质谱仪的初始真空室内的辉光放电装置。 辉光放电装置可以包括设置在真空室中的隔离阀（15）内的管状电极（14）。 可以通过管状电极（14）提供试剂蒸汽，然后其随后通过辉光放电电离。 所得的试剂离子可用于由大气压离子源产生的分析物离子的电子转移离解。 考虑其他实施例，其中由辉光放电装置产生的离子可用于通过质子转移反应来减少分析物离子的电荷状态，或者可以作为锁定质量或参考离子。
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公开(公告)号：US08410437B2
公开(公告)日：2013-04-02
申请号：US12744379
申请日：2008-11-24
IPC分类号： H01J49/40
CPC分类号： H01J49/065 , H01J49/0072
摘要： An ion-ion reaction cell is provided comprising a plurality of electrodes (1) forming an ion guide (2). One or more transient DC voltage waves (8, 9) are applied to the electrodes (2). Reagent anions and analyte cations are arranged to undergo ion-ion reactions within the reaction cell and the resulting fragment ions which are formed within the reaction cell are then subsequently translated out of the reaction cell by means of one or more transient DC voltage waves (8, 9).
摘要翻译： 提供离子离子反应池，其包括形成离子导向器（2）的多个电极（1）。 一个或多个瞬态DC电压波（8,9）被施加到电极（2）。 试剂阴离子和分析物阳离子排列成在反应池内进行离子 - 离子反应，然后在反应池内形成的所得碎片离子随后通过一个或多个瞬态直流电压波（8 ，9）。
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15.发明申请公开(公告)号：US20110114835A1
公开(公告)日：2011-05-19
申请号：US12995778
申请日：2009-06-05
IPC分类号： H01J49/00
CPC分类号： H01J49/0095 , H01J49/0072 , H01J49/062 , H01J49/165 , H01J49/26 , H01J49/36
摘要： A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell 35 by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine.
摘要翻译： 公开了一种质谱仪，其中通过使碎片离子与诸如八氢嘧啶并氮杂吖庚因的中性超碱原料气体反应，母体离子的电子转移离解断裂产生的高电荷碎片离子在质子转移反应池35内在电荷状态下降低。
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公开(公告)号：US20100301206A1
公开(公告)日：2010-12-02
申请号：US12744379
申请日：2008-11-24
IPC分类号： H01J49/00
CPC分类号： H01J49/065 , H01J49/0072
摘要： An ion-ion reaction cell is provided comprising a plurality of electrodes (1) forming an ion guide (2). One or more transient DC voltage waves (8, 9) are applied to the electrodes (2). Reagent anions and analyte cations are arranged to undergo ion-ion reactions within the reaction cell and the resulting fragment ions which are formed within the reaction cell are then subsequently translated out of the reaction cell by means of one or more transient DC voltage waves (8, 9).
摘要翻译： 提供离子离子反应池，其包括形成离子导向器（2）的多个电极（1）。 一个或多个瞬态DC电压波（8,9）被施加到电极（2）。 试剂阴离子和分析物阳离子排列成在反应池内进行离子 - 离子反应，然后在反应池内形成的所得碎片离子随后通过一个或多个瞬态直流电压波（8 ，9）。
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公开(公告)号：US08981286B2
公开(公告)日：2015-03-17
申请号：US13578397
申请日：2011-02-14
申请人： Jeffery Mark Brown
发明人： Jeffery Mark Brown
CPC分类号： H01J49/0031 , G01N27/622 , H01J49/0077 , H01J49/02
摘要： A mass spectrometer is disclosed comprising a hydrogen-deuterium exchange cell. Isomeric ions having different conformations but substantially similar ion mobilities can be differentiated by subjecting the ions to hydrogen-deuterium exchange. Two ions having similar ion mobilities can be differentiated more effectively if they have different surface conformations by determining the relative degree of hydrogen-deuterium exchange.
摘要翻译： 公开了一种包含氢 - 氘交换电池的质谱仪。 具有不同构象但基本上相似的离子迁移率的异构离子可以通过使离子进行氢氘交换来分化。 具有相似离子迁移率的两个离子如果通过确定氢 - 氘交换的相对程度而具有不同的表面构象，可以更有效地区分。
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18.发明授权Time of flight mass spectrometer with analog to digital converter and method of using 有权具有模数转换器的飞行时间质谱仪及其使用方法公开(公告)号：US08809767B2
公开(公告)日：2014-08-19
申请号：US12302168
申请日：2007-06-01
申请人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
发明人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
CPC分类号： H01J49/0036 , G06K9/0053
摘要： A Time of Flight mass analyser is disclosed comprising an ion detector comprising an Analogue to Digital Converter. Output signals from the ion detector are digitised and the arrival times and intensity values relating to ion arrival events are determined. If the determined arrival times from two signals fall within the same time window then the arrival times are added together in a weighted manner and the intensity values are combined.
摘要翻译： 公开了一种飞行时间质量分析仪，其包括离子检测器，该离子检测器包括模数转换器。 来自离子检测器的输出信号被数字化，确定与离子到达事件有关的到达时间和强度值。 如果从两个信号确定的到达时间落在相同的时间窗口内，则以加权的方式将到达时间相加在一起并且强度值被组合。
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公开(公告)号：US08507849B2
公开(公告)日：2013-08-13
申请号：US11721755
申请日：2005-12-19
申请人： Jeffery Mark Brown
发明人： Jeffery Mark Brown
IPC分类号： H01J49/40
CPC分类号： H01J49/004 , H01J49/0031 , H01J49/401
摘要： A mass spectrometer is disclosed comprising a MALDI ion source coupled to an orthogonal acceleration Time of Flight mass analyzer. The mass spectrometer is operated at a first instrument setting wherein specific parent ions are selected by a mass filter and are accelerated to a first axial energy. The fragment ions are then orthogonally accelerated after a first delay time and first mass spectral data is obtained. The mass spectrometer is then operated at a second instrument setting wherein the axial energy of the parent ions is increased and the resulting fragment ions are orthogonally accelerated after a reduced delay time. Second mass spectral data is then obtained. The first and second mass spectral data are then combined to provided a final composite mass spectrum.
摘要翻译： 公开了一种质谱仪，其包括耦合到正交加速时间飞行质量分析仪的MALDI离子源。 质谱仪在第一仪器设置下操作，其中通过质量过滤器选择特定的母体离子并加速至第一轴向能量。 然后，在获得第一延迟时间和第一质谱数据之后，片段离子被正交加速。 然后质谱仪在第二仪器设置下操作，其中母离子的轴向能量增加，并且所产生的碎片离子在减小的延迟时间之后被正交加速。 然后获得第二质谱数据。 然后组合第一和第二质谱数据以提供最终的复合质谱。
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公开(公告)号：US08362424B2
公开(公告)日：2013-01-29
申请号：US12744384
申请日：2008-11-24
IPC分类号： H01J49/40
CPC分类号： H01J49/065 , H01J49/0072
摘要： An ion-ion reaction cell is provided comprising a plurality of electrodes forming an ion guide. A transient DC voltage wave is applied to the electrodes in order to load reagent anions into the ion guide. Analyte cations are then subsequently transmitted through the ion-ion reaction cell by a subsequent transient DC voltage wave. Ion are arranged to undergo ion-ion reactions within the reaction cell and the resulting fragment ions which are formed within the reaction cell are then subsequently translated out of the reaction cell by means of a transient DC voltage wave.
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