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65 条记录 (耗时 0.041 秒)

    Biocompatible monomer and polymer compositions
    11.
    发明授权
    Biocompatible monomer and polymer compositions 失效
    生物相容性单体和聚合物组合物

    公开(公告)号：US5575997A

    公开(公告)日：1996-11-19

    申请号：US461931

    申请日：1995-06-05

    申请人： Jeffrey C. Leung ,  Jeffrey G. Clark

    发明人： Jeffrey C. Leung ,  Jeffrey G. Clark

    IPC分类号： A61L24/00 ,  A61L24/06 ,  C09J4/00 ,  A61K31/785 ,  A61F2/28 ,  A61K9/14 ,  A61K31/795

    CPC分类号： A61L24/06 ,  C09J4/00 ,  Y10S514/963

    摘要： A biocompatible monomer composition contains (A) at least one monomer of the formula:CHR.dbd.CXYwherein X and Y are each strong electron withdrawing groups, and R is H or, provided that X and Y are both cyano groups, a C.sub.1 -C.sub.4 alkyl group; and (B) an effective amount of at least one biocompatible agent effective to reduce active formaldehyde concentration levels, preferably a formaldehyde scavenger compound. The monomer is preferably an alpha-cyanoacrylate. The formaldehyde scavenger compound may be in microencapsulated or non-microencapsulated form. The composition can be applied to a variety of materials and is particularly suitable as in vivo tissue adhesive. A method of joining together in vivo two surfaces, e.g., body tissues, includes (a) applying to at least one of the surfaces a composition containing 1) at least one monomer, preferably an alpha-cyanoacrylate, which forms a polymer whose in vivo biodegradation produces formaldehyde; and 2) an effective amount of at least one biocompatible agent effective to reduce active formaldehyde concentration levels, preferably a formaldehyde scavenger; and (b) maintaining the surfaces in contact until the composition polymerizes.

    摘要翻译： 生物相容性单体组合物含有（A）至少一种下式的单体：CHR = CXY，其中X和Y分别是强吸电子基团，R是H，或者X和Y都是氰基，C1-C4烷基 组; 和（B）有效量的至少一种有效降低活性甲醛浓度水平的生物相容剂，优选甲醛清除剂化合物。 单体优选为α-氰基丙烯酸酯。 甲醛清除剂化合物可以是微囊化或非微囊化形式。 组合物可以应用于各种材料，并且特别适合作为体内组织粘合剂。 在体内将两个表面（例如身体组织）接合在一起的方法包括（a）向至少一个表面施用包含1）至少一种形成其体内聚合物的单体，优选α-氰基丙烯酸酯的组合物 生物降解产生甲醛; 和2）有效量的至少一种有效降低活性甲醛浓度水平的生物相容剂，优选甲醛清除剂; 和（b）保持表面接触直到组合物聚合。

    Biocompatible monomer and formaldehyde producing polymer compositions
    12.
    发明授权
    Biocompatible monomer and formaldehyde producing polymer compositions 失效
    生物相容的单体和生产甲醛的聚合物组合物

    公开(公告)号：US5514372A

    公开(公告)日：1996-05-07

    申请号：US462287

    申请日：1995-06-05

    申请人： Jeffrey C. Leung ,  Jeffrey G. Clark

    发明人： Jeffrey C. Leung ,  Jeffrey G. Clark

    IPC分类号： A61L24/00 ,  A61L24/06 ,  C09J4/00 ,  A61K31/785 ,  A61K9/14 ,  A61K31/795 ,  C08F120/44

    CPC分类号： A61L24/06 ,  C09J4/00 ,  Y10S514/963

    摘要： A biocompatible monomer composition contains (A) at least one monomer of the formula:CHR.dbd.CXYwherein X and Y are each strong electron withdrawing groups, and R is H or, provided that X and Y are both cyano groups, a C.sub.1 -C.sub.4 alkyl group; and (B) an effective amount of at least one biocompatible agent effective to reduce active formaldehyde concentration levels, preferably a formaldehyde scavenger compound. The monomer is preferably an alpha-cyanoacrylate. The formaldehyde scavenger compound may be in microencapsulated or non-microencapsulated form. The composition can be applied to a variety of materials and is particularly suitable as in vivo tissue adhesive. A method of joining together in vivo two surfaces, e.g., body tissues, includes (a) applying to at least one of the surfaces a composition containing 1) at least one monomer, preferably an alphacyanoacrylate, which forms a polymer whose in vivo biodegradation produces formaldehyde; and 2) an effective amount of at least one biocompatible agent effective to reduce active formaldehyde concentration levels, preferably a formaldehyde scavenger; and (b) maintaining the surfaces in contact until the composition polymerizes.

    摘要翻译： 生物相容性单体组合物含有（A）至少一种下式的单体：CHR = CXY其中X和Y各自为强吸电子基团，R为H，或者X和Y均为氰基，C1-C4 烷基; 和（B）有效量的至少一种有效降低活性甲醛浓度水平的生物相容剂，优选甲醛清除剂化合物。 单体优选为α-氰基丙烯酸酯。 甲醛清除剂化合物可以是微囊化或非微囊化形式。 组合物可以应用于各种材料，并且特别适合作为体内组织粘合剂。 在体内将两个表面（例如，身体组织）接合在一起的方法包括（a）向至少一个表面施用包含1）至少一种形成聚合物的组合物的组合物，其优选为α-花生酸丙烯酸酯，所述单体，其体内生物降解产生 甲醛; 和2）有效量的至少一种有效降低活性甲醛浓度水平的生物相容剂，优选甲醛清除剂; 和（b）保持表面接触直到组合物聚合。

    Brachytherapy devices and related methods and computer program products
    13.
    发明授权
    Brachytherapy devices and related methods and computer program products 有权
    近距离放射治疗装置及相关方法及计算机程序产品

    公开(公告)号：US09358377B2

    公开(公告)日：2016-06-07

    申请号：US12728584

    申请日：2010-03-22

    申请人： Robert D. Black ,  Jeffrey C. Leung

    发明人： Robert D. Black ,  Jeffrey C. Leung

    IPC分类号： B05D7/00 ,  A61M37/00 ,  A61N5/10

    CPC分类号： A61M37/0069 ,  A61N5/1027 ,  A61N2005/1023

    摘要： A low-dose-rate (LDR) brachytherapy device having a spatiotemporal radiation profile includes an elongated body having a radioactive material in a spatial pattern to provide a spatial radiation profile with a radiation intensity that varies along a length of the elongated body. The radioactive material includes at least first and second radioisotopes having at least first and second respective decay profiles that together provide a temporal radiation profile that is different from the first and second decay profiles. The spatial radiation profile and the temporal radiation profile form a net spatiotemporal radiation profile configured to provide a radiotherapy plan for a patient.

    摘要翻译： 具有时空辐射轮廓的低剂量率（LDR）近距离放射治疗装置包括具有空间图案的放射性材料的细长体，以提供具有沿细长体的长度变化的辐射强度的空间辐射分布。 放射性材料至少包括具有至少第一和第二相应的衰变曲线的第一和第二放射性同位素，它们一起提供不同于第一和第二衰变曲线的时间辐射分布。 空间辐射分布和时间辐射分布形成净空间时间辐射谱，配置成为患者提供放射治疗计划。

    SELF-RETAINING SUTURES HAVING EFFECTIVE HOLDING STRENGTH AND TENSILE STRENGTH
    19.
    发明申请
    SELF-RETAINING SUTURES HAVING EFFECTIVE HOLDING STRENGTH AND TENSILE STRENGTH 有权
    具有有效的保持强度和拉伸强度的自保护套

    公开(公告)号：US20100298875A1

    公开(公告)日：2010-11-25

    申请号：US12850035

    申请日：2010-08-04

    申请人： Jeffrey C. Leung ,  Gregory L. Ruff ,  Matthew A. Megaro

    发明人： Jeffrey C. Leung ,  Gregory L. Ruff ,  Matthew A. Megaro

    IPC分类号： A61B17/04

    CPC分类号： A61B17/04 ,  A61B17/06166 ,  A61B2017/06028 ,  A61B2017/06057 ,  A61B2017/06176 ,  Y10T83/852

    摘要： A barbed suture with a first end and a second end and a body with a plurality of barbs extending from the body. Each barb causes the suture to resist movement in an opposite direction from which the barb faces. Projections extend from said suture. The projections can also engage tissue. The barbs cover the projections when the first end of the suture is moved in tissue and exposes the projections in order to engage tissue when the suture is moved in the direction of the second end through tissue.

    摘要翻译： 具有第一端和第二端的带刺的缝合线，以及具有从身体延伸的多个倒钩的主体。 每个倒钩使缝合线抵抗与倒钩相反的方向移动。 投影从所述缝合线延伸。 突起也可以接合组织。 当缝合线的第一端在组织中移动时，倒钩覆盖突起，并且当缝合线沿着第二端的方向通过组织移动时，暴露突起以便接合组织。

    SUTURE ANCHOR AND METHOD
    20.
    发明申请
    SUTURE ANCHOR AND METHOD 有权
    固定锚和方法

    公开(公告)号：US20080234731A1

    公开(公告)日：2008-09-25

    申请号：US12119749

    申请日：2008-05-13

    申请人： Jeffrey C. Leung ,  Gregory Ruff ,  Andrew Kaplan

    发明人： Jeffrey C. Leung ,  Gregory Ruff ,  Andrew Kaplan

    IPC分类号： A61B17/04

    CPC分类号： A61B17/06166 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/1146 ,  A61B2017/0412 ,  A61B2017/0427 ,  A61B2017/0462 ,  A61B2017/06057 ,  A61B2017/06176 ,  Y10S606/908 ,  Y10S606/91

    摘要： A suture anchor is provided for approximating tissue to bone or other tissue. The suture anchor comprises an anchor member to fixedly engage the bone for securing the anchor member relative to the bone. A plurality of sutures are mounted to the proximal end of the anchor member so that the sutures extend outwardly from the anchor member. Each suture has a sharp pointed distal end for penetrating the tissue and a plurality of barbs extending from the periphery and disposed along the length of the body of the suture. The barbs permit movement of the sutures through the tissue in a direction of movement of the pointed end and prevent movement of the sutures relative to the tissue in a direction opposite the direction of movement of the pointed end. At least one pointed distal end of at least one suture comprises a needle.

    摘要翻译： 提供缝合锚，用于将组织近似到骨骼或其他组织。 缝合锚固件包括锚定构件以固定地接合骨骼，以相对于骨固定锚定构件。 多个缝合线被安装到锚定构件的近端，使得缝线从锚定构件向外延伸。 每个缝合线具有用于穿透组织的尖锐的尖端，以及从周边延伸并沿着缝合线的主体的长度设置的多个倒钩。 倒刺允许缝合线沿着尖端的移动方向通过组织移动，并且防止缝合线相对于组织在与尖端的移动方向相反的方向上移动。 至少一条缝合线的至少一个尖的远端包括针。