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    Microfluidic valve having free-floating member and method of fabrication
    12.
    发明授权
    Microfluidic valve having free-floating member and method of fabrication 有权
    具有自由浮动部件的微流控阀和制造方法

    公开(公告)号：US07600533B2

    公开(公告)日：2009-10-13

    申请号：US11837450

    申请日：2007-08-10

    申请人： Yu-Chong Tai ,  Po-Jui Chen ,  Damien C. Rodger ,  Mark S. Humayun

    发明人： Yu-Chong Tai ,  Po-Jui Chen ,  Damien C. Rodger ,  Mark S. Humayun

    IPC分类号： F16K15/14

    CPC分类号： F16K99/0005 ,  F16K99/0015 ,  F16K99/0057 ,  Y10T29/49409 ,  Y10T137/0497 ,  Y10T137/7866 ,  Y10T137/7895 ,  Y10T137/7904 ,  Y10T137/7914

    摘要： Micro check valves having a free-floating member for controlling flow of fluid in microfluidic and biomedical applications and methods of fabrication. A micro check valve includes a valve seat, a valve cap that contacts the valve seat and an untethered floating member that can move between the valve seat and the valve cap. Certain micro check valves have zero cracking pressure and no reverse leakage. Certain other valves may be configured to permit flow of fluid within a pressure range. The floating member can be solid or define an orifice, and the valve seat can have one or two levels. Valves can be configured to allow fluid to flow when the floating member is pushed by fluid against the valve cap or against the valve seat. The valve seat may be silicon or another material that is compatible with micromachining processes, and the valve cap and the floating member may be a polymer such as Parylene.

    摘要翻译： 微型止回阀具有用于控制微流体和生物医学应用中的流体流动的自由浮动部件和制造方法。 微型止回阀包括阀座，接触阀座的阀盖和可在阀座与阀盖之间移动的无阻力浮动件。 某些微型止回阀具有零开裂压力，无反向泄漏。 某些其它阀可以被配置为允许流体在压力范围内流动。 浮动构件可以是固定的或限定孔口，并且阀座可以具有一个或两个水平面。 阀可以被配置为当浮动构件被流体压靠在阀盖或阀座上时流体流动。 阀座可以是硅或与微加工过程相容的另一种材料，阀帽和浮动元件可以是聚合物，例如聚对二甲苯。

    Implantable mechanical pressure sensor and method of manufacturing the same
    13.
    发明申请
    Implantable mechanical pressure sensor and method of manufacturing the same 有权
    可植入式机械压力传感器及其制造方法

    公开(公告)号：US20050268722A1

    公开(公告)日：2005-12-08

    申请号：US11148124

    申请日：2005-06-07

    申请人： Yu-Chong Tai ,  Ellis Meng ,  Po-Jui Chen ,  Damien Rodger ,  Mark Humayun

    发明人： Yu-Chong Tai ,  Ellis Meng ,  Po-Jui Chen ,  Damien Rodger ,  Mark Humayun

    IPC分类号： A61B3/16 ,  G01L7/04 ,  G01L7/08

    CPC分类号： A61B3/16 ,  A61B2562/02 ,  A61B2562/028 ,  G01L7/045

    摘要： A biocompatible, mechanical, micromachined pressure sensor and methods of manufacturing such a pressure sensor are provided. The pressure sensor of the current invention comprises a high-aspect-ratio curved-tube structure fabricated through a one-layer parylene process. The pressure sensor of the current invention requires zero power consumption and indicates the pressure variation by changes of the in situ in-plane motion of the sensor, which can be gauged externally by a direct and convenient optical observation. In one embodiment, the pressure sensor of the current invention has been shown to work as an IOP sensor for eye implantation where the intraocular in-plane motion of the sensor can be recorded from outside of the eye, such that the intraocular pressure in glaucoma patients can be constantly monitored.

    摘要翻译： 提供生物相容的，机械的，微加工的压力传感器以及制造这种压力传感器的方法。 本发明的压力传感器包括通过一层聚对二甲苯工艺制造的高纵横比弯曲管结构。 本发明的压力传感器需要零功率消耗，并且通过传感器的原位面内运动的变化来指示压力变化，其可以通过直接和方便的光学观察在外部测量。 在一个实施例中，本发明的压力传感器已经被证明可用作眼睛植入的IOP传感器，其中可以从眼睛外部记录传感器的眼内平面内运动，使得青光眼患者的眼内压 可以不断监控。

    Implantable Intraocular Pressure Drain
    14.
    发明申请
    Implantable Intraocular Pressure Drain 失效
    植入式眼内压排水

    公开(公告)号：US20120289883A1

    公开(公告)日：2012-11-15

    申请号：US13555329

    申请日：2012-07-23

    申请人： Ellis Fan-chuin Meng ,  Po-Jui Chen ,  Damien Rodger ,  Yu-Chong Tai ,  Mark Humayun

    发明人： Ellis Fan-chuin Meng ,  Po-Jui Chen ,  Damien Rodger ,  Yu-Chong Tai ,  Mark Humayun

    IPC分类号： A61F9/00 ,  A61M1/00

    CPC分类号： A61F9/00781 ,  A61B3/16 ,  A61B5/4836 ,  A61B5/6821 ,  A61B2562/0247 ,  A61B2562/028 ,  A61B2562/12 ,  F16K99/0009 ,  F16K99/0057 ,  F16K2099/0086

    摘要： An implanted parylene tube shunt relieves intra-ocular pressure. The device is implanted with an open end in the anterior chamber of the eye, allowing excess fluid to be drained through the tube out of the eye. In one embodiment, only a first end of the tube implanted into the anterior chamber of the eye is open. Intra-ocular pressure (IOP) is then monitored, for example utilizing an implanted sensor. When IOP exceeds a critical valve, a practitioner intervenes, puncturing with a laser a thinned region of the tube lying outside the eye, thereby initiating drainage of fluid and relieving pressure. In accordance with alternative embodiments, the both ends of the tube are open, and the tube includes a one-way valve configured to permit drainage where IOP exceeds the critical value. The tube may include projecting barbs to anchor the tube in the eye without the need for sutures.

    摘要翻译： 植入的聚对二甲苯管分流器可减轻眼内压力。 该装置在眼睛的前房中植入开放端，允许多余的液体通过管排出眼睛。 在一个实施例中，仅植入眼睛前房的管的第一端是开放的。 然后监测眼内压（IOP），例如利用植入的传感器。 当IOP超过临界阀时，从业者介入，用激光穿刺位于眼睛外部的管的薄的区域，从而引起流体排出并释放压力。 根据替代实施例，管的两端是开放的，并且管包括被配置为允许IOP超过临界值的排水的单向阀。 管可以包括突出的倒钩以将管锚定在眼睛中而不需要缝线。

    MICROFLUIDIC VALVE HAVING FREE-FLOATING MEMBER AND METHOD OF FABRICATION
    15.
    发明申请
    MICROFLUIDIC VALVE HAVING FREE-FLOATING MEMBER AND METHOD OF FABRICATION 有权
    具有自由浮动构件的微流控阀和制造方法

    公开(公告)号：US20100025613A1

    公开(公告)日：2010-02-04

    申请号：US12565636

    申请日：2009-09-23

    申请人： Yu-Chong Tai ,  Po-Jui Chen ,  Damien C. Rodger ,  Mark S. Humayun

    发明人： Yu-Chong Tai ,  Po-Jui Chen ,  Damien C. Rodger ,  Mark S. Humayun

    IPC分类号： F16K17/02 ,  B21D53/10

    CPC分类号： F16K99/0005 ,  F16K99/0015 ,  F16K99/0057 ,  Y10T29/49409 ,  Y10T137/0497 ,  Y10T137/7866 ,  Y10T137/7895 ,  Y10T137/7904 ,  Y10T137/7914

    摘要： Micro check valves having a free-floating member for controlling flow of fluid in microfluidic and biomedical applications and methods of fabrication. A micro check valve includes a valve seat, a valve cap that contacts the valve seat and an untethered floating member that can move between the valve seat and the valve cap. Certain micro check valves have zero cracking pressure and no reverse leakage. Certain other valves may be configured to permit flow of fluid within a pressure range. The floating member can be solid or define an orifice, and the valve seat can have one or two levels. Valves can be configured to allow fluid to flow when the floating member is pushed by fluid against the valve cap or against the valve seat. The valve seat may be silicon or another material that is compatible with micromachining processes, and the valve cap and the floating member may be a polymer such as Parylene.

    摘要翻译： 微型止回阀具有用于控制微流体和生物医学应用中的流体流动的自由浮动部件和制造方法。 微型止回阀包括阀座，接触阀座的阀盖和可在阀座与阀盖之间移动的无阻力浮动件。 某些微型止回阀具有零开裂压力，无反向泄漏。 某些其它阀可以被配置为允许流体在压力范围内流动。 浮动构件可以是固定的或限定孔口，并且阀座可以具有一个或两个水平面。 阀可以被配置为当浮动构件被流体压靠在阀盖或阀座上时流体流动。 阀座可以是硅或与微加工过程相容的另一种材料，阀帽和浮动元件可以是聚合物，例如聚对二甲苯。

    MICROFABRICATED IMPLANTABLE WIRELESS PRESSURE SENSOR FOR USE IN BIOMEDICAL APPLICATIONS AND PRESSURE MEASUREMENT AND SENSOR IMPLANTATION METHODS
    17.
    发明申请
    MICROFABRICATED IMPLANTABLE WIRELESS PRESSURE SENSOR FOR USE IN BIOMEDICAL APPLICATIONS AND PRESSURE MEASUREMENT AND SENSOR IMPLANTATION METHODS 有权
    微生物可植入式无线压力传感器，用于生物医学应用和压力测量和传感器植入方法

    公开(公告)号：US20100294041A1

    公开(公告)日：2010-11-25

    申请号：US12848837

    申请日：2010-08-02

    申请人： Yu-Chong Tai ,  Po-Jui Chen ,  Damien C. Rodger ,  Mark S. Humayun

    发明人： Yu-Chong Tai ,  Po-Jui Chen ,  Damien C. Rodger ,  Mark S. Humayun

    IPC分类号： G01L9/12

    CPC分类号： A61B3/16 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/03 ,  G01L9/0072

    摘要： A variable capacitor, a microfabricated implantable pressure sensor including a variable capacitor and an inductor, and related pressure measurement and implantation methods. The inductor may have a fixed or variable inductance. A variable capacitor and pressure sensors include a flexible member that is disposed on a substrate and defines a chamber. Capacitor elements extend indirectly from the flexible member. Sufficient fluidic pressure applied to an exterior surface of the flexible member causes the flexible member to move or deform, thus causing the capacitance and/or inductance to change. Resulting changes in resonant frequency or impedance can be detected to determine pressure, e.g., intraocular pressure.

    摘要翻译： 可变电容器，包括可变电容器和电感器的微加工可植入压力传感器，以及相关的压力测量和植入方法。 电感器可以具有固定或可变电感。 可变电容器和压力传感器包括设置在基板上并限定腔室的柔性构件。 电容元件从柔性元件间接延伸。 施加到柔性构件的外表面上的足够的流体压力导致柔性构件移动或变形，从而导致电容和/或电感改变。 可以检测谐振频率或阻抗的所得变化以确定压力，例如眼内压。

    MICROFABRICATED IMPLANTABLE WIRELESS PRESSURE SENSOR FOR USE IN BIOMEDICAL APPLICATIONS AND PRESSURE MEASUREMENT AND SENSOR IMPLANTATION METHODS
    18.
    发明申请
    MICROFABRICATED IMPLANTABLE WIRELESS PRESSURE SENSOR FOR USE IN BIOMEDICAL APPLICATIONS AND PRESSURE MEASUREMENT AND SENSOR IMPLANTATION METHODS 有权
    微生物可植入式无线压力传感器，用于生物医学应用和压力测量和传感器植入方法

    公开(公告)号：US20080058632A1

    公开(公告)日：2008-03-06

    申请号：US11847262

    申请日：2007-08-29

    申请人： Yu-Chong Tai ,  Po-Jui Chen ,  Damien C. Rodger ,  Mark S. Humayun

    发明人： Yu-Chong Tai ,  Po-Jui Chen ,  Damien C. Rodger ,  Mark S. Humayun

    IPC分类号： A61B3/00 ,  G01L9/12 ,  G01R27/26

    CPC分类号： A61B3/16 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/03 ,  G01L9/0072

    摘要： A variable capacitor, a microfabricated implantable pressure sensor including a variable capacitor and an inductor, and related pressure measurement and implantation methods. The inductor may have a fixed or variable inductance. A variable capacitor and pressure sensors include a flexible member that is disposed on a substrate and defines a chamber. Capacitor elements extend indirectly from the flexible member. Sufficient fluidic pressure applied to an exterior surface of the flexible member causes the flexible member to move or deform, thus causing the capacitance and/or inductance to change. Resulting changes in resonant frequency or impedance can be detected to determine pressure, e.g., intraocular pressure.

    摘要翻译： 可变电容器，包括可变电容器和电感器的微加工可植入压力传感器，以及相关的压力测量和植入方法。 电感器可以具有固定或可变电感。 可变电容器和压力传感器包括设置在基板上并限定腔室的柔性构件。 电容元件从柔性元件间接延伸。 施加到柔性构件的外表面上的足够的流体压力导致柔性构件移动或变形，从而导致电容和/或电感改变。 可以检测谐振频率或阻抗的所得变化以确定压力，例如眼内压。

    Implantable mechanical pressure sensor and method of manufacturing the same
    19.
    发明授权
    Implantable mechanical pressure sensor and method of manufacturing the same 有权
    可植入式机械压力传感器及其制造方法

    公开(公告)号：US07252006B2

    公开(公告)日：2007-08-07

    申请号：US11148124

    申请日：2005-06-07

    申请人： Yu-Chong Tai ,  Ellis Meng ,  Po-Jui Chen ,  Damien C. Rodger ,  Mark Humayun

    发明人： Yu-Chong Tai ,  Ellis Meng ,  Po-Jui Chen ,  Damien C. Rodger ,  Mark Humayun

    IPC分类号： G01L9/00

    CPC分类号： A61B3/16 ,  A61B2562/02 ,  A61B2562/028 ,  G01L7/045

    摘要： A biocompatible, mechanical, micromachined pressure sensor and methods of manufacturing such a pressure sensor are provided. The pressure sensor of the current invention includes a high-aspect-ratio curved-tube structure fabricated through a one-layer parylene process. The pressure sensor of the current invention requires zero power consumption and indicates the pressure variation by changes of the in situ in-plane motion of the sensor, which can be gauged externally by a direct and convenient optical observation. In one embodiment, the pressure sensor of the current invention has been shown to work as an IOP sensor for eye implantation where the intraocular in-plane motion of the sensor can be recorded from outside of the eye, such that the intraocular pressure in glaucoma patients can be constantly monitored.

    摘要翻译： 提供生物相容的，机械的，微加工的压力传感器以及制造这种压力传感器的方法。 本发明的压力传感器包括通过一层聚对二甲苯工艺制造的高纵横比弯曲管结构。 本发明的压力传感器需要零功率消耗，并且通过传感器的原位面内运动的变化来指示压力变化，其可以通过直接和方便的光学观察在外部测量。 在一个实施例中，本发明的压力传感器已经被证明可用作眼睛植入的IOP传感器，其中可以从眼睛外部记录传感器的眼内平面内运动，使得青光眼患者的眼内压 可以不断监控。

    Micromachined tissue anchors for securing implants without sutures
    20.
    发明申请
    Micromachined tissue anchors for securing implants without sutures 审中-公开
    微加工组织锚，用于固定植入物，无缝线

    公开(公告)号：US20060247664A1

    公开(公告)日：2006-11-02

    申请号：US11371219

    申请日：2006-03-07

    申请人： Ellis Meng ,  Yu-Chong Tai ,  Damien Rodger ,  Po-Jui Chen ,  Mark Humayun

    发明人： Ellis Meng ,  Yu-Chong Tai ,  Damien Rodger ,  Po-Jui Chen ,  Mark Humayun

    IPC分类号： A61F2/02 ,  A61B3/16

    CPC分类号： A61B3/16 ,  A61B5/6821 ,  A61B5/6882

    摘要： Systems and methods for attaching an implant device to tissue by mechanically (and non-invasively) anchoring the device to the tissue. The systems and methods provide a safe, practical way to attach an implant device to tissue in a non-invasive, or less invasive manner. According to the present invention, an implant device includes one or more protruding anchor-like structures for securely attaching to tissue. One or more device features, such as sensing elements, may be incorporated on the implant device. The anchor structures are configured and arranged to match the topology and features of the tissue environment where implant is to occur.

    摘要翻译： 通过机械地（而非侵入式）将装置固定在组织上来将植入装置附着到组织的系统和方法。 该系统和方法提供了以非侵入性或较小侵入性方式将植入装置附接到组织的安全且实用的方式。 根据本发明，植入装置包括用于牢固地附接到组织的一个或多个突出的锚固结构。 可以在植入装置上并入一个或多个装置特征，例如感测元件。 锚结构被配置和布置成匹配将要进行植入的组织环境的拓扑和特征。