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公开(公告)号：US20050267200A1
公开(公告)日：2005-12-01
申请号：US11178164
申请日：2005-07-08
IPC分类号： A61K31/381 , A61K31/397 , A61K31/428 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P3/00 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P31/10 , A61P33/00 , A61P35/00 , C07D275/04 , C07D275/06 , C07D333/54 , C07D409/12 , C07D417/12 , C07D521/00 , C07D333/72 , C07D409/02
CPC分类号： C07D417/12 , C07D231/12 , C07D233/56 , C07D249/08 , C07D275/04 , C07D275/06 , C07D333/54 , C07D409/12
摘要： The present invention relates to heteroaromate OSC inhibitors. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
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公开(公告)号：US06951879B2
公开(公告)日：2005-10-04
申请号：US09999424
申请日：2001-10-31
IPC分类号： A61K31/381 , A61K31/397 , A61K31/428 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P3/00 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P31/10 , A61P33/00 , A61P35/00 , C07D275/04 , C07D275/06 , C07D333/54 , C07D409/12 , C07D417/12 , C07D521/00
CPC分类号： C07D417/12 , C07D231/12 , C07D233/56 , C07D249/08 , C07D275/04 , C07D275/06 , C07D333/54 , C07D409/12
摘要： The present invention relates to heteroaromate OSC inhibitors. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及异离子OSC抑制剂。 该化合物可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症，高脂血症，动脉硬化，血管疾病，霉菌病，胆结石，肿瘤和/或过度增殖性疾病相关的疾病，以及治疗和 /或预防糖耐量异常和糖尿病。
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公开(公告)号：US20050065210A1
公开(公告)日：2005-03-24
申请号：US10942154
申请日：2004-09-16
申请人： Jean Ackermann , Johannes Aebi , Henrietta Dehmlow , Georges Hirth , Hans-Peter Maerki , Olivier Morand , Narendra Panday
发明人： Jean Ackermann , Johannes Aebi , Henrietta Dehmlow , Georges Hirth , Hans-Peter Maerki , Olivier Morand , Narendra Panday
IPC分类号： A61P9/10 , C07C271/24 , C07C271/56 , C07C311/20 , C07D239/26 , C07D239/30 , C07D239/42 , C07D295/185 , C07D403/12 , A61K31/325 , A61K31/16 , A61K31/18
CPC分类号： C07D239/26 , C07C271/56 , C07C311/20 , C07C2601/14 , C07D239/30 , C07D295/185 , C07D403/12
摘要： The present invention relates to compounds of formula I wherein R1, R2, R3, R4, R5, U, V, W, k and m are as defined in the description and claims, and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasit infections, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2，R 3，R 4，R 5，U，V，W，k和m如说明书中所定义 并且要求及其药学上可接受的盐和/或其药学上可接受的酯。 该化合物可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶相关的疾病，例如高胆固醇血症，高脂血症，动脉硬化，血管疾病，真菌病，寄生虫感染，胆结石，肿瘤和/或过度增殖性疾病， 以及治疗和/或预防糖耐量异常和糖尿病。
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公开(公告)号：US07102007B2
公开(公告)日：2006-09-05
申请号：US10648451
申请日：2003-08-26
申请人： Johannes Aebi , Jean Ackermann , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller , Narendra Panday
发明人： Johannes Aebi , Jean Ackermann , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller , Narendra Panday
IPC分类号： C07D215/02 , A61K31/47
CPC分类号： C07D215/20 , C07D209/08
摘要： The present invention relates to novel dihydroindole and tetrahydroquinoline derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
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公开(公告)号：US06706751B2
公开(公告)日：2004-03-16
申请号：US10014959
申请日：2001-12-11
申请人： Johannes Aebi , Jean Ackermann , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller , Narendra Panday
发明人： Johannes Aebi , Jean Ackermann , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller , Narendra Panday
IPC分类号： A61P4300
CPC分类号： C07D215/20 , C07D209/08
摘要： The present invention relates to novel dihydroindole and tetrahydroquinoline derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及新的二氢吲哚和四氢喹啉衍生物及其药学上可接受的盐和/或其药学上可接受的酯。 该化合物可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症，高脂血症，动脉硬化，血管疾病，霉菌病，胆结石，肿瘤和/或过度增殖性疾病相关的疾病，以及治疗和 /或预防糖耐量异常和糖尿病。
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公开(公告)号：US06683201B2
公开(公告)日：2004-01-27
申请号：US09906214
申请日：2001-07-16
申请人： Jean Ackermann , Johannes Aebi , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller
发明人： Jean Ackermann , Johannes Aebi , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller
IPC分类号： C07C22900
CPC分类号： C07D213/75 , C07C233/29 , C07C233/75 , C07C235/56 , C07C235/84 , C07C255/57 , C07C271/28 , C07C271/58 , C07C275/34 , C07C275/38 , C07C307/10 , C07C311/13 , C07C311/21 , C07C311/29 , C07C323/44 , C07C335/18 , C07C335/22 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/18 , C07D207/14 , C07D207/20 , C07D209/42 , C07D211/22 , C07D211/42 , C07D211/46 , C07D211/70 , C07D213/81 , C07D213/82 , C07D215/36 , C07D239/42 , C07D261/10 , C07D295/088 , C07D307/14 , C07D307/52 , C07D317/58 , C07D319/18 , C07D333/24 , C07D333/34 , C07D333/38
摘要： The present invention relates to compounds of formula (I) wherein U, Y, V, W, L, X, A1, A2, A3, A4, A5 and A6 are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasite infections, gallstones, tumors and/or hyperproliferative disorders, and/or treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及式（I）化合物，其中U，Y，V，W，L，X，A 1，A 2，A 3，A 4，A 5和A <6>如说明书和权利要求及其药学上可接受的盐和/或其药学上可接受的酯所定义。 该化合物可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶相关的疾病，例如高胆固醇血症，高脂血症，动脉硬化，血管疾病，真菌病，寄生虫感染，胆结石，肿瘤和/或过度增殖性疾病， 和/或治疗和/或预防糖耐量异常和糖尿病。
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公开(公告)号：US06503907B2
公开(公告)日：2003-01-07
申请号：US09998882
申请日：2001-11-20
申请人： Jean Ackermann , Johannes Aebi , Henrietta Dehmlow , Olivier Morand , Narendra Panday , Thomas Weller
发明人： Jean Ackermann , Johannes Aebi , Henrietta Dehmlow , Olivier Morand , Narendra Panday , Thomas Weller
IPC分类号： A61K31535
CPC分类号： C07D401/12 , C07D209/08 , C07D403/12 , C07D417/12
摘要： The present invention relates to indole derivatives, dihydroindole derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
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公开(公告)号：US20050020624A1
公开(公告)日：2005-01-27
申请号：US10648451
申请日：2003-08-26
申请人： Johannes Aebi , Jean Ackermann , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller , Narendra Panday
发明人： Johannes Aebi , Jean Ackermann , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller , Narendra Panday
IPC分类号： A61K31/404 , A61K31/4045 , A61K31/47 , A61K31/4709 , A61P1/16 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/14 , A61P17/00 , A61P31/10 , A61P35/00 , A61P43/00 , C07D209/08 , C07D215/20 , C07D215/58 , C07D409/06 , C07D209/42 , C07D215/38
CPC分类号： C07D215/20 , C07D209/08
摘要： The present invention relates to novel dihydroindole and tetrahydroquinoline derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及新的二氢吲哚和四氢喹啉衍生物及其药学上可接受的盐和/或其药学上可接受的酯。 该化合物可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症，高脂血症，动脉硬化，血管疾病，真菌病，胆结石，肿瘤和/或过度增殖性疾病相关的疾病，以及治疗和 /或预防糖耐量异常和糖尿病。
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公开(公告)号：US06965048B2
公开(公告)日：2005-11-15
申请号：US10883431
申请日：2004-07-01
IPC分类号： C07C271/54 , C07C271/56 , C07C311/20 , C07D211/22 , C07D211/46 , C07C271/44 , A61K31/27
CPC分类号： C07D211/46 , C07C271/54 , C07C271/56 , C07C311/20 , C07C2601/14 , C07D211/22
摘要： The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, X, W, m and n are as defined hereinabove. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasite infections, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及式（I）的化合物，其中R 1，R 2，R 3，R 4， >，X，W，m和n如上所定义。 该化合物可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶相关的疾病，例如高胆固醇血症，高脂血症，动脉硬化，血管疾病，真菌病，寄生虫感染，胆结石，肿瘤和/或过度增殖性疾病， 以及治疗和/或预防糖耐量异常和糖尿病。
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公开(公告)号：US06964974B2
公开(公告)日：2005-11-15
申请号：US09939872
申请日：2001-08-27
申请人： Jean Ackermann , Johannes Aebi , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller
发明人： Jean Ackermann , Johannes Aebi , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller
IPC分类号： A61K31/445 , A61K31/4523 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/55 , A61P1/16 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P31/10 , A61P33/00 , A61P35/00 , A61P43/00 , C07D211/18 , C07D211/22 , C07D211/26 , C07D211/44 , C07D211/46 , C07D211/96 , C07D401/12 , C07D405/12 , C07D417/12
CPC分类号： C07D211/46 , C07D211/22 , C07D211/26 , C07D211/96
摘要： The present invention relates to piperidine derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症，高脂血症，动脉硬化，血管疾病，真菌病，胆结石，肿瘤和/或过度增殖性疾病相关的疾病的哌啶衍生物 ，以及治疗和/或预防糖耐量异常和糖尿病。
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