公开(公告)号：US5697896A

公开(公告)日：1997-12-16

申请号：US353036

申请日：1994-12-08

申请人： Larry A. McNichols ,  John D. Badzinski ,  Ronald P. Haak

发明人： Larry A. McNichols ,  John D. Badzinski ,  Ronald P. Haak

IPC分类号： A61N1/30

CPC分类号： A61N1/0412 ,  A61N1/0428 ,  A61N1/303

摘要： An electrotransport delivery device (410) includes control circuitry for discontinuously delivering a beneficial agent (eg, a drug) through a body surface (eg, skin 400). For example, the device may be the type which is manually activated by the patient or other medical personnel to activate electrotransport drug delivery. Once electrotransport delivery has been activated, a timer (221) counts a transition interval, typically about one minute, during which the device is allowed to operate and the impedance of the body surface (400) is allowed to stabilize. Thereafter, the electrotransport current and voltage are then monitored and compared to predetermined limits. Allowing for the transition interval permits tighter tolerances in monitoring the applied current.

摘要翻译： 电输送装置（410）包括控制电路，用于通过身体表面（例如，皮肤400）不连续地递送有益药剂（例如药物）。 例如，该装置可以是由患者或其他医务人员手动激活以激活电转运药物递送的类型。 一旦电运输递送已被激活，计时器（221）计数通常约1分钟的过渡间隔，在该过程间隔期间该装置被允许操作并允许体表（400）的阻抗稳定。 此后，监测电输送电流和电压，并将其与预定限度进行比较。 允许过渡间隔允许更严格的监测施加电流的公差。

公开(公告)号：US20100076368A1

公开(公告)日：2010-03-25

申请号：US12627230

申请日：2009-11-30

申请人： Larry A. McNichols ,  John D. Badzinski ,  William N. Reining ,  Gary A. Lattin ,  Ronald P. Haak ,  Joseph B. Phipps

发明人： Larry A. McNichols ,  John D. Badzinski ,  William N. Reining ,  Gary A. Lattin ,  Ronald P. Haak ,  Joseph B. Phipps

IPC分类号： A61N1/30

CPC分类号： A61N1/0436 ,  A61N1/0412 ,  A61N1/0428 ,  A61N1/0448 ,  A61N1/30 ,  A61N1/325

摘要： An electrotransport device for delivering one or more therapeutic agents through the skin includes electrodes for contacting the skin, at least one electrode containing the agent, a power source for generating electrical current (IL) for delivering the agent, a current generating and controlling means and a disabling means for permanently and irreversibly disabling the current. The disabling means may include a timer means, a counter means, or a body parameter sensor and limit comparator to effect permanent disabling. The disabling means may be a permanent transition to a disabled logic state, a permanent discharge of a power supply source, or a permanent diversion of electrotransport current from the electrodes, or a combination of the above. The permanent disabling means may include a circuit connection means having a frangible conducting member which permanently fractures and causes an irreversible open circuit in the connection to the electrodes upon removing a disposable/single use electrode assembly from a reusable portion of an electrotransport device.

摘要翻译： 用于通过皮肤递送一种或多种治疗剂的电输送装置包括用于接触皮肤的电极，包含该药剂的至少一个电极，用于产生用于递送药剂的电流（IL）的电源，电流产生和控制装置和 一种永久不可逆地禁用电流的禁用手段。 禁用装置可以包括定时器装置，计数器装置或身体参数传感器和限制比较器以实现永久禁用。 禁用装置可以是永久性转换到禁用的逻辑状态，电源的永久放电，或者电极的电输送电流的永久转移，或上述的组合。 永久性禁用装置可以包括电路连接装置，该电路连接装置具有永久性断裂的易碎导电构件，并且在从电输送装置的可重复使用部分移除一次性/单次使用电极组件时，在与电极的连接中引起不可逆的开路。

公开(公告)号：US07660627B2

公开(公告)日：2010-02-09

申请号：US11334001

申请日：2006-01-18

申请人： Larry A. McNichols ,  Joseph B. Phipps ,  Gary A. Lattin ,  John D. Badzinski ,  Wiliam N. Reining ,  Ronald P. Haak

发明人： Larry A. McNichols ,  Joseph B. Phipps ,  Gary A. Lattin ,  John D. Badzinski ,  Wiliam N. Reining ,  Ronald P. Haak

IPC分类号： A61N1/30

CPC分类号： A61N1/0436 ,  A61N1/0412 ,  A61N1/0428 ,  A61N1/0448 ,  A61N1/30 ,  A61N1/325

摘要： An electrotransport device for delivering one or more therapeutic agents through the skin includes electrodes for contacting the skin, at least one electrode containing the agent, a power source for generating electrical current (IL) for delivering the agent, a current generating and controlling means and a disabling means for permanently and irreversibly disabling the current. The disabling means may include a timer means, a counter means, or a body parameter sensor and limit comparator to effect permanent disabling. The disabling means may be a permanent transition to a disabled logic state, a permanent discharge of a power supply source, or a permanent diversion of electrotransport current from the electrodes, or a combination of the above. The permanent disabling means may include a circuit connection means having a frangible conducting member which permanently fractures and causes an irreversible open circuit in the connection to the electrodes upon removing a disposable/single use electrode assembly from a reusable portion of an electrotransport device.

摘要翻译： 用于通过皮肤递送一种或多种治疗剂的电输送装置包括用于接触皮肤的电极，包含该药剂的至少一个电极，用于产生用于递送药剂的电流（IL）的电源，电流产生和控制装置和 一种永久不可逆地禁用电流的禁用手段。 禁用装置可以包括定时器装置，计数器装置或身体参数传感器和限制比较器以实现永久禁用。 禁用装置可以是永久性转换到禁用的逻辑状态，电源的永久放电，或者电极的电输送电流的永久转移，或上述的组合。 永久性禁用装置可以包括电路连接装置，该电路连接装置具有永久性断裂的易碎导电构件，并且在从电输送装置的可重复使用部分移除一次性/单次使用电极组件时，在与电极的连接中引起不可逆的开路。

公开(公告)号：US5374242A

公开(公告)日：1994-12-20

申请号：US164663

申请日：1993-12-07

申请人： Ronald P. Haak ,  Larry A. Mc Nichols ,  John D. Badzinski

发明人： Ronald P. Haak ,  Larry A. Mc Nichols ,  John D. Badzinski

IPC分类号： A61M37/00 ,  A61N1/30

CPC分类号： A61N1/30

摘要： An iontophoretic drug-delivery device incorporating a power supply which minimizes the cost of the batteries needed by operating the batteries in a series configuration at the start of delivery, when the patient's skin resistance is high, and by switching the batteries into a parallel configuration when skin resistance drops. An automatic switching circuit for achieving this transition is included.

摘要翻译： 一种离子电渗药物输送装置，其包含电源，其在患者开始输送时，当患者的皮肤电阻高时将串联配置中的电池操作所需的电池成本最小化，并且通过将电池切换成并行配置， 皮肤阻力下降。 包括用于实现该转换的自动切换电路。

公开(公告)号：US5207752A

公开(公告)日：1993-05-04

申请号：US671306

申请日：1991-03-21

申请人： Paul D. Sorenson ,  John D. Badzinski ,  Gary A. Lattin ,  Larry A. McNichols

发明人： Paul D. Sorenson ,  John D. Badzinski ,  Gary A. Lattin ,  Larry A. McNichols

IPC分类号： A61N1/30 ,  A61N1/32

CPC分类号： A61N1/0428 ,  A61N1/325

摘要： A two-stage iontophoretic drug delivery system provides that iontophoretic current is delivered at a first level for a first predetermined interval to rapidly introduce a therapeutic agent into the bloodstream and thereafter reduced to a second lower level to maintain a desired steady-state therapeutic level of the agent. One embodiment provides that the initial interval is maintained sufficiently long to provide a peak dosage, thereafter which the current is shut off to allow concentration of the agent to subside in the bloodstream, whereupon a maintenance level of iontophoretic current is initiated. Another embodiment provides that the patient may selectively initiate a brief interval of increased iontophoretic current level to attain a brief interval of increased dosage.

摘要翻译： 两阶段离子电渗药物递送系统提供离子电渗电流在第一水平上递送第一预定间隔，以将治疗剂快速引入血流中，然后还原至第二较低水平，以保持所需的稳态治疗水平 中介。 一个实施方案规定，初始间隔保持足够长以提供峰值剂量，之后电流被切断以允许试剂浓缩在血流中，从而启动离子电渗电流的维持水平。 另一个实施方案提供了患者可以选择性地启动增加的离子电渗电流水平的短暂间隔以获得增加剂量的短暂间隔。

公开(公告)号：US4725263A

公开(公告)日：1988-02-16

申请号：US891081

申请日：1986-07-31

申请人： Larry A. McNichols ,  John D. Badzinski ,  Joseph B. Phipps ,  Gary A. Lattin ,  Paul D. Sorenson ,  Rama Padmanabhan

发明人： Larry A. McNichols ,  John D. Badzinski ,  Joseph B. Phipps ,  Gary A. Lattin ,  Paul D. Sorenson ,  Rama Padmanabhan

IPC分类号： A61N1/30 ,  A61N1/04 ,  A61N1/32 ,  H05K1/00 ,  H05K1/14 ,  H05K1/18

CPC分类号： A61N1/325 ,  A61N1/0428 ,  H05K1/0293 ,  A61N1/0432 ,  H05K1/029 ,  H05K1/144 ,  H05K1/189 ,  H05K2201/09127 ,  H05K2201/10037 ,  H05K2201/10212 ,  H05K2203/0228 ,  H05K2203/175

摘要： An iontophoresis device including a control module and a disposable electrode module. The control module includes a flexible printed circuit board carrying the battery and other electrical components. The control module is so configured that by trimming it along one of several labeled lines, various current levels may be selected. Trimming the control module provides a simple method for varying the dosage of the drug delivered by the iontophoresis device and simultaneously provides an easily readable visual indicator of the dosage level.

公开(公告)号：US4476873A

公开(公告)日：1984-10-16

申请号：US415042

申请日：1982-09-03

申请人： Paul D. Sorenson ,  Dale A. Dickson ,  Larry A. McNichols ,  John D. Badzinski

发明人： Paul D. Sorenson ,  Dale A. Dickson ,  Larry A. McNichols ,  John D. Badzinski

IPC分类号： A61B8/00 ,  A61B8/08 ,  A61B10/00

CPC分类号： A61B8/4209 ,  A61B8/00 ,  A61B8/0858 ,  A61B8/4245

摘要： An ultrasound scanning system particularly adapted for imaging skeletal structure, such as the spinal column. An ultrasound scanning head for generating ultrasound waves and for receiving reflected ultrasound signals is mounted on a transporter for moving it linearily along the spine between a cervical reference point and a sacral reference point. A position transducer monitors the position of the transducer along the spine and a counter measures the time between the ultrasound pulse and its echo to determine the distance from the transducer face to the tissue interface responsible for generating the echo. The distance and range data is smoothed and analyzed in a digital computer using algorithms that distinguish between the echoes received from bone and other tissue such as lung tissue. The bone data is further processed via computer to produce a visual representation of the spine and rib structure sufficient for the diagnosis of spinal misalignment characteristic of scoliosis.

摘要翻译： 一种超声扫描系统，特别适用于成像骨骼结构，如脊柱。 用于产生超声波并用于接收反射超声信号的超声波扫描头安装在运送器上，用于沿着颈部参考点和骶骨参考点之间的脊线线性移动。 位置传感器监测沿着脊柱的换能器的位置，并且计数器测量超声脉冲与其回波之间的时间，以确定从换能器面到负责产生回波的组织界面的距离。 距离和范围数据在数字计算机中平滑和分析，使用区分从骨骼和其他组织（例如肺组织）接收的回波的算法。 通过计算机进一步处理骨数据，以产生脊柱和肋骨结构的视觉表示，足以诊断脊柱侧凸的脊柱不对准特征。