摘要:
The present invention is directed to substituted imidazo[1,2-a]pyridine derivatives, pharmaceutically acceptable salts thereof, and tautomers of such compounds or salts, that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which BACE is involved.
摘要:
The present invention is directed to benzazole compounds that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved.
摘要:
An inter system handovers in a mobile telecommunication system is performed when a dual mode user equipment (UE) covered by both GSM/GPRS network and UMTS network connects a dedicated channel and sets up a call in a BSS region where the GSM/GPRS provides coverage, and then moves to a UTRAN (UMTS Terrestrial Radio Access Network) where the UMTS provides coverage, wherein the method includes the steps of: if the dual mode UE receives an inter system handover command, i.e. from the BSS to the UTRAN, requesting GSM/GPRS data link layer to suspend a GSM/GPRS data link by a sublayer RR of GSM/GPRS network layer in the UE, requesting a GSM/GPRS physical layer to release a physical channel of the GSM/GPRS, and sending the inter system handover command to the UTRAN for authorizing a sublayer RRC of UMTS network layer in the UE to continue a call; requesting, at the RRC in the UE, a UMTS physical channel to be configured as a UMTS physical channel, and monitoring if the UMTS physical layer succeeds to have the configuration of the UMTS physical channel as requested; if the UMTS physical layer succeeds to have the configuration of the UMTS physical channel, requesting, at the RRC in the UE, a UMTS data link layer to configure a UMTS data link, and conveying information to the UTRAN through a UMTS channel that the handover between systems from the BSS to the UTRAN has been successfully performed; and sending, at the RRC, a GSM/GPRS resource release message to RR/GRR, thereby resetting the GSM/GPRS physical layer and the GSM/GPRS data link layer.
摘要:
A method and system of remotely communicating embroidery pattern data to embroidery machines involving providing an embroidery pattern in response to a pattern selection input from a remote user at a local node, the input communicated through a communications connection between the local node and a server, receiving an identification address for an embroidery machine, communicating the embroidery pattern to the embroidery machine for application of the embroidery pattern to a work piece. The system includes a server having circuitry for receiving wireless electronic communications, a local node having a graphical user interface for receiving input from a remote user, the local node in wireless electronic communication with the server, a database of electronically encoded data, the data comprising embroidery patterns, the database in communication with the server, and responsive to the local node input, to retrieve embroidery patterns and to display the embroidery patterns through the server to the remote user, and an embroidery machine in communication with the server, the embroidery machine receiving embroidery patterns from the database through the server.
摘要:
A web server and a shared caching server are described for serving dynamic content to users of at least two different types, where the different types of users receive different versions of the dynamic content. A version of the dynamic content includes a validation header, such as an ETag, that stores information indicative of the currency of the dynamic content and information indicative of a user type for which the version of the dynamic content is intended. In response to a user request for the dynamic content, the shared caching server sends a validation request to the web server with the validation header information. The web server determines, based on the user type of the requestor and/or on the currency of the cached dynamic content whether to instruct the shared caching server to send the cached content or to send updated content for serving to the user.
摘要:
Disclosed is the three-dimensional (3-D) structure of the GLP-1 receptor (GLP-1R) and methods by which the structure may be used to develop compounds that bind to, and/or modulate the GLP-1R. The technology described herein may be applied to the development of compounds that target the GLP-1R, or may be used to develop target compound that may bind to, and/or modulate the activity of the GLP-1R.
摘要:
The present invention is directed to benzazole compounds that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved.
摘要:
Disclosed is the three-dimensional (3-D) structure of the GLP-1 receptor (GLP-1R) and methods by which the structure may be used to develop compounds that bind to, and/or modulate the GLP-1R. The technology described herein may be applied to the development of compounds that target the GLP-1R, or may be used to develop target compound that may bind to, and/or modulate the activity of the GLP-1R.
摘要:
The present invention is directed to benzazole compounds that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved.
摘要:
Embodiments of the present invention provide bissulfonamide compounds that are agonists of GalR1. The present invention further provides compositions comprising bissulfonamide compounds that are agonists of GalR1, and methods of use of such compounds and compositions.