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81 条记录 (耗时 0.036 秒)

    Controlled and directed local delivery of anti-inflammatory compositions
    11.
    发明申请
    Controlled and directed local delivery of anti-inflammatory compositions 审中-公开
    受控和定向的局部递送抗炎组合物

    公开(公告)号：US20060046960A1

    公开(公告)日：2006-03-02

    申请号：US10932878

    申请日：2004-09-02

    申请人： William McKay ,  John Zanella

    发明人： William McKay ,  John Zanella

    IPC分类号： A61K38/17

    CPC分类号： A61K9/0024 ,  A61K38/1709 ,  A61K38/1793 ,  A61K38/1875 ,  A61K2300/00

    摘要： The invention provides a method for alleviating pain associated with neuromuscular or skeletal injury or inflammation by controlled and directed delivery of one or more biological response modifiers to inhibit the inflammatory response which ultimately causes acute or chronic pain. Controlled and directed delivery can be provided by implantable or infusion pumps, implantable controlled release devices, or by sustained release compositions comprising biological response modifiers.

    摘要翻译： 本发明提供了一种通过控制和定向递送一种或多种生物反应调节剂以减轻最终引起急性或慢性疼痛的炎症反应来减轻与神经肌肉或骨骼损伤或炎症相关的疼痛的方法。 可以通过可植入或输注泵，可植入控制释放装置或包含生物反应调节剂的持续释放组合物来提供受控和定向递送。

    Motorized cleaning apparatus
    13.
    发明申请
    Motorized cleaning apparatus 失效
    电动清洁装置

    公开(公告)号：US20050091772A1

    公开(公告)日：2005-05-05

    申请号：US10755494

    申请日：2004-01-12

    申请人： William McKay

    发明人： William McKay

    IPC分类号： A46B13/00 ,  A46B13/02 ,  A46B13/04 ,  A47L1/02 ,  A47L11/02 ,  A47L17/00 ,  A47L23/02 ,  B05C1/00 ,  B05C17/02 ,  B44D5/00 ,  G03D5/06

    CPC分类号： A47L17/00 ,  A46B13/001

    摘要： A cleaning apparatus includes a handle, a support rotatably coupled to the handle for rotation by a drive motor mounted in the handle and a cleaning element mountable on the support. The cleaning element a flexible mat fixed about the support or about a core mountable on the support. An auxiliary cleaning element attachment may be mounted on the end wall of the support. A liquid container may be mounted in the support or used to form the support to dispense fluid to the cleaning element disposed about the support.

    摘要翻译： 清洁装置包括手柄，可旋转地联接到手柄以由安装在手柄中的驱动马达旋转的支撑件和可安装在支撑件上的清洁元件。 清洁元件是围绕支撑件固定的柔性垫，或围绕可安装在支撑件上的芯。 辅助清洁元件附件可以安装在支撑件的端壁上。 液体容器可以安装在支撑件中或用于形成支撑件以将流体分配到围绕支撑件设置的清洁元件。

    Dexamethasone Formulations in a Bioegradable Material
    15.
    发明申请
    Dexamethasone Formulations in a Bioegradable Material 有权
    生物可降解材料中的地塞米松配方

    公开(公告)号：US20090263455A1

    公开(公告)日：2009-10-22

    申请号：US12105864

    申请日：2008-04-18

    申请人： John Zanella ,  Vanja King ,  Christopher M. Hobot ,  Stephen M. Cox ,  William McKay ,  Kathy Remsen

    发明人： John Zanella ,  Vanja King ,  Christopher M. Hobot ,  Stephen M. Cox ,  William McKay ,  Kathy Remsen

    IPC分类号： A61K9/00 ,  A61P43/00

    CPC分类号： A61K31/573 ,  A61K9/0002 ,  A61K9/0024 ,  A61K47/10 ,  A61K47/26 ,  A61K47/34

    摘要： Effective treatments of acute pain for extended periods of time are provided. Through the administration of an effective amount of dexamethasone at or near a target site, one can relieve pain cause by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least twenty-five days. In some embodiments, the relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

    摘要翻译： 提供了长期急性疼痛的有效治疗方法。 通过在目标部位或附近施用有效量的地塞米松，可以减轻不同来源的疼痛，包括但不限于椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛 作为手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少二十五天。 在一些实施例中，浮雕可以是至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

    Compositions comprising biomembrane sealing agent for treatment of pain or inflammation, and methods of use
    18.
    发明申请
    Compositions comprising biomembrane sealing agent for treatment of pain or inflammation, and methods of use 有权
    包含用于治疗疼痛或炎症的生物膜密封剂的组合物和使用方法

    公开(公告)号：US20070258938A1

    公开(公告)日：2007-11-08

    申请号：US11418153

    申请日：2006-05-03

    申请人： Josee Roy ,  William McKay ,  Jeffrey Marx

    发明人： Josee Roy ,  William McKay ,  Jeffrey Marx

    IPC分类号： A61K31/787 ,  A61K31/717 ,  A61K31/765

    CPC分类号： A61K33/14 ,  A61K9/0019 ,  A61K9/0085 ,  A61K31/717 ,  A61K31/765 ,  A61K31/787 ,  A61K33/06 ,  A61K2300/00

    摘要： The invention provides methods and kits for treatment of pain or inflammation. In one embodiment, the kit comprises a biomembrane sealing agent, such as PEG, and a bioactive agent, such as a magnesium compound. The biomembrane sealing agent and/or the bioactive agent an intravenous administration, an intramuscular administration, an intrathecal administration, a subcutaneous administration, an epidural administration, a parenteral administration, an intra-articular administration, a direct application onto or adjacent to a site of the pathological condition, and any combinations thereof. Alternatively, the biomembrane sealing agent and/or the bioactive agent may be delivered from a pump or an implant.

    摘要翻译： 本发明提供了治疗疼痛或炎症的方法和试剂盒。 在一个实施方案中，试剂盒包括生物膜密封剂，例如PEG，以及生物活性剂，例如镁化合物。 生物膜密封剂和/或生物活性剂，静脉内给药，肌内给药，鞘内给药，皮下给药，硬膜外给药，胃肠外给药，关节内给药，直接施用于或邻近 病理状况及其任何组合。 或者，生物膜密封剂和/或生物活性剂可以从泵或植入物递送。

    Facet fusion implants and methods of use
    19.
    发明申请
    Facet fusion implants and methods of use 审中-公开
    方面融合植入物和使用方法

    公开(公告)号：US20070250166A1

    公开(公告)日：2007-10-25

    申请号：US11410803

    申请日：2006-04-25

    申请人： William McKay

    发明人： William McKay

    IPC分类号： A61F2/44

    CPC分类号： A61B17/7064

    摘要： An implant is insertable onto a vertebral facet joint includes a body with an inner surface that mates with one or both articular processes of the facet joint. The inner surface may define an interior cavity that accepts at least a portion of an inferior articular process and a superior articular process forming the facet joint. The body may be constructed of a bone growth material that fuses with the articular processes. The implant may help retain bone growth promoting substance that is inserted between or on articulating surfaces of the facet joint. A receiving portion of an exterior surface of one or both articular process may be prepared to stimulate bone growth. The implant may be placed onto the receiving portion to cover an exterior junction between or on the articulating surfaces of the facet joint. The implant may be secured to one or both of the articular processes.

    摘要翻译： 植入物可插入到椎骨小关节中，包括具有与小关节的一个或两个关节过程相配合的内表面的主体。 内表面可以限定内腔，其接受下关节进程的至少一部分和形成小关节的上关节进程。 身体可以由与关节进程融合的骨生长材料构成。 植入物可以帮助保留插入在小关节的关节表面之间或之上的骨生长促进物质。 可以制备一个或两个关节过程的外表面的接收部分以刺激骨生长。 植入物可以放置在接收部分上以覆盖小面关节的关节表面之间或之上的外部连接。 植入物可以固定在一个或两个关节突的过程中。