公开(公告)号：US20060194264A1

公开(公告)日：2006-08-31

申请号：US11247080

申请日：2005-10-11

申请人： Norman Sheppard ,  Alec Mian ,  Gregory Kellogg ,  Stephen Kieffer-Higgins ,  Bruce Carvalho

发明人： Norman Sheppard ,  Alec Mian ,  Gregory Kellogg ,  Stephen Kieffer-Higgins ,  Bruce Carvalho

IPC分类号： G01N33/542 ,  C12M1/34

CPC分类号： G01N35/00069 ,  A61K38/00 ,  B01F13/0059 ,  B01F15/0233 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/00 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2300/021 ,  B01L2300/024 ,  B01L2300/069 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/168 ,  B01L2300/1805 ,  B01L2300/1861 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0661 ,  B01L2400/0677 ,  C07K14/79 ,  C12N9/2462 ,  G01N15/14 ,  G01N21/07 ,  G01N33/54366 ,  G01N33/569 ,  G01N33/68 ,  Y10S366/03 ,  Y10T436/111666 ,  Y10T436/25375 ,  Y10T436/2575

摘要： This invention provides methods and apparatus for detecting and quantifying particulate matter suspended in a fluid. Specifically, the invention provides an integrated, affinity-binding based, analytical system comprising a platform for performing an affinity-binding based assay for specifically binding particulates including microbial cells, and a detection means for detecting the particulates specifically bound to a defined surface or chamber comprising the platform. Methods for using the analytical systems of the invention are also provided.

摘要翻译： 本发明提供了用于检测和定量悬浮在流体中的颗粒物质的方法和装置。 具体地，本发明提供了一种基于亲和力结合的集成分析系统，其包括用于进行用于特异性结合包含微生物细胞的微粒的基于亲和力结合的测定的平台和用于检测特异性结合到限定表面或室的微粒的检测装置 包括平台。 还提供了使用本发明的分析系统的方法。

公开(公告)号：US20060115323A1

公开(公告)日：2006-06-01

申请号：US11267541

申请日：2005-11-04

申请人： Jonathan Coppeta ,  Kurt Shelton ,  Norman Sheppard ,  Douglas Snell ,  Catherine Santini

发明人： Jonathan Coppeta ,  Kurt Shelton ,  Norman Sheppard ,  Douglas Snell ,  Catherine Santini

IPC分类号： F16B11/00

CPC分类号： B81C1/00269 ,  A61K9/0097 ,  A61M5/14276 ,  A61M2205/0244 ,  A61M2207/00 ,  B23K20/02 ,  B33Y80/00 ,  B81B2201/06 ,  B81C1/00047 ,  B81C1/00095 ,  B81C2203/0109 ,  B81C2203/019 ,  B81C2203/038 ,  F16B4/004 ,  F16B5/08 ,  F16B11/004 ,  H01L23/10 ,  H01L23/3142 ,  H01L2224/05001 ,  H01L2224/05023 ,  H01L2224/051 ,  H01L2224/05568 ,  H01L2224/056 ,  H01L2224/16237 ,  H01L2224/81193 ,  H01L2924/01322 ,  H01L2924/10253 ,  H01L2924/1461 ,  H01L2924/16315 ,  Y10T403/477 ,  H01L2924/00 ,  H01L2924/00014

摘要： Compression cold welding methods, joint structures, and hermetically sealed containment devices are provided. The method includes providing a first substrate having at least one first joint structure which comprises a first joining surface, which surface comprises a first metal; providing a second substrate having at least one second joint structure which comprises a second joining surface, which surface comprises a second metal; and compressing together the at least one first joint structure and the at least one second joint structure to locally deform and shear the joining surfaces at one or more interfaces in an amount effective to form a metal-to-metal bond between the first metal and second metal of the joining surfaces. Overlaps at the joining surfaces are effective to displace surface contaminants and facilitate intimate contact between the joining surfaces without heat input. Hermetically sealed devices can contain drug formulations, biosensors, or MEMS devices.

摘要翻译： 提供压缩冷焊方法，接头结构和密封的密封装置。 该方法包括提供具有至少一个第一接头结构的第一基底，该第一接合结构包括第一接合表面，该表面包括第一金属; 提供具有至少一个第二接头结构的第二基底，所述第二接头结构包括第二接合表面，所述表面包括第二金属; 以及将所述至少一个第一接合结构和所述至少一个第二接头结构压在一起，以在一个或多个界面上局部变形和剪切所述接合表面，所述接合面有效地在所述第一金属和所述第二接头结构之间形成金属与金属之间的接合 金属的接合面。 在接合表面上的重叠有效地移动表面污染物并促进接合表面之间的紧密接触而不需要热量输入。 密封装置可以包含药物制剂，生物传感器或MEMS装置。

公开(公告)号：US20060100608A1

公开(公告)日：2006-05-11

申请号：US11259301

申请日：2005-10-26

申请人： Scott Uhland ,  Benjamin Polito ,  John Maloney ,  Norman Sheppard ,  Stephen Herman ,  Barry Yomtov

发明人： Scott Uhland ,  Benjamin Polito ,  John Maloney ,  Norman Sheppard ,  Stephen Herman ,  Barry Yomtov

IPC分类号： A61K9/22

CPC分类号： A61M25/0082 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/4839 ,  A61M5/14276 ,  A61M25/0069 ,  A61M37/00 ,  A61M2005/1726 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/3653 ,  A61N1/32 ,  Y10T436/25

摘要： Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents exposure of the reservoir contents to molecules outside of the device; an electrical input lead connected to said reservoir cap; and an electrical output lead connected to said reservoir cap, such that upon application of an electrical current through the reservoir cap, via the input lead and output lead, the reservoir cap ruptures to release or expose the reservoir contents. The reservoir contents can comprise a release system containing drug molecules for release or can comprise a secondary device, such as a sensor. In one embodiment, the controlled release system is incorporated into an implantable drug delivery device.