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公开(公告)号：US20060194264A1
公开(公告)日：2006-08-31
申请号：US11247080
申请日：2005-10-11
IPC分类号： G01N33/542 , C12M1/34
CPC分类号： G01N35/00069 , A61K38/00 , B01F13/0059 , B01F15/0233 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L2200/0605 , B01L2200/10 , B01L2300/021 , B01L2300/024 , B01L2300/069 , B01L2300/0806 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/168 , B01L2300/1805 , B01L2300/1861 , B01L2400/0406 , B01L2400/0409 , B01L2400/0661 , B01L2400/0677 , C07K14/79 , C12N9/2462 , G01N15/14 , G01N21/07 , G01N33/54366 , G01N33/569 , G01N33/68 , Y10S366/03 , Y10T436/111666 , Y10T436/25375 , Y10T436/2575
摘要： This invention provides methods and apparatus for detecting and quantifying particulate matter suspended in a fluid. Specifically, the invention provides an integrated, affinity-binding based, analytical system comprising a platform for performing an affinity-binding based assay for specifically binding particulates including microbial cells, and a detection means for detecting the particulates specifically bound to a defined surface or chamber comprising the platform. Methods for using the analytical systems of the invention are also provided.
摘要翻译： 本发明提供了用于检测和定量悬浮在流体中的颗粒物质的方法和装置。 具体地，本发明提供了一种基于亲和力结合的集成分析系统，其包括用于进行用于特异性结合包含微生物细胞的微粒的基于亲和力结合的测定的平台和用于检测特异性结合到限定表面或室的微粒的检测装置 包括平台。 还提供了使用本发明的分析系统的方法。
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公开(公告)号：US06656430B2
公开(公告)日：2003-12-02
申请号：US09989259
申请日：2001-11-20
申请人： Norman F. Sheppard, Jr. , Alec Mian , Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho
发明人： Norman F. Sheppard, Jr. , Alec Mian , Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho
IPC分类号： G01N2100
CPC分类号： G01N35/00069 , A61K38/00 , B01F13/0059 , B01F15/0233 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L2200/0605 , B01L2200/10 , B01L2300/021 , B01L2300/024 , B01L2300/069 , B01L2300/0806 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/168 , B01L2300/1805 , B01L2300/1861 , B01L2400/0406 , B01L2400/0409 , B01L2400/0661 , B01L2400/0677 , C07K14/79 , C12N9/2462 , G01N15/14 , G01N21/07 , G01N33/54366 , G01N33/569 , G01N33/68 , Y10S366/03 , Y10T436/111666 , Y10T436/25375 , Y10T436/2575
摘要： This invention provides methods an apparatus for detecting and quantifying particulate matter suspended in a fluid. Specifically, the invention provides an integrated, affinity-binding based, analytical system comprising a platform for performing an affinity-binding based assay for specifically binding particulates including microbial cells, and a detection means for detecting the particulates specifically bound to a defined surface or chamber comprising the platform. Methods for using the analytical systems of the invention are also provided.
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3.发明授权Device and method for using centripetal acceleration to device fluid movement on a microfluidics system 失效在微流体系统上使用向心加速装置流体移动的装置和方法公开(公告)号：US06302134B1
公开(公告)日：2001-10-16
申请号：US09526496
申请日：2000-03-15
申请人： Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho , Gene A. Davis , John P. Willis , Ted Minior , Laura L. Chapman , Mikayla Kob , Sarah D. Oeltjen , Shari Ommert , Alec Mian
发明人： Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho , Gene A. Davis , John P. Willis , Ted Minior , Laura L. Chapman , Mikayla Kob , Sarah D. Oeltjen , Shari Ommert , Alec Mian
IPC分类号： F16K3102
CPC分类号： H01R39/64 , B01F13/0059 , B01F15/0232 , B01F15/0233 , B01F2215/0037 , B01F2215/0073 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L7/00 , B01L7/52 , B01L9/527 , B01L2200/02 , B01L2200/0605 , B01L2200/0621 , B01L2200/10 , B01L2300/023 , B01L2300/0645 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/1827 , B01L2300/1838 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/0421 , B01L2400/0633 , B01L2400/0661 , B01L2400/0677 , B01L2400/0688 , F16K31/002 , G01N21/07 , G01N35/00069 , H01C17/06586 , Y10S366/03 , Y10S464/90 , Y10T137/1797 , Y10T137/1812 , Y10T137/4643
摘要： This invention provides methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. Specifically, the invention provides a microsystem platform for use with a micromanipulation device to manipulate the platform by rotation, thereby utilizing the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels embedded in the microplatform. The microsystem platforms of the invention are also provided having microfluidics components, resistive heating elements, temperature sensing elements, mixing structures, capillary and sacrificial valves, and methods for using these microsystems platforms for performing biological, enzymatic, immunological and chemical assays. An electronic spindle designed rotor capable of transferring electrical signals to and from the microsystem platforms of the invention is also provided.
摘要翻译： 本发明提供了用于进行微量分析和微合成分析和方法的方法和装置。 具体而言，本发明提供了一种微系统平台，用于与微操纵装置一起通过旋转来操纵平台，由此利用由平台的旋转产生的向心力，以激励通过嵌入在微平台中的微通道的流体运动。 还提供了本发明的微系统平台，其具有微流体组件，电阻加热元件，温度感测元件，混合结构，毛细管和牺牲阀，以及使用这些微系统平台进行生物，酶，免疫学和化学测定的方法。 还提供了一种能够向本发明的微系统平台传送电信号的电子主轴设计的转子。
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4.发明授权Devices and methods for using centripetal acceleration to drive fluid movement on a microfluidics system 失效使用向心加速度驱动微流体系统上的流体运动的装置和方法
公开(公告)号：US6063589A
公开(公告)日：2000-05-16
申请号：US83678
申请日：1998-05-22
申请人： Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho , Gene A. Davis , John P. Willis , Ted Minior , Laura L. Chapman , Mikayla Kob , Sarah D. Oeltjen , Shari Ommert , Alec Mian
发明人： Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho , Gene A. Davis , John P. Willis , Ted Minior , Laura L. Chapman , Mikayla Kob , Sarah D. Oeltjen , Shari Ommert , Alec Mian
IPC分类号： G01N33/48 , B01F13/00 , B01L3/00 , B01L7/00 , B01L9/00 , B81B1/00 , B81B7/04 , F16K13/10 , F16K31/00 , G01N1/10 , G01N21/07 , G01N31/20 , G01N33/483 , G01N35/00 , G01N37/00 , H01C17/06 , H01C17/065 , H01R39/64 , C12Q1/37
CPC分类号： H01R39/64 , B01F13/0059 , B01F15/0232 , B01F15/0233 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L7/52 , F16K31/002 , G01N21/07 , G01N35/00069 , H01C17/06586 , B01F2215/0037 , B01F2215/0073 , B01L2200/02 , B01L2200/0605 , B01L2200/0621 , B01L2200/10 , B01L2300/023 , B01L2300/0645 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/1827 , B01L2300/1838 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/0421 , B01L2400/0633 , B01L2400/0661 , B01L2400/0677 , B01L2400/0688 , B01L3/5025 , B01L3/502707 , B01L3/502753 , B01L9/527 , Y10S366/03 , Y10S464/90 , Y10T137/1797 , Y10T137/1812 , Y10T137/4643
摘要： This invention provides methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. Specifically, the invention provides a microsystem platform for use with a micromanipulation device to manipulate the platform by rotation, thereby utilizing the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels embedded in the microplatform. The microsystem platforms of the invention are also provided having microfluidics components, resistive heating elements, temperature sensing elements, mixing structures, capillary and sacrificial valves, and methods for using these microsystems platforms for performing biological, enzymatic, immunological and chemical assays. An electronic spindle designed rotor capable of transferring electrical signals to and from the microsystem platforms of the invention is also provided.
摘要翻译： 本发明提供了用于进行微量分析和微合成分析和方法的方法和装置。 具体而言，本发明提供了一种微系统平台，用于与微操纵装置一起通过旋转来操纵平台，由此利用由平台的旋转产生的向心力，以激励通过嵌入在微平台中的微通道的流体运动。 还提供了本发明的微系统平台，其具有微流体组件，电阻加热元件，温度感测元件，混合结构，毛细管和牺牲阀，以及使用这些微系统平台进行生物，酶，免疫学和化学测定的方法。 还提供了一种能够向本发明的微系统平台传送电信号的电子主轴设计的转子。
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5.发明授权公开(公告)号：US06953550B2
公开(公告)日：2005-10-11
申请号：US10726337
申请日：2003-11-30
申请人： Norman F. Sheppard, Jr. , Alec Mian , Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho
发明人： Norman F. Sheppard, Jr. , Alec Mian , Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho
IPC分类号： A61K38/00 , B01F13/00 , B01L3/00 , C07K14/79 , C12N9/36 , G01N15/14 , G01N21/07 , G01N33/543 , G01N33/68 , G01N35/00 , G01N21/00
CPC分类号： G01N35/00069 , A61K38/00 , B01F13/0059 , B01F15/0233 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L2200/0605 , B01L2200/10 , B01L2300/021 , B01L2300/024 , B01L2300/069 , B01L2300/0806 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/168 , B01L2300/1805 , B01L2300/1861 , B01L2400/0406 , B01L2400/0409 , B01L2400/0661 , B01L2400/0677 , C07K14/79 , C12N9/2462 , G01N15/14 , G01N21/07 , G01N33/54366 , G01N33/569 , G01N33/68 , Y10S366/03 , Y10T436/111666 , Y10T436/25375 , Y10T436/2575
摘要： This invention provides methods and apparatus for detecting and quantifying particulate matter suspended in a fluid. Specifically, the invention provides an integrated, affinity-binding based, analytical system comprising a platform for performing an affinity-binding based assay for specifically binding particulates including microbial cells, and a detection means for detecting the particulates specifically bound to a defined surface or chamber comprising the platform. Methods for using the analytical systems of the invention are also provided.
摘要翻译： 本发明提供了用于检测和定量悬浮在流体中的颗粒物质的方法和设备。 具体地，本发明提供了一种基于亲和力结合的集成分析系统，其包括用于进行用于特异性结合包含微生物细胞的微粒的基于亲和力结合的测定的平台和用于检测特异性结合到限定表面或室的微粒的检测装置 包括平台。 还提供了使用本发明的分析系统的方法。
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公开(公告)号：US6143247A
公开(公告)日：2000-11-07
申请号：US995056
申请日：1997-12-19
申请人： Norman F. Sheppard, Jr. , Alec Mian , Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho
发明人： Norman F. Sheppard, Jr. , Alec Mian , Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho
IPC分类号： A61K38/00 , B01F13/00 , B01L3/00 , C07K14/79 , C12N9/36 , G01N15/14 , G01N21/07 , G01N33/543 , G01N33/68 , G01N35/00 , G01N9/30 , B01D33/00 , B01L11/00
CPC分类号： G01N35/00069 , B01F13/0059 , B01F15/0233 , B01L3/5027 , C07K14/79 , C12N9/2462 , G01N21/07 , G01N33/54366 , G01N33/569 , G01N33/68 , A61K38/00 , B01L2200/0605 , B01L2200/10 , B01L2300/021 , B01L2300/024 , B01L2300/069 , B01L2300/0806 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/168 , B01L2300/1805 , B01L2300/1861 , B01L2400/0406 , B01L2400/0409 , B01L2400/0661 , B01L2400/0677 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/00 , G01N15/14 , Y10S366/03 , Y10T436/111666 , Y10T436/25375 , Y10T436/2575
摘要： This invention provides methods an apparatus for detecting and quantifying particulate matter suspended in a fluid. Specifically, the invention provides an integrated, affinity-binding based, analytical system comprising a platform for performing an affinity-binding based assay for specifically binding particulates including microbial cells, and a detection means for detecting the particulates specifically bound to a defined surface or chamber comprising the platform. Methods for using the analytical systems of the invention are also provided.
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7.发明授权Electronic spindle for using centripetal acceleration to drive fluid movement in a microfluidics system 失效用于使用向心加速度驱动微流体系统中的流体运动的电子主轴公开(公告)号：US06719682B2
公开(公告)日：2004-04-13
申请号：US10414536
申请日：2003-04-15
申请人： Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho , Gene A. Davis , John P. Willis , Ted Minior , Laura L. Chapman , Mikayla Kob , Sarah D. Oeltjen , Shari Ommert , Alec Mian
发明人： Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho , Gene A. Davis , John P. Willis , Ted Minior , Laura L. Chapman , Mikayla Kob , Sarah D. Oeltjen , Shari Ommert , Alec Mian
IPC分类号： B04B900
CPC分类号： H01R39/64 , B01F13/0059 , B01F15/0232 , B01F15/0233 , B01F2215/0037 , B01F2215/0073 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L7/00 , B01L7/52 , B01L9/527 , B01L2200/02 , B01L2200/0605 , B01L2200/0621 , B01L2200/10 , B01L2300/023 , B01L2300/0645 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/1827 , B01L2300/1838 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/0421 , B01L2400/0633 , B01L2400/0661 , B01L2400/0677 , B01L2400/0688 , F16K31/002 , G01N21/07 , G01N35/00069 , H01C17/06586 , Y10S366/03 , Y10S464/90 , Y10T137/1797 , Y10T137/1812 , Y10T137/4643
摘要： This invention provides methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. Specifically, the invention provides a microsystem platform for use with a micromanipulation device to manipulate the platform by rotation, thereby utilizing the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels embedded in the microplatform. The microsystem platforms of the invention are also provided having microfluidics components, resistive heating elements, temperature sensing elements, mixing structures, capillary and sacrificial valves, and methods for using these microsystems platforms for performing biological, enzymatic, immunological and chemical assays. An electronic spindle designed rotor capable of transferring electrical signals to and from the microsystem platforms of the invention is also provided.
摘要翻译： 本发明提供了用于进行微量分析和微合成分析和方法的方法和装置。 具体而言，本发明提供了一种微系统平台，用于与微操纵装置一起通过旋转来操纵平台，由此利用由平台的旋转产生的向心力，以激励通过嵌入在微平台中的微通道的流体运动。 还提供了本发明的微系统平台，其具有微流体组件，电阻加热元件，温度感测元件，混合结构，毛细管和牺牲阀，以及使用这些微系统平台进行生物，酶，免疫学和化学测定的方法。 还提供了一种能够向本发明的微系统平台传送电信号的电子主轴设计的转子。
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8.发明授权公开(公告)号：US06319468B1
公开(公告)日：2001-11-20
申请号：US09614834
申请日：2000-07-12
申请人： Norman F. Sheppard, Jr. , Alec Mian , Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho
发明人： Norman F. Sheppard, Jr. , Alec Mian , Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho
IPC分类号： G01N930
CPC分类号： G01N35/00069 , A61K38/00 , B01F13/0059 , B01F15/0233 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L2200/0605 , B01L2200/10 , B01L2300/021 , B01L2300/024 , B01L2300/069 , B01L2300/0806 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/168 , B01L2300/1805 , B01L2300/1861 , B01L2400/0406 , B01L2400/0409 , B01L2400/0661 , B01L2400/0677 , C07K14/79 , C12N9/2462 , G01N15/14 , G01N21/07 , G01N33/54366 , G01N33/569 , G01N33/68 , Y10S366/03 , Y10T436/111666 , Y10T436/25375 , Y10T436/2575
摘要： This invention provides methods and apparatus for detecting and quantifying particulate matter suspended in a fluid. Specifically, the invention provides an integrated, affinity-binding based, analytical system comprising a platform for performing an affinity-binding based assay for specifically binding particulates including microbial cells, and a detection device for detecting the particulates specifically bound to a defined surface or chamber comprising the platform. Methods for using the analytical systems of the invention are also provided.
摘要翻译： 本发明提供了用于检测和定量悬浮在流体中的颗粒物质的方法和装置。 具体地，本发明提供了一种基于亲和力结合的集成分析系统，其包括用于进行用于特异性结合包含微生物细胞的微粒的基于亲和力结合的测定的平台和用于检测特异性结合到限定表面或室的微粒的检测装置 包括平台。 还提供了使用本发明的分析系统的方法。
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9.发明授权Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system 失效使用向心加速度驱动微流体系统中的流体运动的装置和方法公开(公告)号：US06548788B2
公开(公告)日：2003-04-15
申请号：US09981007
申请日：2001-10-16
申请人： Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho , Gene A. Davis , John P. Willis , Ted Minior , Laura L. Chapman , Mikayla Kob , Sarah D. Oeltjen , Shari Ommert , Alec Mian
发明人： Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho , Gene A. Davis , John P. Willis , Ted Minior , Laura L. Chapman , Mikayla Kob , Sarah D. Oeltjen , Shari Ommert , Alec Mian
IPC分类号： H05B316
CPC分类号： H01R39/64 , B01F13/0059 , B01F15/0232 , B01F15/0233 , B01F2215/0037 , B01F2215/0073 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L7/00 , B01L7/52 , B01L9/527 , B01L2200/02 , B01L2200/0605 , B01L2200/0621 , B01L2200/10 , B01L2300/023 , B01L2300/0645 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/1827 , B01L2300/1838 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/0421 , B01L2400/0633 , B01L2400/0661 , B01L2400/0677 , B01L2400/0688 , F16K31/002 , G01N21/07 , G01N35/00069 , H01C17/06586 , Y10S366/03 , Y10S464/90 , Y10T137/1797 , Y10T137/1812 , Y10T137/4643
摘要： This system provides methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. Specifically, the system provides a microsystem platform for use with a micromanipulation device to manipulate the platform by rotation, thereby utilizing the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels embedded in the microplatform. The microsystem platforms of the system are also provided having microfluidics components, resistive heating elements, temperature sensing elements, mixing structures, capillary and sacrificial valves, and methods for using these microsystems platforms for performing biological, enzymatic, immunological and chemical assays. An electronic spindle designed rotor capable of transferring electrical signals to and from the microsystem platforms of the system is also provided.
摘要翻译： 该系统提供了执行微量分析和微合成分析和程序的方法和装置。 具体地，该系统提供了一个微系统平台，用于与微操纵装置一起通过旋转来操纵平台，从而利用由平台的旋转产生的向心力，以通过嵌入在微平台中的微通道来激发流体运动。 还提供了具有微流体组件，电阻加热元件，温度感测元件，混合结构，毛细管和牺牲阀的系统的微系统平台，以及使用这些微系统平台进行生物，酶，免疫和化学测定的方法。 还提供了一种能够向系统的微系统平台传送电信号的电子主轴设计的转子。
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公开(公告)号：US6143248A
公开(公告)日：2000-11-07
申请号：US910726
申请日：1997-08-12
IPC分类号： B01F5/04 , B01F13/00 , B01J19/00 , B01L3/00 , B29C59/14 , F15C1/00 , F15C5/00 , F16K99/00 , G01N21/07 , G01N27/447 , G01N30/20 , G01N30/32 , G01N30/60 , G01N33/487 , G01N35/00 , G01N9/30
CPC分类号： B01L3/502715 , B01F13/00 , B01F13/0059 , B01F15/0233 , B01F15/026 , B01J19/0093 , B01L3/502738 , B29C59/14 , F15C1/005 , F15C5/00 , F16K99/0001 , F16K99/0017 , F16K99/0057 , G01N21/07 , G01N27/44704 , G01N27/44791 , G01N35/00069 , G01N35/00732 , G01N35/00871 , B01F2215/0037 , B01F5/0403 , B01J2219/00891 , B01J2219/0097 , B01L2200/0605 , B01L2200/10 , B01L2300/0806 , B01L2300/087 , B01L2300/165 , B01L2400/0409 , B01L2400/0688 , B29C59/142 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , G01N2030/326 , G01N2035/00782 , G01N30/20 , G01N30/6095 , Y10T436/111666
摘要： The invention provides microvalves for controlling fluid flow from microreservoirs into transfer channels using capillary valving mechanisms for use in apparatus useful for performing microanalytic and microsynthetic analyses and procedures, such as microminiaturization of genetic, biochemical and chemical processes related to analysis, synthesis and purification of biological, chemical, environmental and other compounds.
摘要翻译： 本发明提供用于控制流体从微储层流入转移通道的微型阀，其使用用于执行微量分析和微合成分析和程序的设备中使用的设备，所述装置用于与生物分析，合成和纯化相关的遗传，生化和化学过程的微小化 ，化学，环保等化合物。
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