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公开(公告)号：US20110223621A1
公开(公告)日：2011-09-15
申请号：US13048587
申请日：2011-03-15
申请人： Curtis Keith , Alexis Borisy , Grant Zimmermann , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole W. Hurst , Michael A. Foley
发明人： Curtis Keith , Alexis Borisy , Grant Zimmermann , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole W. Hurst , Michael A. Foley
IPC分类号： G01N33/566 , C12N5/078
CPC分类号： A61K45/06 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/675 , A61K2300/00
摘要： The invention features pharmaceutical compositions that include dipyridamole and a corticosteroid.
摘要翻译： 本发明的特征在于药物组合物，其包括双嘧达莫和皮质类固醇。
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12.发明授权Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders 失效组合氯丙嗪和喷他脒治疗肿瘤性疾病公开(公告)号：US06569853B1
公开(公告)日：2003-05-27
申请号：US09706929
申请日：2000-11-06
IPC分类号： A61K3154
CPC分类号： A61K45/06 , A61K31/155 , A61K31/495 , A61K31/54 , A61K31/5415 , A61K31/135 , A61K2300/00
摘要： The invention features a method for treating a patient having a cancer or other neoplasm, by administering to the patient (i) chlorpromazine or a metabolite or analog thereof; and (ii) pentamidine or a metabolite or analog thereof simultaneously or within 14 days of each other in amounts sufficient to inhibit the growth of the neoplasm.
摘要翻译： 本发明的特征在于通过给予患者（i）氯丙嗪或其代谢物或类似物来治疗患有癌症或其他肿瘤的患者的方法; 和（ii）戊脒或其代谢物或类似物同时或彼此之间的14天内以足以抑制肿瘤生长的量。
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13.发明申请公开(公告)号：US20120058979A1
公开(公告)日：2012-03-08
申请号：US13292669
申请日：2011-11-09
申请人： Curtis Keith , Alexis Borisy , Grant R. Zimmermann , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael A. Foley , Michael S. Slavonic , Brendan Smith , Benjamin A. Auspitz
发明人： Curtis Keith , Alexis Borisy , Grant R. Zimmermann , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael A. Foley , Michael S. Slavonic , Brendan Smith , Benjamin A. Auspitz
IPC分类号： A61K31/573 , A61P37/06 , A61K31/575 , A61K31/568 , A61K31/58 , A61K31/57
CPC分类号： A61K31/565 , A61K9/0073 , A61K9/209 , A61K31/519 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.
摘要翻译： 本发明的特征在于一种通过向患者施用四取代的嘧啶并嘧啶，单独或与一种或多种另外的试剂组合来治疗诊断患有或有发展为免疫炎性疾病风险的患者的方法。 本发明还特征在于含有四取代的嘧啶并嘧啶与一种或多种另外的试剂组合的组合物。
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公开(公告)号：US20100009970A1
公开(公告)日：2010-01-14
申请号：US12406626
申请日：2009-03-18
申请人： Lisa M. Johansen , Christopher M. Owens , Christina Mawhinney , Todd W. Chappell , Alexander T. Brown , Michael G. Frank , Michael A. Foley , Ralf Altmeyer , Yu Chen
发明人： Lisa M. Johansen , Christopher M. Owens , Christina Mawhinney , Todd W. Chappell , Alexander T. Brown , Michael G. Frank , Michael A. Foley , Ralf Altmeyer , Yu Chen
IPC分类号： A61K31/136 , A61K31/404 , A61K31/366 , A61K31/505 , A61K31/495 , C07C211/33 , C07C217/56 , A61P25/00 , A61K31/445 , A61K31/551 , A61K31/5375 , A61K31/4965
CPC分类号： A61K31/136 , A61K31/366 , A61K31/404 , A61K31/445 , A61K31/495 , A61K31/4965 , A61K31/505 , A61K31/5375 , A61K31/551 , A61K45/06 , C07C211/33 , C07C217/56 , Y02A50/463 , A61K2300/00
摘要： The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E) and the agent or combination of agents includes sertraline, a sertraline analog, UK-416244, or a UK-416244 analog. Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.
摘要翻译： 本发明的特征在于可用于治疗病毒性疾病的组合物，方法和试剂盒。 在某些实施方案中，病毒性疾病由单链RNA病毒，黄病毒科病毒或肝病毒引起。 在具体实施方案中，病毒性疾病是病毒性肝炎（例如，甲型肝炎，乙型肝炎，丙型肝炎，丙型肝炎，戊型肝炎），并且药剂或药剂组合包括舍曲林，舍曲林类似物，UK-416244或UK- 416244模拟。 还特征在于鉴定可用于治疗病毒性疾病的新化合物的筛选方法。
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公开(公告)号：USD525394S1
公开(公告)日：2006-07-18
申请号：US29189650
申请日：2003-09-08
申请人： Kenneth S. Litke , Michael A. Foley
设计人： Kenneth S. Litke , Michael A. Foley
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16.发明授权Synthesis of combinatorial libraries of compounds reminiscent of natural products 失效化合物组合文库的合成使人联想到天然产物公开(公告)号：US06448443B1
公开(公告)日：2002-09-10
申请号：US09121922
申请日：1998-07-25
IPC分类号： G01N3353
CPC分类号： C07D307/33 , B01J19/0046 , B01J2219/00317 , B01J2219/00364 , B01J2219/00367 , B01J2219/005 , B01J2219/00511 , B01J2219/00531 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/0065 , B01J2219/00659 , B01J2219/00702 , C07C227/10 , C07C231/12 , C07C235/40 , C07C237/20 , C07C237/24 , C07C247/14 , C07C2601/14 , C07C2601/16 , C07D261/20 , C07D493/04 , C40B40/00 , C40B60/14 , C40B80/00 , G01N33/50 , Y10S435/975 , C07C229/34
摘要： The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.
摘要翻译： 本发明提供了使人想起天然产物及其文库的复杂化合物，以及它们生产的方法。 本发明化合物和化合物文库使人联想到天然产物，因为它们含有一种或多种立体中心，并且具有高密度和多样性的功能。 通常，本发明的文库由可分散的支架结构合成，其由易得的或易于合成的模板结构合成。 在某些实施方案中，本发明化合物和文库是由莽草酸基环氧树脂模板合成的可分散支架产生的。 在其它实施方案中，本发明的化合物和文库由从基于吡啶的模板异烟酰胺合成的可分散的支架产生。 本发明还提供了一种新的邻硝基苄基光接枝剂及其合成方法。 此外，本发明提供了用于确定本发明文库成员的一种或多种生物活性的方法和试剂盒。 另外，本发明提供含有一个或多个文库成员的药物组合物。
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公开(公告)号：US08080553B2
公开(公告)日：2011-12-20
申请号：US11517593
申请日：2006-09-07
申请人： Curtis Keith , Alexis Borisy , Grant R. Zimmermann , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael A. Foley , Michael S. Slavonic , Brendan Smith , Benjamin A. Auspitz
发明人： Curtis Keith , Alexis Borisy , Grant R. Zimmermann , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael A. Foley , Michael S. Slavonic , Brendan Smith , Benjamin A. Auspitz
IPC分类号： A01N43/54 , A01N43/90 , A61K31/517 , A61K31/519 , C07D239/42 , C07D401/04
CPC分类号： A61K31/565 , A61K9/0073 , A61K9/209 , A61K31/519 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.
摘要翻译： 本发明的特征在于一种通过向患者施用四取代的嘧啶并嘧啶，单独或与一种或多种另外的试剂组合来治疗诊断患有或有风险发展免疫炎性疾病的患者的方法。 本发明还特征在于含有四取代的嘧啶并嘧啶与一种或多种另外的试剂组合的组合物。
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公开(公告)号：US07253155B2
公开(公告)日：2007-08-07
申请号：US10264991
申请日：2002-10-04
申请人： Curtis Keith , Alexis Borisy , Grant Zimmerman , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael A. Foley
发明人： Curtis Keith , Alexis Borisy , Grant Zimmerman , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael A. Foley
IPC分类号： A61K31/56 , A61K31/517
CPC分类号： A61K45/06 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/675 , A61K2300/00
摘要： The invention features a method for treating a patient having an immunoinflammatory disorder, by administering to the patient (i) a tetra-substituted pyrimidopyrimidine, and (ii) a corticosteroid simultaneously or within 14 days of each other in amounts sufficient to reduce or inhibit immunoinflammation.
摘要翻译： 本发明的特征在于一种治疗具有免疫炎症病症的患者的方法，其通过给予患者（i）四取代的嘧啶并嘧啶，和（ii）皮质类固醇同时或彼此之间的14天内，其量足以减少或抑制免疫炎症 。
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公开(公告)号：US07148216B2
公开(公告)日：2006-12-12
申请号：US11024303
申请日：2004-12-28
IPC分类号： A61K31/54
CPC分类号： A61K45/06 , A61K31/155 , A61K31/495 , A61K31/54 , A61K31/5415 , A61K31/135 , A61K2300/00
摘要： The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient.
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公开(公告)号：US06846816B2
公开(公告)日：2005-01-25
申请号：US10347714
申请日：2003-01-21
IPC分类号： A61K9/72 , A61K31/155 , A61K31/54 , A61K31/5415 , A61K45/06 , A61P35/00 , A61P43/00
CPC分类号： A61K45/06 , A61K31/155 , A61K31/495 , A61K31/54 , A61K31/5415 , A61K31/135 , A61K2300/00
摘要： The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient.
摘要翻译： 本发明的特征在于一种用于治疗患有癌症或其他肿瘤的患者的方法，所述方法通过以足以治疗患者的量彼此同时或相互给药14天内向患者施用两种化合物。
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