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54 条记录 (耗时 0.031 秒)

    Process for producing optically active alcohols
    17.
    发明授权
    Process for producing optically active alcohols 失效
    光学活性醇的制造方法

    公开(公告)号：US4962242A

    公开(公告)日：1990-10-09

    申请号：US66164

    申请日：1987-06-25

    申请人： Nobuo Yamada ,  Toshiyuki Takezawa ,  Noboru Sayo ,  Misao Yagi ,  Hidenori Kumobayashi ,  Susumu Akutagawa ,  Hidemasa Takaya ,  Shinichi Inoue ,  Ryoji Noyori

    发明人： Nobuo Yamada ,  Toshiyuki Takezawa ,  Noboru Sayo ,  Misao Yagi ,  Hidenori Kumobayashi ,  Susumu Akutagawa ,  Hidemasa Takaya ,  Shinichi Inoue ,  Ryoji Noyori

    IPC分类号： C07C29/17

    CPC分类号： C07C29/172 ,  C07B2200/07

    摘要： A process for producing an optically active alcohol represented by formula (I): ##STR1## wherein R.sub.1 is an alkyl group having from 2 to 11 carbon atoms, an alkenyl group having from 3 to 11 carbon atoms, an alkadienyl group having from 6 to 11 carbon atoms, a cyclohexyl group, an cyclohexylmethyl group, or a cyclohexylethyl group, provided that the olefin in the alkenyl group or alkadienyl group is not conjugated to the olefin at the 2-position thereof; and * means an asymmetric carbon atom,is disclosed, comprising subjecting an olefinic alcohol represented by formula (II): ##STR2## wherein R.sub.1 is the same as defined above to asymmetric hydrogenation in the presence of, as a catalyst, a ruthenium-optically active phosphine complex.According to the process of the invention, the desired optically active alcohols which are useful not only as intermediates for the manufacture of perfumes and vitamin E but also as liquid crystal materials can be produced with high optical purities.

    摘要翻译： 一种制备由式（I）表示的光学活性醇的方法：其中R1是具有2至11个碳原子的烷基，具有3至11个碳原子的链烯基，具有 环己基，环己基甲基或环己基乙基，条件是烯基或链二烯基中的烯烃在2-位没有与烯烃共轭; 和*表示不对称碳原子，包括使式（II）表示的烯属醇：其中R 1与上述定义相同，在作为催化剂的存在下进行不对称氢化 钌 - 光学活性膦配合物。 根据本发明的方法，不仅可用于制造香料和维生素E，而且用作液晶材料的中间体所需的光学活性醇可以以高光学纯度生产。

    Process for prostaglandin E.sub.1 production, and novel delta 7-prostaglandins E and 7-hydroxyprostaglandins E
    18.
    发明授权
    Process for prostaglandin E.sub.1 production, and novel delta 7-prostaglandins E and 7-hydroxyprostaglandins E 失效
    前列腺素E1生产方法，新型三角洲7-前列腺素E和7-羟基前列腺素E

    公开(公告)号：US4845282A

    公开(公告)日：1989-07-04

    申请号：US147124

    申请日：1988-01-21

    申请人： Ryoji Noyori ,  Masaaki Suzuki ,  Toshio Kawagishi ,  Seizi Kurozumi

    发明人： Ryoji Noyori ,  Masaaki Suzuki ,  Toshio Kawagishi ,  Seizi Kurozumi

    IPC分类号： C07C405/00

    CPC分类号： C07C405/00

    摘要： The present invention provides an industrially very advantageous process for producing prostaglandins E.sub.1 with fewer steps and in higher yield. The process comprises reacting a 7-hydroxyprostaglandin E with a reactive derivative of an organic sulfonic acid in the presence of a basic compound to form the corresponding 7-organic sulfonyloxyprostaglandin E, treating the resulting 7-organic sulfonyloxyprostaglandin E, after or without isolation, in the presence of a basic compound to form a .DELTA..sup.7 -prostaglandin E, thereafter selectively reducing the carbon-carbon unsaturated bond existing on the .alpha.-chain. Some of the 7-hydroxyprostaglandins E and .DELTA..sup.7 -prostaglandins E used in the process are novel compounds.

    摘要翻译： 本发明提供了一种工业上非常有利的方法，用于以更少的步骤和更高的产率制备前列腺素E1。 该方法包括在碱性化合物的存在下使7-羟基前列腺素E与有机磺酸的活性衍生物反应，形成相应的7-有机磺酰氧基前列腺素E，在得到的7-有机磺酰氧基前列腺素E或分离后，在 碱性化合物的存在形成DELTA 7-前列腺素E，然后选择性地还原存在于α链上的碳 - 碳不饱和键。 该方法中使用的7-羟基前列腺素E和DELTA 7-前列腺素E中的一些是新化合物。

    Process for preparing prostacyclins
    19.
    发明授权
    Process for preparing prostacyclins 失效
    前列环素的制备方法

    公开(公告)号：US4578482A

    公开(公告)日：1986-03-25

    申请号：US563835

    申请日：1983-12-21

    申请人： Ryoji Noyori ,  Masaaki Suzuki ,  Akira Yanagisawa ,  Seizi Kurozumi

    发明人： Ryoji Noyori ,  Masaaki Suzuki ,  Akira Yanagisawa ,  Seizi Kurozumi

    IPC分类号： C07C405/00 ,  C07D307/937 ,  C07D307/935

    CPC分类号： C07D307/937 ,  C07C405/00

    摘要： A process for producing prostacyclins of the formula ##STR1## wherein the symbol G.sup.1, R.sup.1, R.sup.2, R.sup.31 and R.sup.41 are as defined in claim 1,which comprises reacting 5,6-dehydroprostaglandins F.sub.2 of the formula ##STR2## wherein the symbol G, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined in claim 1,with a mercury (II) compound in an inert organic solvent in the presence of tri(C.sub.1 -C.sub.6)alkylamine, treating the reaction product with a boron hydride compound, and if necessary, subjecting the reaction product to deprotecting reaction, hydrolysis reaction, or salt-forming reaction.This process is industrially advantageous process for the preparation of prostacyclin and its derivatives.

    摘要翻译： 制备式IMAGE的前列环素的方法，其中符号G1，R1，R2，R31和R41如权利要求1中所定义，其包括使式“IMAGE”的5,6-脱氢前列腺素F2与符号G， R1，R2，R3和R4如权利要求1中所定义，在三（C 1 -C 6）烷基胺存在下，在惰性有机溶剂中用汞（II）化合物，用硼氢化合物处理反应产物，如果 必要时，使反应产物脱保护反应，水解反应或成盐反应。 该方法在制备前列环素及其衍生物方面是工业上有利的方法。