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    Process for the production of dihydroxybenzenes
    11.
    发明授权
    Process for the production of dihydroxybenzenes 失效
    二羟基苯的制备方法

    公开(公告)号：US4533766A

    公开(公告)日：1985-08-06

    申请号：US587654

    申请日：1984-03-08

    Applicant: Karlheinz Drauz ,  Axel Kleemann

    Inventor： Karlheinz Drauz ,  Axel Kleemann

    IPC: C07C43/23 ,  C07C27/00 ,  C07C37/60 ,  C07C39/08 ,  C07C41/00 ,  C07C41/26 ,  C07C67/00 ,  C07C37/00

    CPC classification number: C07C37/60 ,  C07C41/26 ,  Y02P20/582

    Abstract: The known nuclear hydroxylation of substituted phenols or phenol ethers with organic solutions of hydrogen peroxide in the presence of a catalyst is carried out in improved manner by employing both (1) a special, practically water free solution of hydrogen peroxide in an organic solvent which forms an azeotrope with water, which azeotrope boils below the boiling point of hydrogen peroxide, and (2) sulfur dioxide as a catalyst. Through this, the nuclear hydroxylation is substantially simpler than previously; difficult separations, e.g., from water-phenol, or the separation and recovery of the catalyst are eliminated. Besides, the yields are increased.

    Abstract translation: 在催化剂存在下，用有机过氧化氢溶液对已取代的酚或苯酚醚进行已知的核羟基化反应是通过使用（1）特殊的实际上无水的过氧化氢溶液在有机溶剂中形成的 与水共沸，共沸物沸点低于过氧化氢的沸点，和（2）二氧化硫作为催化剂。 通过这一点，核羟基化比以前简单得多; 难以分离，例如来自水 - 苯酚，或者分离和回收催化剂。 此外，收益率上升。

    Process for the production of L-proline
    12.
    发明授权
    Process for the production of L-proline 失效
    生产L-脯氨酸的方法

    公开(公告)号：US4469876A

    公开(公告)日：1984-09-04

    申请号：US418841

    申请日：1982-09-16

    Applicant: Karlheinz Drauz ,  Axel Kleemann ,  Jurgen Martens ,  Paul Scherberich ,  Franz Effenberger

    Inventor： Karlheinz Drauz ,  Axel Kleemann ,  Jurgen Martens ,  Paul Scherberich ,  Franz Effenberger

    IPC: C07D207/16 ,  C07D207/22 ,  C07D207/12

    CPC classification number: C07D207/16 ,  C07D207/22

    Abstract: L-proline is produced from the methyl or ethyl ester of L-pyroglutamic acid by reacting this with at least twice the molar amount of phosgene to form the corresponding 1-chlorocarbonyl-5,5-dichloroproline ester, producing the corresponding 2-chloro-1-chlorocarbonyl-pyrrolin-(2)-carboxylic acid ester-(5) therefrom by splitting off hydrogen chloride, catalytically hydrogenating the pyrrolin-(2) compound to the corresponding N-chlorocarbonyl-proline ester and hydrolyzing the latter with acid to form L-proline.

    Abstract translation: 通过将其与至少两倍摩尔量的光气反应形成相应的1-氯羰基-5,5-二氯脯氨酸酯，由L-焦谷氨酸的甲酯或乙酯制备L-脯氨酸，产生相应的2-氯 - 通过分离氯化氢，将吡咯啉 - （2）化合物催化氢化成相应的N-氯羰基 - 脯氨酸酯并用酸水解后者形成1-氯羰基 - 吡咯啉 - （2） - 羧酸酯 - （5） L-脯氨酸。

    Process for the production of non-aqueous hydrogen peroxide solutions and their use
    13.
    发明授权
    Process for the production of non-aqueous hydrogen peroxide solutions and their use 失效
    用于生产非水过氧化氢溶液及其用途的方法

    公开(公告)号：US4686010A

    公开(公告)日：1987-08-11

    申请号：US648137

    申请日：1984-09-07

    Applicant: Karlheinz Drauz ,  Axel Kleemann

    Inventor： Karlheinz Drauz ,  Axel Kleemann

    IPC: C07C37/58 ,  B01J27/00 ,  C01B15/017 ,  C07C27/00 ,  C07C67/00 ,  B01D3/36

    CPC classification number: C01B15/017

    Abstract: The production of solutions of hydrogen peroxide in phenol or its derivatives, e.g. hydrocarbyl substituted phenols, halo substituted phenols or phenol ethers, is carried out in a single step. Practically no loss of hydrogen peroxide occurs since a total distillation of hydrogen peroxide together with phenol or phenol derivative is avoided. Simultaneously the solutions obtained are practically free from water. The mixture of phenol or phenol derivative and aqueous hydrogen peroxide is treated with a material that boils below the boiling point of hydrogen peroxide, phenol or phenol derivative or forms an azeotrope with water that boils below the boiling point of hydrogen peroxide, phenol or phenol derivative and the water removed as an azeotrope. The solution of hydrogen peroxide in phenol or phenol derivative which remains behind is suitable for carrying out oxidation reactions and above all, also for hydroxylation reactions.

    Abstract translation: 生产苯酚或其衍生物中过氧化氢的溶液，例如 烃基取代的酚，卤代酚或苯酚醚在一个步骤中进行。 实际上不会发生过氧化氢的损失，因为避免了与苯酚或苯酚衍生物一起完全蒸馏过氧化氢。 同时获得的溶液实际上不含水。 苯酚或苯酚衍生物与过氧化氢水溶液的混合物用沸点低于过氧化氢，苯酚或苯酚衍生物的沸点的物质处理，或与沸点低于过氧化氢，苯酚或苯酚衍生物沸点的水形成共沸物 并将水作为共沸物除去。 过氧化氢在苯酚或苯酚衍生物中残留的溶液适用于进行氧化反应，尤其是羟基化反应。

    Process for the production of water-free organic hydrogen peroxide solution
    14.
    发明授权
    Process for the production of water-free organic hydrogen peroxide solution 失效
    生产无水有机过氧化氢溶液的方法

    公开(公告)号：US4564514A

    公开(公告)日：1986-01-14

    申请号：US510162

    申请日：1983-07-01

    Applicant: Karlheinz Drauz ,  Axel Kleemann ,  Rolf Wirthwein

    Inventor： Karlheinz Drauz ,  Axel Kleemann ,  Rolf Wirthwein

    IPC: C01B15/017 ,  C01B15/023

    CPC classification number: C01B15/017

    Abstract: The production of organic hydrogen peroxide solutions which are practically water-free until now has had the problem of either too high a water content of the solution or too great a loss of hydrogen peroxide through decomposition and passing over as distillate during the distillative drying. By selection of specific esters in combination with commensurately high pressures in the azeotropic removal of water, these disadvantages can be avoided. Extremely low water content solutions of hydrogen peroxide in high boiling solutions are produced by mixing hydrogen peroxide solutions in solvents whose azeotropic boiling point with water is below the boiling point of hydrogen peroxide with higher boiling solvents which form the highest azeotrope with water, whose boiling point is near or above the boiling point of hydrogen peroxide. Thereupon, the mixture is freed from both water and the lower boiling solvent. The mixture can be formed by an in situ method. Production of extremely low water containing solutions of hydrogen peroxide in high boiling solvents are produced by mixing hydrogen peroxide solutions in solvents whose azeotrope boiling point with water is below the boiling point of hydrogen peroxide with higher boiling solvents which form the highest azeotrope with water, whose boiling point is near or above the boiling point of hydrogen peroxide. Thereupon, the mixture is freed from both water and the lower boiling solvent. The above-mentioned mixture can also be produced by an in situ method.

    Abstract translation: 迄今为止几乎无水的有机过氧化氢溶液的生产具有溶液中水含量过高或分解过程中过氧化氢过多或蒸馏干燥过程中作为馏出物流失的问题。 通过选择特定的酯与共沸去除水中相当高的压力相结合，可以避免这些缺点。 过氧化氢在高沸点溶液中的极低含水量溶液是通过将过氧化氢溶液与共沸点与水低于过氧化氢沸点的溶剂混合，通过与沸水形成最高共沸物的较高沸点溶剂混合而制得的，其沸点 接近或高于过氧化氢的沸点。 因此，混合物从水和低沸点溶剂中释放出来。 混合物可以通过原位法形成。 在高沸点溶剂中生产极低含水量的过氧化氢的溶液是通过将过氧化氢溶液与沸点高于沸点溶剂的沸点高于沸点的溶剂在水中沸点高于沸点的溶剂混合， 沸点接近或高于过氧化氢的沸点。 因此，混合物从水和低沸点溶剂中释放出来。 上述混合物也可以通过原位法制备。

    Process for preparing optically active beta-aminocarboxylic acids from racemic n-acylated beta-aminocarboxylic acids
    17.
    发明申请
    Process for preparing optically active beta-aminocarboxylic acids from racemic n-acylated beta-aminocarboxylic acids 审中-公开
    从外消旋的N-酰化β-氨基羧酸制备光学活性β-氨基羧酸的方法

    公开(公告)号：US20050153401A1

    公开(公告)日：2005-07-14

    申请号：US10508088

    申请日：2003-03-07

    Applicant: Harald Groger ,  Harald Trauthwein ,  Karlheinz Drauz ,  Stefan Buchholz ,  Christiane Sacherer ,  Helge Werner

    Inventor： Harald Groger ,  Harald Trauthwein ,  Karlheinz Drauz ,  Stefan Buchholz ,  Christiane Sacherer ,  Helge Werner

    IPC: C12P41/00 ,  C12R1/69 ,  C12P13/04

    CPC classification number: C12P41/007

    Abstract: A process is described for preparing optically active β-atninocarboxylic acids from racemic N-acylated β-aminocarboxylic acids by cnantiosclccthc hydrolysis of the N-acylated β-aminocarboxylic acid in the presence of a hydrolase by way of biocatalyst, wherein the N-acyl substituent of the N-acylated β-aminocarboxylic acid (I) exhibits Structure I in which R1, R2 are each selected, independently of one another, from H, halogen, alkiyl residues, OH, alkoxy residues and aryloxy residues; R3 is selected from halogen, alkoxy residues and aryloxy residues; (II) Structure IIA or IIB or the structure of the corresponding salts or (III) Structure III or the structure of the corresponding salt.

    Abstract translation: 描述了一种用于通过在水解酶存在下通过生物催化剂的N-酰化β-氨基羧酸水解N-外酰基化的β-氨基羧酸来制备光学活性β-阿魏酸的方法，其中N-酰基取代基 的N-酰化的β-氨基羧酸（I）表现出结构I，其中R 1，R 2各自彼此独立地选自H，卤素， 烷基残基，OH，烷氧基残基和芳氧基残基; R 3选自卤素，烷氧基残基和芳氧基残基; （II）结构IIA或IIB或相应盐的结构或（III）结构III或相应盐的结构。

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