利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

26 条记录 (耗时 0.037 秒)

    Synthetic peptides and mixtures thereof for detecting HIV antibodies
    17.
    发明授权
    Synthetic peptides and mixtures thereof for detecting HIV antibodies 失效
    用于检测HIV抗体的合成肽及其混合物

    公开(公告)号：US06218102B1

    公开(公告)日：2001-04-17

    申请号：US07148821

    申请日：1988-01-27

    申请人： Francesco Bellini ,  Gervais Dionne ,  Martial Lacroix

    发明人： Francesco Bellini ,  Gervais Dionne ,  Martial Lacroix

    IPC分类号： C12Q170

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2740/16122 ,  G01N33/56988

    摘要： There is provided cyclic peptides of the general formula where x represents any amino acid sequence or analogues located from amino acid 586 to amino acid 602 gp4l (HIV-1) y represents any amino acid sequence or analogues located from amino acid 611 to amino acid 620 gp4l (HIV-1); and a and b represent the amino and carboxy terminals, respectively, as well as substituents which are effective to make the peptides more useful as an immunodiagnostic reagent. These cyclic peptides alone or in admixture with certain linear peptides are particularly useful in detecting HIV antibodies.

    摘要翻译： 提供一般形式的环肽x代表位于氨基酸586至氨基酸602gp4l（HIV-1）的任何氨基酸序列或类似物，y代表位于氨基酸611至氨基酸620gp4l的任何氨基酸序列或类似物 （HIV-1）; a和b分别表示氨基和羧基末端，以及有效使肽更有用的免疫诊断试剂的取代基。 单独或与某些线性肽混合的这些环肽特别可用于检测HIV抗体。

    Preparation of (D-Trp .sup.6)-LH-RH via the heptapeptide H-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH.sub.2
    18.
    发明授权
    Preparation of (D-Trp .sup.6)-LH-RH via the heptapeptide H-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH.sub.2 失效
    通过七肽H-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH 2制备（D-Trp 6）-LH-RH

    公开(公告)号：US4301066A

    公开(公告)日：1981-11-17

    申请号：US147884

    申请日：1980-05-08

    申请人： Francesco Bellini ,  Hans U. Immer

    发明人： Francesco Bellini ,  Hans U. Immer

    IPC分类号： A61K38/00 ,  C07K7/23 ,  C07C103/52

    CPC分类号： C07K7/23 ,  A61K38/00 ,  Y10S930/13

    摘要： Herein is described a process for preparing the decapeptide Pry-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH.sub.2 ([D-Trp.sup.6 ]-LH-RH) by coupling Pyr-His-Trp-NHNH.sub.2 with H-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH.sub.2. [D-Trp.sup.6 ]-LH-RH had been established to be an efficient agent for causing release of lutenizing hormone and follicle-stimulating hormone in mammals.

    摘要翻译： 本文描述了通过偶联Pyr-His-Trp（[D-Trp6] -LH-RH）制备十肽Pry-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH 2 -NHNH 2与H-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH 2。 [D-Trp6] -LH-RH已被确定为在哺乳动物中引起促黄体激素和促卵泡激素释放的有效药物。

    Antisecretory agents derived from meldrum's acid
    20.
    发明授权
    Antisecretory agents derived from meldrum's acid 失效
    来自梅德拉酸的防菌剂

    公开(公告)号：US4547516A

    公开(公告)日：1985-10-15

    申请号：US543713

    申请日：1983-10-20

    申请人： Francesco Bellini ,  Jehan Bagli

    发明人： Francesco Bellini ,  Jehan Bagli

    IPC分类号： C07D319/06 ,  C07D405/04 ,  C07D409/12 ,  A61K31/38 ,  A61K31/40 ,  C07D233/54

    CPC分类号： C07D405/04 ,  C07D319/06 ,  C07D409/12

    摘要： Disclosed herein are antisecretory agents represented by the formula ##STR1## wherein R.sup.1 is hydrogen and R.sup.2 is lower alkylthio, (2-thienylmethyl)thio or SCH.sub.2 -- COOR.sup.5 wherein R.sup.5 is hydrogen or lower alkyl, or R.sup.1 and R.sup.2 are independently a lower alkylthio or (2-thienylmethyl)thio, or R.sup.1 and R.sup.2 together with the carbon atom to which they are attached form a 2-imidazolidinylidene; and R.sup.3 and R.sup.4 are each the same lower alkyl, or R.sup.3 and R.sup.4 together with the carbon atoms to which they are attached form a cyclohexane wherein said carbon atom is a spiro atom in common with the cyclohexane ring and the adjoining dioxane ring.

    摘要翻译： 本文公开的是由下式表示的抗分泌剂：其中R 1是氢，R 2是低级烷硫基，（2-噻吩基甲基）硫代或SCH 2 -COOR 5，其中R 5是氢或低级烷基，或者R 1和R 2独立地是低级烷硫基或 （2-噻吩甲基）硫代，或R1和R2与它们所连接的碳原子一起形成2-咪唑烷亚基; 并且R 3和R 4各自是相同的低级烷基，或者R 3和R 4与它们所连接的碳原子一起形成环己烷，其中所述碳原子是与环己烷环和相邻的二恶烷环共同的螺原子。