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    Synthetic peptides and mixtures thereof for detecting HIV antibodies
    1.
    发明授权
    Synthetic peptides and mixtures thereof for detecting HIV antibodies 失效
    用于检测HIV抗体的合成肽及其混合物

    公开(公告)号：US06214537B1

    公开(公告)日：2001-04-10

    申请号：US07281205

    申请日：1988-12-08

    申请人： Francesco Bellini ,  Gervais Dionne ,  Martial Lacroix

    发明人： Francesco Bellini ,  Gervais Dionne ,  Martial Lacroix

    IPC分类号： C12Q170

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2740/16122 ,  G01N33/56988

    摘要： There is provided cyclic peptides of the general formula wherein x represents the amino terminus, one amino acid or amino acid sequence starting with amino add 604 and going back as far as amino acid 586 (gp41-HIV-1); and y represents the carboxy terminus, an amino acid or amino acid sequence starting with amino acid 612 and extending up to amino acid 629 (gp41-HIV-1). There is also provided peptides of the general formula wherein x1 represents the amino terminus, one amino acid or amino acid sequence starting with amino add 596 and going back as far as amino acid 578 (gp42-HIV-2) and a and b represent the amino and carboxy terminals, respectively, as well as substituents which are effective to make the peptides more useful as an immunodiagnostic reagent; and y1 represents the carboxy terminus, an amino acid or amino add sequence starting with amino acid 604 and extending up to amino acid 613 (gp42-HIV-2) and a and b are as defined previously. These cyclic peptides alone or in admixture with certain linear peptides are particularly useful in detecting HIV-1 and HIV-2 antibodies.

    摘要翻译： 提供了一般形式的环肽，x代表氨基末端，一个氨基酸或氨基酸序列，起始于氨基加成604，并返回至氨基酸586（gp41-HIV-1）; 和y代表羧基末端，氨基酸或氨基酸序列，起始于氨基酸612并延伸至氨基酸629（gp41-HIV-1）。 还提供了一般形式的肽，其中x1表示氨基末端，一个氨基酸或氨基酸序列以氨基酸596开始，并返回至氨基酸578（gp42-HIV-2），a和b表示氨基 和羧基末端，以及有效使肽更有用的免疫诊断试剂的取代基; 并且y1表示羧基末端，氨基酸或氨基酸序列以氨基酸604开始并延伸至氨基酸613（gp42-HIV-2），a和b如前所定义。 单独或与某些线性肽混合的这些环肽特别可用于检测HIV-1和HIV-2抗体。

    Synthetic peptides and mixtures thereof for detecting HIV antibodies
    2.
    发明授权
    Synthetic peptides and mixtures thereof for detecting HIV antibodies 失效
    用于检测HIV抗体的合成肽及其混合物

    公开(公告)号：US06218102B1

    公开(公告)日：2001-04-17

    申请号：US07148821

    申请日：1988-01-27

    申请人： Francesco Bellini ,  Gervais Dionne ,  Martial Lacroix

    发明人： Francesco Bellini ,  Gervais Dionne ,  Martial Lacroix

    IPC分类号： C12Q170

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2740/16122 ,  G01N33/56988

    摘要： There is provided cyclic peptides of the general formula where x represents any amino acid sequence or analogues located from amino acid 586 to amino acid 602 gp4l (HIV-1) y represents any amino acid sequence or analogues located from amino acid 611 to amino acid 620 gp4l (HIV-1); and a and b represent the amino and carboxy terminals, respectively, as well as substituents which are effective to make the peptides more useful as an immunodiagnostic reagent. These cyclic peptides alone or in admixture with certain linear peptides are particularly useful in detecting HIV antibodies.

    摘要翻译： 提供一般形式的环肽x代表位于氨基酸586至氨基酸602gp4l（HIV-1）的任何氨基酸序列或类似物，y代表位于氨基酸611至氨基酸620gp4l的任何氨基酸序列或类似物 （HIV-1）; a和b分别表示氨基和羧基末端，以及有效使肽更有用的免疫诊断试剂的取代基。 单独或与某些线性肽混合的这些环肽特别可用于检测HIV抗体。

    Synthetic peptides and mixtures thereof for detecting HIV antibodies
    5.
    发明授权
    Synthetic peptides and mixtures thereof for detecting HIV antibodies 失效
    用于检测HIV抗体的合成肽及其混合物

    公开(公告)号：US5241047A

    公开(公告)日：1993-08-31

    申请号：US549964

    申请日：1990-07-09

    申请人： Martial Lacroix

    发明人： Martial Lacroix

    IPC分类号： A61K39/21 ,  A61K39/00 ,  A61P31/12 ,  C07K14/00 ,  C07K14/16 ,  C07K16/00 ,  C07K16/10 ,  G01N33/53 ,  G01N33/569

    CPC分类号： C07K14/005 ,  C07K16/10 ,  G01N33/56988 ,  A61K39/00 ,  C12N2740/16122

    摘要： There is provided cyclic peptides of the general formulae: ##STR1## wherein x represents an amino acid sequence from position 585 to 604 (gp41-HIV-1) such amino acid sequences being characterized by at least one of a lysine at position 586 or a lysine at both positions 585 and 586; x.sup.2 represents an amino acid sequence from position 585 to 604 (gp41-HIV-1); y represents an amino acid sequence from position 612 to 629 (gp41-HIV-1); e and f represent one or more epitopes; and a and b represent the amino and carboxy terminals, respectively, as well as substituents which are effective to make the peptide more useful as an immunodiagnositc reagent. Peptides of formula III have one or both of e and f present.There is also provided peptides of the general formulae: ##STR2## wherein x.sup.1 represents an amino acid sequence from position 577 to 596 (gp36-HIV-2) such amino acid sequences being characterized by at least one of a lysine at position 578 or a lysine at both positions 577 and 578; x.sup.3 represents an amino acid sequence from position 577 to 596 (gp36-HIV-2); y.sup.1 represents an amino acid sequence from position 604 to 613 (gp36-HIV-2); e and f represents one or more epitopes; and a and b are as defined above. Peptides of formula IV have one or both of e and f present.These cyclic peptides alone or in admixture with other peptides are particularly useful in detecting HIV-1 and HIV-2 antibodies in analytes and sera.

    摘要翻译： 提供以下通式的环肽：其中x代表585至604位的氨基酸序列（gp41-HIV-1），其氨基酸序列的特征在于至少 位置586处的赖氨酸或位置585和586处的赖氨酸之一; x2表示从585位至604位的氨基酸序列（gp41-HIV-1）; y表示从612位到629位的氨基酸序列（gp41-HIV-1）; e和f代表一个或多个表位; a和b分别表示氨基和羧基末端，以及有效使肽更有用的免疫诊断试剂的取代基。 式III的肽具有e和f中的一个或两个。 还提供了以下通式的肽：其中x1代表577至596位氨基酸序列（gp36-HIV-2），其氨基酸序列的特征在于至少 578位的赖氨酸或577和578位的赖氨酸之一; x3表示577〜596位氨基酸序列（gp36-HIV-2）。 y1表示604〜613位氨基酸序列（gp36-HIV-2）。 e和f代表一个或多个表位; 和a和b如上所定义。 式IV的肽具有e和f中的一个或两个。 单独或与其他肽混合的这些环肽特别可用于检测分析物和血清中的HIV-1和HIV-2抗体。

    Synthetic peptides and mixtures thereof for detecting HIV antibodies
    7.
    发明授权
    Synthetic peptides and mixtures thereof for detecting HIV antibodies 失效
    用于检测HIV抗体的合成肽及其混合物

    公开(公告)号：US06210874B1

    公开(公告)日：2001-04-03

    申请号：US08432520

    申请日：1995-05-01

    申请人： Martial Lacroix

    发明人： Martial Lacroix

    IPC分类号： C12Q170

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2740/16122 ,  G01N33/56988

    摘要： Cyclic peptides of the general formulae: wherein x represents an amino acid sequence from position 585 to 604 (gp41-HIV-1) with at least one of a lysine at position 586 or a lysine at both positions 585 and 586; x2 represents an amino acid sequence from position 585 to 604 (gp41-HIV-1); y represents an amino acid sequence from position 612 to 629 (gp41-HIV-1); e and f represent one or more epitopes included in the amino acid sequence extending from 586 to 629 (gp41-HIV-1) or from 578 to 613 (gp36-HIV-2); and a and b represent the amino and carboxy terminals, respectively, as well as substituents effective to make the peptide more useful as an immunodiagnostic. Peptides of formula III have one or both of e and f present. Also provided are peptides of the general formulae: wherein x1 represents an amino acid sequence from position 577 to 596 (gp36-HIV-2) with at least one of a lysine at position 578 or a lysine at both positions 577 and 578; x3 represents an amino acid sequence from position 577 to 596 (gp36-HIV-2); y1 represents an amino acid sequence from position 604 to 613 (gp36-HIV-2); e and f represents one or more epitopes included in the amino acid sequence from 578 to 613 (gp36-HIV-2) or 586 to 629 (gp41-HIV-1); and a and b are as defined above. Peptides of formula IV have one or both of e and f present. These peptides are useful in detecting HIV-1 and HIV-2 antibodies.

    摘要翻译： 具有以下通式的环状肽：其中x代表位置586处的赖氨酸或585和586位的赖氨酸中的至少一个的位置585至604（gp41-HIV-1）的氨基酸序列; x2表示从585位至604位的氨基酸序列（gp41-HIV-1）; y表示从612位到629位的氨基酸序列（gp41-HIV-1）; e和f代表从586至629（gp41-HIV-1）或578至613（gp36-HIV-2）延伸的氨基酸序列中包含的一个或多个表位。 和a和b分别表示氨基和羧基末端，以及有效使得肽作为免疫诊断更有用的取代基。 式III的肽具有e和f中的一个或两个。 还提供了以下通式的肽：其中x1代表从577至596位的氨基酸序列（gp36-HIV-2）与578位的赖氨酸或577和578位的赖氨酸中的至少一种; x3表示577〜596位氨基酸序列（gp36-HIV-2）。 y1表示604〜613位氨基酸序列（gp36-HIV-2）。 e和f代表包括在578至613（gp36-HIV-2）或586至629（gp41-HIV-1）的氨基酸序列中的一个或多个表位; 和a和b如上所定义。 式IV的肽具有e和f中的一个或两个。 这些肽可用于检测HIV-1和HIV-2抗体。