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公开(公告)号：US20050190439A1
公开(公告)日：2005-09-01
申请号：US11118320
申请日：2005-05-02
IPC分类号： G01N25/16 , G01N21/41 , G01N21/59 , G01N37/00 , G01Q30/10 , G02B6/12 , G02B6/13 , G02B21/00 , G02B21/02 , G01B9/00 , G02B21/06
CPC分类号： G02B21/0008 , G02B6/13 , G02B21/02 , G02B2006/12102
摘要： A small and portable microscope for ultramicroanalysis having an excellent spatial resolution and a fixed position analyzing ability in which at least a part of an excitation light source (3), a part of a probe light source (4) and a part of a thermal lens microscope optical system are arranged integrally in a device body comprising an analyzing cell (1) and substrates (2A), (2B) supporting the analyzing cell (1).
摘要翻译： 一种用于超微量分析的小型便携式显微镜，具有优异的空间分辨率和固定位置分析能力，其中至少一部分激发光源（3），探针光源（4）的一部分和热透镜的一部分 显微镜光学系统整体地布置在包括分析单元（1）和支撑分析单元（1）的基板（2A），（2B））的设备主体中。
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公开(公告)号：US06542691B2
公开(公告)日：2003-04-01
申请号：US10039501
申请日：2001-10-25
IPC分类号： G02B610
CPC分类号： G01N21/6456 , C03B23/207 , C03B37/15 , G01N2021/6482 , G02B6/032
摘要： A glass capillary array for fluorescence analysis is provided which is capable of preventing reduction of the transmittance of a laser beam through the glass capillaries during electrophoretic DNA fluorescence analysis, and a method of manufacturing the glass capillary array. The glass capillary array for fluorescence analysis is comprised of a plurality of glass capillaries each having a rectangular cross section and having an internal hole formed therein, and arranged in a row along a direction of irradiation of a laser beam for fluorescence analysis. The glass capillary array has a fluorescence analysis section comprising a portion of each of the glass capillaries positioned in a region including an optical axis of the laser beam and a vicinity thereof, and the glass capillaries are joined together substantially into a single body using a transparent material in at least the fluorescence analysis section.
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13.发明授权
公开(公告)号：US5178836A
公开(公告)日：1993-01-12
申请号：US334358
申请日：1989-04-07
IPC分类号： G01N21/63 , G01N15/02 , G01N15/10 , G01N15/14 , G01N21/00 , G01N21/71 , G01N29/00 , G01N29/24
CPC分类号： G01N15/10 , G01N21/718 , G01N29/2418 , G01N2291/02408 , G01N2291/02416 , G01N2291/02809
摘要： This invention relates to an analytical method and a relevant equipment for particulate substances in a sample with the detection of acoustic waves generated in the sample with the irradiation of onto the sample. In this invention, the light power density of the irradiating light onto the sample is set high enough above the breakdown threshold of the particulate substances in the sample, and low enough below the breakdown threshold of the media, and the particulate substances in the sample are counted by detecting the acoustic waves generated by the breakdown of the particulate substances. The particulate substances are also analyzed for their components on the basis of the light signal (emission spectrum) which is detected with a dispersed spectrum from the light which is generated by the breakdown of the particulate substances.
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公开(公告)号：US4808828A
公开(公告)日：1989-02-28
申请号：US937050
申请日：1986-12-02
CPC分类号： G01N29/2425 , G01N21/17 , G01N2021/1704 , G01N2021/1708 , G01N2021/1734 , G01N2021/8472 , G01N21/1702 , G01N21/64 , G01N2291/02809
摘要： A method of and an apparatus for simultaneous determination of constituents are disclosed in which a solution containing trace constituents is irradiated with an intensity-modulated electromagnetic wave having a predetermined wavelength, a photoacoustic signal and radiation from the electromagnetic-wave irradiation trace constituents are detected together with the emission spectrum thereof. The concentrations of the trace constituents are calculated from the magnitude of the photoacoustic signal, the intensity of the radiation, and calibration curves each formed for known concentrations of one of the trace constituents, and the trace constituents are identified by the above emission spectrum.
摘要翻译： 公开了一种用于同时测定组分的方法和装置，其中含有痕量组分的溶液用具有预定波长的强度调制电磁波照射，光声信号和来自电磁波照射痕量成分的辐射被一起检测 其发射光谱。 痕量成分的浓度是根据光声信号的大小，辐射强度和每个为已知浓度的微量成分形成的校准曲线计算的，微量成分由上述发射光谱鉴定。
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公开(公告)号：US08889071B2
公开(公告)日：2014-11-18
申请号：US13262057
申请日：2009-12-07
申请人： Arata Aota , Takehiko Kitamori
发明人： Arata Aota , Takehiko Kitamori
CPC分类号： G01N33/491 , G01N1/4005
摘要： An apparatus for separating plasma by which plasma can be separated from a small amount of whole blood cell sample without centrifugation is disclosed. This apparatus includes a blood channel through which blood flows; and a plasma channel through which plasma separated from said blood flows. The plasma channel is arranged at least partially in parallel with said blood channel and the blood channel and the plasma channel are at least partially in contact with each other along the longitudinal direction of the channels. Blood is made to flow at a flow rate at which blood cell components in the blood flowing through the blood channel axially accumulate and at which hemolysis does not occur. The plasma moves to the plasma channel after being separated into a blood cell layer and a plasma layer.
摘要翻译： 公开了一种用于分离等离子体的装置，通过该装置可以将血浆与少量的全血细胞样品分离而不进行离心。 该装置包括血流通过的血液通道; 以及等离子体通道，血浆从血液中分离出来。 等离子体通道至少部分地与所述血液通道平行布置，并且血液通道和等离子体通道沿着通道的纵向方向至少部分地彼此接触。 使血液以流过血液通道的血液中的血细胞成分轴向积聚并且不发生溶血的流速流动。 在分离成血细胞层和等离子体层之后，等离子体移动到等离子体通道。
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公开(公告)号：US07695684B2
公开(公告)日：2010-04-13
申请号：US11138373
申请日：2005-05-27
IPC分类号： B01L3/02
CPC分类号： G01N35/1097 , G01N2035/00237
摘要： For enlarging the application range of samples capable of being treated, decreasing the amount of samples used, preventing deterioration of samples by a change with the passage of time and preventing mixing of samples by diffusion, a micro fluidics system according to the present invention comprises a sample server which stores plural samples and which has sample efflux portions, a microchip for feeding samples to a treating portion through plural sample introducing portions communicating with the sample efflux portions and further through a microchannel, allowing the samples to be subjected to a predetermined treatment, and a sample feeder for feeding the samples stored in the sample server to the sample introducing portions through the sample efflux portions. The sample feeder comprises valves for opening and closing communication paths between the sample efflux portions of the sample server and the sample introducing portions of the microchip and pressurizing devices for pressurizing the samples stored in the sample server and pushing them out into the sample introducing portions in an open condition of the valves.
摘要翻译： 为了扩大能够处理的样品的应用范围，减少使用的样品量，通过随时间的改变改变样品的劣化并防止样品通过扩散混合，根据本发明的微流体系统包括： 存储多个样品并具有样品外排部分的样品服务器，用于通过与样品排出部分连通的多个样品导入部分进一步将样品供给到处理部分的微芯片，并且进一步通过微通道，允许样品经受预定处理， 以及用于将存储在样品服务器中的样品通过样品排出部分供给到样品引入部分的样品进料器。 样品供给器包括用于打开和关闭样品服务器的样品排出部分和微芯片的样品引入部分之间的连通路径的阀，以及用于对存储在样品服务器中的样品加压并将其推出到样品引入部分中的加压装置 阀的开启状态。
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公开(公告)号：US20100060981A1
公开(公告)日：2010-03-11
申请号：US11815976
申请日：2006-02-10
IPC分类号： G02B21/06
CPC分类号： G01N21/171 , G01N21/19 , G01N2021/1712
摘要： An objective of the present invention is to provide a circular dichroism thermal lens microscope apparatus capable of identifying and quantifying optically active samples in ultra-trace amounts, and which has a higher sensitivity than conventional apparatuses.The objective is achieved by a circular dichroism thermal lens microscope apparatus which beams excitation light and detection light into an optical microscope, where the detection light enters a thermal lens formed by irradiating a sample with the excitation light, and a substance in a sample is detected by determining the diffusion of the detection light by the thermal lens, and where the excitation light is modulated by a phase-modulation element, so as to identify or quantify an optical isomer.
摘要翻译： 本发明的目的是提供一种圆形二色性热透镜显微镜装置，其能够识别和定量超微量的光学活性样品，并且具有比常规装置更高的灵敏度。 目的是通过将激发光和检测光照射到光学显微镜中的圆二色性热透镜显微镜装置来实现，其中检测光进入通过用激发光照射样品而形成的热透镜，并且检测样品中的物质 通过确定通过热透镜的检测光的扩散，并且其中激发光被相位调制元件调制，以便识别或定量光学异构体。
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公开(公告)号：US07604406B2
公开(公告)日：2009-10-20
申请号：US12064456
申请日：2006-08-30
IPC分类号： H05G1/00
CPC分类号： G01N23/223 , B01L3/502715 , B01L3/502792 , B01L2300/0867 , B01L2300/0887 , B01L2300/089 , B01L2300/161 , G01N2223/076
摘要： A plurality of elements can be analyzed simultaneously with high sensitivity using a microchip. The microchip (1) comprises a substrate (30), a channel (23) formed in the substrate (30), and an analyzing part (10) consisting of a part of flat surface of the substrate (30), where the outlet of the channel (23) is formed as an opening (9c) and measurement object liquid overflowed from the opening (9c) stays on the flat surface of the substrate (30) to become a sample of analysis. The measurement object liquid is made to overflow as a sample of analysis to the analyzing part (10) using the microchip (1) and then the sample of analysis is preferably dried before a primary X-ray is made to enter under conditions of total reflection and fluorescent X-rays are detected.
摘要翻译： 可以使用微芯片以高灵敏度同时分析多个元件。 微芯片（1）包括基板（30），形成在基板（30）中的通道（23）和由基板（30）的平坦表面的一部分组成的分析部件（10） 通道（23）形成为开口（9c），并且从开口（9c）溢出的测量对象液体停留在基板（30）的平坦表面上，以成为分析样本。 使用微芯片（1）使测量对象液体作为分析样品溢出作为分析部件（10），然后优选在初步X射线在全反射条件下进入分析样品之前进行干燥 并检测荧光X射线。
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19.发明申请公开(公告)号：US20080123088A1
公开(公告)日：2008-05-29
申请号：US11985823
申请日：2007-11-16
申请人： Masatoshi Nara , Ryo Anraku , Takahiro Asai , Jun Yamaguchi , Akihiko Hattori , Takehiko Kitamori , Manabu Tokeshi , Akihide Hibara , Kazuma Mawatari
发明人： Masatoshi Nara , Ryo Anraku , Takahiro Asai , Jun Yamaguchi , Akihiko Hattori , Takehiko Kitamori , Manabu Tokeshi , Akihide Hibara , Kazuma Mawatari
IPC分类号： G01N21/41
CPC分类号： G01N21/171 , G01N35/08
摘要： There are provided a microchemical system capable of acquiring a highly accurate TLM output value and a method for calculating TLM output thereof. A microchemical system 1 comprises: a microchemical chip having a channel with a depth t in which a sample flows; an exciting light source 13 adapted to irradiate the sample with an exciting light through an objective lens 10 with a numerical aperture NA; a detecting light source 14 adapted to irradiate the sample with a detecting light coaxially with the exciting light through the objective lens 10; and a PD adapted to receive a transmitted light when the detecting light transmits the sample before and after formation of a thermal lens 12. When a TLM output is calculated in the microchemical system 1 on the basis of a received light amount of the PD, the depth t (μm) is set to the range of 75≦t≦300, the numerical aperture NA is set to the range of 0.04≦NA≦0.1 and chromatic aberrations df (nm) for the exciting light and the detecting light of the objective lens 10 is set to the range of 100≦df≦250.
摘要翻译： 提供了能够获得高度精确的TLM输出值的微化学系统和用于计算TLM输出的方法。 微化学系统1包括：具有样品流过深度t的通道的微化学芯片; 激光光源13，其适于通过具有数值孔径NA的物镜10照射具有激发光的样品; 检测光源14，适于通过物镜10与激发光同轴地检测具有检测光的样品; 以及适于在检测光在形成热透镜12之前和之后透射样品时接收透射光的PD。当在微量化学系统1中基于PD的接收光量计算TLM输出时， 深度t（母体）设定为75 <= t <= 300的范围，数值孔径NA设定为0.04 <= NA <= 0.1的范围，激发光的色差df（nm） 物镜10的光被设定在100 <= df <= 250的范围内。
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公开(公告)号：US20080030735A1
公开(公告)日：2008-02-07
申请号：US11701875
申请日：2007-02-05
申请人： Takehiko Kitamori , Manabu Tokeshi , Akira Tsunemi
发明人： Takehiko Kitamori , Manabu Tokeshi , Akira Tsunemi
IPC分类号： G01N21/00
CPC分类号： G02B21/0004 , G02B21/06
摘要： A desktop thermal lens microscope apparatus can detect a chemical reaction in a micro spatial region within a glass chip, or the like, more conveniently and at any given place. The desktop thermal lens microscope apparatus has small laser light sources such as semiconductor lasers as an excitation light source and a probe light source. Since an excitation light source system (P), a probe light source (Q), and a thermal lens microscope optical system (R, S, T) are integrally provided in a single housing, the size of the desktop thermal lens microscope is as small as that of a desktop microscope.
摘要翻译： 台式热学透镜显微镜装置可以在任何给定的位置更方便地检测玻璃芯片内的微空间区域中的化学反应等。 台式热学透镜显微镜装置具有小型激光光源，例如作为激发光源的半导体激光器和探针光源。 由于激光源系统（P），探针光源（Q）和热透镜显微镜光学系统（R，S，T）一体地设置在单个壳体中，所以台式热像仪的尺寸为 像桌面显微镜那样小。
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