公开(公告)号：US08546487B2

公开(公告)日：2013-10-01

申请号：US13147319

申请日：2010-02-15

申请人： Kazunori Kataoka ,  Shourong Wu ,  Takehiko Ishii ,  HyunJin Kim ,  Kanjiro Miyata ,  Nobuhiro Nishiyama

发明人： Kazunori Kataoka ,  Shourong Wu ,  Takehiko Ishii ,  HyunJin Kim ,  Kanjiro Miyata ,  Nobuhiro Nishiyama

IPC分类号： A61K47/48 ,  C08F283/04 ,  A01N25/26

CPC分类号： A61K48/0041 ,  A61K9/5192 ,  A61K31/7088 ,  A61K47/6455 ,  C07K14/001 ,  C07K14/003 ,  C08G69/08 ,  C08G69/10 ,  C08G69/48 ,  C12N15/111 ,  C12N2310/3181 ,  C12N2310/3513 ,  C12N2320/32

摘要： The present invention provides an efficient delivery system for a nucleic acid, more specifically, a cationic poly(amino acid) that has a side chain having a plurality of different amine functional groups in a moiety including a cationic group and that has a hydrophobic group introduced into part of the side chain, and a polyion complex (PIC) of the poly(amino acid) and an oligo- or polynucleotide.

摘要翻译： 本发明提供了一种用于核酸的有效递送系统，更具体地说，一种阳离子聚（氨基酸），该阳离子聚（氨基酸）在包括阳离子基团的部分中具有多个不同胺官能团的侧链，并且具有引入疏水基团 成为侧链的一部分，以及聚（氨基酸）的聚离子复合物（PIC）和寡核苷酸或多核苷酸。

公开(公告)号：US20120046453A1

公开(公告)日：2012-02-23

申请号：US13256605

申请日：2009-09-17

申请人： Kazunori Kataoka ,  Nobuhiro Nishiyama ,  Yan Lee ,  Takehiko Ishii

发明人： Kazunori Kataoka ,  Nobuhiro Nishiyama ,  Yan Lee ,  Takehiko Ishii

IPC分类号： C07K14/00 ,  C07D307/77 ,  C07D307/89 ,  C07D307/32

CPC分类号： C07K1/13 ,  A61K47/60 ,  A61K47/645

摘要： The present invention provides a protein delivery means (e.g., a polyion complex) which allows efficient introduction into cells (particularly into the cytoplasm), is highly stable in serum, and is also widely applicable. The polyion complex of the present invention comprises a cationic polymer having a polycation moiety and a charge-conversional protein whose overall charge is converted from basic or neutral to acidic by a specific charge regulator.

摘要翻译： 本发明提供了允许有效地引入细胞（特别是细胞质）中的蛋白质递送装置（例如，聚离子络合物），在血清中是高度稳定的，并且也可广泛应用。 本发明的聚离子络合物包含具有聚阳离子部分和电荷转移蛋白质的阳离子聚合物，其电荷通过特定的电荷调节剂从碱性或中性转变为酸性。

公开(公告)号：US20130066264A1

公开(公告)日：2013-03-14

申请号：US13699331

申请日：2011-05-24

申请人： Akira Matsumoto ,  Takehiko Ishii ,  Kazunori Kataoka ,  Yuji Miyahara

发明人： Akira Matsumoto ,  Takehiko Ishii ,  Kazunori Kataoka ,  Yuji Miyahara

IPC分类号： A61K31/69 ,  A61M5/00 ,  C07F5/02

CPC分类号： A61M5/1723 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0026 ,  A61K47/32 ,  C07F5/025 ,  C07K14/62 ,  Y10S514/866

摘要： Disclosed are a sugar-responsive gel and a medicine administering device having a pKa more suitable for use in a body environment and capable of administering medicine more autonomously than before. A sugar-responsive gel and an insulin administering device having a pKa more suitable for use in a body environment and capable of administering insulin more autonomously than before, wherein under a body condition of pKa of 7.4 or less and temperature of 35° C.-40° C., when the glucose concentration increases, insulin can be released from a gel body in response thereto, and when the glucose concentration decreases, insulin release from the gel body can be suppressed.

摘要翻译： 公开了一种糖应答凝胶和具有更适合用于身体环境并且能够比以前更自主地给予药物的pKa的给药装置。 一种糖响应性凝胶和具有更适合用于身体环境并能够比以前更自主地施用胰岛素的pKa的胰岛素给药装置，其中在pKa为7.4以下，体温35℃的身体条件下， 40℃时，当葡萄糖浓度增加时，响应于胰岛素可以从凝胶体释放，并且当葡萄糖浓度降低时，可以抑制从凝胶体释放的胰岛素。

公开(公告)号：US20120053295A1

公开(公告)日：2012-03-01

申请号：US13147319

申请日：2010-02-15

申请人： Kazunori Kataoka ,  Shourong Wu ,  Takehiko Ishii ,  HyunJin Kim ,  Kanjiro Miyata ,  Nobuhiro Nishiyama

发明人： Kazunori Kataoka ,  Shourong Wu ,  Takehiko Ishii ,  HyunJin Kim ,  Kanjiro Miyata ,  Nobuhiro Nishiyama

IPC分类号： C08G69/48 ,  C08G65/48

CPC分类号： A61K48/0041 ,  A61K9/5192 ,  A61K31/7088 ,  A61K47/6455 ,  C07K14/001 ,  C07K14/003 ,  C08G69/08 ,  C08G69/10 ,  C08G69/48 ,  C12N15/111 ,  C12N2310/3181 ,  C12N2310/3513 ,  C12N2320/32

摘要： The present invention provides an efficient delivery system for a nucleic acid, more specifically, a cationic poly(amino acid) that has a side chain having a plurality of different amine functional groups in a moiety including a cationic group and that has a hydrophobic group introduced into part of the side chain, and a polyion complex (PIC) of the poly(amino acid) and an oligo- or polynucleotide.

摘要翻译： 本发明提供了一种用于核酸的有效递送系统，更具体地说，一种阳离子聚（氨基酸），该阳离子聚（氨基酸）在包括阳离子基团的部分中具有多个不同胺官能团的侧链，并且具有引入疏水基团 成为侧链的一部分，以及聚（氨基酸）的聚离子复合物（PIC）和寡核苷酸或多核苷酸。

公开(公告)号：US20120283403A1

公开(公告)日：2012-11-08

申请号：US13520710

申请日：2010-12-27

申请人： Akira Matsumoto ,  Takehiko Ishii ,  Kazunori Kataoka ,  Yuji Miyahara

发明人： Akira Matsumoto ,  Takehiko Ishii ,  Kazunori Kataoka ,  Yuji Miyahara

IPC分类号： C07F5/02 ,  C08F230/06 ,  C08F30/06

CPC分类号： C07F5/025 ,  C08F220/56

摘要： Disclosed are a phenylboronic acid monomer and a phenylboronic acid polymer, each of which can have a pKa value suitable for the use under physiological environments and can be used for various applications. The pheanylboronic acid monomer has a structure represented by formula (13) and therefore has high hydrophilicity, can have a satisfactorily low pKa value when the phenyl ring is fluorinated, and can have a polymerizable unsaturated bond. The phenylboronic acid monomer has high hydrophilicity at a pKa value of 7.4 or less which is a physiological level, and can be polymerized with a wide variety of monomers to produce polymers suitable for the intended purposes.

摘要翻译： 公开了苯基硼酸单体和苯基硼酸聚合物，其各自可以具有适合在生理环境下使用的pKa值，并可用于各种应用。 苯基苯基硼酸单体具有式（13）所示的结构，因此具有高亲水性，当苯基环被氟化时，可以具有令人满意的低pKa值，并且可以具有可聚合的不饱和键。 苯基硼酸单体在pKa值为7.4或更低的生物水平下具有高亲水性，并且可以与各种单体聚合以产生适合于预期目的的聚合物。

公开(公告)号：US20120064346A1

公开(公告)日：2012-03-15

申请号：US13320314

申请日：2010-05-13

申请人： Kazunori Kataoka ,  Kanjiro Miyata ,  Nobuhiro Nishiyama ,  Takehiko Ishii ,  Tomoya Suma

发明人： Kazunori Kataoka ,  Kanjiro Miyata ,  Nobuhiro Nishiyama ,  Takehiko Ishii ,  Tomoya Suma

IPC分类号： C08J3/12 ,  B32B5/16 ,  C08G69/48 ,  C08G73/04 ,  B82Y40/00 ,  B82Y5/00

CPC分类号： A61K9/19 ,  A61K9/5123 ,  A61K9/5146 ,  A61K9/5192 ,  A61K31/713 ,  A61K47/62 ,  A61K47/6929 ,  A61K47/6935 ,  C08G69/10 ,  C08G69/40 ,  C08G69/48 ,  C08J3/12 ,  C08J2371/02 ,  C08L71/02 ,  C08L77/04 ,  C08L77/06 ,  C12N15/87 ,  Y10S977/788 ,  Y10S977/84 ,  Y10T428/2982 ,  C08L2666/20 ,  C08L2666/22

摘要： Fine particles of crystalline polyol are provided having a cationic polymer fixed on the crystal surfaces. These fine particles can stably carry an anionically charged compound on their surfaces.

摘要翻译： 提供结晶多元醇的细颗粒，其具有固定在晶体表面上的阳离子聚合物。 这些细颗粒可以在其表面上稳定地携带带阴离子的化合物。

公开(公告)号：US09245012B2

公开(公告)日：2016-01-26

申请号：US13437082

申请日：2012-04-02

申请人： Daisuke Maruyama ,  Kazuo Aoki ,  Takehiko Ishii

发明人： Daisuke Maruyama ,  Kazuo Aoki ,  Takehiko Ishii

IPC分类号： G06F17/30

CPC分类号： G06F17/30707

摘要： An information classification system includes a server including a knowledge base that receives classification information to be classified, conducts language analysis of the classification information to acquire and classify a plurality of keywords into elements made up of a classification target word and a related word that modifies the classification target word, and conducts a search with the related word, so as to assign a classification identification value to the information; a classification candidate extraction section that extracts the classification identification value that the knowledge base assigns to generate an automatic classification result; and a classification update section that receives the automatic classification result and corrects registered items in the knowledge base with a correction value received through a GUI for classification confirmation while referring to log data that is a processing history about automatic classification for the language analysis and the element classification.

摘要翻译： 信息分类系统包括：服务器，其包括接收要分类的分类信息的知识库，进行分类信息的语言分析，以获取并分类多个关键字到由分类目标词和相关词组成的元素中， 分类目标字，并用相关字进行搜索，以便为信息分配分类识别值; 分类候选提取部，其提取知识库分配的分类识别值，生成自动分类结果; 以及分类更新部分，其参考作为用于语言分析的自动分类的处理历史的日志数据和元素，接收自动分类结果并且通过用于分类确认的GUI接收到的校正值来校正知识库中的注册项目， 分类。

公开(公告)号：US09017875B2

公开(公告)日：2015-04-28

申请号：US12325636

申请日：2008-12-01

申请人： Takehiko Ishii

发明人： Takehiko Ishii

IPC分类号： H01M10/36 ,  H01M4/58 ,  H01M4/02 ,  H01M4/62 ,  C01B25/26 ,  G11B5/596 ,  H01M4/136 ,  H01M4/36 ,  H01M10/052

CPC分类号： G11B5/596 ,  H01M4/136 ,  H01M4/364 ,  H01M4/366 ,  H01M4/5825 ,  H01M10/052 ,  H01M2004/021 ,  H01M2004/028 ,  Y02E60/122 ,  Y02P70/54 ,  Y02T10/7011

摘要： The present application provides a nonaqueous electrolyte secondary battery which includes a cathode having a cathode active material layer, an anode, and a nonaqueous electrolyte, wherein the cathode active material layer includes secondary particles of a lithium phosphate compound having olivine structure, an average particle diameter A of primary particles constituting the secondary particles is 50 nm or more and 500 nm or less, and a ratio B/A of a pore diameter B of the secondary particles to the average particle diameter A of the primary particles is 0.10 or more and 0.90 or less.

摘要翻译： 本申请提供了一种非水电解质二次电池，其包括具有正极活性物质层，阳极和非水电解质的阴极，其中，所述正极活性物质层包含具有橄榄石结构的磷酸锂化合物的二次粒子，平均粒径 构成二次粒子的一次粒子的A为50nm以上且500nm以下，二次粒子的孔径B与一次粒子的平均粒径A的比率B / A为0.10以上且0.90以下 或更少。

公开(公告)号：US20130029225A1

公开(公告)日：2013-01-31

申请号：US13558005

申请日：2012-07-25

申请人： Takaaki Matsui ,  Tadashi Matsushita ,  Takehiko Ishii

发明人： Takaaki Matsui ,  Tadashi Matsushita ,  Takehiko Ishii

IPC分类号： H01M4/1391 ,  B29C67/04 ,  H01M4/131

CPC分类号： H01M4/136 ,  H01M4/5825 ,  H01M10/052 ,  H01M2004/021 ,  H01M2010/4271 ,  Y02E60/122 ,  Y02P70/54 ,  Y02T10/7011

摘要： A secondary battery includes: a cathode including an active material; an anode; and an electrolytic solution. The active material has a composition represented by Formula (1) described below. A median diameter (D90) of the active material is from about 10.5 micrometers to about 60 micrometers both inclusive, the median diameter (D90) being measured by a laser diffraction method. A half bandwidth (2θ) of a diffraction peak corresponding to a (020) crystal plane of the active material is from about 0.15 degrees to about 0.24 degrees both inclusive, the half bandwidth (2θ) being measured by an X-ray diffraction method. LiaMnbFecMdPO4  (1) where M represents one or more of Mg, Ni, Co, Al, W, Nb, Ti, Si, Cr, Cu, and Zn; and 0

摘要翻译： 二次电池包括：包含活性物质的阴极; 阳极; 和电解液。 活性物质具有下述式（1）表示的组成。 活性物质的中值粒径（D90）为约10.5微米至约60微米（包括端值），中值粒径（D90）通过激光衍射法测量。 对应于活性材料的（020）晶面的衍射峰的半带宽（2θ）为约0.15度至约0.24度，其中半带宽（2θ）通过X射线衍射测量 方法。 （1）其中M表示Mg，Ni，Co，Al，W，Nb，Ti，Si，Cr，Cu和Zn中的一种或多种; 并且0

公开(公告)号：US08260731B2

公开(公告)日：2012-09-04

申请号：US12342300

申请日：2008-12-23

申请人： Daisuke Maruyama ,  Kazuo Aoki ,  Takehiko Ishii

发明人： Daisuke Maruyama ,  Kazuo Aoki ,  Takehiko Ishii

IPC分类号： G06F17/30

CPC分类号： G06F17/30707

摘要： An information classification system includes a server that includes a knowledge base that receives classification information to be classified, conducts language analysis of the classification information to acquire a plurality of keywords and classify the plurality of keywords into elements made up of a classification target word and a related word that modifies the classification target word, and conduct a search with the related word being for a judgment condition for decision of the classification while separating the classification target word from the related word, so as to assign a classification identification value to the information; a classification candidate extraction section that extracts the classification identification value that the knowledge base assigns to generate an automatic classification result; and a classification update section that receives the automatic classification result, displays a GUI for classification confirmation allowing confirmation of correctness of the automatic classification result, and corrects registered items in the knowledge base with a correction value received through the GUI for classification confirmation while referring to log data that is a processing history about automatic classification for the language analysis and the element classification.

摘要翻译： 信息分类系统包括：服务器，其包括接收要分类的分类信息的知识库，进行分类信息的语言分析以获取多个关键字，并将多个关键词分类成由分类对象词和 相关词，其对分类目标词进行修改，并且在将所述分类目标词与所述相关词分离的同时，对所述分类的判断条件进行搜索，从而对所述分类目标词进行分类，以将所述分类标识值分配给所述信息; 分类候选提取部，其提取知识库分配的分类识别值，生成自动分类结果; 以及分类更新部分，其接收自动分类结果，显示用于分类确认的GUI，允许确认自动分类结果的正确性，并且通过用于分类确认的GUI接收到的校正值来校正知识库中的注册项目，同时参考 日志数据是关于语言分析和元素分类的自动分类的处理历史。