公开(公告)号：US08867033B2

公开(公告)日：2014-10-21

申请号：US13161485

申请日：2011-06-15

Applicant: Keith Carron ,  Mark Watson ,  Shane Buller

Inventor： Keith Carron ,  Mark Watson ,  Shane Buller

IPC: G01J3/28 ,  G01J3/44 ,  G01J3/02 ,  G01N21/65

CPC classification number: G01J3/0237 ,  G01J3/0208 ,  G01J3/44 ,  G01J3/4412 ,  G01N21/65

Abstract: A spectroscopic system including a light source adapted to provide a beam of illumination; an optical system adapted to provide the beam of illumination to a sample and receive a spectroscopy signal from the sample and direct the spectroscopy signal to at least one single channel detector is provided. The optical system comprises an adjustable dispersing element for directing one or more spectral features of the spectroscopy signal to the at least one single channel detector. A calibration detector is adapted to determine a set point of the adjustable dispersing element; and a source synchronization component is adapted to synchronize an operation of the light source and the at least one single channel detector. A method of calibrating a dispersing element of a spectrometer is also provided.

Abstract translation: 一种分光系统，包括适于提供照明光束的光源; 提供了一种光学系统，其适于向样本提供照射束并从样本接收光谱信号，并将光谱信号指向至少一个单通道检测器。 光学系统包括用于将光谱信号的一个或多个光谱特征引导到至少一个单通道检测器的可调分散元件。 校准检测器适于确定可调分散元件的设定点; 并且源同步组件适于同步光源和至少一个单通道检测器的操作。 还提供了校准分光器的分散元件的方法。

公开(公告)号：US20100265499A1

公开(公告)日：2010-10-21

申请号：US12376831

申请日：2007-08-07

Applicant: Keith Carron ,  Mark Watson ,  Shane Butler

Inventor： Keith Carron ,  Mark Watson ,  Shane Butler

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0256 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/28 ,  G01N21/65 ,  G01N2201/0221

Abstract: A programmable Raman transducer is disclosed for detecting the presence or absence of a preselected compound in a sample. The transducer, in a preferred embodiment, includes a laser source for generating laser light for illuminating the sample. Collector optics, absent a spatial filter, are used for collecting Raman-scattered light from the sample. A detector generates spectral data from the Raman-scattered light, and a digital processor compares the spectral data to a database of spectral data on selected compounds, including the preselected compound to generate a binary signal indicating presence or absence of the preselected compound.

Abstract translation: 公开了一种用于检测样品中预选化合物的存在或不存在的可编程拉曼换能器。 在优选实施例中，换能器包括用于产生用于照亮样品的激光的激光源。 无空间滤光片的收集器光学器件用于收集样品中的拉曼散射光。 检测器从拉曼散射光产生光谱数据，并且数字处理器将光谱数据与所选化合物（包括预选化合物）的光谱数据的数据库进行比较，以产生指示预选化合物存在或不存在的二元信号。

公开(公告)号：US20100182594A1

公开(公告)日：2010-07-22

申请号：US12690205

申请日：2010-01-20

Applicant: Keith Carron

Inventor： Keith Carron

IPC: G01N21/00 ,  G01J3/44 ,  G01J3/28

CPC classification number: G01J3/42 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0264 ,  G01J3/0294 ,  G01J3/1809 ,  G01J3/44 ,  G01J2001/4242

Abstract: An apparatus is described for the real-time identification of one or more selected components of a target material. In one embodiment, an infrared spectrometer and a separate Raman spectrometer are coupled to exchange respective spectral information of the target material preferably normalized and presented in a single graph. In an alternative embodiment, both an infrared spectrometer and a Raman spectrometer are included in a single instrument and a common infrared light source is used by both spectrometers. In another embodiment, a vibrational spectrometer and a stoichiometric spectrometer are combined in a single instrument and are coupled to exchange respective spectral information of the target material and to compare the spectral information against a library of spectra to generate a real-time signal if a selected component is present in the target material.

Abstract translation: 描述了用于实时识别目标材料的一个或多个选定部件的装置。 在一个实施例中，红外光谱仪和单独的拉曼光谱仪被耦合以交换目标材料的各个光谱信息，优选地被归一化并呈现在单个图中。 在替代实施例中，红外光谱仪和拉曼光谱仪均包括在单个仪器中，并且两个光谱仪都使用通用的红外光源。 在另一个实施例中，将振动光谱仪和化学计量光谱仪组合在单个仪器中，并耦合以交换目标材料的相应光谱信息，并将光谱信息与光谱库进行比较以产生实时信号，如果选定 组分存在于目标材料中。

公开(公告)号：US20090325318A1

公开(公告)日：2009-12-31

申请号：US12278118

申请日：2007-02-02

Applicant: Keith Carron

Inventor： Keith Carron

IPC: G01N33/553

CPC classification number: G01N33/54326

Abstract: A method of reporting a binding event having increased sensitivity and multiplex capabilities. A reporter supra-nanoparticle assembly is provided that has an inner core made of a polymeric material, a coating on the inner core made of a polymeric material and a plurality of reporter nanoparticles, and a first active group on the surface of the coating.

Abstract translation: 一种报告具有增加的灵敏度和复用能力的绑定事件的方法。 提供了一种记录体超纳米颗粒组件，其具有由聚合物材料制成的内芯，在内芯上的由聚合物材料制成的涂层和多个报道纳米颗粒，以及涂层表面上的第一活性基团。

公开(公告)号：US20080174777A1

公开(公告)日：2008-07-24

申请号：US11786234

申请日：2007-04-11

Applicant: Keith Carron

Inventor： Keith Carron

IPC: G01J3/28 ,  G01J3/00 ,  G01N21/47

CPC classification number: G01J3/1809 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/2803 ,  G01J3/2846 ,  G01J3/2889 ,  G01J3/44 ,  G01J3/443 ,  G01J2001/4242 ,  G01N21/718

Abstract: Echelle gratings and microelectromechanical system (MEMS) digital micromirror device (DMD) detectors are used to provide rapid, small, and highly sensitive spectrometers. The new spectrometers are particularly useful for laser induced breakdown and Raman spectroscopy, but could generally be used with any form of emission spectroscopy. The new spectrometers have particular applicability in the detection of improvised explosive devices.

Abstract translation: Echelle光栅和微机电系统（MEMS）数字微镜器件（DMD）检测器用于提供快速，小型和高灵敏度的光谱仪。 新的光谱仪对于激光诱导击穿和拉曼光谱特别有用，但通常可以用于任何形式的发射光谱。 新型光谱仪特别适用于简易爆炸装置的检测。

公开(公告)号：US20060240572A1

公开(公告)日：2006-10-26

申请号：US11211325

申请日：2005-08-24

Applicant: Keith Carron ,  Bryan Ray

Inventor： Keith Carron ,  Bryan Ray

IPC: G01J3/44 ,  G01N33/551

CPC classification number: G01N33/54326 ,  G01N21/658 ,  G01N33/54353 ,  G01N2021/651

Abstract: A Raman spectroscopy technique allows an analyte, a paramagnetic particle, and a spectral enhancement particle to combine in solution and for the combination product to be localized by a magnetic field for analysis. The spectral enhancement particle may be comprised of an active SERS metal particle with or without a material coating. The spectral enhancement particle may function as a reporter for the presence of the analyte or merely increase the magnitude of the Raman spectrum of the analyte. The technique is applicable to both immunoassays and chemical assays. Multiple spectral enhancement particle reporters may be measured in a single assay that can detect multiple analytes using the SERS effect.

Abstract translation: 拉曼光谱技术允许分析物，顺磁颗粒和光谱增强颗粒在溶液中组合，并且通过磁场定位用于分析的组合产物。 光谱增强颗粒可以由具有或不具有材料涂层的活性SERS金属颗粒组成。 光谱增强颗粒可以作为分析物存在的报告物，或仅增加分析物的拉曼光谱的幅度。 该技术适用于免疫测定和化学测定。 可以在可以使用SERS效应检测多个分析物的单个测定中测量多个光谱增强粒子报告物。