公开(公告)号：US07962199B2

公开(公告)日：2011-06-14

申请号：US11994246

申请日：2006-06-29

Applicant: Keith Carron ,  Mark Towler

Inventor： Keith Carron ,  Mark Towler

IPC: A61B5/05

CPC classification number: G01N21/65 ,  A61B5/0059 ,  A61B5/4504 ,  A61B5/4509 ,  A61B5/7257 ,  A61B5/7275 ,  G06F19/00

Abstract: A method is disclosed for analyzing keratinized tissue, particularly fingernails, of a subject to diagnose osteoporosis and bone fracture risk. A Raman spectrum of a sample of keratinized tissue is generated. Broad spectral background features of the spectrum are removed, preferably by using Fourier transform analysis. Peak heights of Raman features of interest, particularly the S—S bond of cystine, are measured. These peak height measurements are normalized using reference peak heights of Raman features that are invariant between normal and osteoporotic subjects, such as the CH2 bending peak.

Abstract translation: 公开了用于分析受试者的角质化组织，特别是指甲的诊断骨质疏松症和骨折风险的方法。 产生角化组织样品的拉曼光谱。 优选通过使用傅立叶变换分析去除光谱的宽光谱背景特征。 测量了拉曼特征的峰值高度，特别是胱氨酸的S-S键。 使用在正常和骨质疏松受试者之间不变的拉曼特征的参考峰高度，例如CH2弯曲峰，使这些峰高度测量值被归一化。

公开(公告)号：US20050248758A1

公开(公告)日：2005-11-10

申请号：US10859372

申请日：2004-06-01

Applicant: Keith Carron ,  Mark Watson ,  Shane Buller

Inventor： Keith Carron ,  Mark Watson ,  Shane Buller

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/02 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/44 ,  G01J2003/4424 ,  G01N21/65 ,  G01N2201/0221 ,  G01N2201/0612 ,  G01N2201/0813

Abstract: A system, method and apparatus for taking a Raman spectrum of a sample is disclosed. In one embodiment, for example, an integrated Raman spectrometer is provided. In another embodiment, a portable Raman spectrometer is provided. In another embodiment, a Raman spectrometer is provided comprising a collimated beam tube for transmitting excitation radiation to an external optical system, such as a microscope, a telescope or a camera lens. In another embodiment, a method for correcting a Raman spectrum for background interference is provided. In yet another embodiment, a method for rejecting fluorescence in a Raman spectrometer is provided. A chemical reactor comprising a built-in Raman detector for monitoring a chemical reaction in a reaction chamber of the reactor is also provided.

Abstract translation: 公开了一种用于获取样品的拉曼光谱的系统，方法和装置。 在一个实施例中，例如，提供了一种集成的拉曼光谱仪。 在另一个实施例中，提供了便携式拉曼光谱仪。 在另一个实施例中，提供拉曼光谱仪，其包括用于将激发辐射传输到诸如显微镜，望远镜或相机透镜的外部光学系统的准直束管。 在另一实施例中，提供了用于校正背景干扰的拉曼光谱的方法。 在另一个实施方案中，提供了一种用于在拉曼光谱仪中排除荧光的方法。 还提供了一种包括用于监测反应器的反应室中的化学反应的内置拉曼检测器的化学反应器。

公开(公告)号：US20130316467A1

公开(公告)日：2013-11-28

申请号：US13819316

申请日：2011-08-30

Applicant: Keith Carron ,  Shane Buller ,  Mark Watson

Inventor： Keith Carron ,  Shane Buller ,  Mark Watson

IPC: G01N21/65

CPC classification number: G01J3/4406 ,  G01J3/06 ,  G01J3/44 ,  G01J2003/062 ,  G01J2003/064 ,  G01N21/65 ,  G01N21/658 ,  G01N33/536 ,  G01N33/54313 ,  G01N33/54373 ,  G01N2201/0612

Abstract: A spectroscopic assay is provided. The assay comprises: a motive particle configured to move within a solution, the motive particle comprising a first analyte binding reagent for selectively binding to a target analyte; and a spectroscopic reporter particle configured to provide a predetermined spectroscopic signal in response to being interrogated by a spectrometer, the spectroscopic reporter particle comprising a second analyte binding reagent for selectively binding to the target analyte, wherein the motive particle and the spectroscopic reporter particle are configured to provide a sandwich assay in the presence of the target analyte via the first and second analyte binding reagents.

Abstract translation: 提供光谱测定。 该测定包括：构型成在溶液内移动的动力颗粒，所述动力颗粒包含用于选择性结合靶分析物的第一分析物结合试剂; 以及光谱报告颗粒，其被配置为响应于由光谱仪询问而提供预定的光谱信号，所述光谱报告颗粒包含用于选择性地结合靶分析物的第二分析物结合试剂，其中所述运动颗粒和所述光谱报告颗粒被配置 以通过第一和第二分析物结合试剂在目标分析物存在下提供夹心测定。

公开(公告)号：US20120162642A1

公开(公告)日：2012-06-28

申请号：US13221899

申请日：2011-08-31

Applicant: Mark Watson ,  Shane Buller ,  Keith Carron

Inventor： Mark Watson ,  Shane Buller ,  Keith Carron

IPC: G01J3/443

CPC classification number: G01J3/4406 ,  G01J3/06 ,  G01J3/44 ,  G01J2003/062 ,  G01J2003/064 ,  G01N21/65 ,  G01N21/658 ,  G01N33/54313 ,  G01N33/54373 ,  G01N2201/0612

Abstract: A spectrometer is provided. In one implementation, for example, a spectrometer comprises an excitation source, a focusing lens, a movable minor, and an actuator assembly. The focusing lens is adapted to focus an incident beam from the excitation source. The actuator assembly is adapted to control the movable mirror to move a focused incident beam across a surface of the sample.

Abstract translation: 提供光谱仪。 在一个实施方案中，例如，光谱仪包括激发源，聚焦透镜，可移动次要器件和致动器组件。 聚焦透镜适于聚焦来自激发源的入射光束。 致动器组件适于控制可移动镜以将聚焦的入射光束移动穿过样品的表面。

公开(公告)号：US08988678B2

公开(公告)日：2015-03-24

申请号：US13221899

申请日：2011-08-31

Applicant: Mark Watson ,  Shane Buller ,  Keith Carron

Inventor： Mark Watson ,  Shane Buller ,  Keith Carron

IPC: G01J3/00 ,  G01J3/06 ,  G01J3/44 ,  G01N21/65

CPC classification number: G01J3/4406 ,  G01J3/06 ,  G01J3/44 ,  G01J2003/062 ,  G01J2003/064 ,  G01N21/65 ,  G01N21/658 ,  G01N33/54313 ,  G01N33/54373 ,  G01N2201/0612

Abstract: A spectrometer is provided. In one implementation, for example, a spectrometer comprises an excitation source, a focusing lens, a movable mirror, and an actuator assembly. The focusing lens is adapted to focus an incident beam from the excitation source. The actuator assembly is adapted to control the movable mirror to move a focused incident beam across a surface of the sample.

Abstract translation: 提供光谱仪。 在一个实施方案中，例如，光谱仪包括激发源，聚焦透镜，可移动反射镜和致动器组件。 聚焦透镜适于聚焦来自激发源的入射光束。 致动器组件适于控制可移动镜以将聚焦的入射光束移动穿过样品的表面。

公开(公告)号：US20120154801A1

公开(公告)日：2012-06-21

申请号：US13161485

申请日：2011-06-15

Applicant: Keith Carron ,  Mark Watson ,  Shane Buller

Inventor： Keith Carron ,  Mark Watson ,  Shane Buller

IPC: G01J3/44

CPC classification number: G01J3/0237 ,  G01J3/0208 ,  G01J3/44 ,  G01J3/4412 ,  G01N21/65

Abstract: A spectroscopic system is provided. In one embodiment, the spectroscopic system comprises a light source adapted to provide a beam of illumination; an optical system adapted to provide the beam of illumination to a sample and receive a spectroscopy signal from the sample and direct the spectroscopy signal to at least one single channel detector, wherein the optical system comprises an adjustable dispersing element for directing one or more spectral features of the spectroscopy signal to the at least one single channel detector; a calibration detector adapted to determine a set point of the adjustable dispersing element; and a source synchronization component adapted to synchronize an operation of the light source and the at least one single channel detector. A method of calibrating a dispersing element of a spectrometer is also provided. In one embodiment, the method comprises determining a set point along a path of an adjustable dispersing element, wherein the set point corresponds to a position of the dispersing element where a calibration signal of a spectrometer is detected at a calibration sensor of the spectrometer; adjusting the position of the dispersing element along the path by a predetermined offset measurement from the set point; and directing at least a portion of a spectroscopic signal from the dispersing element to a spectroscopic signal detector of the spectrometer.

Abstract translation: 提供光谱系统。 在一个实施例中，分光系统包括适于提供照明光束的光源; 光学系统，其适于向样本提供照射束并从样本接收光谱信号，并将光谱信号引导到至少一个单通道检测器，其中该光学系统包括用于引导一个或多个光谱特征 的至少一个单通道检测器; 校准检测器，适于确定可调分散元件的设定点; 以及源同步部件，其适于使所述光源和所述至少一个单通道检测器的操作同步。 还提供了校准分光器的分散元件的方法。 在一个实施例中，该方法包括确定沿着可调分散元件的路径的设定点，其中该设定点对应于在该分光器的校准传感器处检测到该光谱仪的校准信号的分散元件的位置; 沿着路径将分散元件的位置从设定点调整预定的偏移测量值; 并将来自分散元件的至少一部分光谱信号引导到光谱仪的光谱信号检测器。

公开(公告)号：US20090012403A1

公开(公告)日：2009-01-08

申请号：US11994246

申请日：2006-06-29

Applicant: Keith Carron ,  Mark Towler

Inventor： Keith Carron ,  Mark Towler

IPC: A61B6/00 ,  G01N21/65

CPC classification number: G01N21/65 ,  A61B5/0059 ,  A61B5/4504 ,  A61B5/4509 ,  A61B5/7257 ,  A61B5/7275 ,  G06F19/00

Abstract: A method is disclosed for analyzing keratinized tissue, particularly fingernails, of a subject to diagnose osteoporosis and bone fracture risk. A Raman spectrum of a sample of keratinized tissue is generated. Broad spectral background features of the spectrum are removed, preferably by using Fourier transform analysis. Peak heights of Raman features of interest, particularly the S—S bond of cystine, are measured. These peak height measurements are normalized using reference peak heights of Raman features that are invariant between normal and osteoporotic subjects, such as the CH2 bending peak.

Abstract translation: 公开了用于分析受试者的角质化组织，特别是指甲的诊断骨质疏松症和骨折风险的方法。 产生角化组织样品的拉曼光谱。 优选通过使用傅立叶变换分析去除光谱的宽光谱背景特征。 测量了拉曼特征的峰值高度，特别是胱氨酸的S-S键。 使用在正常和骨质疏松受试者之间不变的拉曼特征的参考峰高度，例如CH2弯曲峰，使这些峰高度测量值被归一化。

公开(公告)号：US20060262304A1

公开(公告)日：2006-11-23

申请号：US11409857

申请日：2006-04-24

Applicant: Keith Carron

Inventor： Keith Carron

IPC: G01J3/28

CPC classification number: G01J3/42 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0264 ,  G01J3/0294 ,  G01J3/1809 ,  G01J3/44 ,  G01J2001/4242

Abstract: An apparatus is described for the real-time identification of one or more selected components of a target material. In one embodiment, an infrared spectrometer and a separate Raman spectrometer are coupled to exchange respective spectral information of the target material preferably normalized and presented in a single graph. In an alternative embodiment, both an infrared spectrometer and a Raman spectrometer are included in a single instrument and a common infrared light source is used by both spectrometers. In another embodiment, a vibrational spectrometer and a stoichiometric spectrometer are combined in a single instrument and are coupled to exchange respective spectral information of the target material and to compare the spectral information against a library of spectra to generate a real-time signal if a selected component is present in the target material.

Abstract translation: 描述了用于实时识别目标材料的一个或多个选定部件的装置。 在一个实施例中，红外光谱仪和单独的拉曼光谱仪被耦合以交换目标材料的各个光谱信息，优选地被归一化并呈现在单个图中。 在替代实施例中，红外光谱仪和拉曼光谱仪均包括在单个仪器中，并且两个光谱仪都使用通用的红外光源。 在另一个实施例中，将振动光谱仪和化学计量光谱仪组合在单个仪器中，并耦合以交换目标材料的相应光谱信息，并将光谱信息与光谱库进行比较以产生实时信号，如果选定 组分存在于目标材料中。

公开(公告)号：US20050037514A1

公开(公告)日：2005-02-17

申请号：US10840090

申请日：2004-05-06

Applicant: Keith Carron ,  Roberta Sulk ,  Vince Martin

Inventor： Keith Carron ,  Roberta Sulk ,  Vince Martin

IPC: G01N21/65 ,  G01N21/62

CPC classification number: G01N21/658

Abstract: An assay method and kit for detecting a chemical. The method and kit utilize a metal surface capable of surface enhanced Raman Scattering. The metal surface may be provided in the form of one or more nanoparticles, to increase the surface enhanced Raman Scattering capability of the metal surface. The nanoparticles may be treated with one or more additives to further enhance or maintain the surface enhanced Raman Scattering capability of the nanoparticles.

Abstract translation: 用于检测化学物质的测定方法和试剂盒。 该方法和试剂盒利用能够进行表面增强拉曼散射的金属表面。 金属表面可以以一种或多种纳米颗粒的形式提供，以增加金属表面的表面增强的拉曼散射能力。 可以用一种或多种添加剂处理纳米颗粒以进一步增强或维持纳米颗粒的表面增强的拉曼散射能力。

公开(公告)号：US10684172B2

公开(公告)日：2020-06-16

申请号：US13819316

申请日：2011-08-30

Applicant: Keith Carron ,  Shane Buller ,  Mark Watson

Inventor： Keith Carron ,  Shane Buller ,  Mark Watson

IPC: G01N33/536 ,  G01J3/44 ,  G01N33/543 ,  G01N21/65 ,  G01J3/06

Abstract: A spectroscopic assay is provided. The assay comprises: a motive particle configured to move within a solution, the motive particle comprising a first analyte binding reagent for selectively binding to a target analyte; and a spectroscopic reporter particle configured to provide a predetermined spectroscopic signal in response to being interrogated by a spectrometer, the spectroscopic reporter particle comprising a second analyte binding reagent for selectively binding to the target analyte, wherein the motive particle and the spectroscopic reporter particle are configured to provide a sandwich assay in the presence of the target analyte via the first and second analyte binding reagents.