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    MICROELECTRONIC BIOSENSOR PLUG
    11.
    发明申请
    MICROELECTRONIC BIOSENSOR PLUG 有权
    微电子生物传感器插头

    公开(公告)号：US20110282171A1

    公开(公告)日：2011-11-17

    申请号：US13192664

    申请日：2011-07-28

    申请人： Robin A. Felder

    发明人： Robin A. Felder

    IPC分类号： A61B5/1468

    CPC分类号： A61B5/1486 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/6821 ,  A61F9/00772

    摘要： A plug capable of providing information relating to a physical or chemical property of a body fluid, or the presence or amount of a molecular component therein in a living organism is disclosed. Specifically, one embodiment plug is capable of being inserted into a portion of a human eyelid in order to provide information relating to tear fluid is disclosed. This embodiment plug includes a body having a passage which allows for the natural flow of tear fluid therethrough. In addition, a sensing mechanism is provided which is capable of measuring, for example, glucose levels in the body of a patient through the analysis of the tear fluid. Such plug may further be designed so as to double as a punctal plug useful in preventing dry eye. Methods of utilizing and implanting such plugs are also disclosed.

    摘要翻译： 公开了一种能够提供与体液的物理或化学性质相关的信息的插头，或其中存在或数量的活体中的分子成分。 具体地，一个实施例的插头能够插入到人眼的一部分中以便提供与泪液相关的信息。 该实施例的塞子包括具有允许泪液自然流过其中的通道的主体。 此外，提供了一种感测机构，其能够通过分析泪液测量例如患者体内的葡萄糖水平。 这样的塞子可以进一步设计成可以用作防止干眼症的泪点塞两倍。 还公开了利用和植入这种插头的方法。

    Method and System for the Derivation of Human Gait Characteristics and Detecting Falls Passively from Floor Vibrations
    12.
    发明申请
    Method and System for the Derivation of Human Gait Characteristics and Detecting Falls Passively from Floor Vibrations 有权
    人类步态特征的推导和检测方法和系统被动地从楼板振动下降

    公开(公告)号：US20110190667A1

    公开(公告)日：2011-08-04

    申请号：US12977899

    申请日：2010-12-23

    申请人： Majd Alwan ,  Robin A. Felder ,  Steven W. Kell ,  Siddharth Dalal

    发明人： Majd Alwan ,  Robin A. Felder ,  Steven W. Kell ,  Siddharth Dalal

    IPC分类号： A61B5/11

    CPC分类号： G01P3/50 ,  A61B5/0002 ,  A61B5/0017 ,  A61B5/1038 ,  A61B5/1117 ,  A61B2562/02 ,  A61B2562/0219 ,  G06K9/00335

    摘要： The gait monitor system and method provides various basic gait parameters including step count, cadence, and step duration, in addition to its ability to distinguish between normal, limping and shuffling gait modes, as well as determine falls. Moreover, this gait monitor may be provided with additional sensors, e.g. beam break at the beginning and end of a corridor to estimate average walking velocity (with the distance between the beams known or determined); this enables the calculation of additional gait characteristics such as average step length and average stride length. These parameters can additionally be used to detect various gait anomalies and other diagnostic information.

    摘要翻译： 步态监视器系统和方法除了能够区分正常，跛行和洗牌步态模式以及确定下降之外，还提供了步数，节奏和步长等各种基本步态参数。 此外，该步态监视器可以设置有附加的传感器，例如。 走廊开始和结束处的横梁断裂，以估计平均步行速度（已知或确定的梁之间的距离）; 这使得能够计算额外的步态特征，例如平均步长和平均步幅长度。 这些参数可以另外用于检测各种步态异常和其他诊断信息。

    G protein-related kinase mutants in essential hypertension
    13.
    发明申请
    G protein-related kinase mutants in essential hypertension 有权
    G蛋白相关激酶突变体在原发性高血压

    公开(公告)号：US20100313286A1

    公开(公告)日：2010-12-09

    申请号：US12315338

    申请日：2008-12-01

    申请人： Robin A. Felder ,  Pedro Jose

    发明人： Robin A. Felder ,  Pedro Jose

    IPC分类号： A61K31/713 ,  C07H21/04 ,  C12N9/12 ,  C12N5/10 ,  C12N9/96 ,  A01K67/027 ,  G01N33/53 ,  G01N33/20 ,  A61K31/7088 ,  A61P13/00

    CPC分类号： C07K14/723 ,  A01K2217/05 ,  A01K2217/056

    摘要： Disclosed are methods for identifying individuals predisposed to essential hypertension and related conditions such as salt sensitivity by detecting the presence of polymorphic or mutant forms of the GRK4 gene, or its expression product. Also disclosed are methods for identifying polymorphic or mutant GRK4s in individuals known to be suffering from such conditions, as well as methods and compositions for conducting drug discovery and therapeutic intervention.

    摘要翻译： 公开了通过检测GRK4基因或其表达产物的多态性或突变体形式的存在来鉴定易发生原发性高血压的个体和相关条件如盐敏感性的方法。 还公开了用于鉴定已知患有这些病症的个体中的多态性或突变型GRK4的方法，以及用于进行药物发现和治疗干预的方法和组合物。

    COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING SALT SENSITIVITY OF BLOOD PRESSURE
    14.
    发明申请
    COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING SALT SENSITIVITY OF BLOOD PRESSURE 审中-公开
    用于诊断和治疗血压的盐敏感性的组合物和方法

    公开(公告)号：US20150005290A1

    公开(公告)日：2015-01-01

    申请号：US14316183

    申请日：2014-06-26

    申请人： Robin A. Felder ,  Julia Carlson ,  John J. Gildea

    发明人： Robin A. Felder ,  Julia Carlson ,  John J. Gildea

    IPC分类号： C12Q1/68 ,  A61K31/554

    CPC分类号： C12Q1/6883 ,  A61K31/554 ,  C12Q2600/158 ,  C12Q2600/178

    摘要： To characterize the urinary exosome miRNome, microarrays were used to identify the miRNA spectrum present within urinary exosomes from ten individuals that were previously classified for their salt sensitivity status. The present application discloses distinct patterns of selected exosomal miRNA expression that were different between salt-sensitive (SS), salt-resistant (SR), and inverse salt-sensitive (ISS) individuals. These miRNAs can be useful as biomarkers either individually or as panels comprising multiple miRNAs. The present invention provides compositions and methods for identifying, diagnosing, monitoring, and treating subjects with salt sensitivity of blood pressure. The applications discloses panels of miRNAs useful for comparing profiles, and in some cases one or more of the miRNAs in a panel can be used. The miRNAs useful for distinguishing SS and SR or ISS and SR subjects. One or more of the 45 miRNAs can be used. Some of the miRNAs have not been previously reported to be circulating. See those miRNAs with asterisks in FIG. 1 and below. The present invention encompasses the use of one or more of these markers for identifying and diagnosing SR, SS, and ISS subjects.

    摘要翻译： 为了表征尿外胚层miRNome，使用微阵列鉴定了先前根据其盐敏感性状态分类的十个个体的尿外泌体中存在的miRNA光谱。 本申请公开了在盐敏感（SS），耐盐（SR）和反盐敏感（ISS）个体之间不同的选择的外来miRNA表达的不同模式。 这些miRNA可以单独使用或作为包含多个miRNA的图谱用作生物标志物。 本发明提供用于识别，诊断，监测和治疗具有盐敏感性的受试者的组合物和方法。 应用公开了可用于比较谱的miRNA片段，在某些情况下可以使用一个或多个miRNA中的miRNA。 这些miRNA可用于区分SS和SR或ISS和SR受试者。 可以使用45种miRNA中的一种或多种。 一些miRNA以前没有报道是循环的。 参见图中具有星号的那些miRNA。 1及以下。 本发明包括使用这些标记物中的一种或多种来鉴定和诊断SR，SS和ISS受试者。

    Automated storage and retrieval apparatus for freezers and related method thereof
    16.
    发明授权
    Automated storage and retrieval apparatus for freezers and related method thereof 有权
    冷冻机自动储存和检索装置及其相关方法

    公开(公告)号：US06941762B2

    公开(公告)日：2005-09-13

    申请号：US10773327

    申请日：2004-02-06

    申请人： Robin A. Felder ,  B. Sean Graves ,  James P. Gunderson

    发明人： Robin A. Felder ,  B. Sean Graves ,  James P. Gunderson

    IPC分类号： F25D11/04 ,  F25D25/00 ,  F25D29/00 ,  G01N1/42 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  F25D13/06

    CPC分类号： G01N35/028 ,  F25B2500/06 ,  F25D11/04 ,  F25D25/00 ,  F25D29/001 ,  G01N1/42 ,  G01N2035/00752 ,  G01N2035/0425

    摘要： An automated cold storage apparatus, and related method thereof, provides a sample process management system that is a revolutionary approach to the storage and retrieval regarding critical samples. The system—a significant technological breakthrough in laboratory automation—is the first ultra low temperature robotic system capable of being validated. Samples in containers are stored and retrieved robotically through an airlock climate-control chamber that is automatically dehumidified by a dry gas purge, such as a carbon dioxide or nitrogen purge or the like. This purge rapidly reduces ambient humidity to a desirable relative humidity (RH), e.g., less than about 15% RH, virtually eliminating the accumulation of frost. Microplates are systematically identified using barcode technology, for example. Once through the climate-controlled chamber, the containers (i.e., samples) are robotically transferred to the rotary mechanism. This mechanism transports the containers to a derived nest location upon the storage means, such as a carousel or to one of the stationary addresses.

    摘要翻译： 一种自动冷藏设备及其相关方法提供了一种样品过程管理系统，其是关于关键样品的存储和检索的革命性方法。 该系统是实验室自动化方面的重大技术突破 - 是能够验证的第一台超低温机器人系统。 容器中的样品通过气闸气候控制室被机器人储存和回收，该空气调节室通过干燥气体吹扫（例如二氧化碳或氮气吹扫等）自动除湿。 这种吹扫将环境湿度快速地降低到所需的相对湿度（RH），例如小于约15％RH，实际上消除了霜冻的积聚。 例如，使用条形码技术系统地识别微孔板。 一旦通过气候控制室，容器（即样品）被机械地转移到旋转机构。 这种机构将容器运送到存储装置（例如转盘或固定地址中的一个）上的衍生嵌套位置。

    G protein-related kinase mutants in essential hypertension
    17.
    发明授权
    G protein-related kinase mutants in essential hypertension 有权
    G蛋白相关激酶突变体在原发性高血压

    公开(公告)号：US06660474B1

    公开(公告)日：2003-12-09

    申请号：US09614748

    申请日：2000-07-12

    申请人： Robin A. Felder ,  Pedro Jose

    发明人： Robin A. Felder ,  Pedro Jose

    IPC分类号： C07H2104

    CPC分类号： C07K14/723 ,  A01K2217/05 ,  A01K2217/056

    摘要： Disclosed are methods for identifying individuals predisposed to essential hypertension and related conditions such as salt sensitivity by detecting the presence of polymorphic or mutant forms of the GRK4 gene, or its expression product. Also disclosed are methods for identifying polymorphic or mutant GRK4s in individuals known to be suffering from such conditions, as well as methods and compositions for conducting drug discovery and therapeutic intervention.

    摘要翻译： 公开了通过检测GRK4基因或其表达产物的多态性或突变体形式的存在来鉴定易发生原发性高血压的个体和相关条件如盐敏感性的方法。 还公开了用于鉴定已知患有这些病症的个体中的多态性或突变型GRK4的方法，以及用于进行药物发现和治疗干预的方法和组合物。

    Method and system for the derivation of human gait characteristics and detecting falls passively from floor vibrations
    18.
    发明授权
    Method and system for the derivation of human gait characteristics and detecting falls passively from floor vibrations 有权
    用于推导人类步态特征和检测的方法和系统被动地从地板振动下降

    公开(公告)号：US08551026B2

    公开(公告)日：2013-10-08

    申请号：US12977899

    申请日：2010-12-23

    申请人： Majd Alwan ,  Robin A. Felder ,  Steven W. Kell ,  Siddharth Dalal

    发明人： Majd Alwan ,  Robin A. Felder ,  Steven W. Kell ,  Siddharth Dalal

    IPC分类号： A61B5/103 ,  A61B5/117 ,  G01C22/00 ,  G01B5/02

    CPC分类号： G01P3/50 ,  A61B5/0002 ,  A61B5/0017 ,  A61B5/1038 ,  A61B5/1117 ,  A61B2562/02 ,  A61B2562/0219 ,  G06K9/00335

    摘要： The gait monitor system and method provides various basic gait parameters including step count, cadence, and step duration, in addition to its ability to distinguish between normal, limping and shuffling gait modes, as well as determine falls. Moreover, this gait monitor may be provided with additional sensors, e.g. beam break at the beginning and end of a corridor to estimate average walking velocity (with the distance between the beams known or determined); this enables the calculation of additional gait characteristics such as average step length and average stride length. These parameters can additionally be used to detect various gait anomalies and other diagnostic information.

    摘要翻译： 步态监视器系统和方法除了能够区分正常，跛行和洗牌步态模式以及确定下降之外，还提供了步数，节奏和步长等各种基本步态参数。 此外，该步态监视器可以设置有附加的传感器，例如。 走廊开始和结束处的横梁断裂，以估计平均步行速度（已知或确定的梁之间的距离）; 这使得能够计算额外的步态特征，例如平均步长和平均步幅长度。 这些参数可以另外用于检测各种步态异常和其他诊断信息。

    Microelectronic biosensor plug
    19.
    发明授权
    Microelectronic biosensor plug 有权
    微电子生物传感器插头

    公开(公告)号：US08364232B2

    公开(公告)日：2013-01-29

    申请号：US13192664

    申请日：2011-07-28

    申请人： Robin A. Felder

    发明人： Robin A. Felder

    IPC分类号： A61B5/05

    CPC分类号： A61B5/1486 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/6821 ,  A61F9/00772

    摘要： A plug capable of providing information relating to a physical or chemical property of a body fluid, or the presence or amount of a molecular component therein in a living organism is disclosed. Specifically, one embodiment plug is capable of being inserted into a portion of a human eyelid in order to provide information relating to tear fluid is disclosed. This embodiment plug includes a body having a passage which allows for the natural flow of tear fluid therethrough. In addition, a sensing mechanism is provided which is capable of measuring, for example, glucose levels in the body of a patient through the analysis of the tear fluid. Such plug may further be designed so as to double as a punctal plug useful in preventing dry eye. Methods of utilizing and implanting such plugs are also disclosed.

    摘要翻译： 公开了一种能够提供与体液的物理或化学性质相关的信息的插头，或其中存在或数量的活体中的分子成分。 具体地，一个实施例的插头能够插入到人眼的一部分中以便提供与泪液相关的信息。 该实施例的塞子包括具有允许泪液自然流过其中的通道的主体。 此外，提供了一种感测机构，其能够通过分析泪液测量例如患者体内的葡萄糖水平。 这样的塞子可以进一步设计成可以用作防止干眼症的泪点塞两倍。 还公开了利用和植入这种插头的方法。