公开(公告)号：US06581395B2

公开(公告)日：2003-06-24

申请号：US10263910

申请日：2002-10-03

申请人： Robin A. Felder ,  B. Sean Graves ,  James P. Gunderson

发明人： Robin A. Felder ,  B. Sean Graves ,  James P. Gunderson

IPC分类号： F25D1700

CPC分类号： G01N35/028 ,  F25B2500/06 ,  F25D11/04 ,  F25D25/00 ,  F25D29/001 ,  G01N1/42 ,  G01N2035/00752 ,  G01N2035/0425

摘要： An automated cold storage apparatus, and related method thereof, provides a sample process management system that is a revolutionary approach to the storage and retrieval regarding critical samples. The system—a significant technological breakthrough in laboratory automation—is the first ultra low temperature robotic system capable of being validated. Samples in containers are stored and retrieved robotically through an airlock climate-control chamber that is automatically dehumidified by a dry gas purge, such as a carbon dioxide or nitrogen purge or the like. This purge rapidly reduces ambient humidity to a desirable relative humidity (RH), e.g., less than about 15% RH, virtually eliminating the accumulation of frost. Microplates are systematically identified using barcode technology, for example. Once through the climate-controlled chamber, the containers (i.e., samples) are robotically transferred to the rotary mechanism. This mechanism transports the containers to a derived nest location upon the storage means, such as a carousel or to one of the stationary addresses.

公开(公告)号：US06688123B2

公开(公告)日：2004-02-10

申请号：US10429490

申请日：2003-05-05

申请人： Robin A. Felder ,  B. Sean Graves ,  James P. Gunderson

发明人： Robin A. Felder ,  B. Sean Graves ,  James P. Gunderson

IPC分类号： F25D1700

CPC分类号： G01N35/028 ,  F25B2500/06 ,  F25D11/04 ,  F25D25/00 ,  F25D29/001 ,  G01N1/42 ,  G01N2035/00752 ,  G01N2035/0425

摘要： An automated cold storage apparatus, and related method thereof, provides a sample process management system that is a revolutionary approach to the storage and retrieval regarding critical samples. The system—a significant technological breakthrough in laboratory automation—is the first ultra low temperature robotic system capable of being validated. Samples in containers are stored and retrieved robotically through an airlock climate-control chamber that is automatically dehumidified by a dry gas purge, such as a carbon dioxide or nitrogen purge or the like. This purge rapidly reduces ambient humidity to a desirable relative humidity (RH), e.g., less than about 15% RH, virtually eliminating the accumulation of frost. Microplates are systematically identified using barcode technology, for example. Once through the climate-controlled chamber, the containers (i.e., samples) are robotically transferred to the rotary mechanism. This mechanism transports the containers to a derived nest location upon the storage means, such as a carousel or to one of the stationary addresses.

公开(公告)号：US06467285B2

公开(公告)日：2002-10-22

申请号：US09935488

申请日：2001-08-23

申请人： Robin A. Felder ,  B. Sean Graves ,  James P. Gunderson

发明人： Robin A. Felder ,  B. Sean Graves ,  James P. Gunderson

IPC分类号： F25D1700

CPC分类号： G01N35/028 ,  F25B2500/06 ,  F25D11/04 ,  F25D25/00 ,  F25D29/001 ,  G01N1/42 ,  G01N2035/00752 ,  G01N2035/0425

摘要： An automated cold storage apparatus, and related method thereof, provides a sample process management system that is a revolutionary approach to the storage and retrieval regarding critical samples. The system—a significant technological breakthrough in laboratory automation—is the first ultra low temperature robotic system capable of being validated. Samples in containers are stored and retrieved robotically through an airlock climate-control chamber that is automatically dehumidified by a dry gas purge, such as a carbon dioxide or nitrogen purge or the like. This purge rapidly reduces ambient humidity to a desirable relative humidity (RH), e.g., less than about 15% RH, virtually eliminating the accumulation of frost. Microplates are systematically identified using barcode technology, for example. Once through the climate-controlled chamber, the containers (i.e., samples) are robotically transferred to the rotary mechanism. This mechanism transports the containers to a derived nest location upon the storage means, such as a carousel or to one of the stationary addresses.

摘要翻译： 一种自动冷藏设备及其相关方法提供了一种样品过程管理系统，其是关于关键样品的存储和检索的革命性方法。 该系统是实验室自动化方面的重大技术突破 - 是能够验证的第一台超低温机器人系统。 容器中的样品通过气闸气候控制室被机器人储存和回收，该空气调节室通过干燥气体吹扫（例如二氧化碳或氮气吹扫等）自动除湿。 这种吹扫将环境湿度快速地降低到所需的相对湿度（RH），例如小于约15％RH，实际上消除了霜冻的积聚。 例如，使用条形码技术系统地识别微孔板。 一旦通过气候控制室，容器（即样品）被机械地转移到旋转机构。 这种机构将容器运送到存储装置（例如转盘或固定地址中的一个）上的衍生嵌套位置。

公开(公告)号：US06941762B2

公开(公告)日：2005-09-13

申请号：US10773327

申请日：2004-02-06

申请人： Robin A. Felder ,  B. Sean Graves ,  James P. Gunderson

发明人： Robin A. Felder ,  B. Sean Graves ,  James P. Gunderson

IPC分类号： F25D11/04 ,  F25D25/00 ,  F25D29/00 ,  G01N1/42 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  F25D13/06

CPC分类号： G01N35/028 ,  F25B2500/06 ,  F25D11/04 ,  F25D25/00 ,  F25D29/001 ,  G01N1/42 ,  G01N2035/00752 ,  G01N2035/0425

摘要： An automated cold storage apparatus, and related method thereof, provides a sample process management system that is a revolutionary approach to the storage and retrieval regarding critical samples. The system—a significant technological breakthrough in laboratory automation—is the first ultra low temperature robotic system capable of being validated. Samples in containers are stored and retrieved robotically through an airlock climate-control chamber that is automatically dehumidified by a dry gas purge, such as a carbon dioxide or nitrogen purge or the like. This purge rapidly reduces ambient humidity to a desirable relative humidity (RH), e.g., less than about 15% RH, virtually eliminating the accumulation of frost. Microplates are systematically identified using barcode technology, for example. Once through the climate-controlled chamber, the containers (i.e., samples) are robotically transferred to the rotary mechanism. This mechanism transports the containers to a derived nest location upon the storage means, such as a carousel or to one of the stationary addresses.

摘要翻译： 一种自动冷藏设备及其相关方法提供了一种样品过程管理系统，其是关于关键样品的存储和检索的革命性方法。 该系统是实验室自动化方面的重大技术突破 - 是能够验证的第一台超低温机器人系统。 容器中的样品通过气闸气候控制室被机器人储存和回收，该空气调节室通过干燥气体吹扫（例如二氧化碳或氮气吹扫等）自动除湿。 这种吹扫将环境湿度快速地降低到所需的相对湿度（RH），例如小于约15％RH，实际上消除了霜冻的积聚。 例如，使用条形码技术系统地识别微孔板。 一旦通过气候控制室，容器（即样品）被机械地转移到旋转机构。 这种机构将容器运送到存储装置（例如转盘或固定地址中的一个）上的衍生嵌套位置。

公开(公告)号：US5366896A

公开(公告)日：1994-11-22

申请号：US739204

申请日：1991-07-30

申请人： Keith S. Margrey ,  Robin A. Felder ,  James C. Boyd ,  J. William Holman ,  Jonathan H. Roberts ,  John Savory ,  Antonia Martinez

发明人： Keith S. Margrey ,  Robin A. Felder ,  James C. Boyd ,  J. William Holman ,  Jonathan H. Roberts ,  John Savory ,  Antonia Martinez

IPC分类号： G01N35/00 ,  G01N35/04 ,  G06F19/00 ,  G06F15/42 ,  G01N1/00

CPC分类号： G01N35/00871 ,  G01N35/0099 ,  G06F19/3406 ,  G06F19/366 ,  G01N2035/00752 ,  G01N2035/00881 ,  G01N2035/0405 ,  G01N2035/0491 ,  G06F19/322 ,  G06F19/3412 ,  G06F19/3418 ,  Y10S436/807 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/115831 ,  Y10T436/12

摘要： The present invention relates to an integrated analytical system which includes a plurality of remote laboratories and a central monitoring station. The remote laboratories include a specimen analysis member and a plurality of peripheral devices. The central monitoring station includes a computer for controlling predetermined functions of the peripheral devices. A local area network provides communication between each of the remote laboratories and the central monitoring station. A computer interface provides bi-directional communication between analytical instruments, robots and peripheral devices and a computer. The system employs a robot which is responsive to computer commands and capable of performing mechanical functions.The mechanical functions include manipulating an analytical instrument, transporting the specimens to be analyzed through a variety of locations, and the manipulation of the container in which the specimen is housed.

摘要翻译： 本发明涉及一种综合分析系统，其包括多个远程实验室和中央监测站。 远程实验室包括样本分析构件和多个外围设备。 中央监控站包括用于控制外围设备的预定功能的计算机。 局域网提供每个远程实验室和中央监测站之间的通信。 计算机接口提供分析仪器，机器人和外围设备以及计算机之间的双向通信。 该系统采用响应于计算机命令并能够执行机械功能的机器人。 机械功能包括操纵分析仪器，通过各种位置运输要分析的样品，以及对容器进行操作。

公开(公告)号：US08894576B2

公开(公告)日：2014-11-25

申请号：US11076604

申请日：2005-03-10

申请人： Majd Alwan ,  Robin A. Felder ,  Steven W. Kell ,  Sarah G. Wood ,  Michael Cvetanovich ,  Beverly L. Turner ,  J. William Holman

发明人： Majd Alwan ,  Robin A. Felder ,  Steven W. Kell ,  Sarah G. Wood ,  Michael Cvetanovich ,  Beverly L. Turner ,  J. William Holman

IPC分类号： A61B5/00 ,  G06F15/177 ,  G06F15/173 ,  A61B5/11

CPC分类号： A61B5/1115 ,  A61B5/0002 ,  A61B5/1112 ,  A61B5/1113 ,  A61B5/1116 ,  A61B5/202 ,  A61B5/6887 ,  A61B5/6889 ,  A61B5/7282 ,  A61B2560/0242 ,  A61B2562/0247 ,  A61B2562/046

摘要： A method and related system to, among other things, automatically infer answers to all of the ADL questions and the first four questions of the IADL in the home. The inference methods detect the relevant activities unobtrusively, continuously, accurately, objectively, quantifiably and without relying on the patient's own memory (which may be fading due to aging or an existing health condition, such as Traumatic Brain Injury (TBI)) or on a caregiver's subjective report. The methods rely on the judicious placement of a number of sensors in the subject's place of residence, including motion detection sensors in every room, the decomposition of each relevant activity into the sub-tasks involved, identification of additional sensors required to detect the relevant sub-tasks and spatial-temporal conditions between the signals of sensors to formulate the rules that will detect the occurrence of the specific activities of interest.

摘要翻译： 一种方法和相关系统，除其他外，自动推断出所有ADL问题和家庭中IADL的前四个问题的答案。 推理方法不间断地，连续地，准确地，客观地，可量化地检测相关活动，而不依赖于患者自己的记忆（可能由于老化或现有健康状况（例如创伤性脑损伤（TBI））而衰退） 看护者的主观报告。 这些方法依赖于在主体居住地点中明智地放置多个传感器，包括每个房间中的运动检测传感器，将每个相关活动分解为所涉及的子任务，识别检测相关子站所需的附加传感器 传感器信号之间的空间和空间 - 时间条件，以制定将检测感兴趣的具体活动的发生的规则。

公开(公告)号：US09074016B2

公开(公告)日：2015-07-07

申请号：US12315338

申请日：2008-12-01

申请人： Robin A. Felder ,  Pedro Jose

发明人： Robin A. Felder ,  Pedro Jose

IPC分类号： C07K14/72

CPC分类号： C07K14/723 ,  A01K2217/05 ,  A01K2217/056

摘要： Disclosed are methods for identifying individuals predisposed to essential hypertension and related conditions such as salt sensitivity by detecting the presence of polymorphic or mutant forms of the GRK4 gene, or its expression product. Also disclosed are methods for identifying polymorphic or mutant GRK4s in individuals known to be suffering from such conditions, as well as methods and compositions for conducting drug discovery and therapeutic intervention.

公开(公告)号：US08090426B2

公开(公告)日：2012-01-03

申请号：US11588974

申请日：2006-10-27

申请人： Robin A. Felder

发明人： Robin A. Felder

IPC分类号： A61B5/05

CPC分类号： A61B5/1486 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/6821 ,  A61F9/00772

摘要： A plug capable of providing information relating to a physical or chemical property of a body fluid, or the presence or amount of a molecular component therein in a living organism is disclosed. Specifically, one embodiment plug is capable of being inserted into a portion of a human eyelid in order to provide information relating to tear fluid is disclosed. This embodiment plug includes a body having a passage which allows for the natural flow of tear fluid therethrough. In addition, a sensing mechanism is provided which is capable of measuring, for example, glucose levels in the body of a patient through the analysis of the tear fluid. Such plug may further be designed so as to double as a punctual plug useful in preventing dry eye. Methods of utilizing and implanting such plugs are also disclosed.

摘要翻译： 公开了一种能够提供与体液的物理或化学性质相关的信息的插头，或其中存在或数量的活体中的分子成分。 具体地，一个实施例的插头能够插入到人眼的一部分中以便提供与泪液相关的信息。 该实施例的塞子包括具有允许泪液自然流过其中的通道的主体。 此外，提供了一种感测机构，其能够通过分析泪液测量例如患者体内的葡萄糖水平。 这种塞子可进一步被设计成可以用作防止干眼症的准时塞子的两倍。 还公开了利用和植入这种插头的方法。

公开(公告)号：US20110282171A1

公开(公告)日：2011-11-17

申请号：US13192664

申请日：2011-07-28

申请人： Robin A. Felder

发明人： Robin A. Felder

IPC分类号： A61B5/1468

CPC分类号： A61B5/1486 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/6821 ,  A61F9/00772

摘要： A plug capable of providing information relating to a physical or chemical property of a body fluid, or the presence or amount of a molecular component therein in a living organism is disclosed. Specifically, one embodiment plug is capable of being inserted into a portion of a human eyelid in order to provide information relating to tear fluid is disclosed. This embodiment plug includes a body having a passage which allows for the natural flow of tear fluid therethrough. In addition, a sensing mechanism is provided which is capable of measuring, for example, glucose levels in the body of a patient through the analysis of the tear fluid. Such plug may further be designed so as to double as a punctal plug useful in preventing dry eye. Methods of utilizing and implanting such plugs are also disclosed.

摘要翻译： 公开了一种能够提供与体液的物理或化学性质相关的信息的插头，或其中存在或数量的活体中的分子成分。 具体地，一个实施例的插头能够插入到人眼的一部分中以便提供与泪液相关的信息。 该实施例的塞子包括具有允许泪液自然流过其中的通道的主体。 此外，提供了一种感测机构，其能够通过分析泪液测量例如患者体内的葡萄糖水平。 这样的塞子可以进一步设计成可以用作防止干眼症的泪点塞两倍。 还公开了利用和植入这种插头的方法。

公开(公告)号：US20110190667A1

公开(公告)日：2011-08-04

申请号：US12977899

申请日：2010-12-23

申请人： Majd Alwan ,  Robin A. Felder ,  Steven W. Kell ,  Siddharth Dalal

发明人： Majd Alwan ,  Robin A. Felder ,  Steven W. Kell ,  Siddharth Dalal

IPC分类号： A61B5/11

CPC分类号： G01P3/50 ,  A61B5/0002 ,  A61B5/0017 ,  A61B5/1038 ,  A61B5/1117 ,  A61B2562/02 ,  A61B2562/0219 ,  G06K9/00335

摘要： The gait monitor system and method provides various basic gait parameters including step count, cadence, and step duration, in addition to its ability to distinguish between normal, limping and shuffling gait modes, as well as determine falls. Moreover, this gait monitor may be provided with additional sensors, e.g. beam break at the beginning and end of a corridor to estimate average walking velocity (with the distance between the beams known or determined); this enables the calculation of additional gait characteristics such as average step length and average stride length. These parameters can additionally be used to detect various gait anomalies and other diagnostic information.

摘要翻译： 步态监视器系统和方法除了能够区分正常，跛行和洗牌步态模式以及确定下降之外，还提供了步数，节奏和步长等各种基本步态参数。 此外，该步态监视器可以设置有附加的传感器，例如。 走廊开始和结束处的横梁断裂，以估计平均步行速度（已知或确定的梁之间的距离）; 这使得能够计算额外的步态特征，例如平均步长和平均步幅长度。 这些参数可以另外用于检测各种步态异常和其他诊断信息。