公开(公告)号：US20070084796A1

公开(公告)日：2007-04-19

申请号：US11637157

申请日：2006-12-12

Applicant: Atsushi Onishi ,  Koichi Murazumi ,  Kozo Tachibana

Inventor： Atsushi Onishi ,  Koichi Murazumi ,  Kozo Tachibana

IPC: B01D15/08

CPC classification number: B01J20/29 ,  B01D15/1821 ,  B01D15/185 ,  B01D15/3833 ,  B01D2215/023 ,  B01J20/286 ,  B01J20/327 ,  B01J20/3274 ,  B01J20/328 ,  C07B57/00

Abstract: The objectives of this invention are to provide a filler for separating optical isomers, capable of efficiently carrying out optical resolution of optical isomer mixtures, and to provide a process for separating optical isomers by a simulated moving bed chromatography utilizing the filler. This invention provides a filler made of a carrier supporting a specific amount of an optically active high molecular weight compound. Separation by the simulated moving bed chromatography using the filler is carried out under the condition that the capacity factors have specific values.

Abstract translation: 本发明的目的是提供一种用于分离光学异构体的填料，其能够有效地进行光学异构体混合物的光学拆分，并提供通过使用填料的模拟移动床色谱分离光学异构体的方法。 本发明提供了由支持特定量的光学活性高分子量化合物的载体制成的填料。 在容量因子具有特定值的条件下，通过使用填料的模拟移动床层析法进行分离。

公开(公告)号：US20050075502A1

公开(公告)日：2005-04-07

申请号：US10398915

申请日：2001-10-12

Applicant: Atsushi Onishi ,  Koichi Murazumi ,  Kozo Tachibana

Inventor： Atsushi Onishi ,  Koichi Murazumi ,  Kozo Tachibana

IPC: A61K31/47 ,  B01D15/08 ,  B01D15/18 ,  B01D15/38 ,  B01J20/26 ,  B01J20/281 ,  B01J20/29 ,  B01J20/32 ,  C07B57/00 ,  C07D215/04 ,  C07D215/14

CPC classification number: B01J20/328 ,  B01D15/185 ,  B01D15/3833 ,  B01J20/262 ,  B01J20/265 ,  B01J20/286 ,  B01J20/29 ,  B01J20/3204 ,  B01J20/3272 ,  B01J2220/54 ,  C07B2200/07 ,  C07D215/14

Abstract: The objective of this invention is to provide a process for producing an optically active isomer of ethyl 7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate by optically resolving an optical isomer mixture of the compound at a high productivity. The process is characterized by employing a filler comprising a carrier and a specific amount of cellulose tris (4-chlorophenyl carbamate) supported the carrier and carrying out chromatographic separation under the condition that the capacity factors have specific values.

Abstract translation: 本发明的目的是提供通过光学制备7- [2-环丙基-4-（4-氟苯基）喹啉-3-基] -3,5-二羟基-6-庚烯酸乙酯的旋光异构体的方法 以高生产率分解化合物的旋光异构体混合物。 该方法的特征在于使用包含载体和特定量的纤维素三（4-氯苯基氨基甲酸酯）的填料负载载体并在容量因子具有特定值的条件下进行色谱分离。

公开(公告)号：US20060089381A1

公开(公告)日：2006-04-27

申请号：US11254864

申请日：2005-10-21

Applicant: Atsushi Onishi ,  Kozo Tachibana

Inventor： Atsushi Onishi ,  Kozo Tachibana

IPC: C07D215/14 ,  A61K31/47 ,  C08B37/00

CPC classification number: C07D215/14 ,  C07B2200/07

Abstract: A method of producing Ethyl (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl]-3,5-dihydroxy-6-heptenoate by means of liquid chromatography using a packing material comprising a carrier and, carried thereon, a polysaccharide derivative, wherein a part or all of the hydrogen atoms of hydroxyl and amino groups of the polysaccharide derivative are substituted with one or more substituents, such as a carbamoyl group wherein one hydrogen atom is substituted with an aromatic group having a specific alkyl group. The method allows the production of the above (3R,5S,6E) isomer with enhanced productivity to a conventional method.

Abstract translation: 通过液相色谱法使用（3R，5S，6E）-7- [2-环丙基-4-（4-氟苯基）喹啉-3-基] -3,5-二羟基-6-庚烯酸乙酯 包含载体的载体和载体上的多糖衍生物，其中多糖衍生物的羟基和氨基的一部分或全部氢原子被一个或多个取代基取代，例如氨基甲酰基，其中一个氢原子是 被具有特定烷基的芳基取代。 该方法允许以常规方法以高生产率生产上述（3R，5S，6E）异构体。

公开(公告)号：US06946557B2

公开(公告)日：2005-09-20

申请号：US10398915

申请日：2001-10-12

Applicant: Atsushi Onishi ,  Koichi Murazumi ,  Kozo Tachibana

Inventor： Atsushi Onishi ,  Koichi Murazumi ,  Kozo Tachibana

IPC: A61K31/47 ,  B01D15/08 ,  B01D15/18 ,  B01D15/38 ,  B01J20/26 ,  B01J20/281 ,  B01J20/29 ,  B01J20/32 ,  C07B57/00 ,  C07D215/04 ,  C07D215/14

CPC classification number: B01J20/328 ,  B01D15/185 ,  B01D15/3833 ,  B01J20/262 ,  B01J20/265 ,  B01J20/286 ,  B01J20/29 ,  B01J20/3204 ,  B01J20/3272 ,  B01J2220/54 ,  C07B2200/07 ,  C07D215/14

Abstract: The objective of this invention is to provide a process for producing an optically active isomer of ethyl 7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate by optically resolving an optical isomer mixture of the compound at a high productivity. The process is characterized by employing a filler comprising a carrier and a specific amount of cellulose tris (4-chlorophenyl carbamate) supported the carrier and carrying out chromatographic separation under the condition that the capacity factors have specific values.

Abstract translation: 本发明的目的是提供通过光学制备7- [2-环丙基-4-（4-氟苯基）喹啉-3-基] -3,5-二羟基-6-庚烯酸乙酯的旋光异构体的方法 以高生产率分解化合物的旋光异构体混合物。 该方法的特征在于使用包含载体和特定量的纤维素三（4-氯苯基氨基甲酸酯）的填料负载载体并在容量因子具有特定值的条件下进行色谱分离。

公开(公告)号：US5514818A

公开(公告)日：1996-05-07

申请号：US386865

申请日：1995-02-10

Applicant: Kozo Tachibana

Inventor： Kozo Tachibana

IPC: B01J20/281 ,  B01J20/24 ,  B01J20/291 ,  C07B57/00 ,  C07D301/00 ,  C07D301/32 ,  C07D303/04 ,  C07D303/08 ,  C07D303/12 ,  C07D303/14 ,  C07D303/16 ,  C07D303/22 ,  C07D303/48 ,  G01N30/02 ,  G01N30/88

CPC classification number: C07D303/22 ,  C07D301/00 ,  C07D301/32 ,  C07D303/04 ,  C07D303/08 ,  C07D303/12 ,  C07D303/16 ,  C07D303/48

Abstract: A method of resolving a mixture of stereoisomers of an aliphatic epoxide containing two or less oxygen atoms is provided. The method comprises utilizing a polysaccharide or a derivative thereof as a resolving agent.

Abstract translation: 提供了一种拆分含有两个或更少氧原子的脂族环氧化物的立体异构体的混合物的方法。 该方法包括使用多糖或其衍生物作为拆分剂。

公开(公告)号：US5412114A

公开(公告)日：1995-05-02

申请号：US15408

申请日：1993-02-09

Applicant: Seiji Shinkai ,  Tsutomu Matsuda ,  Takashi Arimura ,  Hirosuke Kawabata ,  Kozo Tachibana

Inventor： Seiji Shinkai ,  Tsutomu Matsuda ,  Takashi Arimura ,  Hirosuke Kawabata ,  Kozo Tachibana

IPC: C07B57/00 ,  C07C2/86 ,  C07C13/70 ,  C07C41/01 ,  C07C43/20 ,  C07C43/21 ,  C07D213/30 ,  C07D313/00

CPC classification number: C07D213/30 ,  C07C43/21 ,  C07C2103/92

Abstract: The present invention relates to an improvement in the process for preparing a calixarene derivative in which the rotation of its benzene units are hindered and which comprises replacing all or a part of the hydrogen atoms of the hydroxyl groups of a calixarene derivative represented by the general formula: ##STR1## and is characterized by conducting the reaction in the presence of an alkaline earth metal. According to the present invention, an asymmetric calixarene derivative having a "cone" conformation can be selectively prepared by virtue of the template effect of the metal.

Abstract translation: 本发明涉及制备其苯单元旋转受阻的杯芳烃衍生物的制备方法的改进，其包括用通式（I）表示的杯芳烃衍生物的羟基的全部或一部分代替 ：，其特征在于在碱土金属存在下进行反应。 根据本发明，可以通过金属的模板效应选择性地制备具有“锥形”构型的不对称杯芳烃衍生物。