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11.发明授权Medical devices employing conductive polymers for delivery of therapeutic agents 有权使用导电聚合物递送治疗剂的医疗装置公开(公告)号：US08275455B2
公开(公告)日：2012-09-25
申请号：US12487203
申请日：2009-06-18
IPC分类号： A61N1/30
CPC分类号： A61M25/1029 , A61F2002/0081 , A61F2250/0068 , A61K9/0009 , A61K31/00 , A61K31/337 , A61K31/4745 , A61K31/52 , A61L27/50 , A61L27/54 , A61L29/14 , A61L29/16 , A61L2300/416 , A61L2300/602 , A61M25/10 , A61M25/104 , A61M2025/0057 , A61M2025/0058 , A61M2025/1031 , A61M2025/105 , A61M2025/1086 , A61M2025/1088 , A61M2025/1093
摘要： In accordance with one aspect, the invention relates to medical devices which comprise at least one reservoir, a therapeutic-agent-containing region disposed within the reservoir and an electrode comprising a conductive polymer. The devices of the invention are configured such that a rate of release of the therapeutic agent from the reservoir changes upon a change in the oxidation state of the conductive polymer.
摘要翻译： 根据一个方面，本发明涉及包括至少一个贮存器，设置在储存器内的含治疗剂的区域和包含导电聚合物的电极的医疗装置。 本发明的装置被配置成使得治疗剂从贮存器释放的速率随着导电聚合物的氧化态的变化而变化。
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公开(公告)号：US08834912B2
公开(公告)日：2014-09-16
申请号：US11322905
申请日：2005-12-30
CPC分类号： A61L15/46 , A61F2/0077 , A61F2/91 , A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2210/0076 , A61F2230/0054 , A61F2310/00574 , A61F2310/00592 , A61F2310/0097 , A61L27/28 , A61L27/54 , A61L31/08 , A61L31/16 , A61L2300/61 , A61L2400/12 , A61L2420/04
摘要： According to an aspect of the present invention, medical devices are provided, which are adapted for implantation or insertion into a subject and which include at least one multilayer region that contains multiple charged layers of alternating charge. The multiple charged layers, in turn, include the following: (i) at least one charged block copolymer (e.g., a charged block copolymer that contains one or more polyelectrolyte blocks) and (ii) at least one charged therapeutic agent (e.g., a charged therapeutic agent that contains one or more polyelectrolyte blocks).
摘要翻译： 根据本发明的一个方面，提供了适于植入或插入到受试者中并且包括至少一个多层区域的医疗装置，所述至少一个多层区域包含交替充电的多个带电层。 多个带电层又包括以下：（i）至少一个带电荷的嵌段共聚物（例如，含有一个或多个聚电解质嵌段的带电嵌段共聚物）和（ii）至少一种带电荷的治疗剂（例如， 含有一种或多种聚电解质块的电荷治疗剂）。
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公开(公告)号：US08277833B2
公开(公告)日：2012-10-02
申请号：US12489996
申请日：2009-06-23
CPC分类号： A61L31/022 , A61L31/08
摘要： According to an aspect of the present invention, medical devices are provided which comprise a metallic region and a coating on all or part of the metallic region that comprises a multivalent acid.
摘要翻译： 根据本发明的一个方面，提供了包括金属区域和包含多价酸的全部或部分金属区域上的涂层的医疗装置。
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公开(公告)号：US20090324684A1
公开(公告)日：2009-12-31
申请号：US12489996
申请日：2009-06-23
CPC分类号： A61L31/022 , A61L31/08
摘要： According to an aspect of the present invention, medical devices are provided which comprise a metallic region and a coating on all or part of the metallic region that comprises a multivalent acid.
摘要翻译： 根据本发明的一个方面，提供了包括金属区域和包含多价酸的全部或部分金属区域上的涂层的医疗装置。
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公开(公告)号：US20110238153A1
公开(公告)日：2011-09-29
申请号：US13069961
申请日：2011-03-23
申请人： Liliana Atanasoska , Angela Kostrewa , Rajesh Radhakrishnan , Robert W. Warner , Lagiang Tran , James Lee Shippy, III , Edward E. Parsonage
发明人： Liliana Atanasoska , Angela Kostrewa , Rajesh Radhakrishnan , Robert W. Warner , Lagiang Tran , James Lee Shippy, III , Edward E. Parsonage
CPC分类号： C25B3/00 , A61F2/91 , A61F2210/0004 , A61F2210/0076 , A61F2250/0068 , C25F3/00
摘要： Endoprostheses include an endoprosthesis wall that includes a surface layer that includes a metallic material and that defines a plurality of discrete pores. A porous material is disposed in one or more pores of the surface layer. The endoprostheses can, for example, deliver a therapeutic agent, such as a drug, in a controlled manner over an extended period of time.
摘要翻译： 内假体包括内置假体壁，其包括包含金属材料并且限定多个离散孔的表面层。 多孔材料设置在表面层的一个或多个孔中。 内用假体可以例如以长期的控制方式递送诸如药物的治疗剂。
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16.发明申请STENT WITH DIFFERENTIAL TIMING OF ABLUMINAL AND LUMINAL RELEASE OF A THERAPEUTIC AGENT 审中-公开治疗药物的尿素和尿素释放的差异时间公开(公告)号：US20090062910A1
公开(公告)日：2009-03-05
申请号：US11940503
申请日：2007-11-15
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91575 , A61F2230/0013 , A61L31/10 , A61L31/16 , A61L2300/00 , A61L2300/608 , A61L2420/08
摘要： The invention relates generally to a medical device that is useful for delivering a therapeutic agent to the body tissue of a patient, and the method for making such a medical device. More particularly, the invention is directed to a stent having a tubular sidewall with a first coating composition on at least the luminal surface and/or abluminal surface, and a second coating composition disposed on at least a portion of the first coating composition comprising a low diffusivity biodegradable polymer.
摘要翻译： 本发明总体上涉及可用于将治疗剂递送到患者的身体组织的医疗装置以及用于制造这种医疗装置的方法。 更具体地说，本发明涉及一种具有管状侧壁的支架，该管状侧壁至少在腔表面和/或外侧表面上具有第一涂层组合物，第二涂层组合物设置在第一涂层组合物的至少一部分上， 扩散性生物降解聚合物。
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公开(公告)号：US07927362B2
公开(公告)日：2011-04-19
申请号：US11186370
申请日：2005-07-21
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2002/9583
摘要： The stent placement dilation balloon assembly comprises a catheter having a distal end, a distal end portion, and a proximal end, a balloon mounted to, about, and around the distal end portion of the catheter. The assembly further includes an elastic sheath positioned about and around the balloon. The outer surface of the sheath includes a profile which encourages stent securement. A stent is mounted on the sleeve for placement in a vessel in a human body.
摘要翻译： 支架放置扩张气囊组件包括具有远端，远端部分和近端的导管，安装到导管的远端部分周围和周围的气囊。 组件还包括围绕和围绕气球定位的弹性护套。 护套的外表面包括鼓励支架固定的轮廓。 将支架安装在套筒上以放置在人体内的容器中。
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公开(公告)号：US08690824B2
公开(公告)日：2014-04-08
申请号：US13441664
申请日：2012-04-06
CPC分类号： A61M25/1002 , A61F2/958 , A61L29/16 , A61M25/1038 , A61M2025/1004 , A61M2025/1031 , A61M2025/1088
摘要： This disclosure relates to medical devices and related methods. In some embodiments, the methods include applying a material to the balloon and then removing the material from one or more regions of the balloon.
摘要翻译： 本公开涉及医疗装置和相关方法。 在一些实施例中，所述方法包括将材料施加到球囊，然后从气囊的一个或多个区域移除材料。
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公开(公告)号：US08153181B2
公开(公告)日：2012-04-10
申请号：US11599052
申请日：2006-11-14
CPC分类号： A61M25/1002 , A61F2/958 , A61L29/16 , A61M25/1038 , A61M2025/1004 , A61M2025/1031 , A61M2025/1088
摘要： This disclosure relates to medical devices and related methods. In some embodiments, the methods include applying a material to the balloon and then removing the material from one or more regions of the balloon.
摘要翻译： 本公开涉及医疗装置和相关方法。 在一些实施例中，所述方法包括将材料施加到球囊，然后从气囊的一个或多个区域移除材料。
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公开(公告)号：US20120197380A1
公开(公告)日：2012-08-02
申请号：US13441664
申请日：2012-04-06
CPC分类号： A61M25/1002 , A61F2/958 , A61L29/16 , A61M25/1038 , A61M2025/1004 , A61M2025/1031 , A61M2025/1088
摘要： This disclosure relates to medical devices and related methods. In some embodiments, the methods include applying a material to the balloon and then removing the material from one or more regions of the balloon.
摘要翻译： 本公开涉及医疗装置和相关方法。 在一些实施例中，所述方法包括将材料施加到球囊，然后从气囊的一个或多个区域移除材料。
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