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1.发明申请STENT WITH DIFFERENTIAL TIMING OF ABLUMINAL AND LUMINAL RELEASE OF A THERAPEUTIC AGENT 审中-公开治疗药物的尿素和尿素释放的差异时间公开(公告)号：US20090062910A1
公开(公告)日：2009-03-05
申请号：US11940503
申请日：2007-11-15
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91575 , A61F2230/0013 , A61L31/10 , A61L31/16 , A61L2300/00 , A61L2300/608 , A61L2420/08
摘要： The invention relates generally to a medical device that is useful for delivering a therapeutic agent to the body tissue of a patient, and the method for making such a medical device. More particularly, the invention is directed to a stent having a tubular sidewall with a first coating composition on at least the luminal surface and/or abluminal surface, and a second coating composition disposed on at least a portion of the first coating composition comprising a low diffusivity biodegradable polymer.
摘要翻译： 本发明总体上涉及可用于将治疗剂递送到患者的身体组织的医疗装置以及用于制造这种医疗装置的方法。 更具体地说，本发明涉及一种具有管状侧壁的支架，该管状侧壁至少在腔表面和/或外侧表面上具有第一涂层组合物，第二涂层组合物设置在第一涂层组合物的至少一部分上， 扩散性生物降解聚合物。
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公开(公告)号：US08771343B2
公开(公告)日：2014-07-08
申请号：US11763770
申请日：2007-06-15
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61F2/91 , A61F2002/30322 , A61F2250/0026 , A61F2250/0056 , A61F2310/00616 , A61F2310/0097 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/00 , B05D1/32
摘要： Medical devices, such as endoprostheses, and methods of making the devices are described. In some embodiments, a medical device includes a body of interconnected bands and connectors forming an elongated tubular structure having an inner luminal wall surface and an outer abluminal wall surface and defining a central lumen or passageway. The inner luminal wall surface and side wall surface of the bands and connectors forming transverse passageways through the elongated tubular structure can bear a coating of hydrophilic material and the outer abluminal wall surface of the tubular structure can bear a coating of hydrophobic material.
摘要翻译： 描述医疗装置，例如内用假体，以及制造装置的方法。 在一些实施例中，医疗装置包括互连带的主体和形成细长管状结构的连接器，其具有内管腔壁表面和外侧腔壁表面，并限定中央腔或通道。 形成穿过细长管状结构的横向通道的带和连接件的内腔壁表面和侧壁表面可以承受亲水材料的涂层，并且管状结构的外侧壁面可承受疏水材料的涂层。
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4.发明授权Medical devices employing conductive polymers for delivery of therapeutic agents 有权使用导电聚合物递送治疗剂的医疗装置公开(公告)号：US08275455B2
公开(公告)日：2012-09-25
申请号：US12487203
申请日：2009-06-18
IPC分类号： A61N1/30
CPC分类号： A61M25/1029 , A61F2002/0081 , A61F2250/0068 , A61K9/0009 , A61K31/00 , A61K31/337 , A61K31/4745 , A61K31/52 , A61L27/50 , A61L27/54 , A61L29/14 , A61L29/16 , A61L2300/416 , A61L2300/602 , A61M25/10 , A61M25/104 , A61M2025/0057 , A61M2025/0058 , A61M2025/1031 , A61M2025/105 , A61M2025/1086 , A61M2025/1088 , A61M2025/1093
摘要： In accordance with one aspect, the invention relates to medical devices which comprise at least one reservoir, a therapeutic-agent-containing region disposed within the reservoir and an electrode comprising a conductive polymer. The devices of the invention are configured such that a rate of release of the therapeutic agent from the reservoir changes upon a change in the oxidation state of the conductive polymer.
摘要翻译： 根据一个方面，本发明涉及包括至少一个贮存器，设置在储存器内的含治疗剂的区域和包含导电聚合物的电极的医疗装置。 本发明的装置被配置成使得治疗剂从贮存器释放的速率随着导电聚合物的氧化态的变化而变化。
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公开(公告)号：US20100222873A1
公开(公告)日：2010-09-02
申请号：US12715577
申请日：2010-03-02
申请人： Liliana Atanasoska , James Lee Shippy, III , Tom Holman , Michael S. Amey , Victor Schoenle , Frank Genovese , James Q. Feng , Aiden Flanagan , Jan Weber
发明人： Liliana Atanasoska , James Lee Shippy, III , Tom Holman , Michael S. Amey , Victor Schoenle , Frank Genovese , James Q. Feng , Aiden Flanagan , Jan Weber
CPC分类号： A61L31/148 , A61L27/34 , A61L27/446 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/128 , A61L31/16 , A61L2300/416 , A61L2300/604 , A61L2400/12 , A61L2420/04 , C08L67/04
摘要： A medical implant includes a bioerodible portion that includes a bioerodible polymer and a bioerodible metal. The bioerodible polymer matrix degrades under physiological conditions to form acidic degradation products. The bioerodible metal degrades under physiological conditions to form basic degradation products. The acidic degradation products and the basic degradation products buffer at least a portion of the medical implant. In one aspect, the bioerodible portion includes a bioerodible polymer matrix and a bioerodible metal within the bioerodible polymer matrix. In another aspect, the medical implant can include a body, a plurality of discrete deposits of the bioerodible polymer on the body, and a plurality of discrete deposits of the bioerodible metal on the body.
摘要翻译： 医疗植入物包括生物腐蚀性部分，其包括生物可蚀解聚合物和生物腐蚀性金属。 生物可蚀解聚合物基质在生理条件下降解形成酸性降解产物。 生物腐蚀金属在生理条件下降解形成碱性降解产物。 酸性降解产物和碱性降解产物缓冲至少一部分医用植入物。 在一个方面，生物可蚀解部分包括生物可腐蚀聚合物基质和生物可腐蚀的聚合物基质内的生物可腐蚀金属。 在另一方面，医疗植入物可以包括主体，身体上的生物可蚀解聚合物的多个离散沉积物，以及身体上的生物可腐蚀金属的多个离散沉积物。
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公开(公告)号：US08834560B2
公开(公告)日：2014-09-16
申请号：US13051496
申请日：2011-03-18
申请人： Jan Weber , Liliana Atanasoska , James Lee Shippy, III , Torsten Scheuermann , Daniel J. Gregorich , Michael P. Meyer
发明人： Jan Weber , Liliana Atanasoska , James Lee Shippy, III , Torsten Scheuermann , Daniel J. Gregorich , Michael P. Meyer
CPC分类号： A61L31/088 , A61L31/044 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/16 , Y10T29/49826 , C08L67/04
摘要： Among other things, a bio-erodible implantable endoprosthesis comprises a member that includes (a) a core having a surface, and (b) a bio-erodible metal on a least a portion of the surface of the core, wherein the bio-erodible metal erodes more slowly than the core and includes openings through which physiological fluids can access the core upon implantation.
摘要翻译： 除其他之外，生物可蚀刻的可植入内用假体包括一种构件，其包括（a）具有表面的芯，和（b）所述芯的表面的至少一部分上的生物可侵蚀金属，其中所述生物可蚀刻 金属腐蚀比核心更慢，并且包括生理流体在植入时可通过其进入核心的开口。
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7.发明申请MEDICAL DEVICES EMPLOYING CONDUCTIVE POLYMERS FOR DELIVERY OF THERAPEUTIC AGENTS 有权采用导电聚合物输送治疗药物的医疗器械公开(公告)号：US20090318848A1
公开(公告)日：2009-12-24
申请号：US12487203
申请日：2009-06-18
IPC分类号： A61N1/30
CPC分类号： A61M25/1029 , A61F2002/0081 , A61F2250/0068 , A61K9/0009 , A61K31/00 , A61K31/337 , A61K31/4745 , A61K31/52 , A61L27/50 , A61L27/54 , A61L29/14 , A61L29/16 , A61L2300/416 , A61L2300/602 , A61M25/10 , A61M25/104 , A61M2025/0057 , A61M2025/0058 , A61M2025/1031 , A61M2025/105 , A61M2025/1086 , A61M2025/1088 , A61M2025/1093
摘要： In accordance with one aspect, the invention relates to medical devices which comprise at least one reservoir, a therapeutic-agent-containing region disposed within the reservoir and an electrode comprising a conductive polymer. The devices of the invention are configured such that a rate of release of the therapeutic agent from the reservoir changes upon a change in the oxidation state of the conductive polymer.
摘要翻译： 根据一个方面，本发明涉及包括至少一个贮存器，设置在储存器内的含治疗剂的区域和包含导电聚合物的电极的医疗装置。 本发明的装置被配置成使得治疗剂从贮存器释放的速率随着导电聚合物的氧化态的变化而变化。
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公开(公告)号：US08834912B2
公开(公告)日：2014-09-16
申请号：US11322905
申请日：2005-12-30
CPC分类号： A61L15/46 , A61F2/0077 , A61F2/91 , A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2210/0076 , A61F2230/0054 , A61F2310/00574 , A61F2310/00592 , A61F2310/0097 , A61L27/28 , A61L27/54 , A61L31/08 , A61L31/16 , A61L2300/61 , A61L2400/12 , A61L2420/04
摘要： According to an aspect of the present invention, medical devices are provided, which are adapted for implantation or insertion into a subject and which include at least one multilayer region that contains multiple charged layers of alternating charge. The multiple charged layers, in turn, include the following: (i) at least one charged block copolymer (e.g., a charged block copolymer that contains one or more polyelectrolyte blocks) and (ii) at least one charged therapeutic agent (e.g., a charged therapeutic agent that contains one or more polyelectrolyte blocks).
摘要翻译： 根据本发明的一个方面，提供了适于植入或插入到受试者中并且包括至少一个多层区域的医疗装置，所述至少一个多层区域包含交替充电的多个带电层。 多个带电层又包括以下：（i）至少一个带电荷的嵌段共聚物（例如，含有一个或多个聚电解质嵌段的带电嵌段共聚物）和（ii）至少一种带电荷的治疗剂（例如， 含有一种或多种聚电解质块的电荷治疗剂）。
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公开(公告)号：US08728170B1
公开(公告)日：2014-05-20
申请号：US11694436
申请日：2007-03-30
CPC分类号： A61L27/40 , A61L27/14 , A61L27/50 , A61L27/58 , A61L2400/12
摘要： A bioerodible conductive tissue scaffold that can provide, e.g., improved tissue growth.
摘要翻译： 可以提供例如改善的组织生长的生物蚀蚀性导电组织支架。
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公开(公告)号：US08267992B2
公开(公告)日：2012-09-18
申请号：US12715577
申请日：2010-03-02
申请人： Liliana Atanasoska , James Lee Shippy, III , Tom Holman , Michael S. Arney , Victor Schoenle , Frank Genovese , James Q. Feng , Aiden Flanagan , Jan Weber
发明人： Liliana Atanasoska , James Lee Shippy, III , Tom Holman , Michael S. Arney , Victor Schoenle , Frank Genovese , James Q. Feng , Aiden Flanagan , Jan Weber
IPC分类号： A61F2/06
CPC分类号： A61L31/148 , A61L27/34 , A61L27/446 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/128 , A61L31/16 , A61L2300/416 , A61L2300/604 , A61L2400/12 , A61L2420/04 , C08L67/04
摘要： A medical implant includes a bioerodible portion that includes a bioerodible polymer and a bioerodible metal. The bioerodible polymer matrix degrades under physiological conditions to form acidic degradation products. The bioerodible metal degrades under physiological conditions to form basic degradation products. The acidic degradation products and the basic degradation products buffer at least a portion of the medical implant. In one aspect, the bioerodible portion includes a bioerodible polymer matrix and a bioerodible metal within the bioerodible polymer matrix. In another aspect, the medical implant can include a body, a plurality of discrete deposits of the bioerodible polymer on the body, and a plurality of discrete deposits of the bioerodible metal on the body.
摘要翻译： 医疗植入物包括生物腐蚀性部分，其包括生物可蚀解聚合物和生物腐蚀性金属。 生物可蚀解聚合物基质在生理条件下降解形成酸性降解产物。 生物腐蚀金属在生理条件下降解形成碱性降解产物。 酸性降解产物和碱性降解产物缓冲至少一部分医用植入物。 在一个方面，生物可蚀解部分包括生物可腐蚀聚合物基质和生物可腐蚀的聚合物基质内的生物可腐蚀金属。 在另一方面，医疗植入物可以包括主体，身体上的生物可蚀解聚合物的多个离散沉积物，以及身体上的生物可腐蚀金属的多个离散沉积物。
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