利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

19 条记录 (耗时 0.031 秒)

    Implantable therapy systems and methods
    11.
    发明授权
    Implantable therapy systems and methods 失效
    植入式治疗系统和方法

    公开(公告)号：US5487739A

    公开(公告)日：1996-01-30

    申请号：US459815

    申请日：1995-06-02

    申请人： Patrick Aebischer ,  Moses Goddard ,  John G. Moldauer ,  Paul J. Mulhauser ,  Anne M. Rathbun ,  Paul R. Sanberg ,  Alfred V. Vasconcellos ,  Nicholas F. Warner

    发明人： Patrick Aebischer ,  Moses Goddard ,  John G. Moldauer ,  Paul J. Mulhauser ,  Anne M. Rathbun ,  Paul R. Sanberg ,  Alfred V. Vasconcellos ,  Nicholas F. Warner

    IPC分类号： A61F2/02 ,  A61K9/00 ,  A61K9/50 ,  A61K35/12 ,  A61K35/55 ,  A61M31/00 ,  A61M39/02 ,  B01J13/02 ,  C12N5/00 ,  C12N5/071 ,  C12N5/0793 ,  C12N11/04 ,  A61K9/22

    CPC分类号： A61K9/0092 ,  A61F2/022 ,  A61K35/55 ,  A61K9/0024 ,  A61K9/0085 ,  A61M31/002 ,  A61M37/0069 ,  A61M39/0208 ,  B01J13/02 ,  C12N11/04 ,  C12N5/0012 ,  C12N5/0614 ,  C12N5/0619 ,  C12N5/0676 ,  A61K2035/126 ,  A61M2210/0687 ,  A61M2210/0693 ,  C12N2533/30

    摘要： Implantable therapy systems are disclosed for the local and controlled delivery of a biologically active factor to the brain, spinal cord and other target regions of a subject suffering from a debilitating condition. The method of the invention involves surgically exposing an insertion site, generally located above a predetermined treatment site (12), in a patient. A cannula (20), having an obturator (30) or dilator (104) positioned therein, is inserted at the insertion site, defining a pathway to the treatment site. In some instances, the cannula can be inserted along the path of a guidewire (102) previously positioned at the treatment site. The cannula (20) is preferably a low friction polymeric material such as polytetrafluoroethylene. The cannula (20) generally has an open proximal end for receiving the obturator (30) or dilator (104), and an open distal end, preferably a tapered end, for delivery of neurologically active factors to the treatment site (12). The obturator (30) is then removed from the cannula (20), and a biocompatible tethered vehicle (40) containing a biologically active material is inserted into the cannula along the passageway. A pusher can be inserted within the cannula, behind the vehicle (40), to position the proximal end of the vehicle at the distal end of the cannula (20b). Once the vehicle (40) is positioned near the distal end of the cannula (20), the cannula is removed from the passageway, followed by the pusher, leaving the vehicle (40) positioned at the treatment site (12).

    摘要翻译： 公开了植入式治疗系统，用于将局部和受控制的生物活性因子递送至患有衰弱病症的受试者的脑，脊髓和其他目标区域。 本发明的方法涉及通常在患者体内暴露通常位于预定治疗部位（12）上方的插入部位。 具有定位在其中的闭塞器（30）或扩张器（104）的插管（20）插入插入位置，从而限定到治疗部位的通路。 在一些情况下，套管可以沿着预先位于治疗部位的导丝（102）的路径插入。 插管（20）优选为低摩擦聚合材料，例如聚四氟乙烯。 插管（20）通常具有用于接收封闭器（30）或扩张器（104）的开放近端，以及用于将神经活性因子递送至治疗部位（12）的开口远端，优选地为锥形末端。 然后将塞子（30）从插管（20）中取出，并且将包含生物活性物质的生物相容性系留载体（40）沿通道插入插管中。 推动器可以插入插管内，在车辆（40）后面，以将车辆的近端定位在套管（20b）的远端。 一旦车辆（40）定位在套管（20）的远端附近，则套管从通道中移除，随后是推动器，使车辆（40）位于治疗部位（12）处。

    Resuscitation mask having ribs in the air flow conduit and mask body
    12.
    发明授权
    Resuscitation mask having ribs in the air flow conduit and mask body 失效
    在空气流动管道和面罩主体中具有肋的复苏面具

    公开(公告)号：US5465712A

    公开(公告)日：1995-11-14

    申请号：US100592

    申请日：1993-07-30

    申请人： Jerry Malis ,  Jonathan J. Rosen ,  Martin T. Mortimer ,  Alfred V. Vasconcellos

    发明人： Jerry Malis ,  Jonathan J. Rosen ,  Martin T. Mortimer ,  Alfred V. Vasconcellos

    IPC分类号： A61M16/06 ,  A61M16/20 ,  A62B18/02 ,  A62B18/10

    CPC分类号： A61M16/06 ,  A61M16/0048 ,  A62B18/025 ,  A61M16/0683 ,  A61M16/208 ,  Y10S128/912

    摘要： Briefly stated, the present invention comprises a resuscitation mask for administering artificial respiration to a patient. The respiration mask has a container for defining an interior region between the container and the face of the patient. Two conduits are provided through the container wall in order to define two air flow passageways which are in fluid communication with the internal region. A valve is disposed in one air flow passageway for permitting air flow into the internal region and preventing air flow from the internal region. A vent is provided to reduce pressure within the internal region in response to an increase in pressure within the internal region. The container is generally cup-shaped and, in the preferred embodiment, it is formed with a cylindrical member coupled to the one-way air flow conduit. The other airflow passageway is adapted to be detachably coupled to an oxygen source. A pressure openable closure permits pressure within the interior region of the resuscitation mask to be released by a further conduit.

    摘要翻译： 简而言之，本发明包括用于向患者施用人工呼吸的复苏面罩。 呼吸面罩具有用于限定容器和患者面部之间的内部区域的容器。 通过容器壁设置两个管道，以限定与内部区域流体连通的两个气流通道。 阀设置在一个气流通道中，用于允许空气流入内部区域并防止空气从内部区域流出。 提供排气口以响应于内部区域内的压力增加而减小内部区域内的压力。 容器通常为杯形，并且在优选实施例中，其形成有联接到单向空气流动导管的圆柱形构件。 另一气流通道适于可拆卸地联接到氧气源。 压力可打开的封闭件允许在复苏面罩的内部区域内的压力被另外的导管释放。

    Blood recovery system and method
    13.
    发明授权
    Blood recovery system and method 失效
    血液回收系统及方法

    公开(公告)号：US4923438A

    公开(公告)日：1990-05-08

    申请号：US220193

    申请日：1988-07-18

    申请人： Alfred V. Vasconcellos ,  Preston J. Keeler, III

    发明人： Alfred V. Vasconcellos ,  Preston J. Keeler, III

    IPC分类号： A61M1/00 ,  A61M1/36

    CPC分类号： A61M1/3627 ,  A61M1/0007

    摘要： An intraoperative blood recovery system and method for salvaging operative blood while simultaneously delivering previously collected blood to a reinfusion system. A blood collection and transfer reservoir, having multiple compartments which can be separated by vacuum or pressure barriers, is designed to maintain a continuous suction for blood inflow while blood previously collected can be simultaneously transported through the reservoir to achieve an uninterrupted flow of blood into and delivery of blood out of the reservoir.

    Implantable therapy systems and methods
    16.
    发明授权
    Implantable therapy systems and methods 失效
    植入式治疗系统和方法

    公开(公告)号：US06179826B2

    公开(公告)日：2001-01-30

    申请号：US08741228

    申请日：1996-10-29

    申请人： Patrick Aebischer ,  Moses Goddard ,  John G. Moldauer ,  Paul J. Mulhauser ,  Anne M. Rathbun ,  Paul R. Sanberg ,  Alfred V. Vasconcellos ,  Nicholas F. Warner

    发明人： Patrick Aebischer ,  Moses Goddard ,  John G. Moldauer ,  Paul J. Mulhauser ,  Anne M. Rathbun ,  Paul R. Sanberg ,  Alfred V. Vasconcellos ,  Nicholas F. Warner

    IPC分类号： A61M3100

    CPC分类号： A61K9/0092 ,  A61F2/022 ,  A61K9/0024 ,  A61K9/0085 ,  A61K35/55 ,  A61K2035/126 ,  A61M31/002 ,  A61M37/0069 ,  A61M39/0208 ,  A61M2210/0687 ,  A61M2210/0693 ,  B01J13/02 ,  C12N5/0012 ,  C12N5/0614 ,  C12N5/0619 ,  C12N5/0676 ,  C12N11/04 ,  C12N2533/30 ,  A61M2230/005

    摘要： Implantable therapy systems are disclosed for the local and controlled delivery of a biologically active factor to the brain, spinal cord and other target regions of a subject suffering from a dibilatating condition. The method of the invention involves surgically exposing an insertion site, generally located above a predetermined treatment site (12), in a patient. A cannula (20), having an obturator (30) or dilator (104) positioned therein, is inserted at the insertion site, defining a pathway to the treatment site. In some instances, the cannula can be inserted along the path of a guidewire (102) previously positioned at the treatment site. The cannula (20) is preferably a low friction polymeric material such as polytetrafluoroethylene. The cannula (20) generally has an open proximal end for receiving the obturator (30) or dilator (104), and an open distal end, preferably a tapered end, for delivery of neurologically active factors to the treatment site (12). The obturator (30) is then removed from the cannula (20), and a biocompatible tethered vehicle (40) containing a biologically active material is inserted into the cannula along the passageway. A pusher can be inserted within the cannula, behind the vehicle (40), to position the proximal end of the vehicle at the proximal tip of the cannula (20b). Once the vehicle (40) is positioned near the proximal end of the cannula (20), the cannula is removed from the passageway, followed by the pusher, leaving the vehicle (40) positioned at the treatment site (12).

    摘要翻译： 公开了植入式治疗系统，用于将局部和受控制的生物活性因子递送至患有二体化病症的受试者的脑，脊髓和其他靶区域。 本发明的方法涉及通常在患者体内暴露通常位于预定治疗部位（12）上方的插入部位。 具有定位在其中的闭塞器（30）或扩张器（104）的插管（20）插入插入位置，从而限定到治疗部位的通路。 在一些情况下，套管可以沿着预先位于治疗部位的导丝（102）的路径插入。 插管（20）优选为低摩擦聚合材料，例如聚四氟乙烯。 插管（20）通常具有用于接收封闭器（30）或扩张器（104）的开放近端，以及用于将神经活性因子递送至治疗部位（12）的开口远端，优选地为锥形末端。 然后将塞子（30）从插管（20）中取出，并且将包含生物活性物质的生物相容性系留载体（40）沿通道插入插管中。 推动器可以插入插管内，在车辆（40）后面，以将车辆的近端定位在套管（20b）的近端处。 一旦车辆（40）定位在套管（20）的近端附近，则套管从通道中移开，随后是推动器，使车辆（40）位于治疗部位（12）处。

    Blood recovery system and method
    18.
    发明授权
    Blood recovery system and method 失效
    血液回收系统及方法

    公开(公告)号：US5024613A

    公开(公告)日：1991-06-18

    申请号：US515397

    申请日：1990-04-27

    申请人： Alfred V. Vasconcellos ,  Preston J. Keeler, III

    发明人： Alfred V. Vasconcellos ,  Preston J. Keeler, III

    IPC分类号： A61M1/00 ,  A61M1/36

    CPC分类号： A61M1/3627 ,  A61M1/0005

    摘要： An intraoperative blood recovery system and method for salvaging operative blood while simultaneously delivering previously collected blood to a reinfusion system. A blood collection and transfer reservoir, having multiple compartments which can be separated by vacuum or pressure barriers, is designed to maintain a continuous suction for blood inflow while blood previously collected can be simultaneously transported through the reservoir to achieve the uninterrupted flow of blood into and delivery of blood out of the reservoir.

    摘要翻译： 一种术中血液回收系统和方法，用于回收手术血液，同时将以前收集的血液输送到再灌注系统。 设有具有可被真空或压力屏障隔开的多个隔间的血液采集和转运储存器被设计成保持血液流入的连续抽吸，同时先前收集的血液可以同时传送通过储存器，以实现血液不间断流入和 将血液送出水库。

    Surgical instrument for establishing compression anastomosis
    19.
    发明授权
    Surgical instrument for establishing compression anastomosis 失效
    手术器械用于建立压缩吻合

    公开(公告)号：US4907591A

    公开(公告)日：1990-03-13

    申请号：US174570

    申请日：1988-03-29

    申请人： Alfred V. Vasconcellos ,  Ionel E. Teodorescu ,  Joel W. Cummings ,  Dean E. McBeth

    发明人： Alfred V. Vasconcellos ,  Ionel E. Teodorescu ,  Joel W. Cummings ,  Dean E. McBeth

    IPC分类号： A61B17/11 ,  A61B17/115

    CPC分类号： A61B17/115 ,  A61B17/1155

    摘要： A surgical instrument for installing a plurality of interlocking coupling members forming a compression anastomosis assembly, particularly suitable for use in achieving anastomosis of a resected tubular organ, with the instrument having a cutting portion designed and configured for rotational movement as the cutter advances to perform its intended functions of severing tissue and at least a portion of one of the members of the assembly. Also disclosed is a dual locking feature for alternately locking a driving component and an aligning component against movement where, in a first mode, the aligning component is operative when the driving component is locked and, in a second mode, the driving component is operative when the aligning component is locked. Additionally disclosed is a unique aligning component for aligning and exerting a compressive force on members of an associated coupling assembly. Lastly, there is disclosed a surgical instrument capable of assuming a variety of configurations to accommodate a number of anatomical orientations and operating situations.