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公开(公告)号：US4907591A
公开(公告)日：1990-03-13
申请号：US174570
申请日：1988-03-29
IPC分类号： A61B17/11 , A61B17/115
CPC分类号： A61B17/115 , A61B17/1155
摘要： A surgical instrument for installing a plurality of interlocking coupling members forming a compression anastomosis assembly, particularly suitable for use in achieving anastomosis of a resected tubular organ, with the instrument having a cutting portion designed and configured for rotational movement as the cutter advances to perform its intended functions of severing tissue and at least a portion of one of the members of the assembly. Also disclosed is a dual locking feature for alternately locking a driving component and an aligning component against movement where, in a first mode, the aligning component is operative when the driving component is locked and, in a second mode, the driving component is operative when the aligning component is locked. Additionally disclosed is a unique aligning component for aligning and exerting a compressive force on members of an associated coupling assembly. Lastly, there is disclosed a surgical instrument capable of assuming a variety of configurations to accommodate a number of anatomical orientations and operating situations.
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2.发明授权Methods for treatment or prevention of neurodegenerative conditions using immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core 失效使用具有生物相容性护套和生物相容性基质芯的免疫隔离植入式车辆治疗或预防神经变性病症的方法
公开(公告)号：US5871767A
公开(公告)日：1999-02-16
申请号：US449062
申请日：1995-05-24
申请人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
发明人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
IPC分类号： A61F2/02 , A61K9/00 , A61K9/48 , A61K9/50 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/18 , A61K39/395 , A61K47/36 , A61K48/00 , A61L27/00 , C12N5/00 , C12N5/071 , C12N5/077 , A61K9/14
CPC分类号： A61K9/0092 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/185 , A61K48/00 , A61K9/0024 , A61K9/4816 , C12N5/0012 , C12N5/0062 , C12N5/0614 , C12N5/0656 , C12N5/0677 , A61K2035/126 , A61K2035/128 , C12N2510/02 , Y10S514/814 , Y10S514/866
摘要： A method for treatment of a neurodegenerative condition in a patient comprising implanting in the patient at least one immunoisolatory vehicle comprising a corc comprising a volume of at least 1 .mu.l and at least 10.sup.4 living cells which secrete at least one biologically active product, said cells being dispersed in a biocompatible matrix comprising a hydrogel or extracellular matrix components, and an external jacket surrounding the core, the jacket comprising a biocompatible hydrogel or thermoplastic, the jacket being free of cells projecting externally thereof, said jacket having a molecular weight cutoff permitting the passage of the biologically active product from the core through the jacket.
摘要翻译： 一种用于治疗患者神经变性病症的方法，包括在患者体内植入至少一种包含至少1μl的体积的corc和至少分泌至少一种生物活性产物的至少104个活细胞的免疫佐剂，所述细胞 分散在包含水凝胶或细胞外基质组分的生物相容性基质中，以及围绕芯的外护套，所述护套包括生物相容的水凝胶或热塑性塑料，所述护套不含外部突出的细胞，所述护套具有允许 生物活性产物从芯通过夹套。
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3.发明授权Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products 失效用于递送选定治疗产品的植入式生物相容性免疫佐剂
公开(公告)号：US5800828A
公开(公告)日：1998-09-01
申请号：US179151
申请日：1994-01-10
申请人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
发明人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
IPC分类号： A61F2/02 , A61K9/00 , A61K9/48 , A61K9/50 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/18 , A61K39/395 , A61K47/36 , A61K48/00 , A61L27/00 , C12N5/00 , C12N5/071 , C12N5/077 , A61K9/14
CPC分类号： A61K9/0092 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/185 , A61K48/00 , A61K9/0024 , A61K9/4816 , C12N5/0012 , C12N5/0062 , C12N5/0614 , C12N5/0656 , C12N5/0677 , A61K2035/126 , A61K2035/128 , C12N2510/02 , Y10S514/814 , Y10S514/866
摘要： Immunoisolatory vehicles having a core and a surrounding jacket are disclosed, the core having a volume in excess of 1 .mu.l and at least about 10.sup.4 living cells capable of secreting a biologically active product or of providing a biological function to a patient, the cells dispersed in a biocompatible matrix formed of a hydrogel or an extracellular matrix component, and the external jacket being permselective, biocompatible and having a molecular weight cutoff permitting passage of molecules between the patient and the core through said jacket to provide said biological product or function.
摘要翻译： 公开了具有核心和周围护套的免疫佐剂，核心具有超过1μl的体积和至少约104个能够分泌生物活性产物或者向患者提供生物学功能的活细胞，所述细胞分散 在由水凝胶或细胞外基质组分形成的生物相容性基质中，并且所述外部护套是选择性选择性的，生物相容性的并且具有分子量截留允许通过所述护套在患者和核之间通过分子以提供所述生物产物或功能。
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公开(公告)号：USD309350S
公开(公告)日：1990-07-17
申请号：US56565
申请日：1987-06-01
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5.发明申请COMPOSITIONS CONTAINING SERTOLI CELLS AND MYOID CELLS AND USE THEREOF IN CELLULAR TRANSPLANTS 审中-公开含有SERTOLI细胞和MYOID细胞的组合物及其在细胞运输中的应用公开(公告)号：US20090162331A1
公开(公告)日：2009-06-25
申请号：US12118453
申请日：2008-05-09
申请人： Jannette Dufour , Craig Halberstadt , Richelle Hemendinger , Ray V. Rajotte , Alfred V. Vasconcellos , Paul Gores , Dwaine Emerich , Greg Korbutt
发明人： Jannette Dufour , Craig Halberstadt , Richelle Hemendinger , Ray V. Rajotte , Alfred V. Vasconcellos , Paul Gores , Dwaine Emerich , Greg Korbutt
IPC分类号： A61K35/12
CPC分类号： C12N5/0683 , A61K2035/122 , C12N5/0697 , C12N2502/246
摘要： The present invention relates to the use of Sertoli cells and myoid cells for creating an immunologically privileged site in a mammalian subject, thereby facilitating the transplantation of cells that produce a biological factor in the treatment of a disease that results from a deficiency of such biological factor. Pharmaceutical compositions containing Sertoli cells and myoid cells, as well as therapeutic methods relating to the use of these cells are provided by the present invention.
摘要翻译： 本发明涉及用于在哺乳动物受试者中产生免疫特异性位点的Sertoli细胞和骨髓细胞的用途，从而促进产生生物因子的细胞在由这种生物因子的不足导致的疾病的治疗中的移植 。 含有Sertoli细胞和肌细胞的药物组合物以及与这些细胞的使用相关的治疗方法由本发明提供。
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6.发明授权Implantable biocompatable immunoisolatory vehicle for delivery of selected therapeutic products 有权用于递送选定治疗产品的可植入生物相容性免疫佐剂
公开(公告)号：US6083523A
公开(公告)日：2000-07-04
申请号：US148671
申请日：1998-09-04
申请人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
发明人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
IPC分类号： A61F2/02 , A61K9/00 , A61K9/48 , A61K9/50 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/18 , A61K39/395 , A61K47/36 , A61K48/00 , A61L27/00 , C12N5/00 , C12N5/071 , C12N5/077
CPC分类号： A61K9/0092 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/185 , A61K48/00 , A61K9/0024 , A61K9/4816 , C12N5/0012 , C12N5/0062 , C12N5/0614 , C12N5/0656 , C12N5/0677 , A61K2035/126 , A61K2035/128 , C12N2510/02 , Y10S514/814 , Y10S514/866
摘要： An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective, biocompatible, peripheral region free of the isolated cells, which immunoisolates the core yet provides for the delivery of the secreted product or metabolic function to the individual.
摘要翻译： 用于植入到产生所需产品或提供所需代谢功能的细胞个体中的免疫分析载体。 载体由含有分离的细胞和足以维持细胞的材料的核心区域组成，以及不含分离细胞的选择性选择性生物相容的外周区域，所述细胞免疫分离核心，但提供分泌产物或代谢功能的递送， 个人
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公开(公告)号：US5795330A
公开(公告)日：1998-08-18
申请号：US728440
申请日：1996-10-10
IPC分类号： A61J1/05 , A61F2/28 , A61F2/46 , A61J1/00 , A61J1/06 , A61J1/14 , A61J1/20 , A61M37/00 , B01F11/00 , B01F13/00 , B01F15/02
CPC分类号： B01F13/002 , A61F2/28 , A61F2/46 , A61F2/4601 , A61J1/067 , A61J1/2093 , B01F11/0065 , B01F15/0205 , B01F15/0212 , B01F15/026 , B65D81/3266 , A61J1/1468 , A61J1/201 , A61J1/2027 , A61J1/2086 , A61J1/2096 , B01F15/0201
摘要： A mixer for the mixing of a first and a second component, comprising a flexible pouch which contains said first component and which has an inner surface that is non-retaining to the components; means for supplying the second component to the chamber for mixing with the first component; and a neck attached to said pouch.
摘要翻译： 一种用于混合第一和第二部件的混合器，包括含有所述第一部件的柔性袋，并且具有不保持在所述部件上的内表面; 用于将所述第二部件供应到所述室以与所述第一部件混合的装置; 和连接到所述袋的颈部。
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公开(公告)号：US5980482A
公开(公告)日：1999-11-09
申请号：US948435
申请日：1997-10-10
IPC分类号： A61J1/05 , A61F2/28 , A61F2/46 , A61J1/00 , A61J1/06 , A61J1/14 , A61J1/20 , A61M37/00 , B01F11/00 , B01F13/00 , B01F15/02
CPC分类号： B01F13/002 , A61F2/28 , A61F2/46 , A61F2/4601 , A61J1/067 , A61J1/2093 , B01F11/0065 , B01F15/0205 , B01F15/0212 , B01F15/026 , B65D81/3266 , A61J1/1468 , A61J1/201 , A61J1/2027 , A61J1/2086 , A61J1/2096 , B01F15/0201
摘要： A mixer for the mixing of components, comprising a continuous inner surface that is non-retaining to the components, wherein a first portion of the inner surface opposably contacts a second portion of the inner surface during mixing, and a means for supplying a component to the mixer; a kit including the mixer, and methods of using the mixer to prepare compositions.
摘要翻译： 一种用于混合部件的混合器，包括不保持部件的连续内表面，其中内表面的第一部分在混合期间可相对接触内表面的第二部分，以及用于将部件供应到 搅拌机 包括混合器的试剂盒和使用混合器制备组合物的方法。
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9.发明授权Methods for treating diabetes by delivering insulin from biocompatible cell-containing devices 失效通过从含生物相容性细胞的装置递送胰岛素来治疗糖尿病的方法
公开(公告)号：US5869077A
公开(公告)日：1999-02-09
申请号：US449562
申请日：1995-05-24
申请人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
发明人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
IPC分类号： A61F2/02 , A61K9/00 , A61K9/48 , A61K9/50 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/18 , A61K39/395 , A61K47/36 , A61K48/00 , A61L27/00 , C12N5/00 , C12N5/071 , C12N5/077
CPC分类号： A61K9/0092 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/185 , A61K48/00 , A61K9/0024 , A61K9/4816 , C12N5/0012 , C12N5/0062 , C12N5/0614 , C12N5/0656 , C12N5/0677 , A61K2035/126 , A61K2035/128 , C12N2510/02 , Y10S514/814 , Y10S514/866
摘要： A method for treating diabetes in a patient comprising subcutaneously implanting in the patient at least one immunoisolatory vehicle comprising a core comprising a volume of at least 1 .mu.l and at least about 10.sup.4 living cells which secrete insulin, said cells being dispersed in a biocompatible matrix comprising a hydrogel or extracellular matrix components, and a surrounding external jacket of a biocompatible thermoplastic or hydrogel free of said cells projecting externally thereof, said jacket being permselective and immunoisolatory, said jacket having a molecular weight cutoff permitting passage of molecules between the patient and core through said jacket wherein the insulin is released from the immunoisolatory vehicle into the patient's body to treat diabetes.
摘要翻译： 一种用于治疗患者的糖尿病的方法，包括在患者体内皮下植入至少一种免疫隔离性载体，所述至少一种免疫隔离载体包含至少含有至少1μl的体积和分泌胰岛素的至少约104个活细胞的核，所述细胞分散在生物相容性基质 包括水凝胶或细胞外基质组分，以及不含所述细胞从外部突出的生物相容性热塑性或水凝胶的外围护套，所述护套是选择性选择性的和免疫型的，所述护套具有分子量截留允许分子在患者和核心之间通过 通过所述护套，其中将胰岛素从免疫免疫介质释放到患者体内以治疗糖尿病。
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10.发明授权Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core 失效用生物相容性护套和生物相容性基质芯共挤出免疫隔离植入式车辆的方法
公开(公告)号：US5800829A
公开(公告)日：1998-09-01
申请号：US449274
申请日：1995-05-24
申请人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
发明人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
CPC分类号： A61K9/0092 , A61K9/0024 , A61K2035/126 , A61K2035/128 , C12N2510/00
摘要： A method of making an immunoisolatory vehicle comprised of a core comprising living cells dispersed in a biocompatible matrix is disclosed, the cells being capable of secreting a biologically active product or of providing a metabolic or immunologic function to an individual, and an external jacket surrounding said core which is a biocompatible, permselective thermoplastic or hydrogel, said jacket being free of said cells, comprising coextruding a suspension comprising said cells dispersed in a precursor matrix material comprising extracellular matrix components or a biocompatible hydrogel precursor, and a solution of a biocompatible jacket precursor from a nested dual-bore extrusion nozzle, wherein the suspension of (a) is coextruded from the inner bore and the solution of (b) is coextruded from the outer bore of the nozzle, to form said jacket as the solution of (b) and the suspension of (a) arc coextruded; and exposing the vehicle to a treatment that forms a core comprising a volume of at least 1 .mu.l and at least 10.sup.4 cells and comprising a biocompatible matrix from the precursor matrix of solution (a).
摘要翻译： 公开了一种制备由包含分散在生物相容性基质中的活细胞的核心组成的免疫隔离性载体的方法，所述细胞能够分泌生物活性产物或向个体提供代谢或免疫功能，以及围绕所述 核心，其是生物相容的选择性热塑性或水凝胶，所述护套不含所述细胞，包括共挤出包含分散在包含细胞外基质组分或生物相容性水凝胶前体的前体基质材料中的所述细胞的悬浮液，以及生物相容性护套前体 从嵌套的双孔挤出喷嘴中，其中（a）的悬浮液从内孔共挤出并且（b）的溶液从喷嘴的外孔共挤出，形成作为（b）的溶液的所述夹套， 和（a）电弧共挤出的悬浮液; 并将载体暴露于形成包含体积至少为1μl和至少104个细胞并且包含来自溶液（a）的前体基质的生物相容性基质的核心的处理。
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