公开(公告)号：US12030043B2

公开(公告)日：2024-07-09

申请号：US17620392

申请日：2020-06-19

Applicant: MCMASTER UNIVERSITY

Inventor： Leyla Soleymani ,  Igor Zhitomirsky ,  Amanda Victorious ,  Amanda Clifford

IPC: B01J35/39 ,  B01J21/06 ,  B01J31/06 ,  B01J35/23

CPC classification number: B01J35/39 ,  B01J21/063 ,  B01J31/062 ,  B01J35/23

Abstract: This application relates to a photoactive product comprising: a catechol-containing compound, an amine-containing polymer, and photoactive material. The photoactive product can act as a photocatalyst and can be used in photoelectrodes for use in, for example, photoelectrochemical analyte sensing, including biosensing. The photoelectrodes modified with hybrid organic/inorganic materials can provide increased light absorption and charge separation, binding sites for attaching biorecognition probes, and built-in film-forming properties for well-adhered and uniform photoactive frameworks on the collector electrodes.

公开(公告)号：US20220065806A1

公开(公告)日：2022-03-03

申请号：US17466354

申请日：2021-09-03

Applicant: McMaster University

Inventor： Leyla Soleymani ,  Sudip Saha ,  Amanda Victorious

IPC: G01N27/30 ,  G01N27/327

Abstract: This disclosure relates to a biosensor for detecting a target analyte in a sample comprising a first and second photoelectrode each comprising conductive substrate and photoactive material, a first and second capture probe functionalized on the first and second photoelectrode, respectively, and optionally one or more reporter moieties comprising a detectable label, wherein the first and second capture probe each, independently, provides a distance between the detectable label and the photoactive material in the presence of the target analyte, wherein intensity of detection signal dictated by the distance is generated from the first and second photoelectrode by transfer of electrons between the detectable label and the photoactive material, wherein a higher, or higher increase than in absence of sample, in the intensity of the detection signal from the first as compared to the second photoelectrode in the presence of the sample, is indicative of the presence of the target analyte.

公开(公告)号：US20180067102A1

公开(公告)日：2018-03-08

申请号：US15632497

申请日：2017-06-26

Applicant: MCMASTER UNIVERSITY

Inventor： Warren Foster ,  Jocelyn Wessels ,  Sanjay Agarwal ,  Leyla Soleymani

IPC: G01N33/50 ,  G01N33/53 ,  B01L3/00

CPC classification number: G01N33/5023 ,  B01L3/5023 ,  B01L2300/0819 ,  C07K16/22 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/53 ,  G01N33/689 ,  G01N33/74 ,  G01N2333/475 ,  G01N2800/364 ,  G01N2800/52

Abstract: Methods for diagnosing or monitoring endometriosis in a mammal are provided. The methods include the steps of determining the expression levels of BDNF, glycodelin and optionally ZAG, in a biological sample from the mammal, and determining that the mammal has endometriosis when the biomarker expression levels in the sample are elevated.

公开(公告)号：US11221327B2

公开(公告)日：2022-01-11

申请号：US15632497

申请日：2017-06-26

Applicant: MCMASTER UNIVERSITY

Inventor： Warren Foster ,  Jocelyn Wessels ,  Sanjay Agarwal ,  Leyla Soleymani

IPC: G01N33/50 ,  B01L3/00 ,  G01N33/53 ,  C07K16/22 ,  G01N33/74 ,  C12Q1/6883 ,  G01N33/68

Abstract: Methods for diagnosing or monitoring endometriosis in a mammal are provided. The methods include the steps of determining the expression levels of BDNF, glycodelin and optionally ZAG, in a biological sample from the mammal, and determining that the mammal has endometriosis when the biomarker expression levels in the sample are elevated.

公开(公告)号：US11181500B2

公开(公告)日：2021-11-23

申请号：US16097429

申请日：2017-04-28

Applicant: McMaster University

Inventor： Christine Gabardo ,  Leyla Soleymani ,  Robert Chris Adams-McGavin

IPC: G01N27/327 ,  G01N27/30

Abstract: An all-solution electrode fabrication process is provided. The process comprises the steps of: i) preparing and activating a shrinkable polymer substrate for deposition of a a) conductive film; ii) modifying the substrate to incorporate a linker; iii) immobilizing particles of a conductive material on the linkers of the substrate to form a conductive film on the substrate; and vi) heating the modified substrate to a temperature sufficient to cause contraction of the polymer substrate and to result in micro- and/or nano-texturing in the conductive film. The process advantageously yields a novel multi-scale electrode device comprising a polymer substrate; and a textured electro-conductive film linked to the substrate.

公开(公告)号：US10478827B2

公开(公告)日：2019-11-19

申请号：US15060835

申请日：2016-03-04

Applicant: McMaster University

Inventor： Leyla Soleymani ,  Seyed Mohammadamin Hosseini

IPC: B03C1/28 ,  B03C1/033 ,  H01F41/30 ,  H01F7/06

Abstract: A device for manipulating magnetic particles, and the method of fabricating and use thereof. The device includes a substrate; a conductive element formed onto the substrate in a pattern shaped to enhance a magnetic field generated in response to an applied current; an insulating layer to isolate the conductive element from a magnetic element; and a magnetic element formed onto the insulating layer to enhance a magnetic force resulting from the magnetic field generated by the conductive element. The magnetic element can be shaped similarly to the conductive element, and edges of the magnetic element are substantially aligned with edges of the conductive element. During fabrication, the substrate and the conductive element can be heated to cause the substrate to shrink thereby resulting in a wrinkled structure at the conductive element. The device can be used to manipulate the magnetic particles within a biological sample, such as cells and/or biomolecules.

公开(公告)号：US20190154622A1

公开(公告)日：2019-05-23

申请号：US16097429

申请日：2017-04-28

Applicant: McMaster University

Inventor： Christine Gabardo ,  Leyla Soleymani ,  Robert Chris Adams-McGavin

IPC: G01N27/327 ,  G01N27/30

Abstract: An all-solution electrode fabrication process is provided, The process comprises the steps of: i) preparing and activating a shrinkable polymer substrate for deposition of a a) conductive film; ii) modifying the substrate to incorporate a linker; iii) immobilizing particles of a conductive material on the linkers of the substrate to form a conductive film on the substrate; and vi) heating the modified substrate to a temperature sufficient to cause contraction of the polymer substrate and to result in micro- and/or nano-texturing in the conductive film. The process advantageously yields a novel multi-scale electrode device comprising a polymer substrate; and a textured electro-conductive film linked to the substrate.